After testing for biased treatment assignment in an observational study using an unaffected outcome, the sensitivity analysis is constrained to be compatible with that test. The package uses the optimization software gurobi obtainable from <https://www.gurobi.com/>, together with its associated R package, also called gurobi; see: <https://www.gurobi.com/documentation/7.0/refman/installing_the_r_package.html>. The method is a substantial computational and practical enhancement of a concept introduced in Rosenbaum (1992) Detecting bias with confidence in observational studies Biometrika, 79(2), 367-374 <doi:10.1093/biomet/79.2.367>.

Enables the user to find the country, region, district, city, coordinates, zip code, time zone, ISP, domain name, connection type, area code, weather, Mobile Country Code, Mobile Network Code, mobile brand name, elevation, usage type, address type, IAB category and Autonomous system information that any IP address or hostname originates from. Supported IPv4 and IPv6. Please visit <https://www.ip2location.com> to learn more. You may also want to visit <https://lite.ip2location.com> for free database download. This package requires IP2Location Python module. At the terminal, please run pip install IP2Location to install the module.

It provides miscellaneous sequence analysis functions for describing episodes in individual sequences, measuring association between domains in multidimensional sequence analysis (see Piccarreta (2017) <doi:10.1177/0049124115591013>), heat maps of sequence data, Globally Interdependent Multidimensional Sequence Analysis (see Robette et al (2015) <doi:10.1177/0081175015570976>), smoothing sequences for index plots (see Piccarreta (2012) <doi:10.1177/0049124112452394>), coding sequences for Qualitative Harmonic Analysis (see Deville (1982)), measuring stress from multidimensional scaling factors (see Piccarreta and Lior (2010) <doi:10.1111/j.1467-985X.2009.00606.x>), symmetrical (or canonical) Partial Least Squares (see Bry (1996)).

This package provides a wavelet-based LSTM model is a type of neural network architecture that uses wavelet technique to pre-process the input data before passing it through a Long Short-Term Memory (LSTM) network. The wavelet-based LSTM model is a powerful approach that combines the benefits of wavelet analysis and LSTM networks to improve the accuracy of predictions in various applications. This package has been developed using the algorithm of Anjoy and Paul (2017) and Paul and Garai (2021) <DOI:10.1007/s00521-017-3289-9> <doi:10.1007/s00500-021-06087-4>.

seq.hotSPOT provides a resource for designing effective sequencing panels to help improve mutation capture efficacy for ultradeep sequencing projects. Using SNV datasets, this package designs custom panels for any tissue of interest and identify the genomic regions likely to contain the most mutations. Establishing efficient targeted sequencing panels can allow researchers to study mutation burden in tissues at high depth without the economic burden of whole-exome or whole-genome sequencing. This tool was developed to make high-depth sequencing panels to study low-frequency clonal mutations in clinically normal and cancerous tissues.

This package performs hybrid multiple testing that incorporates method selection and assumption evaluations into the analysis using EBP estimates obtained by Grenander density estimation. For instance, for 3-group comparison analysis, Hybrid Multiple testing considers EBPs as weighted EBPs between F-test and H-test with EBPs from Shapiro Wilk test of normality as weight. Instead of just using EBPs from F-test only or using H-test only, this methodology combines both types of EBPs through EBPs from Shapiro Wilk test of normality. This methodology uses then the law of total EBPs.

This package implements two algorithms of detecting Bull and Bear markets in stock prices: the algorithm of Pagan and Sossounov (2002, <doi:10.1002/jae.664>) and the algorithm of Lunde and Timmermann (2004, <doi:10.1198/073500104000000136>). The package also contains functions for printing out the dating of the Bull and Bear states of the market, the descriptive statistics of the states, and functions for plotting the results. For the sake of convenience, the package includes the monthly and daily data on the prices (not adjusted for dividends) of the S&P 500 stock market index.

Shows statistics about bytes contained in a file as a circle graph of deviations from mean in sigma increments. The function can be useful for statistically analyze the content of files in a glimpse: text files are shown as a green centered crown, compressed and encrypted files should be shown as equally distributed variations with a very low CV (sigma/mean), and other types of files can be classified between these two categories depending on their text vs binary content, which can be useful to quickly determine how information is stored inside them (databases, multimedia files, etc).

This package provides novel dendroclimatological methods, primarily used by the Tree-ring research community. There are four core functions. The first one is daily_response(), which finds the optimal sequence of days that are related to one or more tree-ring proxy records. Similar function is daily_response_seascorr(), which implements partial correlations in the analysis of daily response functions. For the enthusiast of monthly data, there is monthly_response() function. The last core function is compare_methods(), which effectively compares several linear and nonlinear regression algorithms on the task of climate reconstruction.

An interface for training Fuzzy DBScan with both Fuzzy Core and Fuzzy Border. Therefore, the package provides a method to initialize and run the algorithm and a function to predict new data w.t.h. of R6'. The package is build upon the paper "Fuzzy Extensions of the DBScan algorithm" from Ienco and Bordogna (2018) <doi:10.1007/s00500-016-2435-0>. A predict function assigns new data according to the same criteria as the algorithm itself. However, the prediction function freezes the algorithm to preserve the trained cluster structure and treats each new prediction object individually.

This package provides functions to access real-time infectious disease data from the disease.sh API', including COVID-19 global, US states, continent, and country statistics, vaccination coverage, influenza-like illness data from Centers for Disease Control and Prevention (CDC), and more. Also includes curated datasets on a variety of infectious diseases such as influenza, measles, dengue, Ebola, tuberculosis, meningitis, AIDS, and others. The package supports epidemiological research and data analysis by combining API access with high-quality historical and survey datasets on infectious diseases. For more details on the disease.sh API', see <https://disease.sh/>.

Fit a time-series model to a crop phenology data, such as time-series rice canopy height. This package returns the model parameters as the summary statistics of crop phenology, and these parameters will be useful to characterize the growth pattern of each cultivar and predict manually-measured traits, such as days to heading and biomass. Please see Taniguchi et al. (2022) <doi:10.3389/fpls.2022.998803> and Taniguchi et al. (2025) <doi: 10.3389/frai.2024.1477637> for detail. This package has been designed for scientific use. Use for commercial purposes shall not be allowed.

This package provides infrastructure for psychometric modeling such as data classes (for item response data and paired comparisons), basic model fitting functions (for Bradley-Terry, Rasch, parametric logistic IRT, generalized partial credit, rating scale, multinomial processing tree models), extractor functions for different types of parameters (item, person, threshold, discrimination, guessing, upper asymptotes), unified inference and visualizations, and various datasets for illustration. It is intended as a common lightweight and efficient toolbox for psychometric modeling and a common building block for fitting psychometric mixture models in package psychomix and trees based on psychometric models in package psychotree.

Trigger-rally is a 3D rally simulation with great physics for drifting on over 200 maps. Different terrain materials like dirt, asphalt, sand, ice, etc. and various weather, light, and fog conditions give this rally simulation the edge over many other games. You need to make it through the maps in often tight time limits and can further improve by beating the recorded high scores. All attached single races must be finished in time in order to win an event, unlocking additional events and cars. Most maps are equipped with spoken co-driver notes and co-driver icons.

Allows the construction selection indices based on estimated breeding values in animal and plant breeding and to calculate several analytic measures around to assess its impact on genetic and phenotypic progress. The methodology thereby allows to analyze genetic gain of traits in the breeding goal which are not part of the actual index and automatically computes several analytic measures. It further allows to retrospectively derive realized economic weights from observed genetic trends. The framework is described in Simianer, H., Heise, J., Rensing, S., Pook, T. Geibel, J. and Reimer, C. (2023) <doi:10.1186/s12711-023-00807-0>.

This package provides functions for cost-optimal control charts with a focus on health care applications. Compared to assumptions in traditional control chart theory, here, we allow random shift sizes, random repair and random sampling times. The package focuses on X-bar charts with a sample size of 1 (representing the monitoring of a single patient at a time). The methods are described in Zempleni et al. (2004) <doi:10.1002/asmb.521>, Dobi and Zempleni (2019) <doi:10.1002/qre.2518> and Dobi and Zempleni (2019) <http://ac.inf.elte.hu/Vol_049_2019/129_49.pdf>.

Computational infrastructure for biogeography, community ecology, and biodiversity conservation (Daru et al. 2020) <doi:10.1111/2041-210X.13478>. It is based on the methods described in Daru et al. (2020) <doi:10.1038/s41467-020-15921-6>. The original conceptual work is described in Daru et al. (2017) <doi:10.1016/j.tree.2017.08.013> on patterns and processes of biogeographical regionalization. Additionally, the package contains fast and efficient functions to compute more standard conservation measures such as phylogenetic diversity, phylogenetic endemism, evolutionary distinctiveness and global endangerment, as well as compositional turnover (e.g., beta diversity).

This package provides basic functions that support an implementation of object case (Case 1) best-worst scaling: a function for converting a two-level orthogonal main-effect design/balanced incomplete block design into questions; two functions for creating a data set suitable for analysis; a function for calculating count-based scores; a function for calculating shares of preference; and a function for generating artificial responses to questions. See Louviere et al. (2015) <doi:10.1017/CBO9781107337855> for details on best-worst scaling, and Aizaki and Fogarty (2023) <doi:10.1016/j.jocm.2022.100394> for the package.

The ProteinGymR package provides analysis-ready data resources from ProteinGym, generated by Notin et al., 2023, as well as built-in functionality to visualize the data. ProteinGym comprises a collection of benchmarks for evaluating the performance of models predicting the effect of point mutations. This package provides access to 1. deep mutational scanning (DMS) scores from 217 assays measuring the impact of all possible amino acid substitutions across 186 proteins, 2. model performance metrics and prediction scores from 79 variant prediction models in the zero-shot setting and 12 models in the semi-supervised setting.

This package provides a function that facilitates fitting three types of models for contrast-based Bayesian Network Meta Analysis. The first model is that which is described in Lu and Ades (2006) <doi:10.1198/016214505000001302>. The other two models are based on a Bayesian nonparametric methods that permit ties when comparing treatment or for a treatment effect to be exactly equal to zero. In addition to the model fits, the package provides a summary of the interplay between treatment effects based on the procedure described in Barrientos, Page, and Lin (2023) <doi:10.48550/arXiv.2207.06561>.

Three semi-parametric methods for detection of outliers in environmental data based on kernel regression and subsequent analysis of smoothing residuals. The first method (Campulova, Michalek, Mikuska and Bokal (2018) <DOI: 10.1002/cem.2997>) analyzes the residuals using changepoint analysis, the second method is based on control charts (Campulova, Veselik and Michalek (2017) <DOI: 10.1016/j.apr.2017.01.004>) and the third method (Holesovsky, Campulova and Michalek (2018) <DOI: 10.1016/j.apr.2017.06.005>) analyzes the residuals using extreme value theory (Holesovsky, Campulova and Michalek (2018) <DOI: 10.1016/j.apr.2017.06.005>).

This package provides an extensive collection of datasets related to medicine, diseases, treatments, drugs, and public health. This package covers topics such as drug effectiveness, vaccine trials, survival rates, infectious disease outbreaks, and medical treatments. The included datasets span various health conditions, including AIDS, cancer, bacterial infections, and COVID-19, along with information on pharmaceuticals and vaccines. These datasets are sourced from the R ecosystem and other R packages, remaining unaltered to ensure data integrity. This package serves as a valuable resource for researchers, analysts, and healthcare professionals interested in conducting medical and public health data analysis in R.

Computes how the correlation between 2 time-series changes over time. To do so, the package follows the method from Choi & Shin (2021) <doi:10.1007/s42952-020-00073-6>. It performs a non-parametric kernel smoothing (using a common bandwidth) of all underlying components required for the computation of a correlation coefficient (i.e., x, y, x^2, y^2, xy). An automatic selection procedure for the bandwidth parameter is implemented. Alternative kernels can be used (Epanechnikov, box and normal). Both Pearson and Spearman correlation coefficients can be estimated and change in correlation over time can be tested.

Assay for Transpose-Accessible Chromatin using sequencing (ATAC-seq) is a technique to assess genome-wide chromatin accessibility by probing open chromatin with hyperactive mutant Tn5 Transposase that inserts sequencing adapters into open regions of the genome. ATACseqTFEA is an improvement of the current computational method that detects differential activity of transcription factors (TFs). ATACseqTFEA not only uses the difference of open region information, but also (or emphasizes) the difference of TFs footprints (cutting sites or insertion sites). ATACseqTFEA provides an easy, rigorous way to broadly assess TF activity changes between two conditions.