When a network is partially observed (here, NAs in the adjacency matrix rather than 1 or 0 due to missing information between node pairs), it is possible to account for the underlying process that generates those NAs. missSBM', presented in Barbillon, Chiquet and Tabouy (2022) <doi:10.18637/jss.v101.i12>, adjusts the popular stochastic block model from network data sampled under various missing data conditions, as described in Tabouy, Barbillon and Chiquet (2019) <doi:10.1080/01621459.2018.1562934>.

The unique function of this package allows representing in a single graph the relative occurrence and co-occurrence of events measured in a sample. As examples, the package was applied to describe the occurrence and co-occurrence of different species of bacterial or viral symbionts infecting arthropods at the individual level. The graphics allows determining the prevalence of each symbiont and the patterns of multiple infections (i.e. how different symbionts share or not the same individual hosts). We named the package after the famous painter as the graphical output recalls Mondrianâ s paintings.

Supply functions for the creation and handling of missing data as well as tools to evaluate missing data methods. Nearly all possibilities of generating missing data discussed by Santos et al. (2019) <doi:10.1109/ACCESS.2019.2891360> and some additional are implemented. Functions are supplied to compare parameter estimates and imputed values to true values to evaluate missing data methods. Evaluations of these types are done, for example, by Cetin-Berber et al. (2019) <doi:10.1177/0013164418805532> and Kim et al. (2005) <doi:10.1093/bioinformatics/bth499>.

Quantifies ecological memory in long time-series using Random Forest models ('Benito', Gil-Romera', and Birks 2019 <doi:10.1111/ecog.04772>) fitted with ranger (Wright and Ziegler 2017 <doi:10.18637/jss.v077.i01>). Ecological memory is assessed by modeling a response variable as a function of lagged predictors, distinguishing endogenous memory (lagged response) from exogenous memory (lagged environmental drivers). Designed for palaeoecological datasets and simulated pollen curves from virtualPollen', but applicable to any long time-series with environmental drivers and a biotic response.

This package provides a comprehensive set of tools for working with order statistics, including functions for simulating order statistics, censored samples (Type I and Type II), and record values from various continuous distributions. Additionally, it offers functions to compute moments (mean, variance, skewness, kurtosis) of order statistics for several continuous distributions. These tools assist researchers and statisticians in understanding and analyzing the properties of order statistics and related data. The methods and algorithms implemented in this package are based on several published works, including Ahsanullah et al (2013, ISBN:9789491216831), Arnold and Balakrishnan (2012, ISBN:1461236444), Harter and Balakrishnan (1996, ISBN:9780849394522), Balakrishnan and Sandhu (1995) <doi:10.1080/00031305.1995.10476150>, Genç (2012) <doi:10.1007/s00362-010-0320-y>, Makouei et al (2021) <doi:10.1016/j.cam.2021.113386> and Nagaraja (2013) <doi:10.1016/j.spl.2013.06.028>.

Fast imputations under the object-oriented programming paradigm. Moreover there are offered a few functions built to work with popular R packages such as data.table or dplyr'. The biggest improvement in time performance can be achieved for a calculation where a grouping variable is used. A single evaluation of a quantitative model for the multiple imputations is another major enhancement. A new major improvement is one of the fastest predictive mean matching in the R world because of presorting and binary search.

This package provides a collection of functions for converting and visualization the free induction decay of mono dimensional nuclear magnetic resonance (NMR) spectra into an audio file. It facilitates the conversion of Bruker datasets in files WAV. The sound of NMR signals could provide an alternative to the current representation of the individual metabolic fingerprint and supply equally significant information. The package includes also NMR spectra of the urine samples provided by four healthy donors. Based on Cacciatore S, Saccenti E, Piccioli M. Hypothesis: the sound of the individual metabolic phenotype? Acoustic detection of NMR experiments. OMICS. 2015;19(3):147-56. <doi:10.1089/omi.2014.0131>.

This package provides a four step change point detection method that can detect break points with the presence of missing values proposed by Liu and Safikhani (2023) <https://drive.google.com/file/d/1a8sV3RJ8VofLWikTDTQ7W4XJ76cEj4Fg/view?usp=drive_link>.

Implementation of custom tidymodels metrics for multi-class prediction models with a single negative class. Currently are implemented macro-average sensitivity and specificity as in Mortaz, Ebrahim (2020) "Imbalance accuracy metric for model selection in multi-class imbalance classification problemsâ <doi:10.1016/j.knosys.2020.106490> and a generalized weighted Youden index as in Li, D.L., Shen F., Yin Y., Peng J.X and Chen P.Y. (2013) â Weighted Youden index and its two-independent-sample comparison based on weighted sensitivity and specificityâ <doi:10.3760/cma.j.issn.0366-6999.20123102>.

Deep Learning library that extends the mlr3 framework by building upon the torch package. It allows to conveniently build, train, and evaluate deep learning models without having to worry about low level details. Custom architectures can be created using the graph language defined in mlr3pipelines'.

An interface to build machine learning models for classification and regression problems. mikropml implements the ML pipeline described by TopçuoÄ lu et al. (2020) <doi:10.1128/mBio.00434-20> with reasonable default options for data preprocessing, hyperparameter tuning, cross-validation, testing, model evaluation, and interpretation steps. See the website <https://www.schlosslab.org/mikropml/> for more information, documentation, and examples.

Interactions between different biological entities are crucial for the function of biological systems. In such networks, nodes represent biological elements, such as genes, proteins and microbes, and their interactions can be defined by edges, which can be either binary or weighted. The dysregulation of these networks can be associated with different clinical conditions such as diseases and response to treatments. However, such variations often occur locally and do not concern the whole network. To capture local variations of such networks, we propose multiplex network differential analysis (MNDA). MNDA allows to quantify the variations in the local neighborhood of each node (e.g. gene) between the two given clinical states, and to test for statistical significance of such variation. Yousefi et al. (2023) <doi:10.1101/2023.01.22.525058>.

Build CPMs (cumulative probability models, also known as cumulative link models) to account for detection limits (both single and multiple detection limits) in response variables. Conditional quantiles and conditional CDFs can be calculated based on fitted models. The package implements methods described in Tian, Y., Li, C., Tu, S., James, N. T., Harrell, F. E., & Shepherd, B. E. (2022). "Addressing Detection Limits with Semiparametric Cumulative Probability Models". <arXiv:2207.02815>.

The Cauchy distribution is a special case of the t distribution when the degrees of freedom are equal to 1. The functions are related to the multivariate Cauchy distribution and include simulation, computation of the density, maximum likelihood estimation, contour plot of the bivariate Cauchy distribution, and discriminant analysis. References include: Nadarajah S. and Kotz S. (2008). "Estimation methods for the multivariate t distribution". Acta Applicandae Mathematicae, 102(1): 99--118. <doi:10.1007/s10440-008-9212-8>, and Kanti V. Mardia, John T. Kent and John M. Bibby (1979). "Multivariate analysis", ISBN:978-0124712522. Academic Press, London.

Local adaptation and evaluation of maps of continuous attributes in raster format by use of point location data.

This package provides functions for estimating structural equation models using instrumental variables.

Compute the average of a sequence of random vectors in a moving expanding window using a fixed amount of memory.

Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see Cnaan, Laird and Slasor (1997) <doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E> for a tutorial and Mallinckrodt, Lane, Schnell, Peng and Mancuso (2008) <doi:10.1177/009286150804200402> for a review. This package implements MMRM based on the marginal linear model without random effects using Template Model Builder ('TMB') which enables fast and robust model fitting. Users can specify a variety of covariance matrices, weight observations, fit models with restricted or standard maximum likelihood inference, perform hypothesis testing with Satterthwaite or Kenward-Roger adjustment, and extract least square means estimates by using emmeans'.

Computation of an estimation of the long-memory parameters and the long-run covariance matrix using a multivariate model (Lobato (1999) <doi:10.1016/S0304-4076(98)00038-4>; Shimotsu (2007) <doi:10.1016/j.jeconom.2006.01.003>). Two semi-parametric methods are implemented: a Fourier based approach (Shimotsu (2007) <doi:10.1016/j.jeconom.2006.01.003>) and a wavelet based approach (Achard and Gannaz (2016) <doi:10.1111/jtsa.12170>).

Multi-Fidelity emulator for data from computer simulations of the same underlying system but at different input locations and fidelity level, where both the input locations and fidelity level can be continuous. Active Learning can be performed with an implementation of the Integrated Mean Square Prediction Error (IMSPE) criterion developed by Boutelet and Sung (2025, <doi:10.48550/arXiv.2503.23158>).

This package provides a way to estimate and test marginal mediation effects for zero-inflated compositional mediators. Estimates of Natural Indirect Effect (NIE), Natural Direct Effect (NDE) of each taxon, as well as their standard errors and confident intervals, were provided as outputs. Zeros will not be imputed during analysis. See Wu et al. (2022) <doi:10.3390/genes13061049>.

Clustering via parsimonious Gaussian Mixtures of Experts using the MoEClust models introduced by Murphy and Murphy (2020) <doi:10.1007/s11634-019-00373-8>. This package fits finite Gaussian mixture models with a formula interface for supplying gating and/or expert network covariates using a range of parsimonious covariance parameterisations from the GPCM family via the EM/CEM algorithm. Visualisation of the results of such models using generalised pairs plots and the inclusion of an additional noise component is also facilitated. A greedy forward stepwise search algorithm is provided for identifying the optimal model in terms of the number of components, the GPCM covariance parameterisation, and the subsets of gating/expert network covariates.

This package provides some function to perform posterior estimation for some distribution, with emphasis to extreme value distributions. It contains some extreme datasets, and functions that perform the runs of posterior points of the GPD and GEV distribution. The package calculate some important extreme measures like return level for each t periods of time, and some plots as the predictive distribution, and return level plots.

Supports Bayesian models with full and partial (hence arbitrary) dependencies between random variables. Discrete and continuous variables are supported, and conditional joint probabilities and probability densities are estimated using Kernel Density Estimation (KDE). The full general form, which implements an extension to Bayes theorem, as well as the simple form, which is just a Bayesian network, both support regression through segmentation and KDE and estimation of probability or relative likelihood of discrete or continuous target random variables. This package also provides true statistical distance measures based on Bayesian models. Furthermore, these measures can be facilitated on neighborhood searches, and to estimate the similarity and distance between data points. Related work is by Bayes (1763) <doi:10.1098/rstl.1763.0053> and by Scutari (2010) <doi:10.18637/jss.v035.i03>.