This package performs mean shift classification using linear and k-d tree based nearest neighbor implementations for the Gaussian, Epanechnikov, and biweight product kernels.

This package provides a causal mediation framework for single-cell data that incorporates two key features ('MedZIsc', pronounced Magics): (1) zero-inflation using beta regression and (2) overdispersed expression counts using negative binomial regression. This approach also includes a screening step based on penalized and marginal models to handle high-dimensionality. Full methodological details are available in our recent preprint by Ahn S and Li Z (2025) <doi:10.48550/arXiv.2505.22986>.

Facilitates creation and manipulation of metric graphs, such as street or river networks. Further facilitates operations and visualizations of data on metric graphs, and the creation of a large class of random fields and stochastic partial differential equations on such spaces. These random fields can be used for simulation, prediction and inference. In particular, linear mixed effects models including random field components can be fitted to data based on computationally efficient sparse matrix representations. Interfaces to the R packages INLA and inlabru are also provided, which facilitate working with Bayesian statistical models on metric graphs. The main references for the methods are Bolin, Simas and Wallin (2024) <doi:10.3150/23-BEJ1647>, Bolin, Kovacs, Kumar and Simas (2023) <doi:10.1090/mcom/3929> and Bolin, Simas and Wallin (2023) <doi:10.48550/arXiv.2304.03190> and <doi:10.48550/arXiv.2304.10372>.

This package provides tools for estimating multivariate probit models, calculating conditional and unconditional expectations, and calculating marginal effects on conditional and unconditional expectations.

This package provides programmatic access to the Meetup GraphQL API (<https://www.meetup.com/graphql/>), enabling users to retrieve information about groups, events, and members from Meetup (<https://www.meetup.com/>). Supports authentication via OAuth2 and includes functions for common queries and data manipulation tasks.

Offers automation tools to parallelize Mplus operations when using R for data generation. It facilitates streamlined integration between Mplus and R', allowing users to run and manage multiple Mplus models simultaneously and efficiently in R'.

Inference of a multi-states birth-death model from a phylogeny, comprising a number of states N, birth and death rates for each state and on which edges each state appears. Inference is done using a hybrid approach: states are progressively added in a greedy approach. For a fixed number of states N the best model is selected via maximum likelihood. Reference: J. Barido-Sottani, T. G. Vaughan and T. Stadler (2018) <doi:10.1098/rsif.2018.0512>.

This package provides a simple tool allowing users to easily and dynamically explore or document a data set using a tree structure.

Constructs trees for multivariate survival data using marginal and frailty models. Grows, prunes, and selects the best-sized tree.

It computes arbitrary products moments (mean vector and variance-covariance matrix), for some double truncated (and folded) multivariate distributions. These distributions belong to the family of selection elliptical distributions, which includes well known skewed distributions as the unified skew-t distribution (SUT) and its particular cases as the extended skew-t (EST), skew-t (ST) and the symmetric student-t (T) distribution. Analogous normal cases unified skew-normal (SUN), extended skew-normal (ESN), skew-normal (SN), and symmetric normal (N) are also included. Density, probabilities and random deviates are also offered for these members.

Various functions for random number generation, density estimation, classification, curve fitting, and spatial data analysis.

This package provides a set of tools for testing networks. It includes functions for univariate and multivariate conditional uniform graph and quadratic assignment procedure testing, and network regression. The package is a complement to Multimodal Political Networks (2021, ISBN:9781108985000), and includes various datasets used in the book. Built on the manynet package, all functions operate with matrices, edge lists, and igraph', network', and tidygraph objects, and on one-mode and two-mode (bipartite) networks.

This package implements methods for estimating generalized estimating equations (GEE) with advanced options for flexible modeling and handling missing data. This package provides tools to fit and analyze GEE models for longitudinal data, allowing users to address missingness using a variety of imputation techniques. It supports both univariate and multivariate modeling, visualization of missing data patterns, and facilitates the transformation of data for efficient statistical analysis. Designed for researchers working with complex datasets, it ensures robust estimation and inference in longitudinal and clustered data settings.

This package provides a flexible framework for fitting multivariate ordinal regression models with composite likelihood methods. Methodological details are given in Hirk, Hornik, Vana (2020) <doi:10.18637/jss.v093.i04>.

Multivariate ARIMA and ARIMA-X estimation using Spliid's algorithm (marima()) and simulation (marima.sim()).

Perform correlation and linear regression test among the numeric fields in a data.frame automatically and make plots using pairs or lattice::parallelplot.

Simple helpers for matrix multiplication on data.frames. These allow for more concise code during low level mathematical operations, and help ensure code is more easily read, understood, and serviced.

Gibbs sampler for fitting multivariate Bayesian linear regression with shrinkage priors (MBSP), using the three parameter beta normal family. The method is described in Bai and Ghosh (2018) <doi:10.1016/j.jmva.2018.04.010>.

This package provides a function for plotting multivariate time series data.

Local recombination rates are graphically estimated across a genome using Marey maps.

Bayesian estimation of inverse variance weighted (IVW), Burgess et al. (2013) <doi:10.1002/gepi.21758>, and MR-Egger, Bowden et al. (2015) <doi:10.1093/ije/dyv080>, summary data models for Mendelian randomization analyses.

Supply functions for the creation and handling of missing data as well as tools to evaluate missing data methods. Nearly all possibilities of generating missing data discussed by Santos et al. (2019) <doi:10.1109/ACCESS.2019.2891360> and some additional are implemented. Functions are supplied to compare parameter estimates and imputed values to true values to evaluate missing data methods. Evaluations of these types are done, for example, by Cetin-Berber et al. (2019) <doi:10.1177/0013164418805532> and Kim et al. (2005) <doi:10.1093/bioinformatics/bth499>.

The Multivariate Asymptotic Non-parametric Test of Association (MANTA) enables non-parametric, asymptotic P-value computation for multivariate linear models. MANTA relies on the asymptotic null distribution of the PERMANOVA test statistic. P-values are computed using a highly accurate approximation of the corresponding cumulative distribution function. Garrido-Martà n et al. (2022) <doi:10.1101/2022.06.06.493041>.

This package provides a macro language for R programs, which provides a macro facility similar to SAS®'. This package contains basic macro capabilities like defining macro variables, executing conditional logic, and defining macro functions.