Linear regression model and generalized linear models with nonparametric network effects on network-linked observations. The model is originally proposed by Le and Li (2022) <doi:10.48550/arXiv.2007.00803> and is assumed on observations that are connected by a network or similar relational data structure. A more recent work by Wang, Le and Li (2024) <doi:10.48550/arXiv.2410.01163> further extends the framework to generalized linear models. All these models are implemented in the current package. The model does not assume that the relational data or network structure to be precisely observed; thus, the method is provably robust to a certain level of perturbation of the network structure. The package contains the estimation and inference function for the model.

This package provides a calculator for the two-dimensional clinical Disease Activity index for Psoriatic Arthritis (TwoDcDAPSA), a principal component-derived measure that complements the conventional clinical DAPSA score. TwoDcDAPSA captures residual variation in patient-reported outcomes (pain and patient global assessment) and joint counts (swollen and tender) after adjusting for standardized cDAPSA using natural spline coefficients derived from published models. Residuals are standardized and combined with fixed principal component loadings to yield two continuous component scores: the PROs-Joint Contrast (PJC) and the Swollenâ Tender joints Contrast (STC), along with quartile-based groupings (including optional combined quartile groupings). The package applies pre-specified coefficients, residual standardization, and loadings to new datasets but does not estimate spline models or principal components itself.

The core algorithm is described in "Ball mapper: a shape summary for topological data analysis" by Pawel Dlotko, (2019) <arXiv:1901.07410>. Please consult the following youtube video <https://www.youtube.com/watch?v=M9Dm1nl_zSQfor> the idea of functionality. Ball Mapper provide a topologically accurate summary of a data in a form of an abstract graph. To create it, please provide the coordinates of points (in the points array), values of a function of interest at those points (can be initialized randomly if you do not have it) and the value epsilon which is the radius of the ball in the Ball Mapper construction. It can be understood as the minimal resolution on which we use to create the model of the data.

Conley (1999) <doi:10.1016/S0304-4076(98)00084-0> spatial heteroscedasticity and autocorrelation consistent (HAC) standard errors for fixed effects panel and cross-sectional models estimated with felm() from the lfe package (ordinary least squares and instrumental variables) or with feols(), feglm(), and fepois() from the fixest package. Instrumental-variable support is limited to ordinary two-stage least squares. Generalized linear model fits use the M-estimation sandwich built from the stored scores and inverse Hessian. The spatial path uses score accumulation, a three-dimensional cell-grid neighbour search, and compressed sparse row neighbour lists instead of dense distance matrices, yielding large speedups over the original conley package <https://github.com/rbluhm/conley> on big cross-sections and high-dimensional regressions.

This package provides a model-agnostic safety layer for developers building with large language model (LLM) applications. Maps starter controls to the Open Worldwide Application Security Project Top 10 for Large Language Model Applications 2025 risk categories <https://genai.owasp.org/llm-top-10/> via a modular rule engine. Supports regular-expression rules, lightweight natural language processing (NLP) intent checks, optional scanners, and semantic large language model reviewer checks on prompts, conversations, retrieved context, tool inputs and outputs, streaming chunks, and model outputs. Supports workflows with the Ollama local web service <https://ollama.com/> via ellmer', remote reviewer endpoints, and other chat interfaces callable from R'. Intended as an experimental guardrail layer that teams should evaluate against their own workflows before relying on it in production.

Statistical inference with non-probability samples when auxiliary information from external sources such as probability samples or population totals or means is available. The package implements various methods such as inverse probability (propensity score) weighting, mass imputation and doubly robust approach. Details can be found in: Chen et al. (2020) <doi:10.1080/01621459.2019.1677241>, Yang et al. (2020) <doi:10.1111/rssb.12354>, Kim et al. (2021) <doi:10.1111/rssa.12696>, Yang et al. (2021) <https://www150.statcan.gc.ca/n1/pub/12-001-x/2021001/article/00004-eng.htm> and Wu (2022) <https://www150.statcan.gc.ca/n1/pub/12-001-x/2022002/article/00002-eng.htm>. For details on the package and its functionalities see <doi:10.18637/jss.v117.i02>.

This package performs genomic prediction of hybrid performance using eight GS methods including GBLUP, BayesB, RKHS, PLS, LASSO, Elastic net, XGBoost and LightGBM. GBLUP: genomic best liner unbiased prediction, RKHS: reproducing kernel Hilbert space, PLS: partial least squares regression, LASSO: least absolute shrinkage and selection operator, XGBoost: extreme gradient boosting, LightGBM: light gradient boosting machine. It also provides fast cross-validation and mating design scheme for training population (Xu S et al (2016) <doi:10.1111/tpj.13242>; Xu S (2017) <doi:10.1534/g3.116.038059>). A complete manual for this package is provided in the manual folder of the package installation directory. You can locate the manual by running the following command in R: system.file("manual", package = "predhy.GUI").

This toolkit is designed for manipulation and analysis of peptides. It provides functionalities to assist researchers in peptide engineering and proteomics. Users can manipulate peptides by adding amino acids at every position, count occurrences of each amino acid at each position, and transform amino acid counts based on probabilities. The package offers functionalities to select the best versus the worst peptides and analyze these peptides, which includes counting specific residues, reducing peptide sequences, extracting features through One Hot Encoding (OHE), and utilizing Quantitative Structure-Activity Relationship (QSAR) properties (based in the package Peptides by Osorio et al. (2015) <doi:10.32614/RJ-2015-001>). This package is intended for both researchers and bioinformatics enthusiasts working on peptide-based projects, especially for their use with machine learning.

This package provides an integrated pipeline for the analysis of PAR-CLIP data. PAR-CLIP-induced transitions are first discriminated from sequencing errors, SNPs and additional non-experimental sources by a non- parametric mixture model. The protein binding sites (clusters) are then resolved at high resolution and cluster statistics are estimated using a rigorous Bayesian framework. Post-processing of the results, data export for UCSC genome browser visualization and motif search analysis are provided. In addition, the package integrates RNA-Seq data to estimate the False Discovery Rate of cluster detection. Key functions support parallel multicore computing. While wavClusteR was designed for PAR-CLIP data analysis, it can be applied to the analysis of other NGS data obtained from experimental procedures that induce nucleotide substitutions (e.g. BisSeq).

The Datasaurus Dozen is a set of datasets with the same summary statistics. They retain the same summary statistics despite having radically different distributions. The datasets represent a larger and quirkier object lesson that is typically taught via Anscombe's Quartet (available in the 'datasets' package). Anscombe's Quartet contains four very different distributions with the same summary statistics and as such highlights the value of visualisation in understanding data, over and above summary statistics. As well as being an engaging variant on the Quartet, the data is generated in a novel way. The simulated annealing process used to derive datasets from the original Datasaurus is detailed in "Same Stats, Different Graphs: Generating Datasets with Varied Appearance and Identical Statistics through Simulated Annealing" doi:10.1145/3025453.3025912.

epidecodeR is a package capable of analysing impact of degree of DNA/RNA epigenetic chemical modifications on dysregulation of genes or proteins. This package integrates chemical modification data generated from a host of epigenomic or epitranscriptomic techniques such as ChIP-seq, ATAC-seq, m6A-seq, etc. and dysregulated gene lists in the form of differential gene expression, ribosome occupancy or differential protein translation and identify impact of dysregulation of genes caused due to varying degrees of chemical modifications associated with the genes. epidecodeR generates cumulative distribution function (CDF) plots showing shifts in trend of overall log2FC between genes divided into groups based on the degree of modification associated with the genes. The tool also tests for significance of difference in log2FC between groups of genes.

This package provides a graph community detection algorithm that aims to be performant on large graphs and robust, returning consistent results across runs. SpeakEasy 2 (SE2), the underlying algorithm, is described in Chris Gaiteri, David R. Connell & Faraz A. Sultan et al. (2023) <doi:10.1186/s13059-023-03062-0>. The core algorithm is written in C', providing speed and keeping the memory requirements low. This implementation can take advantage of multiple computing cores without increasing memory usage. SE2 can detect community structure across scales, making it a good choice for biological data, which often has hierarchical structure. Graphs can be passed to the algorithm as adjacency matrices using base R matrices, the Matrix library, igraph graphs, or any data that can be coerced into a matrix.

This package provides model data and functions for easily using machine learning models that use data from the DNA methylome to classify cancer type and phenotype from a sample. The primary motivation for the development of this package is to abstract away the granular and accessibility-limiting code required to utilize machine learning models in R. Our package provides this abstraction for RandomForest, e1071 Support Vector, Extreme Gradient Boosting, and Tensorflow models. This is paired with an ExperimentHub component, which contains models developed for epigenetic cancer classification and predicting phenotypes. This includes CNS tumor classification, Pan-cancer classification, race prediction, cell of origin classification, and subtype classification models. The package links to our models on ExperimentHub. The package currently supports HM450, EPIC, EPICv2, MSA, and MM285.

Given one or multiple paths to files produced by a PULSE multi-channel or a PULSE one-channel system (<https://electricblue.eu/pulse>) from a single experiment: [1] check pulse files for inconsistencies and read/merge all data, [2] split across time windows, [3] interpolate and smooth to optimize the dataset, [4] compute the heart rate frequency for each channel/window, and [5] facilitate quality control, summarising and plotting. Heart rate frequency is calculated using the Automatic Multi-scale Peak Detection algorithm proposed by Felix Scholkmann and team. For more details see Scholkmann et al (2012) <doi:10.3390/a5040588>. Check original code at <https://github.com/ig248/pyampd>. ElectricBlue is a non-profit technology transfer startup creating research-oriented solutions for the scientific community (<https://electricblue.eu>).

This package provides a powerful and flexible tool for visualizing proportional data across spatially resolved contexts. By combining the concepts of scatter plots and stacked bar charts, scatterbar allows users to create scattered bar chart plots, which effectively display the proportions of different categories at each (x, y) location. This visualization is particularly useful for applications where understanding the distribution of categories across spatial coordinates is essential. This package features automatic determination of optimal scaling factors based on data, customizable scaling and padding options for both x and y axes, flexibility to specify custom colors for each category, options to customize the legend title, and integration with ggplot2 for robust and high-quality visualizations. For more details, see Velazquez et al. (2024) <doi:10.1101/2024.08.14.606810>.

Representation-dependent gene level operations of a genetic algorithm with binary coded genes for the R-package xega <https://CRAN.R-project.org/package=xega>: Initialization of random binary genes, several gene maps for binary genes, several mutation operators, several crossover operators with 1 and 2 kids, replication pipelines for 1 and 2 kids, and, last but not least, function factories for configuration. See Goldberg, D. E. (1989, ISBN:0-201-15767-5). For crossover operators, see Syswerda, G. (1989, ISBN:1-55860-066-3), Spears, W. and De Jong, K. (1991, ISBN:1-55860-208-9). For mutation operators, see Stanhope, S. A. and Daida, J. M. (1996, ISBN:0-18-201-031-7). For xega''s architecture, see Geyer-Schulz, A. (2025) <doi:10.5445/IR/1000187255>.

The current version (0.3.0) streamlines the underlying code, adds a feasibility check to maicWt and maxessWt', extends exmWt.2ipd with options target.ipd and method for one-sided MAIC weighting between two IPDs, and adds wtTrtDiff for the weighted treatment-effect difference with a Wald confidence interval based on Section 5 of Glimm & Yau (2026). The second version (0.2.0) contains implementation for exact matching which is an alternative to propensity score matching (see Glimm & Yau (2026) <doi:10.1080/19466315.2025.2507378>). The initial version (0.1.2) contains a collection of easy-to-implement tools for checking whether a MAIC can be conducted, as well as an alternative way of calculating weights (see Glimm & Yau (2022) <doi:10.1002/pst.2210>.).

DNA methylation is generally considered to be associated with transcriptional silencing. However, comprehensive, genome-wide investigation of this relationship requires the evaluation of potentially millions of correlation values between the methylation of individual genomic loci and expression of associated transcripts in a relatively large numbers of samples. Methodical makes this process quick and easy while keeping a low memory footprint. It also provides a novel method for identifying regions where a number of methylation sites are consistently strongly associated with transcriptional expression. In addition, Methodical enables housing DNA methylation data from diverse sources (e.g. WGBS, RRBS and methylation arrays) with a common framework, lifting over DNA methylation data between different genome builds and creating base-resolution plots of the association between DNA methylation and transcriptional activity at transcriptional start sites.

Runs, classifies, interprets and reports sensitivity analyses for unmeasured confounding across the partial R-squared robustness value approach (Cinelli and Hazlett, 2020, <doi:10.1111/rssb.12348>), E-values (VanderWeele and Ding, 2017, <doi:10.7326/M16-2607>), and the impact threshold for a confounding variable and robustness of inference to replacement (Frank, 2000, <doi:10.1177/0049124100029002001>; Frank, Maroulis, Duong and Kelcey, 2013, <doi:10.3102/0162373713493129>). An ordinary least squares crosswalk reports the robustness values, impact threshold and replacement percentage computed from the focal t statistic and residual degrees of freedom, makes explicit that their agreement is largely fixed by that shared input, and flags the boundary band in which they disagree. Template-based plain-language reports are included, with optional integration with the confoundvis package for plots.

In computer experiments space-filling designs are having great impact. Most popularly used space-filling designs are Uniform designs (UDs), Latin hypercube designs (LHDs) etc. For further references one can see Mckay (1979) <DOI:10.1080/00401706.1979.10489755> and Fang (1980) <https://cir.nii.ac.jp/crid/1570291225616774784>. In this package, we have provided algorithms for generate efficient LHDs and UDs. Here, generated LHDs are efficient as they possess lower value of Maxpro measure, Phi_p value and Maximum Absolute Correlation (MAC) value based on the weightage given to each criterion. On the other hand, the produced UDs are having good space-filling property as they always attain the lower bound of Discrete Discrepancy measure. Further, some useful functions added in this package for adding more value to this package.

Unleash the power of time-series data visualization with ease using our package. Designed with simplicity in mind, it offers three key features through the shiny package output. The first tab shows time- series charts with forecasts, allowing users to visualize trends and changes effortlessly. The second one displays Averages per country presented in tables with accompanying sparklines, providing a quick and attractive overview of the data. The last tab presents A customizable world map colored based on user-defined variables for any chosen number of countries, offering an advanced visual approach to understanding geographical data distributions. This package operates with just a few simple arguments, enabling users to conduct sophisticated analyses without the need for complex programming skills. Transform your time-series data analysis experience with our user-friendly tool.

Data analysis often requires coding, especially when data are collected through interviews, observations, or questionnaires. As a result, code counting and data preparation are essential steps in the analysis process. Analysts may need to count the codes in a text (Tokenization, counting of pre-established codes, computing the co-occurrence matrix by line) and prepare the data (e.g., min-max normalization, Z-score, robust scaling, Box-Cox transformation, and non-parametric bootstrap). For the Box-Cox transformation (Box & Cox, 1964, <https://www.jstor.org/stable/2984418>), the optimal Lambda is determined using the log-likelihood method. Non-parametric bootstrap involves randomly sampling data with replacement. Two random number generators are also integrated: a Lehmer congruential generator for uniform distribution and a Box-Muller generator for normal distribution. Package for educational purposes.

The cyclotomic numbers are complex numbers that can be thought of as the rational numbers extended with the roots of unity. They are represented exactly, enabling exact computations. They contain the Gaussian rationals (complex numbers with rational real and imaginary parts) as well as the square roots of all rational numbers. They also contain the sine and cosine of all rational multiples of pi. The algorithms implemented in this package are taken from the Haskell package cyclotomic', whose algorithms are adapted from code by Martin Schoenert and Thomas Breuer in the GAP project (<https://www.gap-system.org/>). Cyclotomic numbers have applications in number theory, algebraic geometry, algebraic number theory, coding theory, and in the theory of graphs and combinatorics. They have connections to the theory of modular functions and modular curves.

This package provides a customisable R shiny app for immersively visualising, mapping and annotating panospheric (360 degree) imagery. The flexible interface allows annotation of any geocoded images using up to 4 user specified drop-down menus. The app uses leaflet to render maps that display the geo-locations of images and Panellum <https://pannellum.org/>, a lightweight panorama viewer for the web, to render images in virtual 360 degree viewing mode. Key functions include the ability to draw on & export parts of 360 images for downstream applications. Users can also draw polygons and points on map imagery related to the panoramic images and export them for further analysis. Downstream applications include using annotations to train Artificial Intelligence/Machine Learning (AI/ML) models and geospatial modelling and analysis of camera based survey data.