Bayesian hidden Ising models are implemented to identify IP-enriched genomic regions from ChIP-seq data. They can be used to analyze ChIP-seq data with and without controls and replicates.

MODA can be used to estimate and construct condition-specific gene co-expression networks, and identify differentially expressed subnetworks as conserved or condition specific modules which are potentially associated with relevant biological processes.

Phenotypes comparison based on a pathway consensus approach. Assess the relationship between candidate genes and a set of phenotypes based on additional genes related to the candidate (e.g. Pathways or network neighbors).

This package implements the regularized Gaussian maximum likelihood estimation of the inverse of a covariance matrix. It uses Newton's method and coordinate descent to solve the regularized inverse covariance matrix estimation problem.

This package provides an R interface to the Lawson-Hanson implementation of an algorithm for non-negative least squares (NNLS). It also allows the combination of non-negative and non-positive constraints.

This package provides functions and datasets for bootstrapping from the book "Bootstrap Methods and Their Application" by A.C. Davison and D.V. Hinkley (1997, CUP), originally written by Angelo Canty for S.

This package provides several utility functions for the book entitled "Practices of Medical and Health Data Analysis using R" (Pearson Education Japan, 2007) with Japanese demographic data and some demographic analysis related functions.

It contains functions that solve least squares linear regression problems under linear equality/inequality constraints. Functions for solving quadratic programming problems are also available, which transform such problems into least squares ones first.

This package provides a model of single-layer groundwater flow in steady-state under the Dupuit-Forchheimer assumption can be created by placing elements such as wells, area-sinks and line-sinks at arbitrary locations in the flow field. Output variables include hydraulic head and the discharge vector. Particle traces can be computed numerically in three dimensions. The underlying theory is described in Haitjema (1995) <doi:10.1016/B978-0-12-316550-3.X5000-4> and references therein.

By placing on a circle 10 points numbered from 1 to 10, and connecting them by a straight line to the point corresponding to its multiplication by 2. (1 must be connected to 1 * 2 = 2, point 2 must be set to 2 * 2 = 4, point 3 to 3 * 2 = 6 and so on). You will obtain an amazing geometric figure that complicates and beautifies itself by varying the number of points and the multiplication table you use.

SEA performs simultaneous feature-set testing for (gen)omics data. It tests the unified null hypothesis and controls the family-wise error rate for all possible pathways. The unified null hypothesis is defined as: "The proportion of true features in the set is less than or equal to a threshold." Family-wise error rate control is provided through use of closed testing with Simes test. There are some practical functions to play around with the pathways of interest.

This package provides reference classes implementing some useful data structures. The package implements these data structures by using the reference class R6. Therefore, the classes of the data structures are also reference classes which means that their instances are passed by reference. The implemented data structures include stack, queue, double-ended queue, doubly linked list, set, dictionary and binary search tree. See for example <https://en.wikipedia.org/wiki/Data_structure> for more information about the data structures.

Tensor Factor Models (TFM) are appealing dimension reduction tools for high-order tensor time series, and have wide applications in economics, finance and medical imaging. We propose an one-step projection estimator by minimizing the least-square loss function, and further propose a robust estimator with an iterative weighted projection technique by utilizing the Huber loss function. The methods are discussed in Barigozzi et al. (2022) <arXiv:2206.09800>, and Barigozzi et al. (2023) <arXiv:2303.18163>.

Efficient solvers for 10 regularized multi-task learning algorithms applicable for regression, classification, joint feature selection, task clustering, low-rank learning, sparse learning and network incorporation. Based on the accelerated gradient descent method, the algorithms feature a state-of-art computational complexity O(1/k^2). Sparse model structure is induced by the solving the proximal operator. The detail of the package is described in the paper of Han Cao and Emanuel Schwarz (2018) <doi:10.1093/bioinformatics/bty831>.

This package provides a collection of R functions for use with Stock Synthesis, a fisheries stock assessment modeling platform written in ADMB by Dr. Richard D. Methot at the NOAA Northwest Fisheries Science Center. The functions include tools for summarizing and plotting results, manipulating files, visualizing model parameterizations, and various other common stock assessment tasks. This version of r4ss is compatible with Stock Synthesis versions 3.24 through 3.30 (specifically version 3.30.19.01, from April 2022).

This package provides a flexible and easy-to-use interface for the Physiological Processes Predicting Growth (3-PG) model written in Fortran. The r3PG serves as a flexible and easy-to-use interface for the 3-PGpjs (monospecific, evenaged and evergreen forests) described in Landsberg & Waring (1997) <doi:10.1016/S0378-1127(97)00026-1> and the 3-PGmix (deciduous, uneven-aged or mixed-species forests) described in Forrester & Tang (2016) <doi:10.1016/j.ecolmodel.2015.07.010>.

This package provides a robust alternative to the traditional principal component estimator is proposed within the framework of factor models, known as Robust Exponential Factor Analysis, specifically designed for the modeling of high-dimensional datasets with heavy-tailed distributions. The algorithm estimates the latent factors and the loading by minimizing the exponential squared loss function. To determine the appropriate number of factors, we propose a modified rank minimization technique, which has been shown to significantly enhance finite-sample performance.

This package provides a compositional mediation model for continuous outcome and binary outcomes to deal with mediators that are compositional data. Lin, Ziqiang et al. (2022) <doi:10.1016/j.jad.2021.12.019>.

Extends the did package to improve efficiency and handling of unbalanced panel data. Bellego, Benatia, and Dortet-Bernadet (2024), "The Chained Difference-in-Differences", Journal of Econometrics, <doi:10.1016/j.jeconom.2024.105783>.

This package provides a collection of cardiovascular research datasets and analytical tools, including methods for cardiovascular procedural data, such as electrocardiography, echocardiography, and catheterization data. Additional methods exist for analysis of procedural billing codes.

This package provides a key-value dictionary data structure based on R6 class which is designed to be similar usages with other languages dictionary (e.g. Python') with reference semantics and extendabilities by R6.

Implement weighted higher-order initialization and angle-based iteration for multi-way spherical clustering under degree-corrected tensor block model. See reference Jiaxin Hu and Miaoyan Wang (2023) <doi:10.1109/TIT.2023.3239521>.

Smooth testing of goodness of fit. These tests are data driven (alternative hypothesis is dynamically selected based on data). In this package you will find various tests for exponent, Gaussian, Gumbel and uniform distribution.

This package provides tools for downloading and analyzing floristic quality assessment data. See Freyman et al. (2015) <doi:10.1111/2041-210X.12491> for more information about floristic quality assessment and the associated database.