This package provides functions for the creation/generation and analysis of multilayer social networks <doi:10.18637/jss.v098.i08>.

MHCnuggets (<https://github.com/KarchinLab/mhcnuggets>) is a Python tool to predict MHC class I and MHC class II epitopes. This package allows one to call MHCnuggets from R.

Display processing results using the GWR (Geographically Weighted Regression) method, display maps, and show the results of the Mixed GWR (Mixed Geographically Weighted Regression) model which automatically selects global variables based on variability between regions. This function refers to Yasin, & Purhadi. (2012). "Mixed Geographically Weighted Regression Model (Case Study the Percentage of Poor Households in Mojokerto 2008)". European Journal of Scientific Research, 188-196. <https://www.researchgate.net/profile/Hasbi-Yasin-2/publication/289689583_Mixed_geographically_weighted_regression_model_case_study_The_percentage_of_poor_households_in_Mojokerto_2008/links/58e46aa40f7e9bbe9c94d641/Mixed-geographically-weighted-regression-model-case-study-The-percentage-of-poor-households-in-Mojokerto-2008.pdf>.

This package provides a comprehensive and computationally fast framework to analyze high dimensional data associated with an experimental design based on Multiple ANOVAs (MultANOVA). It includes testing the overall significance of terms in the model, post-hoc analyses of significant terms and variable selection. Details may be found in Mahieu, B., & Cariou, V. (2025). MultANOVA Followed by Post Hoc Analyses for Designed Highâ Dimensional Data: A Comprehensive Framework That Outperforms ASCA, rMANOVA, and VASCA. Journal of Chemometrics, 39(7). <doi:10.1002/cem.70039>.

This package provides methods and models for analysing multigraphs as introduced by Shafie (2015) <doi:10.21307/joss-2019-011>, including methods to study local and global properties <doi:10.1080/0022250X.2016.1219732> and goodness of fit tests.

Various affine invariant multivariate normality tests are provided. It is designed to accompany the survey article Ebner, B. and Henze, N. (2020) <arXiv:2004.07332> titled "Tests for multivariate normality -- a critical review with emphasis on weighted L^2-statistics". We implement new and time honoured L^2-type tests of multivariate normality, such as the Baringhaus-Henze-Epps-Pulley (BHEP) test, the Henze-Zirkler test, the test of Henze-Jiménes-Gamero, the test of Henze-Jiménes-Gamero-Meintanis, the test of Henze-Visage, the Dörr-Ebner-Henze test based on harmonic oscillator and the Dörr-Ebner-Henze test based on a double estimation in a PDE. Secondly, we include the measures of multivariate skewness and kurtosis by Mardia, Koziol, Malkovich and Afifi and Móri, Rohatgi and Székely, as well as the associated tests. Thirdly, we include the tests of multivariate normality by Cox and Small, the energy test of Székely and Rizzo, the tests based on spherical harmonics by Manzotti and Quiroz and the test of Pudelko. All the functions and tests need the data to be a n x d matrix where n is the samplesize (number of rows) and d is the dimension (number of columns).

Visualization of decision rules for binary classification and Receiver Operating Characteristic (ROC) curve estimation under different generalizations proposed in the literature: - making the classification subsets flexible to cover those scenarios where both extremes of the marker are associated with a higher risk of being positive, considering two thresholds (gROC() function); - transforming the marker by a proper function trying to improve the classification performance (hROC() function); - when dealing with multivariate markers, considering a proper transformation to univariate space trying to maximize the resulting AUC of the TPR for each FPR (multiROC() function). The classification regions behind each point of the ROC curve are displayed in both static graphics (plot_buildROC(), plot_regions() or plot_funregions() function) or videos (movieROC() function).

Causal and statistical inference on an arbitrary treatment effect curve requires care in both estimation and inference. This package, implements the Method of Direct Estimation and Inference as introduced in "Estimation and Inference on Nonlinear and Heterogeneous Effects" by Ratkovic and Tingley (2023) <doi:10.1086/723811>. The method takes an outcome, variable of theoretical interest (treatment), and set of variables and then returns a partial derivative (marginal effect) of the treatment variable at each point along with uncertainty intervals. The approach offers two advances. First, a split-sample approach is used as a guard against over-fitting. Second, the method uses a data-driven interval derived from conformal inference, rather than relying on a normality assumption on the error terms.

In the case of multivariate ordinal responses, parameter estimates can be severely biased if personal response styles are ignored. This packages provides methods to account for personal response styles and to explain the effects of covariates on the response style, as proposed by Schauberger and Tutz 2021 <doi:10.1177/1471082X20978034>. The method is implemented both for the multivariate cumulative model and the multivariate adjacent categories model.

Conducts and visualizes propensity score analysis for multilevel, or clustered data. Bryer & Pruzek (2011) <doi:10.1080/00273171.2011.636693>.

Calculates Model-Averaged Tail Area Wald (MATA-Wald) confidence intervals, and MATA-Wald confidence densities and distributions, which are constructed using single-model frequentist estimators and model weights. See Turek and Fletcher (2012) <doi:10.1016/j.csda.2012.03.002> and Fletcher et al (2019) <doi:10.1007/s10651-019-00432-5> for details.

Use standard genomics file format (BED) and a table of orthologs to illustrate synteny conservation at the genome-wide scale. Significantly conserved linkage groups are identified as described in Simakov et al. (2020) <doi:10.1038/s41559-020-1156-z> and displayed on an Oxford Grid (Edwards (1991) <doi:10.1111/j.1469-1809.1991.tb00394.x>) or a chord diagram as in Simakov et al. (2022) <doi:10.1126/sciadv.abi5884>. The package provides a function that uses a network-based greedy algorithm to find communities (Clauset et al. (2004) <doi:10.1103/PhysRevE.70.066111>) and so automatically order the chromosomes on the plot to improve interpretability.

Lightweight maps of mammals of the world. These maps are a comprehensive collection of maps aligned with the Mammal Diversity Database taxonomy of the American Society of Mammalogists. They are generated at low resolution for easy access, consultation and manipulation in shapefile format. The package connects to a binary backup hosted in the Digital Ocean cloud service and allows individual or batch download of any mammal species in the mdd taxonomy by providing the scientific species name.

This package provides tools for calculating Laspeyres, Paasche, and Fisher price and quantity indices.

Apply the marginal classification method to achieve the purpose of providing the point and interval estimates for the minimal clinically important difference based on the classical anchor-based method. For more details of the methodology, please see Zehua Zhou, Leslie J. Bisson and Jiwei Zhao (2021) <arXiv:2108.11589>.

Fit generalized linear models with binomial responses using a median modified score approach (Kenne Pagui et al., 2016, <https://arxiv.org/abs/1604.04768>) to median bias reduction. This method respects equivariance under reparameterizations for each parameter component and also solves the infinite estimates problem (data separation).

This package provides methods to analyze cluster alternatives based on multi-objective optimization of cluster validation indices. For details see Kraus et al. (2011) <doi:10.1007/s00180-011-0244-6>.

This package provides a simple in-memory, LRU cache that can be wrapped around any function to memoize it. The cache is keyed on a hash of the input data (using digest') or on pointer equivalence.

Evaluate whether a microbiome sample is a mixture of two samples, by fitting a model for the number of read counts as a function of single nucleotide polymorphism (SNP) allele and the genotypes of two potential source samples. Lobo et al. (2021) <doi:10.1093/g3journal/jkab308>.

Based on the work of Curi, Converse, Hajewski, and Oliveira (2019) <doi:10.1109/IJCNN.2019.8852333>. This package provides easy-to-use functions which create a variational autoencoder (VAE) to be used for parameter estimation in Item Response Theory (IRT) - namely the Multidimensional Logistic 2-Parameter (ML2P) model. To use a neural network as such, nontrivial modifications to the architecture must be made, such as restricting the nonzero weights in the decoder according to some binary matrix Q. The functions in this package allow for straight-forward construction, training, and evaluation so that minimal knowledge of tensorflow or keras is required.

An S4 implementation of the unbiased extension of the model- assisted synthetic-regression estimator proposed by Mandallaz (2013) <DOI:10.1139/cjfr-2012-0381>, Mandallaz et al. (2013) <DOI:10.1139/cjfr-2013-0181> and Mandallaz (2014) <DOI:10.1139/cjfr-2013-0449>. It yields smaller variances than the standard bias correction, the generalised regression estimator.

The nonparametric two-stage Bayesian adaptive design is a novel phase II clinical trial design for finding the minimum effective dose (MinED). This design is motivated by the top priority and concern of clinicians when testing a new drug, which is to effectively treat patients and minimize the chance of exposing them to subtherapeutic or overly toxic doses. It is used to design single-agent trials.

This is a thin wrapper around the MOEX ISS REST interface, see <https://iss.moex.com>. It allows to quickly fetch price candles for a particular security, obtain its profile information and so on.

Takes a .state file generated by IQ-TREE as an input and, for each ancestral node present in the file, generates a FASTA-formatted maximum likelihood (ML) sequence as well as an âAltAllâ sequence in which uncertain sites, determined by the two parameters thres_1 and thres_2, have the maximum likelihood state swapped with the next most likely state as described in Geeta N. Eick, Jamie T. Bridgham, Douglas P. Anderson, Michael J. Harms, and Joseph W. Thornton (2017), "Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty" <doi:10.1093/molbev/msw223>.