This package implements two algorithms of detecting Bull and Bear markets in stock prices: the algorithm of Pagan and Sossounov (2002, <doi:10.1002/jae.664>) and the algorithm of Lunde and Timmermann (2004, <doi:10.1198/073500104000000136>). The package also contains functions for printing out the dating of the Bull and Bear states of the market, the descriptive statistics of the states, and functions for plotting the results. For the sake of convenience, the package includes the monthly and daily data on the prices (not adjusted for dividends) of the S&P 500 stock market index.

This package provides novel dendroclimatological methods, primarily used by the Tree-ring research community. There are four core functions. The first one is daily_response(), which finds the optimal sequence of days that are related to one or more tree-ring proxy records. Similar function is daily_response_seascorr(), which implements partial correlations in the analysis of daily response functions. For the enthusiast of monthly data, there is monthly_response() function. The last core function is compare_methods(), which effectively compares several linear and nonlinear regression algorithms on the task of climate reconstruction.

Fit a time-series model to a crop phenology data, such as time-series rice canopy height. This package returns the model parameters as the summary statistics of crop phenology, and these parameters will be useful to characterize the growth pattern of each cultivar and predict manually-measured traits, such as days to heading and biomass. Please see Taniguchi et al. (2022) <doi:10.3389/fpls.2022.998803> and Taniguchi et al. (2025) <doi: 10.3389/frai.2024.1477637> for detail. This package has been designed for scientific use. Use for commercial purposes shall not be allowed.

The ProteinGymR package provides analysis-ready data resources from ProteinGym, generated by Notin et al., 2023, as well as built-in functionality to visualize the data. ProteinGym comprises a collection of benchmarks for evaluating the performance of models predicting the effect of point mutations. This package provides access to 1. deep mutational scanning (DMS) scores from 217 assays measuring the impact of all possible amino acid substitutions across 186 proteins, 2. model performance metrics and prediction scores from 79 variant prediction models in the zero-shot setting and 12 models in the semi-supervised setting.

Allows the construction selection indices based on estimated breeding values in animal and plant breeding and to calculate several analytic measures around to assess its impact on genetic and phenotypic progress. The methodology thereby allows to analyze genetic gain of traits in the breeding goal which are not part of the actual index and automatically computes several analytic measures. It further allows to retrospectively derive realized economic weights from observed genetic trends. The framework is described in Simianer, H., Heise, J., Rensing, S., Pook, T. Geibel, J. and Reimer, C. (2023) <doi:10.1186/s12711-023-00807-0>.

This package provides functions to access real-time infectious disease data from the disease.sh API', including COVID-19 global, US states, continent, and country statistics, vaccination coverage, influenza-like illness data from the Centers for Disease Control and Prevention (CDC), and more. Also includes curated datasets on a variety of infectious diseases such as influenza, measles, dengue, Ebola, tuberculosis, meningitis, AIDS, and others. The package supports epidemiological research and data analysis by combining API access with high-quality historical and survey datasets on infectious diseases. For more details on the disease.sh API', see <https://disease.sh/>.

This package provides functions for cost-optimal control charts with a focus on health care applications. Compared to assumptions in traditional control chart theory, here, we allow random shift sizes, random repair and random sampling times. The package focuses on X-bar charts with a sample size of 1 (representing the monitoring of a single patient at a time). The methods are described in Zempleni et al. (2004) <doi:10.1002/asmb.521>, Dobi and Zempleni (2019) <doi:10.1002/qre.2518> and Dobi and Zempleni (2019) <http://ac.inf.elte.hu/Vol_049_2019/129_49.pdf>.

Computational infrastructure for biogeography, community ecology, and biodiversity conservation (Daru et al. 2020) <doi:10.1111/2041-210X.13478>. It is based on the methods described in Daru et al. (2020) <doi:10.1038/s41467-020-15921-6>. The original conceptual work is described in Daru et al. (2017) <doi:10.1016/j.tree.2017.08.013> on patterns and processes of biogeographical regionalization. Additionally, the package contains fast and efficient functions to compute more standard conservation measures such as phylogenetic diversity, phylogenetic endemism, evolutionary distinctiveness and global endangerment, as well as compositional turnover (e.g., beta diversity).

This package provides basic functions that support an implementation of object case (Case 1) best-worst scaling: a function for converting a two-level orthogonal main-effect design/balanced incomplete block design into questions; two functions for creating a data set suitable for analysis; a function for calculating count-based scores; a function for calculating shares of preference; and a function for generating artificial responses to questions. See Louviere et al. (2015) <doi:10.1017/CBO9781107337855> for details on best-worst scaling, and Aizaki and Fogarty (2023) <doi:10.1016/j.jocm.2022.100394> for the package.

Assay for Transpose-Accessible Chromatin using sequencing (ATAC-seq) is a technique to assess genome-wide chromatin accessibility by probing open chromatin with hyperactive mutant Tn5 Transposase that inserts sequencing adapters into open regions of the genome. ATACseqTFEA is an improvement of the current computational method that detects differential activity of transcription factors (TFs). ATACseqTFEA not only uses the difference of open region information, but also (or emphasizes) the difference of TFs footprints (cutting sites or insertion sites). ATACseqTFEA provides an easy, rigorous way to broadly assess TF activity changes between two conditions.

This package provides a function that facilitates fitting three types of models for contrast-based Bayesian Network Meta Analysis. The first model is that which is described in Lu and Ades (2006) <doi:10.1198/016214505000001302>. The other two models are based on a Bayesian nonparametric methods that permit ties when comparing treatment or for a treatment effect to be exactly equal to zero. In addition to the model fits, the package provides a summary of the interplay between treatment effects based on the procedure described in Barrientos, Page, and Lin (2023) <doi:10.48550/arXiv.2207.06561>.

Three semi-parametric methods for detection of outliers in environmental data based on kernel regression and subsequent analysis of smoothing residuals. The first method (Campulova, Michalek, Mikuska and Bokal (2018) <DOI: 10.1002/cem.2997>) analyzes the residuals using changepoint analysis, the second method is based on control charts (Campulova, Veselik and Michalek (2017) <DOI: 10.1016/j.apr.2017.01.004>) and the third method (Holesovsky, Campulova and Michalek (2018) <DOI: 10.1016/j.apr.2017.06.005>) analyzes the residuals using extreme value theory (Holesovsky, Campulova and Michalek (2018) <DOI: 10.1016/j.apr.2017.06.005>).

This package provides an extensive collection of datasets related to medicine, diseases, treatments, drugs, and public health. This package covers topics such as drug effectiveness, vaccine trials, survival rates, infectious disease outbreaks, and medical treatments. The included datasets span various health conditions, including AIDS, cancer, bacterial infections, and COVID-19, along with information on pharmaceuticals and vaccines. These datasets are sourced from the R ecosystem and other R packages, remaining unaltered to ensure data integrity. This package serves as a valuable resource for researchers, analysts, and healthcare professionals interested in conducting medical and public health data analysis in R.

Computes how the correlation between 2 time-series changes over time. To do so, the package follows the method from Choi & Shin (2021) <doi:10.1007/s42952-020-00073-6>. It performs a non-parametric kernel smoothing (using a common bandwidth) of all underlying components required for the computation of a correlation coefficient (i.e., x, y, x^2, y^2, xy). An automatic selection procedure for the bandwidth parameter is implemented. Alternative kernels can be used (Epanechnikov, box and normal). Both Pearson and Spearman correlation coefficients can be estimated and change in correlation over time can be tested.

G-quadruplexes (G4s) are unique nucleic acid secondary structures predominantly found in guanine-rich regions and have been shown to be involved in various biological regulatory processes. G4SNVHunter is an R package designed to rapidly identify genomic sequences with G4-forming propensity and to accurately screen user-provided single nucleotide variants—as well as other small-scale variants such as indels and MNVs—for their potential to destabilize these structures. This allows researchers to then screen these critical variants for deeper study, digging into how they might influence biological functions—think gene regulation, for instance—by impairing G4 formation propensity.

This package provides a package for detecting differential methylation. It exploits a Bayesian hidden Markov model that incorporates location dependence among genomic loci, unlike most existing methods that assume independence among observations. Bayesian priors are applied to permit information sharing across an entire chromosome for improved power of detection. The direct output of our software package is the best sequence of methylation states, eliminating the use of a subjective, and most of the time an arbitrary, threshold of p-value for determining significance. At last, our methodology does not require replication in either or both of the two comparison groups.

In meta regression sometimes the studies have multiple effects that are correlated. For this reason cluster robust standard errors must be computed. However, since the clusters are unbalanced the wild bootstrap is suggested. See Oczkowski E. and Doucouliagos H. (2015). "Wine prices and quality ratings: a meta-regression analysis". American Journal of Agricultural Economics, 97(1): 103--121. <doi:10.1093/ajae/aau057> and Cameron A. C., Gelbach J. B. and Miller D. L. (2008). "Bootstrap-based improvements for inference with clustered errors". The Review of Economics and Statistics, 90(3): 414--427. <doi:10.1162/rest.90.3.414>.

This package provides a set of utilities for matching products in different classification codes used in international trade research. It supports concordance between the Harmonized System (HS0, HS1, HS2, HS3, HS4, HS5, HS combined), the Standard International Trade Classification (SITC1, SITC2, SITC3, SITC4), the North American Industry Classification System (NAICS combined), as well as the Broad Economic Categories (BEC), the International Standard of Industrial Classification (ISIC), and the Standard Industrial Classification (SIC). It also provides code nomenclature/descriptions look-up, Rauch classification look-up (via concordance to SITC2), and trade elasticity look-up (via concordance to HS0 or SITC3 codes).

Implementation of selected Tidyverse functions within DataSHIELD', an open-source federated analysis solution in R. Currently, DataSHIELD contains very limited tools for data manipulation, so the aim of this package is to improve the researcher experience by implementing essential functions for data manipulation, including subsetting, filtering, grouping, and renaming variables. This is the serverside package which should be installed on the server holding the data, and is used in conjuncture with the clientside package dsTidyverseClient which is installed in the local R environment of the analyst. For more information, see <https://tidyverse.org/> and <https://datashield.org/>.

Testing of soil for the contents of organic carbon, and available macro- and micro-nutrients is a crucial part of soil fertility assessment. This package computes some routinely tested soil properties viz. organic carbon (C), total nitrogen (N), available N, mineral N, available phosphorus (P), available potassium (K), available iron (Fe), available zinc (Zn), available manganese (Mn), available copper (Cu), and available nickel (Ni) in soil based on laboratory analysis data obtained by most commonly followed protocols. Besides, it can also draw standard curves based on absorption/emission vs. concentration data, and give out unknown concentrations from absorption/emission readings.

Forecasting competitions are of increasing importance as a mean to learn best practices and gain knowledge. Data leakage is one of the most common issues that can often be found in competitions. Data leaks can happen when the training data contains information about the test data. For example: randomly chosen blocks of time series are concatenated to form a new time series, scale-shifts, repeating patterns in time series, white noise is added in the original time series to form a new time series, etc. tsdataleaks package can be used to detect data leakages in a collection of time series.

This package provides R users with direct access to genomic and clinical data from the cBioPortal web resource via user-friendly functions that wrap cBioPortal's existing API endpoints <https://www.cbioportal.org/api/swagger-ui/index.html>. Users can browse and query genomic data on mutations, copy number alterations and fusions, as well as data on tumor mutational burden ('TMB'), microsatellite instability status ('MSI'), FACETS and select clinical data points (depending on the study). See <https://www.cbioportal.org/> and Gao et al., (2013) <doi:10.1126/scisignal.2004088> for more information on the cBioPortal web resource.

Two method new of multigroup and simulation of data. The first technique called multigroup PCA (mgPCA) this multivariate exploration approach that has the idea of considering the structure of groups and / or different types of variables. On the other hand, the second multivariate technique called Multigroup Dimensionality Reduction (MDR) it is another multivariate exploration method that is based on projections. In addition, a method called Single Dimension Exploration (SDE) was incorporated for to analyze the exploration of the data. It could help us in a better way to observe the behavior of the multigroup data with certain variables of interest.

This package provides functions and graphics for projecting daily incidence based on past incidence, and estimates of the serial interval and reproduction number. Projections are based on a branching process using a Poisson-distributed number of new cases per day, similar to the model used for estimating R in EpiEstim or in earlyR', and described by Nouvellet et al. (2017) <doi:10.1016/j.epidem.2017.02.012>. The package provides the S3 class projections which extends matrix', with accessors and additional helpers for handling, subsetting, merging, or adding these objects, as well as dedicated printing and plotting methods.