This package provides a companion to the Chinese book ``Modern Statistical Graphics''.

Defines the classes used to explore, cluster and visualize distance matrices, especially those arising from binary data. See Abrams and colleagues, 2021, <doi:10.1093/bioinformatics/btab037>.

Estimation/multiple imputation programs for mixed categorical and continuous data.

Matrix eQTL is designed for fast eQTL analysis on large datasets. Matrix eQTL can test for association between genotype and gene expression using linear regression with either additive or ANOVA genotype effects. The models can include covariates to account for factors as population stratification, gender, and clinical variables. It also supports models with heteroscedastic and/or correlated errors, false discovery rate estimation and separate treatment of local (cis) and distant (trans) eQTLs. For more details see Shabalin (2012) <doi:10.1093/bioinformatics/bts163>.

Uses dplyr and tidyeval to fit statistical models inside the database. It currently supports KMeans and linear regression models.

Mapping Averaged Pairwise Information (MAPI) is an exploratory method providing graphical representations summarizing the spatial variation of pairwise metrics (eg. distance, similarity coefficient, ...) computed between georeferenced samples.

This package provides methods for detecting signals related to (adverse event, medical product e.g. drugs, vaccines) pairs, a data generation function for simulating pharmacovigilance datasets, and various utility functions. For more details please see Liu A., Mukhopadhyay R., and Markatou M. <doi:10.48550/arXiv.2410.01168>.

MHCnuggets (<https://github.com/KarchinLab/mhcnuggets>) is a Python tool to predict MHC class I and MHC class II epitopes. This package allows one to call MHCnuggets from R.

This package provides functions similar to the SAS macros previously provided to accompany Collins, Dziak, and Li (2009) <DOI:10.1037/a0015826> and Dziak, Nahum-Shani, and Collins (2012) <DOI:10.1037/a0026972>, papers which outline practical benefits and challenges of factorial and fractional factorial experiments for scientists interested in developing biological and/or behavioral interventions, especially in the context of the multiphase optimization strategy (see Collins, Kugler & Gwadz 2016) <DOI:10.1007/s10461-015-1145-4>. The package currently contains three functions. First, RelativeCosts1() draws a graph of the relative cost of complete and reduced factorial designs versus other alternatives. Second, RandomAssignmentGenerator() returns a dataframe which contains a list of random numbers that can be used to conveniently assign participants to conditions in an experiment with many conditions. Third, FactorialPowerPlan() estimates the power, detectable effect size, or required sample size of a factorial or fractional factorial experiment, for main effects or interactions, given several possible choices of effect size metric, and allowing pretests and clustering.

Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the premier technology for profiling genome-wide localization of chromatin-binding proteins, including transcription factors and histones with various modifications. This package provides a robust method for normalizing ChIP-seq signals across individual samples or groups of samples. It also designs a self-contained system of statistical models for calling differential ChIP-seq signals between two or more biological conditions as well as for calling hypervariable ChIP-seq signals across samples. Refer to Tu et al. (2021) <doi:10.1101/gr.262675.120> and Chen et al. (2022) <doi:10.1186/s13059-022-02627-9> for associated statistical details.

Causal moderated mediation analysis using the methods proposed by Qin and Wang (2023) <doi:10.3758/s13428-023-02095-4>. Causal moderated mediation analysis is crucial for investigating how, for whom, and where a treatment is effective by assessing the heterogeneity of mediation mechanism across individuals and contexts. This package enables researchers to estimate and test the conditional and moderated mediation effects, assess their sensitivity to unmeasured pre-treatment confounding, and visualize the results. The package is built based on the quasi-Bayesian Monte Carlo method, because it has relatively better performance at small sample sizes, and its running speed is the fastest. The package is applicable to a treatment of any scale, a binary or continuous mediator, a binary or continuous outcome, and one or more moderators of any scale.

This is the core package offering a portal to the many packages universe. It includes functions to help researchers access, work across, and maintain ensembles of datasets on global governance called datacubes.

Explore and retrieve marine spatial data from the Marine Regions Gazetteer <https://marineregions.org/gazetteer.php?p=webservices> and the Marine Regions Data Products <https://marineregions.org/webservices.php>.

Estimates key quantities in causal mediation analysis - including average causal mediation effects (indirect effects), average direct effects, total effects, and proportions mediated - in the presence of multiple uncausally related mediators. Methods are described by Jérolon et al., (2021) <doi:10.1515/ijb-2019-0088> and extended to accommodate survival outcomes as described by Domingo-Relloso et al., (2024) <doi:10.1101/2024.02.16.24302923>.

Fitting and testing multinomial processing tree (MPT) models, a class of nonlinear models for categorical data. The parameters are the link probabilities of a tree-like graph and represent the latent cognitive processing steps executed to arrive at observable response categories (Batchelder & Riefer, 1999 <doi:10.3758/bf03210812>; Erdfelder et al., 2009 <doi:10.1027/0044-3409.217.3.108>; Riefer & Batchelder, 1988 <doi:10.1037/0033-295x.95.3.318>).

This package provides a complete toolkit to process the Munich ChronoType Questionnaire (MCTQ) for its three versions (standard, micro, and shift). MCTQ is a quantitative and validated tool to assess chronotypes using peoples sleep behavior, originally presented by Till Roenneberg, Anna Wirz-Justice, and Martha Merrow (2003, <doi:10.1177/0748730402239679>).

Complex niche models show low performance in identifying the most important range-limiting environmental variables and in transferring habitat suitability to novel environmental conditions (Warren and Seifert, 2011 <DOI:10.1890/10-1171.1>; Warren et al., 2014 <DOI:10.1111/ddi.12160>). This package helps to identify the most important set of uncorrelated variables and to fine-tune Maxent's regularization multiplier. In combination, this allows to constrain complexity and increase performance of Maxent niche models (assessed by information criteria, such as AICc (Akaike, 1974 <DOI:10.1109/TAC.1974.1100705>), and by the area under the receiver operating characteristic (AUC) (Fielding and Bell, 1997 <DOI:10.1017/S0376892997000088>). Users of this package should be familiar with Maxent niche modelling.

This package provides a set of evolutionary algorithms to solve many-objective optimization. Hybridization between the algorithms are also facilitated. Available algorithms are: SMS-EMOA <doi:10.1016/j.ejor.2006.08.008> NSGA-III <doi:10.1109/TEVC.2013.2281535> MO-CMA-ES <doi:10.1145/1830483.1830573> The following many-objective benchmark problems are also provided: DTLZ1'-'DTLZ4 from Deb, et al. (2001) <doi:10.1007/1-84628-137-7_6> and WFG4'-'WFG9 from Huband, et al. (2005) <doi:10.1109/TEVC.2005.861417>.

This package creates and runs Bayesian mixing models to analyze biological tracer data (i.e. stable isotopes, fatty acids), which estimate the proportions of source (prey) contributions to a mixture (consumer). MixSIAR is not one model, but a framework that allows a user to create a mixing model based on their data structure and research questions, via options for fixed/ random effects, source data types, priors, and error terms. MixSIAR incorporates several years of advances since MixSIR and SIAR'.

Designing multi-arm multi-stage studies with (asymptotically) normal endpoints and known variance.

This will allow easier management of a CRAN-style repository on local networks (i.e. not on CRAN). This might be necessary where hosted packages contain intellectual property owned by a corporation.

This package provides methods for color labeling, calculation of eigengenes, merging of closely related modules.

Several functions can be used to analyze multiblock multivariable data. If the input is a single matrix, then principal components analysis (PCA) is implemented. If the input is a list of matrices, then multiblock PCA is implemented. If the input is two matrices, for exploratory and objective variables, then partial least squares (PLS) analysis is implemented. If the input is two lists of matrices, for exploratory and objective variables, then multiblock PLS analysis is implemented. Additionally, if an extra outcome variable is specified, then a supervised version of the methods above is implemented. For each method, sparse modeling is also incorporated. Functions for selecting the number of components and regularized parameters are also provided.

Maximum a posteriori (MAP) estimation for topic models (i.e., Latent Dirichlet Allocation) in text analysis, as described in Taddy (2012) On estimation and selection for topic models'. Previous versions of this code were included as part of the textir package. If you want to take advantage of openmp parallelization, uncomment the relevant flags in src/MAKEVARS before compiling.