This package provides methods to construct multivariate grids, which can be used for multivariate quadrature. This grids can be based on different quadrature rules like Newton-Cotes formulas (trapezoidal-, Simpson's- rule, ...) or Gauss quadrature (Gauss-Hermite, Gauss-Legendre, ...). For the construction of the multidimensional grid the product-rule or the combination- technique can be applied.

Statistical Analyses and Pooling after Multiple Imputation. A large variety of repeated statistical analysis can be performed and finally pooled. Statistical analysis that are available are, among others, Levene's test, Odds and Risk Ratios, One sample proportions, difference between proportions and linear and logistic regression models. Functions can also be used in combination with the Pipe operator. More and more statistical analyses and pooling functions will be added over time. Heymans (2007) <doi:10.1186/1471-2288-7-33>. Eekhout (2017) <doi:10.1186/s12874-017-0404-7>. Wiel (2009) <doi:10.1093/biostatistics/kxp011>. Marshall (2009) <doi:10.1186/1471-2288-9-57>. Sidi (2021) <doi:10.1080/00031305.2021.1898468>. Lott (2018) <doi:10.1080/00031305.2018.1473796>. Grund (2021) <doi:10.31234/osf.io/d459g>.

Analyzing longitudinal clinical data from Electronic Health Records (EHRs) using linear mixed models (LMM) and visualizing the results as networks. It includes functions for fitting LMM, normalizing adjacency matrices, and comparing networks. The package is designed for researchers in clinical and biomedical fields who need to model longitudinal data and explore relationships between variables For more details see Bates et al. (2015) <doi:10.18637/jss.v067.i01>.

Converts results from the manymome package, presented in Cheung and Cheung (2023) <doi:10.3758/s13428-023-02224-z>, to publication-ready tables.

Correlation coefficients for multivariate data, namely the squared correlation coefficient and the RV coefficient (multivariate generalization of the squared Pearson correlation coefficient). References include Mardia K.V., Kent J.T. and Bibby J.M. (1979). "Multivariate Analysis". ISBN: 978-0124712522. London: Academic Press.

This package provides a standalone package combining several stop-word lists for 65 languages with a median of 329 stop words for language and over 1,000 entries for English, Breton, Latin, Slovenian, and Ancient Greek! The user automatically gets access to all the unique stop words contained in: the StopwordISO repository; the Natural Language Toolkit for python'; the Snowball stop-word list; the R package quanteda'; the marimo repository; the Perseus project; and A. Berra's list of stop words for Ancient Greek and Latin.

This package provides functions for detecting multicollinearity. This test gives statistical support to two of the most famous methods for detecting multicollinearity in applied work: Kleinâ s rule and Variance Inflation Factor (VIF). See the URL for the papers associated with this package, as for instance, Morales-Oñate and Morales-Oñate (2015) <doi:10.33333/rp.vol51n2.05>.

This package provides an extension of the shadow-test approach to computerized adaptive testing (CAT) implemented in the TestDesign package for the assessment framework involving multiple tests administered periodically throughout the year. This framework is referred to as the Multiple Administrations Adaptive Testing (MAAT) and supports multiple item pools vertically scaled and multiple phases (stages) of CAT within each test. Between phases and tests, transitioning from one item pool (and associated constraints) to another is allowed as deemed necessary to enhance the quality of measurement.

Meta-analysis traditionally assigns more weight to studies with lower standard errors, assuming higher precision. However, in observational research, precision must be estimated and is vulnerable to manipulation, such as p-hacking, to achieve statistical significance. This can lead to spurious precision, invalidating inverse-variance weighting and bias-correction methods like funnel plots. Common methods for addressing publication bias, including selection models, often fail or exacerbate the problem. This package introduces an instrumental variable approach to limit bias caused by spurious precision in meta-analysis. Methods are described in Irsova et al. (2025) <doi:10.1038/s41467-025-63261-0>.

Enhances mlexperiments <https://CRAN.R-project.org/package=mlexperiments> with additional machine learning ('ML') learners for survival analysis. The package provides R6-based survival learners for the following algorithms: glmnet <https://CRAN.R-project.org/package=glmnet>, ranger <https://CRAN.R-project.org/package=ranger>, xgboost <https://CRAN.R-project.org/package=xgboost>, and rpart <https://CRAN.R-project.org/package=rpart>. These can be used directly with the mlexperiments R package.

This package provides spatially survey balanced designs using the quasi-random number method described Robinson et al. (2013) <doi:10.1111/biom.12059> and adjusted in Robinson et al. (2017) <doi:10.1016/j.spl.2017.05.004>. Designs using MBHdesign can: 1) accommodate, without substantial detrimental effects on spatial balance, legacy sites (Foster et al., 2017 <doi:10.1111/2041-210X.12782>); 2) be based on points or transects (foster et al. 2020 <doi:10.1111/2041-210X.13321> and produce clustered samples (Foster et al. (in press). Additional information about the package use itself is given in Foster (2021) <doi:10.1111/2041-210X.13535>.

This package provides a collection of functions for conducting meta-analysis using a structural equation modeling (SEM) approach via the OpenMx and lavaan packages. It also implements various procedures to perform meta-analytic structural equation modeling on the correlation and covariance matrices, see Cheung (2015) <doi:10.3389/fpsyg.2014.01521>.

The implemented methods reach out to scientists that seek to estimate multiplicity of infection (MOI) and lineage (allele) frequencies and prevalences at molecular markers using the maximum-likelihood method described in Schneider (2018) <doi:10.1371/journal.pone.0194148>, and Schneider and Escalante (2014) <doi:10.1371/journal.pone.0097899>. Users can import data from Excel files in various formats, and perform maximum-likelihood estimation on the imported data by the package's moimle() function.

This package provides a framework which should improve reproducibility and transparency in data processing. It provides functionality such as automatic meta data creation and management, rudimentary quality management, data caching, work-flow management and data aggregation. * The title is a wish not a promise. By no means we expect this package to deliver everything what is needed to achieve full reproducibility and transparency, but we believe that it supports efforts in this direction.

Fits a Bayesian Regression Model for multivariate count data. This model assumes that the data is distributed according to the Conway-Maxwell-Poisson distribution, and for each response variable it is associate different covariates. This model allows to account for correlations between the counts by using latent effects based on the Chib and Winkelmann (2001) <http://www.jstor.org/stable/1392277> proposal.

Check concordance of a vector of mutation impacts with standard dictionaries such as Sequence Ontology (SO) <http://www.sequenceontology.org/>, Mutation Annotation Format (MAF) <https://docs.gdc.cancer.gov/Encyclopedia/pages/Mutation_Annotation_Format_TCGAv2/> or Prediction and Annotation of Variant Effects (PAVE) <https://github.com/hartwigmedical/hmftools/tree/master/pave>. It enables conversion between SO/PAVE and MAF terms and selection of the most severe consequence where multiple ampersand (&) delimited impacts are given.

This package provides tools for the integration, visualisation, and modelling of spatial epidemiological data using the method described in Azeez, A., & Noel, C. (2025). Predictive Modelling and Spatial Distribution of Pancreatic Cancer in Africa Using Machine Learning-Based Spatial Model <doi:10.5281/zenodo.16529986> and <doi:10.5281/zenodo.16529016>. It facilitates the analysis of geographic health data by combining modern spatial mapping tools with advanced machine learning (ML) algorithms. mlspatial enables users to import and pre-process shapefile and associated demographic or disease incidence data, generate richly annotated thematic maps, and apply predictive models, including Random Forest, XGBoost', and Support Vector Regression, to identify spatial patterns and risk factors. It is suited for spatial epidemiologists, public health researchers, and GIS analysts aiming to uncover hidden geographic patterns in health-related outcomes and inform evidence-based interventions.

Perform correlation and linear regression test among the numeric fields in a data.frame automatically and make plots using pairs or lattice::parallelplot.

This package provides a tool to simulate salmon metapopulations and apply financial portfolio optimization concepts. The package accompanies the paper Anderson et al. (2015) <doi:10.1101/2022.03.24.485545>.

Fit and plot macroecological patterns predicted by the Maximum Entropy Theory of Ecology (METE).

This package provides a utility library to facilitate the generalization of statistical methods built on a regression framework. Package developers can use modelObj methods to initiate a regression analysis without concern for the details of the regression model and the method to be used to obtain parameter estimates. The specifics of the regression step are left to the user to define when calling the function. The user of a function developed within the modelObj framework creates as input a modelObj that contains the model and the R methods to be used to obtain parameter estimates and to obtain predictions. In this way, a user can easily go from linear to non-linear models within the same package.

Analyses species distribution models and evaluates their performance. It includes functions for variation partitioning, extracting variable importance, computing several metrics of model discrimination and calibration performance, optimizing prediction thresholds based on a number of criteria, performing multivariate environmental similarity surface (MESS) analysis, and displaying various analytical plots. Initially described in Barbosa et al. (2013) <doi:10.1111/ddi.12100>.

Epistasis, commonly defined as the interaction between genetic loci, is known to play an important role in the phenotypic variation of complex traits. As a result, many statistical methods have been developed to identify genetic variants that are involved in epistasis, and nearly all of these approaches carry out this task by focusing on analyzing one trait at a time. Previous studies have shown that jointly modeling multiple phenotypes can often dramatically increase statistical power for association mapping. In this package, we present the multivariate MArginal ePIstasis Test ('mvMAPIT') â a multi-outcome generalization of a recently proposed epistatic detection method which seeks to detect marginal epistasis or the combined pairwise interaction effects between a given variant and all other variants. By searching for marginal epistatic effects, one can identify genetic variants that are involved in epistasis without the need to identify the exact partners with which the variants interact â thus, potentially alleviating much of the statistical and computational burden associated with conventional explicit search based methods. Our proposed mvMAPIT builds upon this strategy by taking advantage of correlation structure between traits to improve the identification of variants involved in epistasis. We formulate mvMAPIT as a multivariate linear mixed model and develop a multi-trait variance component estimation algorithm for efficient parameter inference and P-value computation. Together with reasonable model approximations, our proposed approach is scalable to moderately sized genome-wide association studies. Crawford et al. (2017) <doi:10.1371/journal.pgen.1006869>. Stamp et al. (2023) <doi:10.1093/g3journal/jkad118>. Stamp et al. (2025) <doi:10.1016/j.ajhg.2025.07.004>.

Generate interactive html reports that enable quick visual review of multiple related time series stored in a data frame. For static datasets, this can help to identify any temporal artefacts that may affect the validity of subsequent analyses. For live data feeds, regularly scheduled reports can help to pro-actively identify data feed problems or unexpected trends that may require action. The reports are self-contained and shareable without a web server.