Calculates k-best solutions and costs for an assignment problem following the method outlined in Murty (1968) <doi:10.1287/opre.16.3.682>.

This package performs multi-omic differential network analysis by revealing differential interactions between molecular entities (genes, proteins, transcription factors, or other biomolecules) across the omic datasets provided. For each omic dataset, a differential network is constructed where links represent statistically significant differential interactions between entities. These networks are then integrated into a comprehensive visualization using distinct colors to distinguish interactions from different omic layers. This unified display allows interactive exploration of cross-omic patterns, such as differential interactions present at both transcript and protein levels. For each link, users can access differential statistical significance metrics (p values or adjusted p values, calculated via robust or traditional linear regression with interaction term) and differential regression plots. The methods implemented in this package are described in Sciacca et al. (2023) <doi:10.1093/bioinformatics/btad192>.

Sixteen tools for bioinformatics processing and analysis of major histocompatibility complex (MHC) data. The functions are tailored for amplicon data sets that have been filtered using the dada2 method (for more information on dada2, visit <https://benjjneb.github.io/dada2/> ), but even other types of data sets can be analyzed. The ReplMatch() function matches replicates in data sets in order to evaluate genotyping success. The GetReplTable() and GetReplStats() functions perform such an evaluation. The CreateFas() function creates a fasta file with all the sequences in the data set. The CreateSamplesFas() function creates individual fasta files for each sample in the data set. The DistCalc() function calculates Grantham, Sandberg, or p-distances from pairwise comparisons of all sequences in a data set, and mean distances of all pairwise comparisons within each sample in a data set. The function additionally outputs five tables with physico-chemical z-descriptor values (based on Sandberg et al. 1998) for each amino acid position in all sequences in the data set. These tables may be useful for further downstream analyses, such as estimation of MHC supertypes. The BootKmeans() function is a wrapper for the kmeans() function of the stats package, which allows for bootstrapping. Bootstrapping k-estimates may be desirable in data sets, where e.g. BIC- vs. k-values do not produce clear inflection points ("elbows"). BootKmeans() performs multiple runs of kmeans() and estimates optimal k-values based on a user-defined threshold of BIC reduction. The method is an automated and bootstrapped version of visually inspecting elbow plots of BIC- vs. k-values. The ClusterMatch() function is a tool for evaluating whether different k-means() clustering models identify similar clusters, and summarize bootstrap model stats as means for different estimated values of k. It is designed to take files produced by the BootKmeans() function as input, but other data can be analyzed if the descriptions of the required data formats are observed carefully. The SynDist() function analyses of synonymous variation among aligned protein-coding DNA sequences, that is, nucleotide substitutions that do not translate to changes in the amino acid sequences due to degeneracy of the genetic code. The SynDist() function calculates synonymous nucleotide changes per base and per codon in pairwise sequence comparisons, as well as mean synonymous variation among all pairwise comparisons of the sequences within each sample in a data set. The PapaDiv() function compares parent pairs in the data set and calculate their joint MHC diversity, taking into account sequence variants that occur in both parents. The HpltFind() function infers putative haplotypes from families in the data set. The GetHpltTable() and GetHpltStats() functions evaluate the accuracy of the haplotype inference. The CreateHpltOccTable() function creates a binary (logical) haplotype-sequence occurrence matrix from the output of HpltFind(), for easy overview of which sequences are present in which haplotypes. The HpltMatch() function compares haplotypes to help identify overlapping and potentially identical types. The NestTablesXL() function translates the output from HpltFind() to an Excel workbook, that provides a convenient overview for evaluation and curating of the inferred putative haplotypes.

Using this package, one can determine the minimum sample size required so that the mean square error of the sample mean and the population mean of a distribution becomes less than some pre-determined epsilon, i.e. it helps the user to determine the minimum sample size required to attain the pre-fixed precision level by minimizing the difference between the sample mean and population mean.

Enhances mlexperiments <https://CRAN.R-project.org/package=mlexperiments> with additional machine learning ('ML') learners. The package provides R6-based learners for the following algorithms: glmnet <https://CRAN.R-project.org/package=glmnet>, ranger <https://CRAN.R-project.org/package=ranger>, xgboost <https://CRAN.R-project.org/package=xgboost>, and lightgbm <https://CRAN.R-project.org/package=lightgbm>. These can be used directly with the mlexperiments R package.

MTrackJ is an ImageJ plugin for motion tracking and analysis (see <https://imagescience.org/meijering/software/mtrackj/>). This package reads and writes MTrackJ Data Files ('.mdf', see <https://imagescience.org/meijering/software/mtrackj/format/>). It supports 2D data and read/writes cluster, point, and channel information. If desired, generates track identifiers that are unique over the clusters. See the project page for more information and examples.

This is a R implementation of "Minimum SNPs" software as described in "Price E.P., Inman-Bamber, J., Thiruvenkataswamy, V., Huygens, F and Giffard, P.M." (2007) <doi:10.1186/1471-2105-8-278> "Computer-aided identification of polymorphism sets diagnostic for groups of bacterial and viral genetic variants.".

Efficiently estimates single- and multilevel latent class models with covariates, allowing for output visualization in all specifications. For more technical details, see Lyrvall et al. (2025) <doi:10.1080/00273171.2025.2473935>.

Automate the explanatory analysis of machine learning predictive models. Generate advanced interactive model explanations in the form of a serverless HTML site with only one line of code. This tool is model-agnostic, therefore compatible with most of the black-box predictive models and frameworks. The main function computes various (instance and model-level) explanations and produces a customisable dashboard, which consists of multiple panels for plots with their short descriptions. It is possible to easily save the dashboard and share it with others. modelStudio facilitates the process of Interactive Explanatory Model Analysis introduced in Baniecki et al. (2023) <doi:10.1007/s10618-023-00924-w>.

Tabulate and plot directional and other multivariate histograms.

This package provides methods for fitting mixture distributions to univariate data using expectation maximization, HWHM and other methods. Supports Gaussian, Cauchy, Student's t and von Mises mixtures. For more details see Merkys (2018) <https://www.lvb.lt/permalink/370LABT_NETWORK/1m6ui06/alma9910036312108451>.

This package provides methods and classes for adding m-activation ("multiplicative activation") layers to MLR or multivariate logistic regression models. M-activation layers created in this library detect and add input interaction (polynomial) effects into a predictive model. M-activation can detect high-order interactions -- a traditionally non-trivial challenge. Details concerning application, methodology, and relevant survey literature can be found in this library's vignette, "About.".

An implementation of the iterative proportional fitting (IPFP), maximum likelihood, minimum chi-square and weighted least squares procedures for updating a N-dimensional array with respect to given target marginal distributions (which, in turn can be multidimensional). The package also provides an application of the IPFP to simulate multivariate Bernoulli distributions.

This package provides a function to perform bias diagnostics on linear mixed models fitted with lmer() from the lme4 package. Implements permutation tests for assessing the bias of fixed effects, as described in Karl and Zimmerman (2021) <doi:10.1016/j.jspi.2020.06.004>. Karl and Zimmerman (2020) <doi:10.17632/tmynggddfm.1> provide R code for implementing the test using mvglmmRank output. Development of this package was assisted by GPT o1-preview for code structure and documentation.

The routine twosample_test() in this package runs the two-sample test using various test statistic for multivariate data. The user can also run several tests and then find a p value adjusted for simultaneous inference. The p values are found via permutation or via the parametric bootstrap. The routine twosample_power() allows the estimation of the power of the tests. The routine run.studies() allows a user to quickly study the power of a new method and how it compares to those included in the package. For details of the methods and references see the included vignettes.

Identifying maturation stages across young athletes is paramount for talent identification. Furthermore, the concept of biobanding, or grouping of athletes based on their biological development, instead of their chronological age, has been widely researched. The goal of this package is to help professionals working in the field of strength & conditioning and talent ID obtain common maturation metrics and as well as to quickly visualize this information via several plotting options. For the methods behind the computed maturation metrics implemented in this package refer to Khamis, H. J., & Roche, A. F. (1994) <https://pubmed.ncbi.nlm.nih.gov/7936860/>, Mirwald, R.L et al., (2002) <https://pubmed.ncbi.nlm.nih.gov/11932580/> and Cumming, Sean P. et al., (2017) <doi:10.1519/SSC.0000000000000281>.

Three generalizations of the synthetic control method (which has already an implementation in package Synth') are implemented: first, MSCMT allows for using multiple outcome variables, second, time series can be supplied as economic predictors, and third, a well-defined cross-validation approach can be used. Much effort has been taken to make the implementation as stable as possible (including edge cases) without losing computational efficiency. A detailed description of the main algorithms is given in Becker and Klöà ner (2018) <doi:10.1016/j.ecosta.2017.08.002>.

This package provides a tool for implementing so called deft approach (see Fisher, David J., et al. (2017) <DOI:10.1136/bmj.j573>) and model visualization.

Covariate measurement error correction is implemented by means of regression calibration by Carroll RJ, Ruppert D, Stefanski LA & Crainiceanu CM (2006, ISBN:1584886331), efficient regression calibration by Spiegelman D, Carroll RJ & Kipnis V (2001) <doi:10.1002/1097-0258(20010115)20:1%3C139::AID-SIM644%3E3.0.CO;2-K> and maximum likelihood estimation by Bartlett JW, Stavola DBL & Frost C (2009) <doi:10.1002/sim.3713>. Outcome measurement error correction is implemented by means of the method of moments by Buonaccorsi JP (2010, ISBN:1420066560) and efficient method of moments by Keogh RH, Carroll RJ, Tooze JA, Kirkpatrick SI & Freedman LS (2014) <doi:10.1002/sim.7011>. Standard error estimation of the corrected estimators is implemented by means of the Delta method by Rosner B, Spiegelman D & Willett WC (1990) <doi:10.1093/oxfordjournals.aje.a115715> and Rosner B, Spiegelman D & Willett WC (1992) <doi:10.1093/oxfordjournals.aje.a116453>, the Fieller method described by Buonaccorsi JP (2010, ISBN:1420066560), and the Bootstrap by Carroll RJ, Ruppert D, Stefanski LA & Crainiceanu CM (2006, ISBN:1584886331).

Matching with string distance has never been easier! messy.cats contains various functions that employ string distance tools in order to make data management easier for users working with categorical data. Categorical data, especially user inputted categorical data that often tends to be plagued by typos, can be difficult to work with. messy.cats aims to provide functions that make cleaning categorical data simple and easy.

Framework to facilitate patient subtyping with similarity network fusion and meta clustering. The similarity network fusion (SNF) algorithm was introduced by Wang et al. (2014) in <doi:10.1038/nmeth.2810>. SNF is a data integration approach that can transform high-dimensional and diverse data types into a single similarity network suitable for clustering with minimal loss of information from each initial data source. The meta clustering approach was introduced by Caruana et al. (2006) in <doi:10.1109/ICDM.2006.103>. Meta clustering involves generating a wide range of cluster solutions by adjusting clustering hyperparameters, then clustering the solutions themselves into a manageable number of qualitatively similar solutions, and finally characterizing representative solutions to find ones that are best for the user's specific context. This package provides a framework to easily transform multi-modal data into a wide range of similarity network fusion-derived cluster solutions as well as to visualize, characterize, and validate those solutions. Core package functionality includes easy customization of distance metrics, clustering algorithms, and SNF hyperparameters to generate diverse clustering solutions; calculation and plotting of associations between features, between patients, and between cluster solutions; and standard cluster validation approaches including resampled measures of cluster stability, standard metrics of cluster quality, and label propagation to evaluate generalizability in unseen data. Associated vignettes guide the user through using the package to identify patient subtypes while adhering to best practices for unsupervised learning.

Enhances mlexperiments <https://CRAN.R-project.org/package=mlexperiments> with additional machine learning ('ML') learners for survival analysis. The package provides R6-based survival learners for the following algorithms: glmnet <https://CRAN.R-project.org/package=glmnet>, ranger <https://CRAN.R-project.org/package=ranger>, xgboost <https://CRAN.R-project.org/package=xgboost>, and rpart <https://CRAN.R-project.org/package=rpart>. These can be used directly with the mlexperiments R package.

This package provides functions to interpolate irregularly and regularly spaced data using Multilevel B-spline Approximation (MBA). Functions call portions of the SINTEF Multilevel B-spline Library written by à yvind Hjelle which implements methods developed by Lee, Wolberg and Shin (1997; <doi:10.1109/2945.620490>).

This package implements Meta Fuzzy Functions (MFFs) for regression Tak and Ucan (2026) <doi:10.1016/j.asoc.2026.114592> by aggregating predictions from multiple base learners using membership weights learned in the prediction space of validation set. The package supports fuzzy and crisp meta-ensemble structures via Fuzzy C-Means (FCM) Tak (2018) <doi:10.1016/j.asoc.2018.08.009>, Possibilistic FCM (PFCM) Tak (2021) <doi:10.1016/j.ins.2021.01.024>, and k-means, and provides a workflow to (i) generate validation/test prediction matrices from common regression learners (linear and penalized regression via glmnet', random forests, gradient boosting with xgboost and lightgbm'), (ii) fit cluster-wise meta fuzzy functions and compute membership-based weights, (iii) tune clustering-related hyperparameters (number of clusters/functions, fuzziness exponent, possibilistic regularization) via grid search on validation loss, and (iv) predict on new/test prediction matrices and evaluate performance using standard regression metrics (MAE, RMSE, MAPE, SMAPE, MSE, MedAE). This enables flexible, interpretable ensemble regression where different base models contribute to different meta components according to learned memberships.