This package provides a multi-core R package that allows for the statistical modeling of multi-group multivariate mixed data using Gaussian graphical models. Combining the Gaussian copula framework with the fused graphical lasso penalty, the heteromixgm package can handle a wide variety of datasets found in various sciences. The package also includes an option to perform model selection using the AIC, BIC and EBIC information criteria, a function that plots partial correlation graphs based on the selected precision matrices, as well as simulate mixed heterogeneous data for exploratory or simulation purposes and one multi-group multivariate mixed agricultural dataset pertaining to maize yields. The package implements the methodological developments found in Hermes et al. (2024) <doi:10.1080/10618600.2023.2289545>.

This package provides tools for the analysis and visualization of animal and plant pedigrees. Analytical methods include equivalent complete generations, generation intervals, effective population size (via inbreeding, coancestry, and demographic approaches), founder and ancestor contributions, partial inbreeding, genetic diversity indices, and additive (A), dominance (D), and epistatic (AA) relationship matrices. Core algorithms â ancestry tracing, topological sorting, inbreeding coefficients, and matrix construction â are implemented in C++ ('Rcpp', RcppArmadillo') and data.table', scaling to pedigrees with over one million individuals. Pedigree graphs are rendered via igraph with support for compact full-sib family display; relationship matrices can be visualized as heatmaps. Supports complex mating systems, including selfing and pedigrees in which the same individual can appear as both sire and dam.

Various algorithms for segmentation of 2D and 3D images, such as computed tomography and satellite remote sensing. This package implements Bayesian image analysis using the hidden Potts model with external field prior of Moores et al. (2015) <doi:10.1016/j.csda.2014.12.001>. Latent labels are sampled using chequerboard updating or Swendsen-Wang. Algorithms for the smoothing parameter include pseudolikelihood, path sampling, the exchange algorithm, approximate Bayesian computation (ABC-MCMC and ABC-SMC), and the parametric functional approximate Bayesian (PFAB) algorithm. Refer to Moores, Pettitt & Mengersen (2020) <doi:10.1007/978-3-030-42553-1_6> for an overview and also to <doi:10.1007/s11222-014-9525-6> and <doi:10.1214/18-BA1130> for further details of specific algorithms.

An R implementation of methods employed in the field of pedometrics, soil science discipline dedicated to studying the spatial, temporal, and spatio-temporal variation of soil using statistical and computational methods. The methods found here include the calibration of linear regression models using covariate selection strategies, computation of summary validation statistics for predictions, generation of summary plots, evaluation of the local quality of a geostatistical model of uncertainty, and so on. Other functions simply extend the functionalities of or facilitate the usage of functions from other packages that are commonly used for the analysis of soil data. Formerly available versions of suggested packages no longer available from CRAN can be obtained from the CRAN archive <https://cran.r-project.org/src/contrib/Archive/>.

Computation of sparse eigenvectors of a matrix (aka sparse PCA) with running time 2-3 orders of magnitude lower than existing methods and better final performance in terms of recovery of sparsity pattern and estimation of numerical values. Can handle covariance matrices as well as data matrices with real or complex-valued entries. Different levels of sparsity can be specified for each individual ordered eigenvector and the method is robust in parameter selection. See vignette for a detailed documentation and comparison, with several illustrative examples. The package is based on the paper: K. Benidis, Y. Sun, P. Babu, and D. P. Palomar (2016). "Orthogonal Sparse PCA and Covariance Estimation via Procrustes Reformulation," IEEE Transactions on Signal Processing <doi:10.1109/TSP.2016.2605073>.

This package provides a version of the Titanic survival data tailored for people analytics demonstrations and practice. While another package, titanic', reproduces the Kaggle competition files with minimal preprocessing, tidytitanic combines the train and test datasets into the single dataset, passengers', for exploration and summary across all passengers. It also extracts personal identifiersâ such as first names, last names, and titles from the raw name field, enabling demographic analysis. The passengers data does not cover the crew, but this package also provides the more bare-bones, crew-containing datasets tidy_titanic and flat_titanic based on the Titanic data set from datasets for further exploration. This human-centered data package is designed to support exploratory data analysis, feature engineering, and pedagogical use cases.

Increasingly powerful techniques for high-throughput sequencing open the possibility to comprehensively characterize microbial communities, including rare species. However, a still unresolved issue are the substantial error rates in the experimental process generating these sequences. To overcome these limitations we propose an approach, where each sample is split and the same amplification and sequencing protocol is applied to both halves. This procedure should allow to detect likely PCR and sequencing artifacts, and true rare species by comparison of the results of both parts. The AmpliconDuo package, whereas amplicon duo from here on refers to the two amplicon data sets of a split sample, is intended to help interpret the obtained read frequency distribution across split samples, and to filter the false positive reads.

This package provides a Bayesian framework to estimate the Student's t-distribution's degrees of freedom is developed. Markov Chain Monte Carlo sampling routines are developed as in <doi:10.3390/axioms11090462> to sample from the posterior distribution of the degrees of freedom. A random walk Metropolis algorithm is used for sampling when Jeffrey's and Gamma priors are endowed upon the degrees of freedom. In addition, the Metropolis-adjusted Langevin algorithm for sampling is used under the Jeffrey's prior specification. The Log-normal prior over the degrees of freedom is posed as a viable choice with comparable performance in simulations and real-data application, against other prior choices, where an Elliptical Slice Sampler is used to sample from the concerned posterior.

Meta-package for statistical and machine learning with a unified interface for model fitting, prediction, performance assessment, and presentation of results. Approaches for model fitting and prediction of numerical, categorical, or censored time-to-event outcomes include traditional regression models, regularization methods, tree-based methods, support vector machines, neural networks, ensembles, data preprocessing, filtering, and model tuning and selection. Performance metrics are provided for model assessment and can be estimated with independent test sets, split sampling, cross-validation, or bootstrap resampling. Resample estimation can be executed in parallel for faster processing and nested in cases of model tuning and selection. Modeling results can be summarized with descriptive statistics; calibration curves; variable importance; partial dependence plots; confusion matrices; and ROC, lift, and other performance curves.

This package provides a package for selecting the most relevant features (genes) in the high-dimensional binary classification problems. The discriminative features are identified using analyzing the overlap between the expression values across both classes. The package includes functions for measuring the proportional overlapping score for each gene avoiding the outliers effect. The used measure for the overlap is the one defined in the "Proportional Overlapping Score (POS)" technique for feature selection. A gene mask which represents a gene's classification power can also be produced for each gene (feature). The set size of the selected genes might be set by the user. The minimum set of genes that correctly classify the maximum number of the given tissue samples (observations) can be also produced.

Visualization of next generation sequencing (NGS) data is essential for interpreting high-throughput genomics experiment results. GenomicPlot facilitates plotting of NGS data in various formats (bam, bed, wig and bigwig); both coverage and enrichment over input can be computed and displayed with respect to genomic features (such as UTR, CDS, enhancer), and user defined genomic loci or regions. Statistical tests on signal intensity within user defined regions of interest can be performed and represented as boxplots or bar graphs. Parallel processing is used to speed up computation on multicore platforms. In addition to genomic plots which is suitable for displaying of coverage of genomic DNA (such as ChIPseq data), metagenomic (without introns) plots can also be made for RNAseq or CLIPseq data as well.

General purpose toolbox for simulating quantum versions of game theoretic models (Flitney and Abbott 2002) <arXiv:quant-ph/0208069>. Quantum (Nielsen and Chuang 2010, ISBN:978-1-107-00217-3) versions of models that have been handled are: Penny Flip Game (David A. Meyer 1998) <arXiv:quant-ph/9804010>, Prisoner's Dilemma (J. Orlin Grabbe 2005) <arXiv:quant-ph/0506219>, Two Person Duel (Flitney and Abbott 2004) <arXiv:quant-ph/0305058>, Battle of the Sexes (Nawaz and Toor 2004) <arXiv:quant-ph/0110096>, Hawk and Dove Game (Nawaz and Toor 2010) <arXiv:quant-ph/0108075>, Newcomb's Paradox (Piotrowski and Sladkowski 2002) <arXiv:quant-ph/0202074> and Monty Hall Problem (Flitney and Abbott 2002) <arXiv:quant-ph/0109035>.

This package provides a shiny app-based GUI wrapper for ggplot with built-in statistical analysis. Import data from file and use dropdown menus and checkboxes to specify the plotting variables, graph type, and look of your plots. Once created, plots can be saved independently or stored in a report that can be saved as a pdf. If new data are added to the file, the report can be refreshed to include new data. Statistical tests can be selected and added to the graphs. Analysis of flow cytometry data is especially integrated with plotGrouper. Count data can be transformed to return the absolute number of cells in a sample (this feature requires inclusion of the number of beads per sample and information about any dilution performed).

This package provides comprehensive cytokine profiling analysis through quality control using biologically meaningful cutoffs on raw cytokine measurements and by testing for distributional symmetry to recommend appropriate transformations. Offers exploratory data analysis with summary statistics, enhanced boxplots, and barplots, along with univariate and multivariate analytical capabilities for in-depth cytokine profiling such as Principal Component Analysis based on Andrzej MaÄ kiewicz and Waldemar Ratajczak (1993) <doi:10.1016/0098-3004(93)90090-R>, Sparse Partial Least Squares Discriminant Analysis based on Lê Cao K-A, Boitard S, and Besse P (2011) <doi:10.1186/1471-2105-12-253>, Random Forest based on Breiman, L. (2001) <doi:10.1023/A:1010933404324>, and Extreme Gradient Boosting based on Tianqi Chen and Carlos Guestrin (2016) <doi:10.1145/2939672.2939785>.

Also abbreviates to "CCSeq". Finds clusters of colocalized sequences in .bed annotation files up to a specified cut-off distance. Two sequences are colocalized if they are within the cut-off distance of each other, and clusters are sets of sequences where each sequence is colocalized to at least one other sequence in the cluster. For a set of .bed annotation tables provided in a list along with a cut-off distance, the program will output a file containing the locations of each cluster. Annotated .bed files are from the pwmscan application at <https://ccg.epfl.ch/pwmtools/pwmscan.php>. Personal machines might crash or take excessively long depending on the number of annotated sequences in each file and whether chromsearch() or gensearch() is used.

This package provides a regression framework for response variables which are continuous self-rating scales such as the Visual Analog Scale (VAS) used in pain assessment, or the Linear Analog Self-Assessment (LASA) scales in quality of life studies. These scales measure subjects perception of an intangible quantity, and cannot be handled as ratio variables because of their inherent non-linearity. We treat them as ordinal variables, measured on a continuous scale. A function (the g function) connects the scale with an underlying continuous latent variable. The link function is the inverse of the CDF of the assumed underlying distribution of the latent variable. A variety of link functions are currently implemented. Such models are described in Manuguerra et al (2020) <doi:10.18637/jss.v096.i08>.

Includes functions for the construction of matched samples that are balanced and representative by design. Among others, these functions can be used for matching in observational studies with treated and control units, with cases and controls, in related settings with instrumental variables, and in discontinuity designs. Also, they can be used for the design of randomized experiments, for example, for matching before randomization. By default, designmatch uses the highs optimization solver, but its performance is greatly enhanced by the Gurobi optimization solver and its associated R interface. For their installation, please follow the instructions at <https://www.gurobi.com/getting-started/> and <https://docs.gurobi.com/projects/optimizer/en/current/reference/r/setup.html>. We have also included directions in the gurobi_installation file in the inst folder.

This package provides an efficient tool for creating custom-time bioclimatic and derived environmental summary variables from user-supplied raster data for user-defined timeframes. The package overcomes computational bottlenecks by automatically switching between an in-memory framework using the terra package to maximize speed for smaller datasets, and an on-disk tiling framework for rasters that exceed available RAM, leveraging exactextractr and Rfast to process data in chunks. The core functions, derive_bioclim() and derive_statistics(), offer a unified interface with flexibility for custom time periods beyond standard quarters and the use of fixed temporal indices, facilitating the creation of temporally-matched environmental variables for ecological and biogeographical modeling. Visit the package website <https://gepinillab.github.io/fastbioclim/> to find tutorials in English and Spanish.

Interlinearized glossed texts (IGT) are used in descriptive linguistics for representing a morphological analysis of a text through a morpheme-by-morpheme gloss. InterlineaR provide a set of functions that targets several popular formats of IGT ('SIL Toolbox', EMELD XML') and that turns an IGT into a set of data frames following a relational model (the tables represent the different linguistic units: texts, sentences, word, morphems). The same pieces of software ('SIL FLEX', SIL Toolbox') typically produce dictionaries of the morphemes used in the glosses. InterlineaR provide a function for turning the LIFT XML dictionary format into a set of data frames following a relational model in order to represent the dictionary entries, the sense(s) attached to the entries, the example(s) attached to senses, etc.

This package provides an efficient method to recover the missing block of an approximately low-rank matrix. Current literature on matrix completion focuses primarily on independent sampling models under which the individual observed entries are sampled independently. Motivated by applications in genomic data integration, we propose a new framework of structured matrix completion (SMC) to treat structured missingness by design [Cai T, Cai TT, Zhang A (2016) <doi:10.1080/01621459.2015.1021005>]. Specifically, our proposed method aims at efficient matrix recovery when a subset of the rows and columns of an approximately low-rank matrix are observed. The main function in our package, smc.FUN(), is for recovery of the missing block A22 of an approximately low-rank matrix A given the other blocks A11, A12, A21.

In gene therapy, stem cells are modified using viral vectors to deliver the therapeutic transgene and replace functional properties since the genetic modification is stable and inherited in all cell progeny. The retrieval and mapping of the sequences flanking the virus-host DNA junctions allows the identification of insertion sites (IS), essential for monitoring the evolution of genetically modified cells in vivo. A comprehensive toolkit for the analysis of IS is required to foster clonal trackign studies and supporting the assessment of safety and long term efficacy in vivo. This package is aimed at (1) supporting automation of IS workflow, (2) performing base and advance analysis for IS tracking (clonal abundance, clonal expansions and statistics for insertional mutagenesis, etc.), (3) providing basic biology insights of transduced stem cells in vivo.

This package provides a framework to infer causality on binary data using techniques in frequent pattern mining and estimation statistics. Given a set of individual vectors S=x where x(i) is a realization value of binary variable i, the framework infers empirical causal relations of binary variables i,j from S in a form of causal graph G=(V,E) where V is a set of nodes representing binary variables and there is an edge from i to j in E if the variable i causes j. The framework determines dependency among variables as well as analyzing confounding factors before deciding whether i causes j. The publication of this package is at Chainarong Amornbunchornvej, Navaporn Surasvadi, Anon Plangprasopchok, and Suttipong Thajchayapong (2023) <doi:10.1016/j.heliyon.2023.e15947>.

Fits single-species (univariate) and multi-species (multivariate) non-spatial and spatial abundance models in a Bayesian framework using Markov Chain Monte Carlo (MCMC). Spatial models are fit using Nearest Neighbor Gaussian Processes (NNGPs). Details on NNGP models are given in Datta, Banerjee, Finley, and Gelfand (2016) <doi:10.1080/01621459.2015.1044091> and Finley, Datta, and Banerjee (2022) <doi:10.18637/jss.v103.i05>. Fits single-species and multi-species spatial and non-spatial versions of generalized linear mixed models (Gaussian, Poisson, Negative Binomial), N-mixture models (Royle 2004 <doi:10.1111/j.0006-341X.2004.00142.x>) and hierarchical distance sampling models (Royle, Dawson, Bates (2004) <doi:10.1890/03-3127>). Multi-species spatial models are fit using a spatial factor modeling approach with NNGPs for computational efficiency.

Implementation of the bootstrapping approach for the estimation of clustering stability and its application in estimating the number of clusters, as introduced by Yu et al (2016)<doi:10.1142/9789814749411_0007>. Implementation of the non-parametric bootstrap approach to assessing the stability of module detection in a graph, the extension for the selection of a parameter set that defines a graph from data in a way that optimizes stability and the corresponding visualization functions, as introduced by Tian et al (2021) <doi:10.1002/sam.11495>. Implemented out-of-bag stability estimation function and k-select Smin-based k-selection function as introduced by Liu et al (2022) <doi:10.1002/sam.11593>. Implemented ensemble clustering method based-on k-means clustering method, spectral clustering method and hierarchical clustering method.