Use standard genomics file format (BED) and a table of orthologs to illustrate synteny conservation at the genome-wide scale. Significantly conserved linkage groups are identified as described in Simakov et al. (2020) <doi:10.1038/s41559-020-1156-z> and displayed on an Oxford Grid (Edwards (1991) <doi:10.1111/j.1469-1809.1991.tb00394.x>) or a chord diagram as in Simakov et al. (2022) <doi:10.1126/sciadv.abi5884>. The package provides a function that uses a network-based greedy algorithm to find communities (Clauset et al. (2004) <doi:10.1103/PhysRevE.70.066111>) and so automatically order the chromosomes on the plot to improve interpretability.

This package provides a glycolipid mass spectrometry technology has the potential to accurately identify individual bacterial species from polymicrobial samples. To develop bacterial identification algorithms (e.g. machine learning) using this glycolipid technology, it is necessary to generate a large number of various in-silico polymicrobial mass spectra that are similar to real mass spectra. MGMS2 (Membrane Glycolipid Mass Spectrum Simulator) generates such in-silico mass spectra, considering errors in m/z (mass-to-charge ratio) and variances of intensity values, occasions of missing signature ions, and noise peaks. It estimates summary statistics of monomicrobial mass spectra for each strain or species and simulates polymicrobial glycolipid mass spectra using the summary statistics of monomicrobial mass spectra. References: Ryu, S.Y., Wendt, G.A., Chandler, C.E., Ernst, R.K. and Goodlett, D.R. (2019) <doi:10.1021/acs.analchem.9b03340> "Model-based Spectral Library Approach for Bacterial Identification via Membrane Glycolipids." Gibb, S. and Strimmer, K. (2012) <doi:10.1093/bioinformatics/bts447> "MALDIquant: a versatile R package for the analysis of mass spectrometry data.".

This package provides a color palette generator inspired by Mexican politics, with colors ranging from red on the left to gray in the middle and green on the right. Palette options range from only a few colors to several colors, but with discrete and continuous options to offer greatest flexibility to the user. This package allows for a range of applications, from mapping brief discrete scales (e.g., four colors for Morena, PRI, and PAN) to continuous interpolated arrays including dozens of shades graded from red to green.

Calculate various indices, like Crude Migration Rate, different Gini indices or the Coefficient of Variation among others, to show the (un)equality of migration.

Highly variable gene selection methods, including popular public available methods, and also the mixture of multiple highly variable gene selection methods, <https://github.com/RuzhangZhao/mixhvg>. Reference: <doi:10.1101/2024.08.25.608519>.

This package provides functions that allow you to create your own color palette from an image, using mathematical algorithms.

The Markov Decision Processes (MDP) toolbox proposes functions related to the resolution of discrete-time Markov Decision Processes: finite horizon, value iteration, policy iteration, linear programming algorithms with some variants and also proposes some functions related to Reinforcement Learning.

Send server-side tracking data from R. The Measurement Protocol version 2 <https://developers.google.com/analytics/devguides/collection/protocol/ga4> allows sending HTTP tracking events from R code.

This package implements three families of parsimonious hidden Markov models (HMMs) for matrix-variate longitudinal data using the Expectation-Conditional Maximization (ECM) algorithm. The package supports matrix-variate normal, t, and contaminated normal distributions as emission distributions. For each hidden state, parsimony is achieved through the eigen-decomposition of the covariance matrices associated with the emission distribution. This approach results in a comprehensive set of 98 parsimonious HMMs for each type of emission distribution. Atypical matrix detection is also supported, utilizing the fitted (heavy-tailed) models.

An approach to identifies metabolic biomarker signature for metabolic data by discovering predictive metabolite for predicting survival and classifying patients into risk groups. Classifiers are constructed as a linear combination of predictive/important metabolites, prognostic factors and treatment effects if necessary. Several methods were implemented to reduce the metabolomics matrix such as the principle component analysis of Wold Svante et al. (1987) <doi:10.1016/0169-7439(87)80084-9> , the LASSO method by Robert Tibshirani (1998) <doi:10.1002/(SICI)1097-0258(19970228)16:4%3C385::AID-SIM380%3E3.0.CO;2-3>, the elastic net approach by Hui Zou and Trevor Hastie (2005) <doi:10.1111/j.1467-9868.2005.00503.x>. Sensitivity analysis on the quantile used for the classification can also be accessed to check the deviation of the classification group based on the quantile specified. Large scale cross validation can be performed in order to investigate the mostly selected predictive metabolites and for internal validation. During the evaluation process, validation is accessed using the hazard ratios (HR) distribution of the test set and inference is mainly based on resampling and permutations technique.

It can be used to create/encode molecular "license-plates" from sequences and to also decode the "license-plates" back to sequences. While initially created for transfer RNA-derived small fragments (tRFs), this tool can be used for any genomic sequences including but not limited to: tRFs, microRNAs, etc. The detailed information can reference to Pliatsika V, Loher P, Telonis AG, Rigoutsos I (2016) <doi:10.1093/bioinformatics/btw194>. It can also be used to annotate tRFs. The detailed information can reference to Loher P, Telonis AG, Rigoutsos I (2017) <doi:10.1038/srep41184>.

Compose generic monadic function pipelines with %>>% and %>-% based on implementing the S7 generics fmap() and bind(). Methods are provided for the built-in list type and the maybe class from the maybe package. The concepts are modelled directly after the Monad typeclass in Haskell, but adapted for idiomatic use in R.

Extends the mlr3 ecosystem to functional analysis by adding support for irregular and regular functional data as defined in the tf package. The package provides PipeOps for preprocessing functional columns and for extracting scalar features, thereby allowing standard machine learning algorithms to be applied afterwards. Available operations include simple functional features such as the mean or maximum, smoothing, interpolation, flattening, and functional PCA'.

Advanced methods for a valuable quantitative environmental risk assessment using Bayesian inference of survival and reproduction Data. Among others, it facilitates Bayesian inference of the general unified threshold model of survival (GUTS). See our companion paper Baudrot and Charles (2021) <doi:10.21105/joss.03200>, as well as complementary details in Baudrot et al. (2018) <doi:10.1021/acs.est.7b05464> and Delignette-Muller et al. (2017) <doi:10.1021/acs.est.6b05326>.

This package provides a collection of machine learning helper functions, particularly assisting in the Exploratory Data Analysis phase. Makes heavy use of the data.table package for optimal speed and memory efficiency. Highlights include a versatile bin_data() function, sparsify() for converting a data.table to sparse matrix format with one-hot encoding, fast evaluation metrics, and empirical_cdf() for calculating empirical Multivariate Cumulative Distribution Functions.

Algorithms for solving various Maximum Weight Connected Subgraph Problems, including variants with budget constraints, cardinality constraints, weighted edges and signals. The package represents an R interface to high-efficient solvers based on relax-and-cut approach (Ã lvarez-Miranda E., Sinnl M. (2017) <doi:10.1016/j.cor.2017.05.015>) mixed-integer programming (Loboda A., Artyomov M., and Sergushichev A. (2016) <doi:10.1007/978-3-319-43681-4_17>) and simulated annealing.

This package provides tools for analyzing metabolic pathway completeness, abundance, and transcripts using KEGG Orthology (KO) data from (meta)genomic and (meta)transcriptomic studies. Supports both completeness (presence/absence) and abundance-weighted analyses. Includes built-in KEGG reference datasets. For more details see Li et al. (2023) <doi:10.1038/s41467-023-42193-7>.

Given a CSV file with titles and abstracts, the package creates a document-term matrix that is lemmatized and stemmed and can directly be used to train machine learning methods for automatic title-abstract screening in the preparation of a meta analysis.

Sometimes data for analysis are obtained using more convenient or less expensive means yielding "surrogate" variables for what could be obtained more accurately, albeit with less convenience; or less conveniently or at more expense yielding "reference" variables, thought of as being measured without error. Analysis of the surrogate variables measured with error generally yields biased estimates when the objective is to make inference about the reference variables. Often it is thought that ignoring the measurement error in surrogate variables only biases effects toward the null hypothesis, but this need not be the case. Measurement errors may bias parameter estimates either toward or away from the null hypothesis. If one has a data set with surrogate variable data from the full sample, and also reference variable data from a randomly selected subsample, then one can assess the bias introduced by measurement error in parameter estimation, and use this information to derive improved estimates based upon all available data. Formulaically these estimates based upon the reference variables from the validation subsample combined with the surrogate variables from the whole sample can be interpreted as starting with the estimate from reference variables in the validation subsample, and "augmenting" this with additional information from the surrogate variables. This suggests the term "augmented" estimate. The meerva package calculates these augmented estimates in the regression setting when there is a randomly selected subsample with both surrogate and reference variables. Measurement errors may be differential or non-differential, in any or all predictors (simultaneously) as well as outcome. The augmented estimates derive, in part, from the multivariate correlation between regression model parameter estimates from the reference variables and the surrogate variables, both from the validation subset. Because the validation subsample is chosen at random any biases imposed by measurement error, whether non-differential or differential, are reflected in this correlation and these correlations can be used to derive estimates for the reference variables using data from the whole sample. The main functions in the package are meerva.fit which calculates estimates for a dataset, and meerva.sim.block which simulates multiple datasets as described by the user, and analyzes these datasets, storing the regression coefficient estimates for inspection. The augmented estimates, as well as how measurement error may arise in practice, is described in more detail by Kremers WK (2021) <arXiv:2106.14063> and is an extension of the works by Chen Y-H, Chen H. (2000) <doi:10.1111/1467-9868.00243>, Chen Y-H. (2002) <doi:10.1111/1467-9868.00324>, Wang X, Wang Q (2015) <doi:10.1016/j.jmva.2015.05.017> and Tong J, Huang J, Chubak J, et al. (2020) <doi:10.1093/jamia/ocz180>.

Train and make predictions from a multi-layer perceptron neural network with optional partial monotonicity constraints.

Tool for exploring DNA and amino acid variation and inferring the presence of target lineages from microbial high-throughput genomic DNA samples that potentially contain mixtures of variants/lineages. MixviR was originally created to help analyze environmental SARS-CoV-2/Covid-19 samples from environmental sources such as wastewater or dust, but can be applied to any microbial group. Inputs include reference genome information in commonly-used file formats (fasta, bed) and one or more variant call format (VCF) files, which can be generated with programs such as Illumina's DRAGEN, the Genome Analysis Toolkit, or bcftools. See DePristo et al (2011) <doi:10.1038/ng.806> and Danecek et al (2021) <doi:10.1093/gigascience/giab008> for these tools, respectively. Available outputs include a table of mutations observed in the sample(s), estimates of proportions of target lineages in the sample(s), and an R Shiny dashboard to interactively explore the data.

Analyzes non-normal data via the Multiple Comparison Procedures and Modeling approach (MCP-Mod). Many functions rely on the DoseFinding package. This package makes it so the user does not need to provide or calculate the mu vector and S matrix. Instead, the user typically supplies the data in its raw form, and this package will calculate the needed objects and passes them into the DoseFinding functions. If the user wishes to primarily use the functions provided in the DoseFinding package, a singular function (prepareGen()) will provide mu and S. The package currently handles power analysis and the MCP-Mod procedure for negative binomial, Poisson, and binomial data. The MCP-Mod procedure can also be applied to survival data, but power analysis is not available. Bretz, F., Pinheiro, J. C., and Branson, M. (2005) <doi:10.1111/j.1541-0420.2005.00344.x>. Buckland, S. T., Burnham, K. P. and Augustin, N. H. (1997) <doi:10.2307/2533961>. Pinheiro, J. C., Bornkamp, B., Glimm, E. and Bretz, F. (2014) <doi:10.1002/sim.6052>.

This package provides a variety of functions useful for data analysis, selection, manipulation, and graphics.

Multivariate Information-based Inductive Causation, better known by its acronym MIIC, is a causal discovery method, based on information theory principles, which learns a large class of causal or non-causal graphical models from purely observational data, while including the effects of unobserved latent variables. Starting from a complete graph, the method iteratively removes dispensable edges, by uncovering significant information contributions from indirect paths, and assesses edge-specific confidences from randomization of available data. The remaining edges are then oriented based on the signature of causality in observational data. The recent more interpretable MIIC extension (iMIIC) further distinguishes genuine causes from putative and latent causal effects, while scaling to very large datasets (hundreds of thousands of samples). Since the version 2.0, MIIC also includes a temporal mode (tMIIC) to learn temporal causal graphs from stationary time series data. MIIC has been applied to a wide range of biological and biomedical data, such as single cell gene expression data, genomic alterations in tumors, live-cell time-lapse imaging data (CausalXtract), as well as medical records of patients. MIIC brings unique insights based on causal interpretation and could be used in a broad range of other data science domains (technology, climatology, economy, ...). For more information, you can refer to: Simon et al., eLife 2024, <doi:10.1101/2024.02.06.579177>, Ribeiro-Dantas et al., iScience 2024, <doi:10.1016/j.isci.2024.109736>, Cabeli et al., NeurIPS 2021, <https://why21.causalai.net/papers/WHY21_24.pdf>, Cabeli et al., Comput. Biol. 2020, <doi:10.1371/journal.pcbi.1007866>, Li et al., NeurIPS 2019, <https://papers.nips.cc/paper/9573-constraint-based-causal-structure-learning-with-consistent-separating-sets>, Verny et al., PLoS Comput. Biol. 2017, <doi:10.1371/journal.pcbi.1005662>, Affeldt et al., UAI 2015, <https://auai.org/uai2015/proceedings/papers/293.pdf>. Changes from the previous 1.5.3 release on CRAN are available at <https://github.com/miicTeam/miic_R_package/blob/master/NEWS.md>.