This package implements methodologies for modelling interval data by Normal and Skew-Normal distributions, considering appropriate parameterizations of the variance-covariance matrix that takes into account the intrinsic nature of interval data, and lead to four different possible configuration structures. The Skew-Normal parameters can be estimated by maximum likelihood, while Normal parameters may be estimated by maximum likelihood or robust trimmed maximum likelihood methods.

Fast approximate methods for mixed logistic regression in genome-wide analysis studies (GWAS). Two computationnally efficient methods are proposed for obtaining effect size estimates (beta) in Mixed Logistic Regression in GWAS: the Approximate Maximum Likelihood Estimate (AMLE), and the Offset method. The wald test obtained with AMLE is identical to the score test. Data can be genotype matrices in plink format, or dosage (VCF files). The methods are described in details in Milet et al (2020) <doi:10.1101/2020.01.17.910109>.

Exploratory and predictive methods for the analysis of several blocks of variables measured on the same individuals.

This package provides the facility to calculate non-isotropic accumulated cost surface, least-cost paths, least-cost corridors, least-cost networks using a number of human-movement-related cost functions that can be selected by the user. It just requires a Digital Terrain Model, a start location and (optionally) destination locations. See Alberti (2019) <doi:10.1016/j.softx.2019.100331>.

Implementations of MOSUM-based statistical procedures and algorithms for detecting multiple changes in the mean. This comprises the MOSUM procedure for estimating multiple mean changes from Eichinger and Kirch (2018) <doi:10.3150/16-BEJ887> and the multiscale algorithmic extension from Cho and Kirch (2022) <doi:10.1007/s10463-021-00811-5>, as well as the bootstrap procedure for generating confidence intervals about the locations of change points as proposed in Cho and Kirch (2022) <doi:10.1016/j.csda.2022.107552>. See also Meier, Kirch and Cho (2021) <doi:10.18637/jss.v097.i08> which accompanies the R package.

Procedures for simulating biomes by equilibrium vegetation models, with a special focus on paleoenvironmental applications. Three widely used equilibrium biome models are currently implemented in the package: the Holdridge Life Zone (HLZ) system (Holdridge 1947, <doi:10.1126/science.105.2727.367>), the Köppen-Geiger classification (KGC) system (Köppen 1936, <https://koeppen-geiger.vu-wien.ac.at/pdf/Koppen_1936.pdf>) and the BIOME model (Prentice et al. 1992, <doi:10.2307/2845499>). Three climatic forest-steppe models are also implemented. An approach for estimating monthly time series of relative sunshine duration from temperature and precipitation data (Yin 1999, <doi:10.1007/s007040050111>) is also adapted, allowing process-based biome models to be combined with high-resolution paleoclimate simulation datasets (e.g., CHELSA-TraCE21k v1.0 dataset: <https://chelsa-climate.org/chelsa-trace21k/>).

Analyzing longitudinal clinical data from Electronic Health Records (EHRs) using linear mixed models (LMM) and visualizing the results as networks. It includes functions for fitting LMM, normalizing adjacency matrices, and comparing networks. The package is designed for researchers in clinical and biomedical fields who need to model longitudinal data and explore relationships between variables For more details see Bates et al. (2015) <doi:10.18637/jss.v067.i01>.

Query, extract, and plot genealogical data from The Mathematics Genealogy Project <https://mathgenealogy.org/>. Data is gathered from the WebSocket server run by the geneagrapher-core project <https://github.com/davidalber/geneagrapher-core>.

Comprehensive analytical tools are provided to characterize infectious disease superspreading from contact tracing surveillance data. The underlying theoretical frameworks of this toolkit include branching process with transmission heterogeneity (Lloyd-Smith et al. (2005) <doi:10.1038/nature04153>), case cluster size distribution (Nishiura et al. (2012) <doi:10.1016/j.jtbi.2011.10.039>, Blumberg et al. (2014) <doi:10.1371/journal.ppat.1004452>, and Kucharski and Althaus (2015) <doi:10.2807/1560-7917.ES2015.20.25.21167>), and decomposition of reproduction number (Zhao et al. (2022) <doi:10.1371/journal.pcbi.1010281>).

This package provides access to teaching materials for various statistics courses, including R and Python programs, Shiny apps, data, and PDF/HTML documents. These materials are stored on the Internet as a ZIP file (e.g., in a GitHub repository) and can be downloaded and displayed or run locally. The content of the ZIP file is temporarily or permanently stored. By default, the package uses the GitHub repository sigbertklinke/mmstat4.data. Additionally, the package includes association_measures.R from the archived package ryouready by Mark Heckman and some auxiliary functions.

Some enhancements, extensions and additions to the facilities of the recommended MASS package that are useful mainly for teaching purposes, with more convenient default settings and user interfaces. Key functions from MASS are imported and re-exported to avoid masking conflicts. In addition we provide some additional functions mainly used to illustrate coding paradigms and techniques, such as Gramm-Schmidt orthogonalisation and generalised eigenvalue problems.

Providing the kubernetes-like class ManagedCloudProvider as a child class of the CloudProvider class in the DockerParallel package. The class is able to manage the cloud instance made by the non-kubernetes cloud service. For creating a provider for the non-kubernetes cloud service, the developer needs to define a reference class inherited from ManagedCloudProvider and define the method for the generics runDockerWorkerContainers(), getDockerWorkerStatus() and killDockerWorkerContainers(). For more information, please see the vignette in this package and <https://CRAN.R-project.org/package=DockerParallel>.

The inference in multi-state models is traditionally performed under a Markov assumption that claims that past and future of the process are independent given the present state. In this package, we consider tests of the Markov assumption that are applicable to general multi-state models. Three approaches using existing methodology are considered: a simple method based on including covariates depending on the history in Cox models for the transition intensities; methods based on measuring the discrepancy of the non-Markov estimators of the transition probabilities to the Markov Aalen-Johansen estimators; and, finally, methods that were developed by considering summaries from families of log-rank statistics where patients are grouped by the state occupied of the process at a particular time point (see Soutinho G, Meira-Machado L (2021) <doi:10.1007/s00180-021-01139-7> and Titman AC, Putter H (2020) <doi:10.1093/biostatistics/kxaa030>).

Colour palettes and helper functions for visualising Mycobacterium tuberculosis genomic and epidemiological data with ggplot2 and ggtree'. The package provides predefined palettes, scale functions, tree/cladogram helpers, and convenient preview tools to ensure consistent branding in pathogen-omics visualisations. The palettes were developed as part of the mycolorsTB project <https://github.com/PathoGenOmics-Lab/mycolorsTB>.

Measures mobility in a population through transition matrices and mobility indices. Relative, mixed, and absolute transition matrices are supported. The Prais-Bibby, Absolute Movement, Origin Specific, and Weighted Group Mobility indices are supported. Example income and grade data are included.

Our approach uses a mixture of multilayer stochastic block models to group co-membership matrices with similar information into components and to partition observations into different clusters. See De Santiago (2023, ISBN: 978-2-87587-088-9).

Generates internet memes that optionally include a superimposed inset plot and other atypical features, combining the visual impact of an attention-grabbing meme with graphic results of data analysis. The package differs from related packages that focus on imitating and reproducing standard memes. Some packages do this by interfacing with online meme generators whereas others achieve this natively. This package takes the latter approach. It does not interface with online meme generators or require any authentication with external websites. It reads images directly from local files or via URL and meme generation is done by the package. While this is similar to the meme package available on CRAN, it differs in that the focus is on allowing for non-standard meme layouts and hybrids of memes mixed with graphs. While this package can be used to make basic memes like an online meme generator would produce, it caters primarily to hybrid graph-meme plots where the meme presentation can be seen as a backdrop highlighting foreground graphs of data analysis results. The package also provides support for an arbitrary number of meme text labels with arbitrary size, position and other attributes rather than restricting to the standard top and/or bottom text placement. This is useful for proper aesthetic interleaving of plots of data between meme image backgrounds and overlain text labels. The package offers a selection of templates for graph placement and appearance with respect to the underlying meme. Graph templates also permit additional template-specific customization. Animated gif support is provided but this is optional and functional only if the magick package is installed. magick is not required unless gif functionality is desired.

Two functions for simulating the solution of initial value problems of the form g'(x) = G(x, g) with g(x0) = g0. One is an acceptance-rejection method. The other is a method based on the Mean Value Theorem.

Facilitate frequentist and Bayesian meta-analysis of diagnosis and prognosis research studies. It includes functions to summarize multiple estimates of prediction model discrimination and calibration performance (Debray et al., 2019) <doi:10.1177/0962280218785504>. It also includes functions to evaluate funnel plot asymmetry (Debray et al., 2018) <doi:10.1002/jrsm.1266>. Finally, the package provides functions for developing multivariable prediction models from datasets with clustering (de Jong et al., 2021) <doi:10.1002/sim.8981>.

The mycobacrvR package contains utilities to provide detailed information for B cell and T cell epitopes for predicted adhesins from various servers such as ABCpred, Bcepred, Bimas, Propred, NetMHC and IEDB. Please refer the URL below to download data files (data_mycobacrvR.zip) used in functions of this package.

Data-driven approach for Exploratory Factor Analysis (EFA) that uses Model Implied Instrumental Variables (MIIVs). The method starts with a one factor model and arrives at a suggested model with enhanced interpretability that allows cross-loadings and correlated errors.

This package provides functions for fitting monotone polynomials to data. Detailed discussion of the methodologies used can be found in Murray, Mueller and Turlach (2013) <doi:10.1007/s00180-012-0390-5> and Murray, Mueller and Turlach (2016) <doi:10.1080/00949655.2016.1139582>.

This package implements large-scale hypothesis testing by variance mixing. It takes two statistics per testing unit -- an estimated effect and its associated squared standard error -- and fits a nonparametric, shape-constrained mixture separately on two latent parameters. It reports local false discovery rates (lfdr) and local false sign rates (lfsr). Manuscript describing algorithm of MixTwice: Zheng et al(2021) <doi: 10.1093/bioinformatics/btab162>.

This package provides tools and functions to fit a multilevel index of dissimilarity.