This package provides functions for cost-optimal control charts with a focus on health care applications. Compared to assumptions in traditional control chart theory, here, we allow random shift sizes, random repair and random sampling times. The package focuses on X-bar charts with a sample size of 1 (representing the monitoring of a single patient at a time). The methods are described in Zempleni et al. (2004) <doi:10.1002/asmb.521>, Dobi and Zempleni (2019) <doi:10.1002/qre.2518> and Dobi and Zempleni (2019) <http://ac.inf.elte.hu/Vol_049_2019/129_49.pdf>.

Pearson and Spearman correlation coefficients are commonly used to quantify the strength of bivariate associations of genomic variables. For example, correlations of gene-level DNA copy number and gene expression measurements may be used to assess the impact of DNA copy number changes on gene expression in tumor tissue. MVisAGe enables users to quickly compute and visualize the correlations in order to assess the effect of regional genomic events such as changes in DNA copy number or DNA methylation level. Please see Walter V, Du Y, Danilova L, Hayward MC, Hayes DN, 2018. Cancer Research <doi:10.1158/0008-5472.CAN-17-3464>.

Multi-penalty linear, logistic and cox ridge regression, including estimation of the penalty parameters by efficient (repeated) cross-validation and marginal likelihood maximization. Multiple high-dimensional data types that require penalization are allowed, as well as unpenalized variables. Paired and preferential data types can be specified. See Van de Wiel et al. (2021), <arXiv:2005.09301>.

Meta-CART integrates classification and regression trees (CART) into meta-analysis. Meta-CART is a flexible approach to identify interaction effects between moderators in meta-analysis. The method is described in Dusseldorp et al. (2014) <doi:10.1037/hea0000018> and Li et al. (2017) <doi:10.1111/bmsp.12088>.

This package provides a declarative language for specifying multilevel models, solving for population parameters based on specified variance-explained effect size measures, generating data, and conducting power analyses to determine sample size recommendations. The specification allows for any number of within-cluster effects, between-cluster effects, covariate effects at either level, and random coefficients. Moreover, the models do not assume orthogonal effects, and predictors can correlate at either level and accommodate models with multiple interaction effects.

Deep Learning library that extends the mlr3 framework by building upon the torch package. It allows to conveniently build, train, and evaluate deep learning models without having to worry about low level details. Custom architectures can be created using the graph language defined in mlr3pipelines'.

Takes QC signal for each day and normalize metabolomic data that has been acquired in a certain period of time. At least three QC per day are required.

This package provides a set of evolutionary algorithms to solve many-objective optimization. Hybridization between the algorithms are also facilitated. Available algorithms are: SMS-EMOA <doi:10.1016/j.ejor.2006.08.008> NSGA-III <doi:10.1109/TEVC.2013.2281535> MO-CMA-ES <doi:10.1145/1830483.1830573> The following many-objective benchmark problems are also provided: DTLZ1'-'DTLZ4 from Deb, et al. (2001) <doi:10.1007/1-84628-137-7_6> and WFG4'-'WFG9 from Huband, et al. (2005) <doi:10.1109/TEVC.2005.861417>.

Access to several Numerical Weather Prediction services both in raster format and as a time series for a location. Currently it works with GFS <https://www.ncei.noaa.gov/products/weather-climate-models/global-forecast>, MeteoGalicia <https://www.meteogalicia.gal/web/modelos/threddsIndex.action>, NAM <https://www.ncei.noaa.gov/products/weather-climate-models/north-american-mesoscale>, and RAP <https://www.ncei.noaa.gov/products/weather-climate-models/rapid-refresh-update>.

Offers a gentle introduction to machine learning concepts for practitioners with a statistical pedigree: decomposition of model error (bias-variance trade-off), nonlinear correlations, information theory and functional permutation/bootstrap simulations. Székely GJ, Rizzo ML, Bakirov NK. (2007). <doi:10.1214/009053607000000505>. Reshef DN, Reshef YA, Finucane HK, Grossman SR, McVean G, Turnbaugh PJ, Lander ES, Mitzenmacher M, Sabeti PC. (2011). <doi:10.1126/science.1205438>.

This package creates an object that stores a matrix ensemble, matrices that share the same common properties, where rows and columns can be annotated. Matrices must have the same dimension and dimnames. Operators to manipulate these objects are provided as well as mechanisms to apply functions to these objects.

Convert Markdown ('.md') or R Markdown ('.Rmd') texts, R scripts, directory structures, and other hierarchical structured documents into mind map widgets or Freemind codes or Mermaid mind map codes, and vice versa. Freemind mind map ('.mm') files can be opened by or imported to common mind map software such as Freemind (<https://freemind.sourceforge.io/wiki/index.php/Main_Page>). Mermaid mind map codes (<https://mermaid.js.org/>) can be directly embedded in documents.

This package provides a comprehensive suite of estimation tools for meanimiles, a general class of (risk) functionals. This package includes nonparametric estimators for univariate meanimile evaluation, copula-based estimation for portfolio risk aggregation (full parametric, semiparametric, and nonparametric), and novel estimators for meanimiles in regression settings. Following the articles D. Debrauwer, I. Gijbels, and K. Herrmann (2025) <doi:10.1214/25-EJS2391>, D. Debrauwer and I. Gijbels (2026) <doi:10.1007/s00184-026-01022-9>.

Acoustic template detection and monitoring database interface. Create, modify, save, and use templates for detection of animal vocalizations. View, verify, and extract results. Upload a MySQL schema to a existing instance, manage survey metadata, write and read templates and detections locally or to the database.

This GUI for the mi package walks the user through the steps of multiple imputation and the analysis of completed data.

Solve scalar-on-function linear models, including generalized linear mixed effect model and quantile linear regression model, and bias correction estimation methods due to measurement error. Details about the measurement error bias correction methods, see Luan et al. (2023) <doi:10.48550/arXiv.2305.12624>, Tekwe et al. (2022) <doi:10.1093/biostatistics/kxac017>, Zhang et al. (2023) <doi:10.5705/ss.202021.0246>, Tekwe et al. (2019) <doi:10.1002/sim.8179>.

Methods-first tooling for reproducing and extending the partial least squares regression studies on incomplete data described in Nengsih et al. (2019) <doi:10.1515/sagmb-2018-0059>. The package provides simulation helpers, missingness generators, imputation wrappers, component-selection utilities, real-data diagnostics, and reproducible study orchestration for Nonlinear Iterative Partial Least Squares (NIPALS)-Partial Least Squares (PLS) workflows.

This package provides functions for the robust estimation of parametric families of copulas using minimization of the Maximum Mean Discrepancy, following the article Alquier, Chérief-Abdellatif, Derumigny and Fermanian (2022) <doi:10.1080/01621459.2021.2024836>.

This package provides tools and functions to fit a multilevel index of dissimilarity.

Computes efficient data distributions from highly inconsistent datasets with many missing values using multi-set intersections. Based upon hash functions, mulset can quickly identify intersections from very large matrices of input vectors across columns and rows and thus provides scalable solution for dealing with missing values. Tomic et al. (2019) <doi:10.1101/545186>.

Regression methods to quantify the relation between two measurement methods are provided by this package. In particular it addresses regression problems with errors in both variables and without repeated measurements. It implements the Clinical Laboratory Standard International (CLSI) recommendations (see J. A. Budd et al. (2018, <https://clsi.org/standards/products/method-evaluation/documents/ep09/>) for analytical method comparison and bias estimation using patient samples. Furthermore, algorithms for Theil-Sen and equivariant Passing-Bablok estimators are implemented, see F. Dufey (2020, <doi:10.1515/ijb-2019-0157>) and J. Raymaekers and F. Dufey (2022, <arXiv:2202:08060>). Further the robust M-Deming and MM-Deming (experimental) are available, see G. Pioda (2021, <arXiv:2105:04628>). A comprehensive overview over the implemented methods and references can be found in the manual pages mcrPioda-package and mcreg'.

This package provides a set of tools for fitting Markov-modulated linear regression, where responses Y(t) are time-additive, and model operates in the external environment, which is described as a continuous time Markov chain with finite state space. Model is proposed by Alexander Andronov (2012) <arXiv:1901.09600v1> and algorithm of parameters estimation is based on eigenvalues and eigenvectors decomposition. Markov-switching regression models have the same idea of varying the regression parameters randomly in accordance with external environment. The difference is that for Markov-modulated linear regression model the external environment is described as a continuous-time homogeneous irreducible Markov chain with known parameters while switching models consider Markov chain as unobserved and estimation procedure involves estimation of transition matrix. These models have significant differences in terms of the analytical approach. Also, package provides a set of data simulation tools for Markov-modulated linear regression (for academical/research purposes). Research project No. 1.1.1.2/VIAA/1/16/075.

The rapid screening of effective and optimal therapies from large numbers of candidate combinations, as well as exploring subgroup efficacy, remains challenging, which necessitates innovative, integrated, and efficient trial designs(Yuan, Y., et al. (2016) <doi:10.1002/sim.6971>). MIDAS-2 package enables quick and continuous screening of promising combination strategies and exploration of their subgroup effects within a unified platform design framework. We used a regression model to characterize the efficacy pattern in subgroups. Information borrowing was applied through Bayesian hierarchical model to improve trial efficiency considering the limited sample size in subgroups(Cunanan, K. M., et al. (2019) <doi:10.1177/1740774518812779>). MIDAS-2 provides an adaptive drug screening and subgroup exploring framework to accelerate immunotherapy development in an efficient, accurate, and integrated fashion(Wathen, J. K., & Thall, P. F. (2017) <doi: 10.1177/1740774517692302>).

Conduct random forests-based meta-analysis, obtain partial dependence plots for metaforest and classic meta-analyses, and cross-validate and tune metaforest- and classic meta-analyses in conjunction with the caret package. A requirement of classic meta-analysis is that the studies being aggregated are conceptually similar, and ideally, close replications. However, in many fields, there is substantial heterogeneity between studies on the same topic. Classic meta-analysis lacks the power to assess more than a handful of univariate moderators. MetaForest, by contrast, has substantial power to explore heterogeneity in meta-analysis. It can identify important moderators from a larger set of potential candidates (Van Lissa, 2020). This is an appealing quality, because many meta-analyses have small sample sizes. Moreover, MetaForest yields a measure of variable importance which can be used to identify important moderators, and offers partial prediction plots to explore the shape of the marginal relationship between moderators and effect size.