R codes for the (adaptive) Sum of Powered Score ('SPU and aSPU') tests, inverse variance weighted Sum of Powered score ('SPUw and aSPUw') tests and gene-based and some pathway based association tests (Pathway based Sum of Powered Score tests ('SPUpath'), adaptive SPUpath ('aSPUpath') test, GEEaSPU test for multiple traits - single SNP (single nucleotide polymorphism) association in generalized estimation equations, MTaSPUs test for multiple traits - single SNP association with Genome Wide Association Studies ('GWAS') summary statistics, Gene-based Association Test that uses an extended Simes procedure ('GATES'), Hybrid Set-based Test ('HYST') and extended version of GATES test for pathway-based association testing ('GATES-Simes'). ). The tests can be used with genetic and other data sets with covariates. The response variable is binary or quantitative. Summary; (1) Single trait-'SNP set association with individual-level data ('aSPU', aSPUw', aSPUr'), (2) Single trait-'SNP set association with summary statistics ('aSPUs'), (3) Single trait-pathway association with individual-level data ('aSPUpath'), (4) Single trait-pathway association with summary statistics ('aSPUsPath'), (5) Multiple traits-single SNP association with individual-level data ('GEEaSPU'), (6) Multiple traits- single SNP association with summary statistics ('MTaSPUs'), (7) Multiple traits-'SNP set association with summary statistics('MTaSPUsSet'), (8) Multiple traits-pathway association with summary statistics('MTaSPUsSetPath').