This package implements the RUV (Remove Unwanted Variation) algorithms. These algorithms attempt to adjust for systematic errors of unknown origin in high-dimensional data. The algorithms were originally developed for use with genomic data, especially microarray data, but may be useful with other types of high-dimensional data as well. The algorithms require the user to specify a set of negative control variables, as described in the references. The algorithms included in this package are RUV-2, RUV-4, RUV-inv, RUV-rinv, RUV-I, and RUV-III, along with various supporting algorithms.