The Clinical Trials Network (CTN) of the U.S. National Institute of Drug Abuse sponsored the CTN-0094 research team to harmonize data sets from three nationally-representative clinical trials for opioid use disorder (OUD). The CTN-0094 team herein provides a coded collection of trial outcomes and endpoints used in various OUD clinical trials over the past 50 years. These coded outcome functions are used to contrast and cluster different clinical outcome functions based on daily or weekly patient urine screenings. Note that we abbreviate urine drug screen as "UDS" and urine opioid screen as "UOS". For the example data sets (based on clinical trials data harmonized by the CTN-0094 research team), UDS and UOS are largely interchangeable.

This package provides tools for the analysis, visualization, and manipulation of dynamical, social (Saqr et al. (2024) <doi:10.1007/978-3-031-54464-4_10>) and complex networks (Saqr et al. (2025) <doi:10.1145/3706468.3706513>). The package supports multiple network formats and offers flexible tools for heterogeneous, multi-layer, and hierarchical network analysis with simple syntax and extensive toolset.

This package provides functions to assess complex heterogeneity in the strength of a surrogate marker with respect to multiple baseline covariates, in either a randomized treatment setting or observational setting. For a randomized treatment setting, the functions assess and test for heterogeneity using both a parametric model and a semiparametric two-step model. More details for the randomized setting are available in: Knowlton, R., Tian, L., & Parast, L. (2025). "A General Framework to Assess Complex Heterogeneity in the Strength of a Surrogate Marker," Statistics in Medicine, 44(5), e70001 <doi:10.1002/sim.70001>. For an observational setting, functions in this package assess complex heterogeneity in the strength of a surrogate marker using meta-learners, with options for different base learners. More details for the observational setting will be available in the future in: Knowlton, R., Parast, L. (2025) "Assessing Surrogate Heterogeneity in Real World Data Using Meta-Learners." A tutorial for this package can be found at <https://www.laylaparast.com/cohetsurr>.

High dimensional discriminant analysis with compositional data is performed. The compositional data are first transformed using the alpha-transformation of Tsagris M., Preston S. and Wood A.T.A. (2011) <doi:10.48550/arXiv.1106.1451>, and then the High Dimensional Discriminant Analysis (HDDA) algorithm of Bouveyron C. Girard S. and Schmid C. (2007) <doi:10.1080/03610920701271095> is applied.

Cases are matched to controls in an efficient, optimal and computationally flexible way. It uses the idea of sub-sampling in the level of the case, by creating pseudo-observations of controls. The user can select between replacement and without replacement, the number of controls, and several covariates to match upon. See Mamouris (2021) <doi:10.1186/s12874-021-01256-3> for an overview.

Method for identifying the instar of Curculionid larvae from the observed distribution of the headcapsule size of mature larvae.

Computer algebra via the SymPy library (<https://www.sympy.org/>). This makes it possible to solve equations symbolically, find symbolic integrals, symbolic sums and other important quantities.

Enables creation of visualizations using the CanvasXpress framework in R. CanvasXpress is a standalone JavaScript library for reproducible research with complete tracking of data and end-user modifications stored in a single PNG image that can be played back. See <https://www.canvasxpress.org> for more information.

This package provides functions to construct finite-sample calibrated predictive intervals for Bayesian models, following the approach in Barber et al. (2021) <doi:10.1214/20-AOS1965>. These intervals are calculated efficiently using importance sampling for the leave-one-out residuals. By default, the intervals will also reflect the relative uncertainty in the Bayesian model, using the locally-weighted conformal methods of Lei et al. (2018) <doi:10.1080/01621459.2017.1307116>.

Enable seamless interaction with Consibio Cloud <https://consibio.cloud> API <https://api.v2.consibio.com/api-docs/>. This package provides tools to query data from resources like projects, elements, devices, and datalogs.

This package contains functions to detect and visualise periods of climate sensitivity (climate windows) for a given biological response. Please see van de Pol et al. (2016) <doi:10.1111/2041-210X.12590> and Bailey and van de Pol (2016) <doi:10.1371/journal.pone.0167980> for details.

Although discrete choice (choice-based conjoint) analysis has become a widely used technique for the elicitation of consumer preferences and hence a foundation for product design, to the best of our knowledge, there exists neither free and open-source nor commercial software that covers the game-theoretic simulation of competitive reactions among firms based on discrete choice models to improve decision making beyond traditional product (line) optimization. The package does not only provide functions to fill this gap but comprises an entire simulation pipeline including the upstream processes of discrete choice analysis itself. It ranges from preference generation, choice design, design assessment, error and response simulation, through hierarchical Bayesian estimation of mixed logit models as well as convergence and model assessment, to Nash equilibrium computation. Doing so, it partly draws from established packages concerned with discrete choice analysis. While its structure generally aims towards end-to-end simulation as well as simulation of competitive dynamics based on real data, all its key elements mentioned above may be of use independently of each other. For implementation and application details, see Dressler et al. (2026) <doi:10.48550/arXiv.2606.15593>.

This package implements the instruments for complex-valued modelling, including time series analysis and forecasting. This is based on the monograph by Svetunkov & Svetunkov (2024) <doi: 10.1007/978-3-031-62608-1>.

Fits a variety of cure models using excess hazard modeling methodology such as the mixture model proposed by Phillips et al. (2002) <doi:10.1002/sim.1101> The Weibull distribution is used to represent the survival function of the uncured patients; Fits also non-mixture cure model such as the time-to-null excess hazard model proposed by Boussari et al. (2020) <doi:10.1111/biom.13361>.

Given a patient-sharing network, calculate either the classic care density as proposed by Pollack et al. (2013) <doi:10.1007/s11606-012-2104-7> or the fragmented care density as proposed by Engels et al. (2024) <doi:10.1186/s12874-023-02106-0>. By utilizing the igraph and data.table packages, the provided functions scale well for very large graphs.

Execute Nonlinear Mixed Effects (NLME) models for pharmacometrics using a shiny interface. Specify engine parameters and select from different run options, including simple estimation, stepwise covariate search, bootstrapping, simulation, visual predictive check, and more. Models are executed using the Certara.RsNLME package.

Implementation of the Coarsened Exact Matching algorithm discussed along with its properties in Iacus, King, Porro (2011) <DOI:10.1198/jasa.2011.tm09599>; Iacus, King, Porro (2012) <DOI:10.1093/pan/mpr013> and Iacus, King, Porro (2019) <DOI:10.1017/pan.2018.29>.

This package provides a unified toolkit for cointegration testing including Fourier-based cointegration tests (FADL, FEG, FEG2, Tsong) that accommodate smooth structural breaks via flexible Fourier terms, and panel CADF cointegration tests with structural breaks using the Common Correlated Effects (CCE) estimator following Banerjee, Arcabic and Lee (2017) <doi:10.1016/j.econmod.2017.03.004>, Tsong, Lee, Tsai and Hu (2016) <doi:10.1007/s00181-015-1028-6>, and Banerjee and Carrion-i-Silvestre (2025) <doi:10.1080/07350015.2024.2327844>.

Reads and writes CSV with selected conventions. Uses the same generic function for reading and writing to promote consistent formats.

Implementation of a procedure---Domingue (2012) <https://eric.ed.gov/?id=ED548657>, Domingue (2014) <doi:10.1007/s11336-013-9342-4>; see also Karabatsos (2001) <https://psycnet.apa.org/record/2002-01665-005> and Kyngdon (2011) <doi:10.1348/2044-8317.002004>---to test the single and double cancellation axioms of conjoint measure in data that is dichotomously coded and measured with error.

Package to assess the calibration of probabilistic classifiers using confidence bands for monotonic functions. Besides testing the classical goodness-of-fit null hypothesis of perfect calibration, the confidence bands calculated within that package facilitate inverted goodness-of-fit tests whose rejection allows for a sought-after conclusion of a sufficiently well-calibrated model. The package creates flexible graphical tools to perform these tests. For construction details see also Dimitriadis, Dümbgen, Henzi, Puke, Ziegel (2022) <arXiv:2203.04065>.

Calculate the confidence interval and p value for change in C-statistic. The adjusted C-statistic is calculated by using formula as "Somers Dxy rank correlation"/2+0.5. The confidence interval was calculated by using the bootstrap method. The p value was calculated by using the Z testing method. Please refer to the article of Peter Ganz et al. (2016) <doi:10.1001/jama.2016.5951>.

This package provides functions to prepare and filter an origin-destination matrix for thematic flow mapping purposes. This comes after Bahoken, Francoise (2016), Mapping flow matrix a contribution, PhD in Geography - Territorial sciences. See Bahoken (2017) <doi:10.4000/netcom.2565>.

This package performs biomedical named entity recognition, Unified Medical Language System (UMLS) concept mapping, and negation detection using the Python spaCy', scispaCy', and medspaCy packages, and transforms extracted data into a wide format for inclusion in machine learning models. The development of the scispaCy package is described by Neumann (2019) <doi:10.18653/v1/W19-5034>. The medspacy package uses ConText', an algorithm for determining the context of clinical statements described by Harkema (2009) <doi:10.1016/j.jbi.2009.05.002>. Clinspacy also supports entity embeddings from scispaCy and UMLS cui2vec concept embeddings developed by Beam (2018) <arXiv:1804.01486>.