The beta-binomial test is used for significance analysis of independent samples by Pham et al. (2010) <doi:10.1093/bioinformatics/btp677>. The inverted beta-binomial test is used for paired sample testing, e.g. pre-treatment and post-treatment data, by Pham and Jimenez (2012) <doi:10.1093/bioinformatics/bts394>.

Calculate p-values and confidence intervals using cluster-adjusted t-statistics (based on Ibragimov and Muller (2010) <DOI:10.1198/jbes.2009.08046>, pairs cluster bootstrapped t-statistics, and wild cluster bootstrapped t-statistics (the latter two techniques based on Cameron, Gelbach, and Miller (2008) <DOI:10.1162/rest.90.3.414>. Procedures are included for use with GLM, ivreg, plm (pooling or fixed effects), and mlogit models.

Under natural conditions, nest temperatures fluctuate daily around a mean value, whereas in captivity they are often held constant. The Constant Temperature Equivalent is designed to bridge the gap between the two by calculating a single temperature value for wild nests that corresponds with the amount of development that would occur in an incubator set to the same temperature. The theory and formulas behind this method were developed by Professor Author Georges and are implemented here as a single function.

The c060 package provides additional functions to perform stability selection, model validation and parameter tuning for glmnet models.

This package provides functions for fitting GEV and POT (via point process fitting) models for extremes in climate data, providing return values, return probabilities, and return periods for stationary and nonstationary models. Also provides differences in return values and differences in log return probabilities for contrasts of covariate values. Functions for estimating risk ratios for event attribution analyses, including uncertainty. Under the hood, many of the functions use functions from extRemes', including for fitting the statistical models. Details are given in Paciorek, Stone, and Wehner (2018) <doi:10.1016/j.wace.2018.01.002>.

Logic game in the style of the early 1980s home computers that can be played in the R console. This game is inspired by Mastermind, a game that became popular in the 1970s. Can you break the code?

This package provides methods and functions to implement a Recommendation System based on Collaborative Filtering Methodology. See Aggarwal (2016) <doi:10.1007/978-3-319-29659-3> for an overview.

This package provides a comprehensive reproducibility framework designed for R and bioinformatics workflows. Automatically captures the entire analysis environment including R session info, package versions, external tool versions ('Samtools', STAR', BWA', etc.), conda environments, reference genomes, data provenance with smart checksumming for large files, parameter choices, random seeds, and hardware specifications. Generates executable scripts with Docker', Singularity', and renv configurations. Integrates with workflow managers ('Nextflow', Snakemake', WDL', CWL') to ensure complete reproducibility of computational research workflows.

Encrypts and decrypts strings using either the Caesar cipher or a pseudorandom number generation (using set.seed()) method.

Create and integrate maps in your R workflow. This package helps to design cartographic representations such as proportional symbols, choropleth, typology, flows or discontinuities maps. It also offers several features that improve the graphic presentation of maps, for instance, map palettes, layout elements (scale, north arrow, title...), labels or legends. See Giraud and Lambert (2017) <doi:10.1007/978-3-319-57336-6_13>.

Finds the most likely originating tissue(s) and developmental stage(s) of tissue-specific RNA sequencing data. The package identifies both pure transcriptomes and mixtures of transcriptomes. The most likely identity is found through comparisons of the sequencing data with high-throughput in situ hybridisation patterns. Typical uses are the identification of cancer cell origins, validation of cell culture strain identities, validation of single-cell transcriptomes, and validation of identity and purity of flow-sorting and dissection sequencing products.

Computes a confidence interval for a specified linear combination of the regression parameters in a linear regression model with iid normal errors with known variance when there is uncertain prior information that a distinct specified linear combination of the regression parameters takes a given value. This confidence interval, found by numerical nonlinear constrained optimization, has the required minimum coverage and utilizes this uncertain prior information through desirable expected length properties. This confidence interval has the following three practical applications. Firstly, if the error variance has been accurately estimated from previous data then it may be treated as being effectively known. Secondly, for sufficiently large (dimension of the response vector) minus (dimension of regression parameter vector), greater than or equal to 30 (say), if we replace the assumed known value of the error variance by its usual estimator in the formula for the confidence interval then the resulting interval has, to a very good approximation, the same coverage probability and expected length properties as when the error variance is known. Thirdly, some more complicated models can be approximated by the linear regression model with error variance known when certain unknown parameters are replaced by estimates. This confidence interval is described in Mainzer, R. and Kabaila, P. (2019) <doi:10.32614/RJ-2019-026>, and is a member of the family of confidence intervals proposed by Kabaila, P. and Giri, K. (2009) <doi:10.1016/j.jspi.2009.03.018>.

Applies the change-in-effect estimate method to assess confounding effects in medical and epidemiological research (Greenland & Pearce (2016) <doi:10.1146/annurev-publhealth-031914-122559> ). It starts with a crude model including only the outcome and exposure variables. At each of the subsequent steps, one variable which creates the largest change among the remaining variables is selected. This process is repeated until all variables have been entered into the model (Wang Z. Stata Journal 2007; 7, Number 2, pp. 183â 196). Currently, the chest package has functions for linear regression, logistic regression, negative binomial regression, Cox proportional hazards model and conditional logistic regression.

This package provides a collection of useful helper routines developed by students of the Center for Mathematical Research, Stankin, Moscow.

Data from statistical agencies and other institutions often need to be protected before they can be published. This package can be used to perturb statistical tables in a consistent way. The main idea is to add - at the micro data level - a record key for each unit. Based on these keys, for any cell in a statistical table a cell key is computed as a function on the record keys contributing to a specific cell. Values that are added to the cell in order to perturb it are derived from a lookup-table that maps values of cell keys to specific perturbation values. The theoretical basis for the methods implemented can be found in Thompson, Broadfoot and Elazar (2013) <https://unece.org/fileadmin/DAM/stats/documents/ece/ces/ge.46/2013/Topic_1_ABS.pdf> which was extended and enhanced by Giessing and Tent (2019) <https://unece.org/fileadmin/DAM/stats/documents/ece/ces/ge.46/2019/mtg1/SDC2019_S2_Germany_Giessing_Tent_AD.pdf>.

Quick and easy access to datasets that let you replicate the empirical examples in Cameron and Trivedi (2005) "Microeconometrics: Methods and Applications" (ISBN: 9780521848053).The data are available as soon as you install and load the package (lazy-loading) as data frames. The documentation includes reference to chapter sections and page numbers where the datasets are used.

Computes the density and probability for the conditional truncated multivariate normal (Horrace (2005) p. 4, <doi:10.1016/j.jmva.2004.10.007>). Also draws random samples from this distribution.

This package performs biomedical named entity recognition, Unified Medical Language System (UMLS) concept mapping, and negation detection using the Python spaCy', scispaCy', and medspaCy packages, and transforms extracted data into a wide format for inclusion in machine learning models. The development of the scispaCy package is described by Neumann (2019) <doi:10.18653/v1/W19-5034>. The medspacy package uses ConText', an algorithm for determining the context of clinical statements described by Harkema (2009) <doi:10.1016/j.jbi.2009.05.002>. Clinspacy also supports entity embeddings from scispaCy and UMLS cui2vec concept embeddings developed by Beam (2018) <arXiv:1804.01486>.

Implementation of the categorical instrumental variable (CIV) estimator proposed by Wiemann (2023) <arXiv:2311.17021>. CIV allows for optimal instrumental variable estimation in settings with relatively few observations per category. To obtain valid inference in these challenging settings, CIV leverages a regularization assumption that implies existence of a latent categorical variable with fixed finite support achieving the same first stage fit as the observed instrument.

Fit Cox proportional hazards models containing both fixed and random effects. The random effects can have a general form, of which familial interactions (a "kinship" matrix) is a particular special case. Note that the simplest case of a mixed effects Cox model, i.e. a single random per-group intercept, is also called a "frailty" model. The approach is based on Ripatti and Palmgren, Biometrics 2002.

Calculate with spectral properties of light sources, materials, cameras, eyes, and scanners. Build complex systems from simpler parts using a spectral product algebra. For light sources, compute CCT, CRI, SSI, and IES TM-30 reports. For object colors, compute optimal colors and Logvinenko coordinates. Work with the standard CIE illuminants and color matching functions, and read spectra from text files, including CGATS files. Estimate a spectrum from its response. A user guide and 9 vignettes are included.

Allows users to seamlessly query several CDC PLACES APIs (<https://data.cdc.gov/browse?q=PLACES%20&sortBy=relevance>) by geography, state, measure, and release year. This package also contains a function to explore the available measures for each release year.

Load and analyze updated time series worldwide data of reported cases for the Novel Coronavirus Disease (COVID-19) from different sources, including the Johns Hopkins University Center for Systems Science and Engineering (JHU CSSE) data repository <https://github.com/CSSEGISandData/COVID-19>, "Our World in Data" <https://github.com/owid/> among several others. The datasets reporting the COVID-19 cases are available in two main modalities, as a time series sequences and aggregated data for the last day with greater spatial resolution. Several analysis, visualization and modelling functions are available in the package that will allow the user to compute and visualize total number of cases, total number of changes and growth rate globally or for an specific geographical location, while at the same time generating models using these trends; generate interactive visualizations and generate Susceptible-Infected-Recovered (SIR) model for the disease spread.

This package provides generation and estimation of censored factor models for high-dimensional data with censored errors (normal, t, logistic). Includes Sparse Orthogonal Principal Components (SOPC), and evaluation metrics. Based on Guo G. (2023) <doi:10.1007/s00180-022-01270-z>.