Create a details HTML tag around R objects to place in a Markdown, Rmarkdown and roxygen2 documentation.

Get Drug information from given differential expression profile. The package search for the bioactive compounds from reference databases such as LINCS containing the genome-wide gene expression signature (GES) from tens of thousands of drug and genetic perturbations (Subramanian et al. (2017) <DOI:10.1016/j.cell.2017.10.049>).

Measure of agreement delta was originally by Martà n & Femia (2004) <DOI:10.1348/000711004849268>. Since then has been considered as agreement measure for different fields, since their behavior is usually better than the usual kappa index by Cohen (1960) <DOI:10.1177/001316446002000104>. The main issue with delta is that can not be computed by hand contrary to kappa. The current algorithm is based on the Version 5 of the delta windows program that can be found on <https://www.ugr.es/~bioest/software/delta/cmd.php?seccion=downloads>.

Simple Principal Components Analysis (PCA) and (Multiple) Correspondence Analysis (CA) based on the Singular Value Decomposition (SVD). This package provides S4 classes and methods to compute, extract, summarize and visualize results of multivariate data analysis. It also includes methods for partial bootstrap validation described in Greenacre (1984, ISBN: 978-0-12-299050-2) and Lebart et al. (2006, ISBN: 978-2-10-049616-7).

Works as a virtual CRAN snapshot for source packages. It automatically downloads and installs tar.gz files with dependencies, all of which were available on a specific day.

This package performs the identification of differential risk hotspots (Briz-Redon et al. 2019) <doi:10.1016/j.aap.2019.105278> along a linear network. Given a marked point pattern lying on the linear network, the method implemented uses a network-constrained version of kernel density estimation (McSwiggan et al. 2017) <doi:10.1111/sjos.12255> to approximate the probability of occurrence across space for the type of event specified by the user through the marks of the pattern (Kelsall and Diggle 1995) <doi:10.2307/3318678>. The goal is to detect microzones of the linear network where the type of event indicated by the user is overrepresented.

Smooth testing of goodness of fit. These tests are data driven (alternative hypothesis is dynamically selected based on data). In this package you will find various tests for exponent, Gaussian, Gumbel and uniform distribution.

The deltaPlotR package implements Angoff's Delta Plot method to detect dichotomous DIF. Several detection thresholds are included, either from multivariate normality assumption or by prior determination. Item purification is supported (Magis and Facon (2014) <doi:10.18637/jss.v059.c01>).

Hash an expression with its dependencies and store its value, reloading it from a file as long as both the expression and its dependencies stay the same.

Weighted frequency and contingency tables of categorical variables and of the comparison of the mean value of a numerical variable by the levels of a factor, and methods to produce xtable objects of the tables and to plot them. There are also functions to facilitate the character encoding conversion of objects, to quickly convert fixed width files into csv ones, and to export a data.frame to a text file with the necessary R and SPSS codes to reread the data.

Ecological Metadata Language or EML is a long-established format for describing ecological datasets to facilitate sharing and re-use. Because EML is effectively a modified xml schema, however, it is challenging to write and manipulate for non-expert users. delma supports users to write metadata statements in R Markdown or Quarto markdown format, and parse them to EML and (optionally) back again.

This package provides a Graphical User Interface (GUI) to import, save, detrend and perform standard tree-ring analyses. The interactive detrending allows the user to check how well the detrending curve fits each time-series and change it when needed.

Abstract of Manuscript. Differential gene expression analysis using RNA sequencing (RNA-seq) data is a standard approach for making biological discoveries. Ongoing large-scale efforts to process and normalize publicly available gene expression data enable rapid and systematic reanalysis. While several powerful tools systematically process RNA-seq data, enabling their reanalysis, few resources systematically recompute differentially expressed genes (DEGs) generated from individual studies. We developed a robust differential expression analysis pipeline to recompute 3162 human DEG lists from The Cancer Genome Atlas, Genotype-Tissue Expression Consortium, and 142 studies within the Sequence Read Archive. After measuring the accuracy of the recomputed DEG lists, we built the Differential Expression Enrichment Tool (DEET), which enables users to interact with the recomputed DEG lists. DEET, available through CRAN and RShiny, systematically queries which of the recomputed DEG lists share similar genes, pathways, and TF targets to their own gene lists. DEET identifies relevant studies based on shared results with the userâ s gene lists, aiding in hypothesis generation and data-driven literature review. Sokolowski, Dustin J., et al. "Differential Expression Enrichment Tool (DEET): an interactive atlas of human differential gene expression." Nucleic Acids Research Genomics and Bioinformatics (2023).

Computes a new measure, DNSL betweenness, via the creation of a new graph from an existing one, duplicating nodes with self-loops. This betweenness centrality does not drop this essential information. Implements Merelo & Molinari (2024) <doi:10.1007/s42001-023-00245-4>.

Analyze and visualize the rhythmic behavior of animals using the degree of functional coupling (See Scheibe (1999) <doi:10.1076/brhm.30.2.216.1420>), compute and visualize harmonic power, actograms, average activity and diurnality index.

Utilities for mixed frequency data. In particular, use to aggregate and normalize tabular mixed frequency data, index dates to end of period, and seasonally adjust tabular data.

Work with data on Venetian doges and dogaresse and the noble families of the Republic of Venice, and use it for social network analysis, as used in Merelo (2022) <doi:10.48550/arXiv.2209.07334>.

Low level functions for implementing maximum likelihood estimating procedures for complex models using data cloning and Bayesian Markov chain Monte Carlo methods as described in Solymos 2010 <doi:10.32614/RJ-2010-011>. Sequential and parallel MCMC support for JAGS', WinBUGS', OpenBUGS', and Stan'.

This package provides extra functions to manipulate dendrograms that build on the base functions provided by the stats package. The main functionality it is designed to add is the ability to colour all the edges in an object of class dendrogram according to cluster membership i.e. each subtree is coloured, not just the terminal leaves. In addition it provides some utility functions to cut dendrogram and hclust objects and to set/get labels.

Displays a terrible joke, the kind only dads crack.

This package provides efficient Markov chain Monte Carlo (MCMC) algorithms for dynamic shrinkage processes, which extend global-local shrinkage priors to the time series setting by allowing shrinkage to depend on its own past. These priors yield locally adaptive estimates, useful for time series and regression functions with irregular features. The package includes full MCMC implementations for trend filtering using dynamic shrinkage on signal differences, producing locally constant or linear fits with adaptive credible bands. Also included are models with static shrinkage and normal-inverse-Gamma priors for comparison. Additional tools cover dynamic regression with time-varying coefficients and B-spline models with shrinkage on basis differences, allowing for flexible curve-fitting with unequally spaced data. Some support for heteroscedastic errors, outlier detection, and change point estimation. Methods in this package are described in Kowal et al. (2019) <doi:10.1111/rssb.12325>, Wu et al. (2024) <doi:10.1080/07350015.2024.2362269>, Schafer and Matteson (2024) <doi:10.1080/00401706.2024.2407316>, and Cho and Matteson (2024) <doi:10.48550/arXiv.2408.11315>.

It is used to identify dysregulated pathways based on a pre-ranked gene pair list. A fast algorithm is used to make the computation really fast. The data in package DysPIAData is needed.

Likelihood-based inference methods with doubly-truncated data are developed under various models. Nonparametric models are based on Efron and Petrosian (1999) <doi:10.1080/01621459.1999.10474187> and Emura, Konno, and Michimae (2015) <doi:10.1007/s10985-014-9297-5>. Parametric models from the special exponential family (SEF) are based on Hu and Emura (2015) <doi:10.1007/s00180-015-0564-z> and Emura, Hu and Konno (2017) <doi:10.1007/s00362-015-0730-y>. The parametric location-scale models are based on Dorre et al. (2021) <doi:10.1007/s00180-020-01027-6>.

The DWD provides gridded radar data for Germany in binary format. dwdradar reads these files and enables a fast conversion into numerical format.