Identification of hub genes in a gene co-expression network from gene expression data. The differential network analysis for two contrasting conditions leads to the identification of various types of hubs like Housekeeping, Unique to stress (Disease) and Unique to control (Normal) hub genes.

Providing six different algorithms that can be used to split the available data into training, test and validation subsets with similar distribution for hydrological model developments. The dataSplit() function will help you divide the data according to specific requirements, and you can refer to the par.default() function to set the parameters for data splitting. The getAUC() function will help you measure the similarity of distribution features between the data subsets. For more information about the data splitting algorithms, please refer to: Chen et al. (2022) <doi:10.1016/j.jhydrol.2022.128340>, Zheng et al. (2022) <doi:10.1029/2021WR031818>.

Implementation of DetMCD, a new algorithm for robust and deterministic estimation of location and scatter. The benefits of robust and deterministic estimation are explained in Hubert, Rousseeuw and Verdonck (2012) <doi:10.1080/10618600.2012.672100>.

Nonparametric kernel density estimation, bandwidth selection, and other utilities for analyzing directional data. Implements the estimator in Bai, Rao and Zhao (1987) <doi:10.1016/0047-259X(88)90113-3>, the cross-validation bandwidth selectors in Hall, Watson and Cabrera (1987) <doi:10.1093/biomet/74.4.751> and the plug-in bandwidth selectors in Garcà a-Portugués (2013) <doi:10.1214/13-ejs821>.

Containing the Detrended Fluctuation Analysis (DFA), Detrended Cross-Correlation Analysis (DCCA), Detrended Cross-Correlation Coefficient (rhoDCCA), Delta Amplitude Detrended Cross-Correlation Coefficient (DeltarhoDCCA), log amplitude Detrended Fluctuation Analysis (DeltalogDFA), and the Activity Balance Index, it also includes two DFA automatic methods for identifying crossover points and a Deltalog automatic method for identifying reference channels.

Compressed spatial vector data originally from <https://dawadocs.dataforsyningen.dk/> saved as Simple Features, SF, objects with data on population, age and gender from Statistics Denmark <https://www.dst.dk/da/>.

This package provides a collection of functions for directional data (including massive data, with millions of observations) analysis. Hypothesis testing, discriminant and regression analysis, MLE of distributions and more are included. The standard textbook for such data is the "Directional Statistics" by Mardia, K. V. and Jupp, P. E. (2000). Other references include: a) Paine J.P., Preston S.P., Tsagris M. and Wood A.T.A. (2018). "An elliptically symmetric angular Gaussian distribution". Statistics and Computing 28(3): 689-697. <doi:10.1007/s11222-017-9756-4>. b) Tsagris M. and Alenazi A. (2019). "Comparison of discriminant analysis methods on the sphere". Communications in Statistics: Case Studies, Data Analysis and Applications 5(4):467--491. <doi:10.1080/23737484.2019.1684854>. c) Paine J.P., Preston S.P., Tsagris M. and Wood A.T.A. (2020). "Spherical regression models with general covariates and anisotropic errors". Statistics and Computing 30(1): 153--165. <doi:10.1007/s11222-019-09872-2>. d) Tsagris M. and Alenazi A. (2024). "An investigation of hypothesis testing procedures for circular and spherical mean vectors". Communications in Statistics-Simulation and Computation, 53(3): 1387--1408. <doi:10.1080/03610918.2022.2045499>. e) Yu Z. and Huang X. (2024). A new parameterization for elliptically symmetric angular Gaussian distributions of arbitrary dimension. Electronic Journal of Statistics, 18(1): 301--334. <doi:10.1214/23-EJS2210>. f) Tsagris M. and Alzeley O. (2025). "Circular and spherical projected Cauchy distributions: A Novel Framework for Circular and Directional Data Modeling". Australian & New Zealand Journal of Statistics, 67(1): 77--103. <doi:10.1111/anzs.12434>. g) Tsagris M., Papastamoulis P. and Kato S. (2025). "Directional data analysis: spherical Cauchy or Poisson kernel-based distribution". Statistics and Computing, 35:51. <doi:10.1007/s11222-025-10583-0>.

Estimate the Deterministic Input, Noisy "And" Gate (DINA) cognitive diagnostic model parameters using the Gibbs sampler described by Culpepper (2015) <doi:10.3102/1076998615595403>.

We provide a comprehensive software to estimate general K-stage DTRs from SMARTs with Q-learning and a variety of outcome-weighted learning methods. Penalizations are allowed for variable selection and model regularization. With the outcome-weighted learning scheme, different loss functions - SVM hinge loss, SVM ramp loss, binomial deviance loss, and L2 loss - are adopted to solve the weighted classification problem at each stage; augmentation in the outcomes is allowed to improve efficiency. The estimated DTR can be easily applied to a new sample for individualized treatment recommendations or DTR evaluation.

This package provides wrapper of various machine learning models. In applied machine learning, there is a strong belief that we need to strike a balance between interpretability and accuracy. However, in field of the interpretable machine learning, there are more and more new ideas for explaining black-box models, that are implemented in R'. DALEXtra creates DALEX Biecek (2018) <arXiv:1806.08915> explainer for many type of models including those created using python scikit-learn and keras libraries, and java h2o library. Important part of the package is Champion-Challenger analysis and innovative approach to model performance across subsets of test data presented in Funnel Plot.

Fast fitting of generalised linear models on moderately large datasets, by taking an initial sample, fitting in memory, then evaluating the score function for the full data in the database. Thomas Lumley <doi:10.1080/10618600.2019.1610312>.

In tumor tissue, underlying genomic instability can lead to DNA copy number alterations, e.g., copy number gains or losses. Sporadic copy number alterations occur randomly throughout the genome, whereas recurrent alterations are observed in the same genomic region across multiple independent samples, perhaps because they provide a selective growth advantage. This package implements the DiNAMIC procedure for assessing the statistical significance of recurrent DNA copy number aberrations (Bioinformatics (2011) 27(5) 678 - 685).

DataSHIELD is an infrastructure and series of R packages that enables the remote and non-disclosive analysis of sensitive research data. This package is the DataSHIELD interface implementation to analyze data shared on a MOLGENIS Armadillo server. MOLGENIS Armadillo is a light-weight DataSHIELD server using a file store and an RServe server.

Geodesic distance between phylogenetic trees and associated functions. The theoretical background of distory is published in Billera et al. (2001) "Geometry of the space of phylogenetic trees." <doi:10.1006/aama.2001.0759>.

This package provides a collection of methods for automated data cleaning where all actions are logged.

Programmatic interface to the Daymet web services (<http://daymet.ornl.gov>). Allows for easy downloads of Daymet climate data directly to your R workspace or your computer. Routines for both single pixel data downloads and gridded (netCDF) data are provided.

The Directed Prediction Index ('DPI') is a quasi-causal inference (causal discovery) method for observational data designed to quantify the relative endogeneity (relative dependence) of outcome (Y) versus predictor (X) variables in regression models. By comparing the proportion of variance explained (R-squared) between the Y-as-outcome model and the X-as-outcome model while controlling for a sufficient number of possible confounders, it can suggest a plausible (admissible) direction of influence from a less endogenous variable (X) to a more endogenous variable (Y). Methodological details are provided at <https://psychbruce.github.io/DPI/>. This package also includes functions for data simulation and network analysis (correlation, partial correlation, and Bayesian networks).

Ecological Metadata Language or EML is a long-established format for describing ecological datasets to facilitate sharing and re-use. Because EML is effectively a modified xml schema, however, it is challenging to write and manipulate for non-expert users. delma supports users to write metadata statements in R Markdown or Quarto markdown format, and parse them to EML and (optionally) back again.

Multivariate Gaussian mixture model with a determinant point process prior to promote the discovery of parsimonious components from observed data. See Xu, Mueller, Telesca (2016) <doi:10.1111/biom.12482>.

This package provides functions for discordant kinship modeling (and other sibling-based quasi-experimental designs). Contains data restructuring functions and functions for generating biometrically informed data for kin pairs. See [Garrison and Rodgers, 2016 <doi:10.1016/j.intell.2016.08.008>], [Sims, Trattner, and Garrison, 2024 <doi:10.3389/fpsyg.2024.1430978>] for empirical examples, and Garrison and colleagues for theoretical work <https://osf.io/zpdwt/>.

This package provides a weekly, monthly, yearly summary of dengue cases by state/ province/ country.

It provides the ability to generate images from documents of different types. Three main features are provided: functions for generating document thumbnails, functions for performing visual tests of documents and a function for updating fields and table of contents of a Microsoft Word or RTF document. In order to work, LibreOffice must be installed on the machine and or Microsoft Word'. If the latter is available, it can be used to produce PDF documents or images identical to the originals; otherwise, LibreOffice is used and the rendering can be sometimes different from the original documents.

Generally, most of the packages specify the probability density function, cumulative distribution function, quantile function, and random numbers generation of the probability distributions. The present package allows to compute some important distributional properties, including the first four ordinary and central moments, Pearson's coefficient of skewness and kurtosis, the mean and variance, coefficient of variation, median, and quartile deviation at some parametric values of several well-known and extensively used probability distributions.

This package provides Python-based extensions to enhance data analytics workflows, particularly for tasks involving data preprocessing and predictive modeling. Includes tools for data sampling, transformation, feature selection, balancing strategies (e.g., SMOTE), and model construction. These capabilities leverage Python libraries via the reticulate interface, enabling seamless integration with a broader machine learning ecosystem. Supports instance selection and hybrid workflows that combine R and Python functionalities for flexible and reproducible analytical pipelines. The architecture is inspired by the Experiment Lines approach, which promotes modularity, extensibility, and interoperability across tools. More information on Experiment Lines is available in Ogasawara et al. (2009) <doi:10.1007/978-3-642-02279-1_20>.