R codes for the (adaptive) Sum of Powered Score ('SPU and aSPU') tests, inverse variance weighted Sum of Powered score ('SPUw and aSPUw') tests and gene-based and some pathway based association tests (Pathway based Sum of Powered Score tests ('SPUpath'), adaptive SPUpath ('aSPUpath') test, GEEaSPU test for multiple traits - single SNP (single nucleotide polymorphism) association in generalized estimation equations, MTaSPUs test for multiple traits - single SNP association with Genome Wide Association Studies ('GWAS') summary statistics, Gene-based Association Test that uses an extended Simes procedure ('GATES'), Hybrid Set-based Test ('HYST') and extended version of GATES test for pathway-based association testing ('GATES-Simes'). ). The tests can be used with genetic and other data sets with covariates. The response variable is binary or quantitative. Summary; (1) Single trait-'SNP set association with individual-level data ('aSPU', aSPUw', aSPUr'), (2) Single trait-'SNP set association with summary statistics ('aSPUs'), (3) Single trait-pathway association with individual-level data ('aSPUpath'), (4) Single trait-pathway association with summary statistics ('aSPUsPath'), (5) Multiple traits-single SNP association with individual-level data ('GEEaSPU'), (6) Multiple traits- single SNP association with summary statistics ('MTaSPUs'), (7) Multiple traits-'SNP set association with summary statistics('MTaSPUsSet'), (8) Multiple traits-pathway association with summary statistics('MTaSPUsSetPath').

This package implements a framework for creating boxplots where the whisker lengths are determined by formal multiple testing procedures, making them adaptive to sample size and data characteristics. The function bh_boxplot() generates boxplots that control the False Discovery Rate (FDR) via the Benjamini-Hochberg procedure, and the function holm_boxplot() generates boxplots that control the Family-Wise Error Rate (FWER) via the Holm procedure. The methods are based on the framework in Gang, Lin, and Tong (2025) <doi:10.48550/arXiv.2510.20259>.

Dynamic regression for time series using Extreme Gradient Boosting with hyper-parameter tuning via Bayesian Optimization or Random Search.

Easily estimate the introduction rates of alien species given first records data. It specializes in addressing the role of sampling on the pattern of discoveries, thus providing better estimates than using Generalized Linear Models which assume perfect immediate detection of newly introduced species.

Use the Amazon Alexa Web Information Services API to find information about domains, including the kind of content that they carry, how popular are they---rank and traffic history, sites linking to them, among other things. See <https://aws.amazon.com/awis/> for more information.

This package provides adaptive direct sparse regression for high-dimensional multimodal data with heterogeneous missing patterns and measurement errors. AdapDISCOM extends the DISCOM framework with modality-specific adaptive weighting to handle varying data structures and error magnitudes across blocks. The method supports flexible block configurations (any K blocks) and includes robust variants for heavy-tailed distributions ('AdapDISCOM'-Huber) and fast implementations for large-scale applications (Fast-'AdapDISCOM'). Designed for realistic multimodal scenarios where different data sources exhibit distinct missing data patterns and contamination levels. Diakité et al. (2025) <doi:10.48550/arXiv.2508.00120>.

Estimate group aggregates, where one can set user-defined conditions that each group of records must satisfy to be suitable for aggregation. If a group of records is not suitable, it is expanded using a collapsing scheme defined by the user. A paper on this package was published in the Journal of Statistical Software <doi:10.18637/jss.v112.i04>.

Automate the modelling of age-structured population data using survey data, grid population estimates and urban-rural extents.

The Aligned Corpus Toolkit (act) is designed for linguists that work with time aligned transcription data. It offers functions to import and export various annotation file formats ('ELAN .eaf, EXMARaLDA .exb and Praat .TextGrid files), create print transcripts in the style of conversation analysis, search transcripts (span searches across multiple annotations, search in normalized annotations, make concordances etc.), export and re-import search results (.csv and Excel .xlsx format), create cuts for the search results (print transcripts, audio/video cuts using FFmpeg and video sub titles in Subrib title .srt format), modify the data in a corpus (search/replace, delete, filter etc.), interact with Praat using Praat'-scripts, and exchange data with the rPraat package. The package is itself written in R and may be expanded by other users.

An implementation of the additive heredity model for the mixture-of-mixtures experiments of Shen et al. (2019) in Technometrics <doi:10.1080/00401706.2019.1630010>. The additive heredity model considers an additive structure to inherently connect the major components with the minor components. The additive heredity model has a meaningful interpretation for the estimated model because of the hierarchical and heredity principles applied and the nonnegative garrote technique used for variable selection.

Offers a graphical user interface for the calculation of the mean measure of divergence, with facilities for trait selection and graphical representations <doi:10.1002/ajpa.23336>.

Autoregressive-based decomposition of a time series based on the approach in West (1997). Particular cases include the extraction of trend and seasonal components.

Randomly splits data into testing and training sets. Then, uses stepwise selection to fit numerous multiple regression models on the training data, and tests them on the test data. Returned for each model are plots comparing model Akaike Information Criterion (AIC), Pearson correlation coefficient (r) between the predicted and actual values, Mean Absolute Error (MAE), and R-Squared among the models. Each model is ranked relative to the other models by the model evaluation metrics (i.e., AIC, r, MAE, and R-Squared) and the model with the best mean ranking among the model evaluation metrics is returned. Model evaluation metric weights for AIC, r, MAE, and R-Squared are taken in as arguments as aic_wt, r_wt, mae_wt, and r_squ_wt, respectively. They are equally weighted as default but may be adjusted relative to each other if the user prefers one or more metrics to the others, Field, A. (2013, ISBN:978-1-4462-4918-5).

Flagger to detect acute kidney injury (AKI) in a patient dataset.

This package provides a modeling package compiling applicability domain methods in R. It combines different methods to measure the amount of extrapolation new samples can have from the training set. See Gadaleta et al (2016) <doi:10.4018/IJQSPR.2016010102> for an overview of applicability domains.

This package provides the ASUS procedure for estimating a high dimensional sparse parameter in the presence of auxiliary data that encode side information on sparsity. It is a robust data combination procedure in the sense that even when pooling non-informative auxiliary data ASUS would be at least as efficient as competing soft thresholding based methods that do not use auxiliary data. For more information, please see the paper Adaptive Sparse Estimation with Side Information by Banerjee, Mukherjee and Sun (JASA 2020).

This package implements a parsimonious evolutionary model to analyze and predict gene-functional annotations in phylogenetic trees as described in Vega Yon et al. (2021) <doi:10.1371/journal.pcbi.1007948>. Focusing on computational efficiency, aphylo makes it possible to estimate pooled phylogenetic models, including thousands (hundreds) of annotations (trees) in the same run. The package also provides the tools for visualization of annotated phylogenies, calculation of posterior probabilities (prediction) and goodness-of-fit assessment featured in Vega Yon et al. (2021).

Estimate diagnosis performance (Sensitivity, Specificity, Positive predictive value, Negative predicted value) of a diagnostic test where can not measure the golden standard but can estimate it using the attributable fraction.

Collect your data on digital marketing campaigns from Amazon S3 using the Windsor.ai API <https://windsor.ai/api-fields/>.

R Interface to AutoKeras <https://autokeras.com/>. AutoKeras is an open source software library for Automated Machine Learning (AutoML). The ultimate goal of AutoML is to provide easily accessible deep learning tools to domain experts with limited data science or machine learning background. AutoKeras provides functions to automatically search for architecture and hyperparameters of deep learning models.

This package provides ANOCVA (ANalysis Of Cluster VAriability), a non-parametric statistical test to compare clustering structures with applications in functional magnetic resonance imaging data (fMRI). The ANOCVA allows us to compare the clustering structure of multiple groups simultaneously and also to identify features that contribute to the differential clustering.

This package provides functions to access data from public RESTful APIs including the ArgentinaDatos API', REST Countries API', and World Bank API related to Argentina's exchange rates, inflation, political figures, holidays, economic indicators, and general country-level statistics. Additionally, the package includes curated datasets related to Argentina, covering topics such as economic indicators, biodiversity, agriculture, human rights, genetic data, and consumer prices. The package supports research and analysis focused on Argentina by integrating open APIs with high-quality datasets from various domains. For more details on the APIs, see: ArgentinaDatos API <https://argentinadatos.com/>, REST Countries API <https://restcountries.com/>, and World Bank API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392>.

Understanding morphological variation is an important task in many applications. Recent studies in computational biology have focused on developing computational tools for the task of sub-image selection which aims at identifying structural features that best describe the variation between classes of shapes. A major part in assessing the utility of these approaches is to demonstrate their performance on both simulated and real datasets. However, when creating a model for shape statistics, real data can be difficult to access and the sample sizes for these data are often small due to them being expensive to collect. Meanwhile, the landscape of current shape simulation methods has been mostly limited to approaches that use black-box inference---making it difficult to systematically assess the power and calibration of sub-image models. In this R package, we introduce the alpha-shape sampler: a probabilistic framework for simulating realistic 2D and 3D shapes based on probability distributions which can be learned from real data or explicitly stated by the user. The ashapesampler package supports two mechanisms for sampling shapes in two and three dimensions. The first, empirically sampling based on an existing data set, was highlighted in the original main text of the paper. The second, probabilistic sampling from a known distribution, is the computational implementation of the theory derived in that paper. Work based on Winn-Nunez et al. (2024) <doi:10.1101/2024.01.09.574919>.

This package provides tools to simulate alphanumeric alleles, impute genetic missing data and reconstruct non-recombinant haplotypes from pedigree databases in a deterministic way. Allelic simulations can be implemented taking into account many factors (such as number of families, markers, alleles per marker, probability and proportion of missing genotypes, recombination rate, etc). Genotype imputation can be used with simulated datasets or real databases (previously loaded in .ped format). Haplotype reconstruction can be carried out even with missing data, since the program firstly imputes each family genotype (without a reference panel), to later reconstruct the corresponding haplotypes for each family member. All this considering that each individual (due to meiosis) should unequivocally have two alleles per marker (one inherited from each parent) and thus imputation and reconstruction results can be deterministically calculated.