This package provides a method for identifying responses to experimental stimulation in mass or flow cytometry that uses high dimensional analysis of measured parameters and can be performed with an end-to-end unsupervised approach. In the context of in vitro stimulation assays where high-parameter cytometry was used to monitor intracellular response markers, using cell populations annotated either through automated clustering or manual gating for a combined set of stimulated and unstimulated samples, HDStIM labels cells as responding or non-responding. The package also provides auxiliary functions to rank intracellular markers based on their contribution to identifying responses and generating diagnostic plots.

This package performs a homogeneity analysis (multiple correspondence analysis) and various extensions. Rank restrictions on the category quantifications can be imposed (nonlinear PCA). The categories are transformed by means of optimal scaling with options for nominal, ordinal, and numerical scale levels (for rank-1 restrictions). Variables can be grouped into sets, in order to emulate regression analysis and canonical correlation analysis.

Enhances the H2O platform by providing tools for detailed evaluation of machine learning models. It includes functions for bootstrapped performance evaluation, extended F-score calculations, and various other metrics, aimed at improving model assessment.

Inference approach for jointly modeling correlated count and binary outcomes. This formulation allows simultaneous modeling of zero inflation via the Bernoulli component while providing a more accurate assessment of the Hierarchical Zero-Inflated Poisson's parsimony (Lizandra C. Fabio, Jalmar M. F. Carrasco, Victor H. Lachos and Ming-Hui Chen, Likelihood-based inference for joint modeling of correlated count and binary outcomes with extra variability and zeros, 2025, under submission).

Historical borrowing in clinical trials can improve precision and operating characteristics. This package supports a hierarchical model and a mixture model to borrow historical control data from other studies to better characterize the control response of the current study. It also quantifies the amount of borrowing through benchmark models (independent and pooled). Some of the methods are discussed by Viele et al. (2013) <doi:10.1002/pst.1589>.

Functions, Shiny apps and data for the book "Introduction to Statistics" by Wolfgang Karl Härdle, Sigbert Klinke, and Bernd Rönz (2015) <doi:10.1007/978-3-319-17704-5>.

Antitrust analysis of healthcare markets. Contains functions to implement the semiparametric estimation technique described in Raval, Rosenbaum, and Tenn (2017) "A Semiparametric Discrete Choice Model: An Application to Hospital Mergers" <doi:10.1111/ecin.12454>.

HTTP Request protocols. Implements the GET, POST and multipart POST request.

This package provides the heuristics miner algorithm for process discovery as proposed by Weijters et al. (2011) <doi:10.1109/CIDM.2011.5949453>. The algorithm builds a causal net from an event log created with the bupaR package. Event logs are a set of ordered sequences of events for which bupaR provides the S3 class eventlog(). The discovered causal nets can be visualised as htmlwidgets and it is possible to annotate them with the occurrence frequency or processing and waiting time of process activities.

This package provides HE plot and other functions for visualizing hypothesis tests in multivariate linear models. HE plots represent sums-of-squares-and-products matrices for linear hypotheses and for error using ellipses (in two dimensions) and ellipsoids (in three dimensions). It also provides other tools for analysis and graphical display of the models such as robust methods and homogeneity of variance covariance matrices. The related candisc package provides visualizations in a reduced-rank canonical discriminant space when there are more than a few response variables.

This package provides a tool for Hierarchical Climate Regionalization applicable to any correlation-based clustering. It adds several features and a new clustering method (called, regional linkage) to hierarchical clustering in R ('hclust function in stats library): data regridding, coarsening spatial resolution, geographic masking, contiguity-constrained clustering, data filtering by mean and/or variance thresholds, data preprocessing (detrending, standardization, and PCA), faster correlation function with preliminary big data support, different clustering methods, hybrid hierarchical clustering, multivariate clustering (MVC), cluster validation, visualization of regionalization results, and exporting region map and mean timeseries into NetCDF-4 file. The technical details are described in Badr et al. (2015) <doi:10.1007/s12145-015-0221-7>.

Efficient sampling from high-dimensional truncated Gaussian distributions, or multivariate truncated normal (MTN). Techniques include zigzag Hamiltonian Monte Carlo as in Akihiko Nishimura, Zhenyu Zhang and Marc A. Suchard (2024) <doi:10.1080/01621459.2024.2395587>, and harmonic Monte in Ari Pakman and Liam Paninski (2014) <doi:10.1080/10618600.2013.788448>.

It is used to construct run sequences with minimum changes for half replicate of two level factorial run order. Experimenter can save time and resources by minimizing the number of changes in levels of individual factor and therefore the total number of changes. It consists of the function minimal_hrtlf(). This technique can be employed to any half replicate of two level factorial run order where the number of factors are greater than two. In Design of Experiments (DOE) theory, two level of a factor can be represented as integers e.g. - 1 for low and 1 for high. User is expected to enter total number of factors to be considered in the experiment. minimal_hrtlf() provides the required run sequences for the input number of factors. The output also gives the number of changes of each factor along with total number of changes in the run sequence. Due to restricted randomization the minimally changed run sequences of half replicate of two level factorial run order will be affected by trend effect. The output also provides the Trend Factor value of the run order. Trend factor value will lies between 0 to 1. Higher the values, lesser the influence of trend effects on the run order.

This package provides an example HiC dataset and two examples of HiCociety outputs from a function named hic2community(). The data are intended for demonstration purposes only and kept small enough to be distributed via CRAN.

This package contains most of the hex font files from the GNU Unifont Project <https://unifoundry.com/unifont/> compressed by xz'. GNU Unifont is a duospaced bitmap font that attempts to cover all the official Unicode glyphs plus several of the artificial scripts in the (Under-)ConScript Unicode Registry <https://www.kreativekorp.com/ucsur/>. Provides a convenience function for loading in several of them at the same time as a bittermelon bitmap font object for easy rendering of the glyphs in an R terminal or graphics device.

Fits sparse interaction models for continuous and binary responses subject to the strong (or weak) hierarchy restriction that an interaction between two variables only be included if both (or at least one of) the variables is included as a main effect. For more details, see Bien, J., Taylor, J., Tibshirani, R., (2013) "A Lasso for Hierarchical Interactions." Annals of Statistics. 41(3). 1111-1141.

The heterogeneous multi-task feature learning is a data integration method to conduct joint feature selection across multiple related data sets with different distributions. The algorithm can combine different types of learning tasks, including linear regression, Huber regression, adaptive Huber, and logistic regression. The modified version of Bayesian Information Criterion (BIC) is produced to measure the model performance. Package is based on Yuan Zhong, Wei Xu, and Xin Gao (2022) <https://www.fields.utoronto.ca/talk-media/1/53/65/slides.pdf>.

This package provides a utility to quickly obtain clean and tidy men's basketball play by play data. Provides functions to access live play by play and box score data from ESPN<https://www.espn.com> with shot locations when available. It is also a full NBA Stats API<https://www.nba.com/stats/> wrapper. It is also a scraping and aggregating interface for Ken Pomeroy's men's college basketball statistics website<https://kenpom.com>. It provides users with an active subscription the capability to scrape the website tables and analyze the data for themselves.

In medical research, supervised heterogeneity analysis has important implications. Assume that there are two types of features. Using both types of features, our goal is to conduct the first supervised heterogeneity analysis that satisfies a hierarchical structure. That is, the first type of features defines a rough structure, and the second type defines a nested and more refined structure. A penalization approach is developed, which has been motivated by but differs significantly from penalized fusion and sparse group penalization. Reference: Ren, M., Zhang, Q., Zhang, S., Zhong, T., Huang, J. & Ma, S. (2022). "Hierarchical cancer heterogeneity analysis based on histopathological imaging features". Biometrics, <doi:10.1111/biom.13426>.

The Harmonised Index of Consumer Prices (HICP) is the key economic figure to measure inflation in the euro area. The methodology underlying the HICP is documented in the HICP Methodological Manual (<https://ec.europa.eu/eurostat/web/products-manuals-and-guidelines/w/ks-gq-24-003>). Based on the manual, this package provides functions to access and work with HICP data from Eurostat's public database (<https://ec.europa.eu/eurostat/data/database>).

This package provides a set of tools supporting more flexible heatmaps. The graphics is grid-like using the old graphics system. The main function is heatmap.n2(), which is a wrapper around the various functions constructing individual parts of the heatmap, like sidebars, picket plots, legends etc. The function supports zooming and splitting, i.e., having (unlimited) small heatmaps underneath each other in one plot deriving from the same data set, e.g., clustered and ordered by a supervised clustering method.

Efficient Bayesian multinomial logistic regression based on heavy-tailed (hyper-LASSO, non-convex) priors. The posterior of coefficients and hyper-parameters is sampled with restricted Gibbs sampling for leveraging the high-dimensionality and Hamiltonian Monte Carlo for handling the high-correlation among coefficients. A detailed description of the method: Li and Yao (2018), Journal of Statistical Computation and Simulation, 88:14, 2827-2851, <doi:10.48550/arXiv.1405.3319>.

We present this package for fitting structural equation models using the hierarchical likelihood method. This package allows extended structural equation model, including dynamic structural equation model. We illustrate the use of our packages with well-known data sets. Therefore, this package are able to handle two serious problems inadmissible solution and factor indeterminacy <doi:10.3390/sym13040657>.

This package performs iterative extrapolation of species haplotype accumulation curves using a nonparametric stochastic (Monte Carlo) optimization method for assessment of specimen sampling completeness based on the approach of Phillips et al. (2015) <doi:10.1515/dna-2015-0008>, Phillips et al. (2019) <doi:10.1002/ece3.4757> and Phillips et al. (2020) <doi: 10.7717/peerj-cs.243>. HACSim outputs a number of useful summary statistics of sampling coverage ("Measures of Sampling Closeness"), including an estimate of the likely required sample size (along with desired level confidence intervals) necessary to recover a given number/proportion of observed unique species haplotypes. Any genomic marker can be targeted to assess likely required specimen sample sizes for genetic diversity assessment. The method is particularly well-suited to assess sampling sufficiency for DNA barcoding initiatives. Users can also simulate their own DNA sequences according to various models of nucleotide substitution. A Shiny app is also available.