Interface to the OpenGWAS database API <https://api.opengwas.io/api/>. Includes a wrapper to make generic calls to the API, plus convenience functions for specific queries.

It facilitates the calculation of 40 different insulin sensitivity indices based on fasting, oral glucose tolerance test (OGTT), lipid (adipose), and tracer (palmitate and glycerol rate) and dxa (fat mass) measurement values. It enables easy and accurate assessment of insulin sensitivity, critical for understanding and managing metabolic disorders like diabetes and obesity. Indices calculated are described in Gastaldelli (2022). <doi:10.1002/oby.23503> and Lorenzo (2010). <doi:10.1210/jc.2010-1144>.

Estimation of joint models for multivariate longitudinal markers (with various distributions available) and survival outcomes (possibly accounting for competing risks) with Integrated Nested Laplace Approximations (INLA). The flexible and user friendly function joint() facilitates the use of the fast and reliable inference technique implemented in the INLA package for joint modeling. More details are given in the help page of the joint() function (accessible via ?joint in the R console) and the vignette associated to the joint() function (accessible via vignette("INLAjoint") in the R console).

Estimates the intraclass correlation coefficient for trajectory data using a matrix of distances between trajectories. The distances implemented are the extended Hausdorff distances (Min et al. 2007) <doi:10.1080/13658810601073315> and the discrete Fréchet distance (Magdy et al. 2015) <doi:10.1109/IntelCIS.2015.7397286>.

This package performs Goodness of Fit for regression models using Integrated Regression method. Works for several different fitting techniques.

Builds statistical control charts with exact limits for univariate and multivariate cases.

Calculates insulin secretion rates from C-peptide values based on the methods described in Van Cauter et al. (1992) <doi:10.2337/diab.41.3.368>. Includes functions to calculate estimated insulin secretion rates using linear or cubic spline interpolation of c-peptide values (see Eaton et al., 1980 <doi:10.1210/jcem-51-3-520> and Polonsky et al., 1986 <doi:10.1172/JCI112308>) and to calculate estimates of input coefficients (volume of distribution, short half life, long half life, and fraction attributed to short half life) as described by Van Cauter. Although the generated coefficients are specific to insulin secretion, the two-compartment secretion model used here is useful for certain applications beyond insulin.

The iterLap (iterated Laplace approximation) algorithm approximates a general (possibly non-normalized) probability density on R^p, by repeated Laplace approximations to the difference between current approximation and true density (on log scale). The final approximation is a mixture of multivariate normal distributions and might be used for example as a proposal distribution for importance sampling (eg in Bayesian applications). The algorithm can be seen as a computational generalization of the Laplace approximation suitable for skew or multimodal densities.

Launches a shiny based application for Nuclear Magnetic Resonance (NMR)data importation and Statistical TOtal Correlation SpectroscopY (STOCSY) analyses in a full interactive approach. The theoretical background and applications of STOCSY method could be found at Cloarec, O., Dumas, M. E., Craig, A., Barton, R. H., Trygg, J., Hudson, J., Blancher, C., Gauguier, D., Lindon, J. C., Holmes, E. & Nicholson, J. (2005) <doi:10.1021/ac048630x>.

Utility functions that implement and automate common sets of validation tasks. These functions are particularly useful to validate inputs, intermediate objects and output values in user-defined functions, resulting in tidier and less verbose functions.

Multivariate outlier detection is performed using invariant coordinates where the package offers different methods to choose the appropriate components. ICS is a general multivariate technique with many applications in multivariate analysis. ICSOutlier offers a selection of functions for automated detection of outliers in the data based on a fitted ICS object or by specifying the dataset and the scatters of interest. The current implementation targets data sets with only a small percentage of outliers.

This package provides tools for importing, merging, and analysing data from international assessment studies (TIMSS, PIRLS, PISA, ICILS, and PIAAC).

Develops a General Equilibrium (GE) Model, which estimates key variables such as wages, the number of residents and workers, the prices of the floor space, and its distribution between commercial and residential use, as in Ahlfeldt et al., (2015) <doi:10.3982/ECTA10876>. By doing so, the model allows understanding the economic influence of different urban policies.

This package performs iterative proportional updating given a seed table and an arbitrary number of marginal distributions. This is commonly used in population synthesis, survey raking, matrix rebalancing, and other applications. For example, a household survey may be weighted to match the known distribution of households by size from the census. An origin/ destination trip matrix might be balanced to match traffic counts. The approach used by this package is based on a paper from Arizona State University (Ye, Xin, et. al. (2009) <http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.537.723&rep=rep1&type=pdf>). Some enhancements have been made to their work including primary and secondary target balance/importance, general marginal agreement, and weight restriction.

Interactive plots for R.

Computes individual contributions to the overall Gini and Theil's T and Theil's L measures and their decompositions by groups such as race, gender, national origin, with the three functions of iGini(), iTheiT(), and iTheilL(). For details, see Tim F. Liao (2019) <doi:10.1177/0049124119875961>.

Graphical visualization tools for analyzing the data produced by irace'. The iraceplot package enables users to analyze the performance and the parameter space data sampled by the configuration during the search process. It provides a set of functions that generate different plots to visualize the configurations sampled during the execution of irace and their performance. The functions just require the log file generated by irace and, in some cases, they can be used with user-provided data.

This package provides a fast (C) implementation of the iterative proportional fitting procedure.

Partitioning clustering algorithms divide data sets into k subsets or partitions so-called clusters. They require some initialization procedures for starting the algorithms. Initialization of cluster prototypes is one of such kind of procedures for most of the partitioning algorithms. Cluster prototypes are the centers of clusters, i.e. centroids or medoids, representing the clusters in a data set. In order to initialize cluster prototypes, the package inaparc contains a set of the functions that are the implementations of several linear time-complexity and loglinear time-complexity methods in addition to some novel techniques. Initialization of fuzzy membership degrees matrices is another important task for starting the probabilistic and possibilistic partitioning algorithms. In order to initialize membership degrees matrices required by these algorithms, a number of functions based on some traditional and novel initialization techniques are also available in the package inaparc'.

Implementations of the weighted Kozachenko-Leonenko entropy estimator and independence tests based on this estimator, (Kozachenko and Leonenko (1987) <http://mi.mathnet.ru/eng/ppi797>). Also includes a goodness-of-fit test for a linear model which is an independence test between covariates and errors.

Send emails using the mailgun api. To use this package you will need an account from <https://www.mailgun.com> .

Implementation of some of the formulations for the thermodynamic and transport properties released by the International Association for the Properties of Water and Steam (IAPWS). More specifically, the releases R1-76(2014), R5-85(1994), R6-95(2018), R7-97(2012), R8-97, R9-97, R10-06(2009), R11-24, R12-08, R15-11, R16-17(2018), R17-20 and R18-21 at <https://iapws.org>.

Read and process isotopocule data from an Orbitrap Isotope Solutions mass spectrometer. Citation: Kantnerova et al. (Nature Protocols, 2024).

Spatial interpolation toolkit designed for environmental and geospatial applications. It includes a range of methods, from traditional techniques to advanced machine learning approaches, ensuring accurate and efficient estimation of values in unobserved locations.