This package provides a pipeline to annotate a number of peaks from the IDSL.IPA peaklists using an exhaustive chemical enumeration-based approach. This package can perform elemental composition calculations using the following 15 elements : C, B, Br, Cl, K, S, Si, N, H, As, F, I, Na, O, and P.

This package provides native R access to Interactive Brokers Trader Workstation API.

This package provides a user-friendly interface, using Shiny, to analyse glucose-stimulated insulin secretion (GSIS) assays in pancreatic beta cells or islets. The package allows the user to import several sets of experiments from different spreadsheets and to perform subsequent steps: summarise in a tidy format, visualise data quality and compare experimental conditions without omitting to account for technical confounders such as the date of the experiment or the technician. Together, insane is a comprehensive method that optimises pre-processing and analyses of GSIS experiments in a friendly-user interface. The Shiny App was initially designed for EndoC-betaH1 cell line following method described in Ndiaye et al., 2017 (<doi:10.1016/j.molmet.2017.03.011>).

Currently using the proportional hazards (PH) model. More methods under other semiparametric regression models will be included in later versions.

Semiparametric regression models on the cumulative incidence function for interval-censored competing risks data as described in Bakoyannis, Yu, & Yiannoutsos (2017) /doi10.1002/sim.7350 and the models with missing event types as described in Park, Bakoyannis, Zhang, & Yiannoutsos (2021) \doi10.1093/biostatistics/kxaa052. The proportional subdistribution hazards model (Fine-Gray model), the proportional odds model, and other models that belong to the class of semiparametric generalized odds rate transformation models.

Takes in vivo toxicokinetic concentration-time data and fits parameters of 1-compartment and 2-compartment models for each chemical. These methods are described in detail in "Informatics for Toxicokinetics" (2025).

An implementation of the Otsu's Image Segmentation Method described in the paper: "A C++ Implementation of Otsu's Image Segmentation Method". The algorithm is explained at <doi:10.5201/ipol.2016.158>.

This package provides a statistical method based on Bayesian Additive Regression Trees with Global Standard Error Permutation Test (BART-G.SE) for descriptor selection and symbolic regression. It finds the symbolic formula of the regression function y=f(x) as described in Ye, Senftle, and Li (2023) <arXiv:2110.10195>.

This package provides user-friendly functions for programmatic access to macroeconomic data from the International Monetary Fund's SDMX 3.0 IMF Data API <https://data.imf.org/en/Resource-Pages/IMF-API>.

This package provides functions to download and parse information from INEGI (Official Mexican statistics agency). To learn more about the API, see <https://www.inegi.org.mx/servicios/api_indicadores.html>.

This package provides a variety of improved shrinkage estimators in the area of statistical analysis: unrestricted; restricted; preliminary test; improved preliminary test; Stein; and positive-rule Stein. More details can be found in chapter 7 of Saleh, A. K. Md. E. (2006) <ISBN: 978-0-471-56375-4>.

Estimation of the most-left informative set of gross returns (i.e., the informative set). The procedure to compute the informative set adjusts the method proposed by Mariani et al. (2022a) <doi:10.1007/s11205-020-02440-6> and Mariani et al. (2022b) <doi:10.1007/s10287-022-00422-2> to gross returns of financial assets. This is accomplished through an adaptive algorithm that identifies sub-groups of gross returns in each iteration by approximating their distribution with a sequence of two-component log-normal mixtures. These sub-groups emerge when a significant change in the distribution occurs below the median of the financial returns, with their boundary termed as the â change point" of the mixture. The process concludes when no further change points are detected. The outcome encompasses parameters of the leftmost mixture distributions and change points of the analyzed financial time series. The functionalities of the INFOSET package include: (i) modelling asset distribution detecting the parameters which describe left tail behaviour (infoset function), (ii) clustering, (iii) labeling of the financial series for predictive and classification purposes through a Left Risk measure based on the first change point (LR_cp function) (iv) portfolio construction (ptf_construction function). The package also provide a specific function to construct rolling windows of different length size and overlapping time.

Multivariate smoothing using iterative bias reduction with kernel, thin plate splines, Duchon splines or low rank splines.

An implementation to reconstruct individual patient data from Kaplan-Meier (K-M) survival curves, visualize and assess the accuracy of the reconstruction, then perform secondary analysis on the reconstructed data. We involve a simple function to extract the coordinates form the published K-M curves. The function is developed based on Poisot T. â s digitize package (2011) <doi:10.32614/RJ-2011-004> . For more complex and tangled together graphs, digitizing software, such as DigitizeIt (for MAC or windows) or ScanIt'(for windows) can be used to get the coordinates. Additional information should also be involved to increase the accuracy, like numbers of patients at risk (often reported at 5-10 time points under the x-axis of the K-M graph), total number of patients, and total number of events. The package implements the modified iterative K-M estimation algorithm (modified-iKM) improved upon the approach proposed by Guyot (2012) <doi:10.1186/1471-2288-12-9> with some modifications.

Data sets and scripts for text examples and exercises in P. Dalgaard (2008), `Introductory Statistics with R', 2nd ed., Springer Verlag, ISBN 978-0387790534.

This package performs exploratory data analysis and variable screening for binary classification models using weight-of-evidence (WOE) and information value (IV). In order to make the package as efficient as possible, aggregations are done in data.table and creation of WOE vectors can be distributed across multiple cores. The package also supports exploration for uplift models (NWOE and NIV).

Use R to make requests to the US Census Bureau's International Data Base API. Results are returned as R data frames. For more information about the IDB API, visit <https://www.census.gov/data/developers/data-sets/international-database.html>.

Immunotherapy has revolutionized cancer treatment, but predicting patient response remains challenging. Here, we presented Intelligent Predicting Response to cancer Immunotherapy through Systematic Modeling (iPRISM), a novel network-based model that integrates multiple data types to predict immunotherapy outcomes. It incorporates gene expression, biological functional network, tumor microenvironment characteristics, immune-related pathways, and clinical data to provide a comprehensive view of factors influencing immunotherapy efficacy. By identifying key genetic and immunological factors, it provides an insight for more personalized treatment strategies and combination therapies to overcome resistance mechanisms.

Allows access to data from the Rio de Janeiro Public Security Institute (ISP), such as criminal statistics, data on gun seizures and femicide. The package also contains the spatial data of Pacifying Police Units (UPPs) and Integrated Public Safety Regions, Areas and Circumscriptions.

The main purpose of this package is to generate the structure of the analysis of variance (ANOVA) table of the two-phase experiments. The user only need to input the design and the relationships of the random and fixed factors using the Wilkinson-Rogers syntax, this package can then quickly generate the structure of the ANOVA table with the coefficients of the variance components for the expected mean squares. Thus, the balanced incomplete block design and provides the efficiency factors of the fixed effects can also be studied and compared much easily.

Fit a full or subsampling bagging survival tree on a mixture of population (susceptible and nonsusceptible) using either a pseudo R2 criterion or an adjusted Logrank criterion. The predictor is evaluated using the Out Of Bag Integrated Brier Score (IBS) and several scores of importance are computed for variable selection. The thresholds values for variable selection are computed using a nonparametric permutation test. See Cyprien Mbogning and Philippe Broet (2016)<doi:10.1186/s12859-016-1090-x> for an overview about the methods implemented in this package.

An interface to the algorithms of Interpretable AI <https://www.interpretable.ai> from the R programming language. Interpretable AI provides various modules, including Optimal Trees for classification, regression, prescription and survival analysis, Optimal Imputation for missing data imputation and outlier detection, and Optimal Feature Selection for exact sparse regression. The iai package is an open-source project. The Interpretable AI software modules are proprietary products, but free academic and evaluation licenses are available.

Automatically detects Copy Number Variations (CNV) from Next Generation Sequencing data using a machine learning algorithm, Isolation forest. More details about the method can be found in the paper by Cabello-Aguilar (2022) <doi:10.1101/2022.01.03.474771>.

The improved trimmed weighted Hochberg procedure provides increased statistical power and relaxes the dependence assumptions for familywise error rate control compared to the original weighted Hochberg procedure. This package computes the boundaries required for implementing the proposed methodology and includes sample size optimization methods. See Gou, J., Chang, Y., Li, T., and Zhang, F.(2025). Improved trimmed weighted Hochberg procedures with two endpoints and sample size optimization. Technical Report.