Select set of parametric and non-parametric statistical tests. inferr builds upon the solid set of statistical tests provided in stats package by including additional data types as inputs, expanding and restructuring the test results. The tests included are t tests, variance tests, proportion tests, chi square tests, Levene's test, McNemar Test, Cochran's Q test and Runs test.

Perform fast and memory efficient time-weighted averaging of values measured over intervals into new arbitrary intervals. This package is useful in the context of data measured or represented as constant values over intervals on a one-dimensional discrete axis (e.g. time-integrated averages of a curve over defined periods). This package was written specifically to deal with air pollution data recorded or predicted as averages over sampling periods. Data in this format often needs to be shifted to non-aligned periods or averaged up to periods of longer duration (e.g. averaging data measured over sequential non-overlapping periods to calendar years).

This package provides a set of tools for writing documents according to Geneva Graduate Institute conventions and regulations. The most common use is for writing and compiling theses or thesis chapters, as drafts or for examination with correct preamble formatting. However, the package also offers users to create HTML presentation slides with xaringan', complete problem sets, format posters, and, for course instructors, prepare a syllabus. The package includes additional functions for institutional color palettes, an institutional ggplot theme, a function for counting manuscript words, and a bibliographical analysis toolkit.

This package provides a comprehensive toolkit for clinical Human Leukocyte Antigen (HLA) informatics, built on tidyverse <https://tidyverse.tidyverse.org/> principles and making use of Genotype List String (GL String, Mack et al. (2023) <doi:10.1111/tan.15126>) for storing and computing HLA genotype data. Specific functionalities include: coercion of HLA data in tabular format to and from GL String; calculation of matching and mismatching in all directions, with multiple output formats; automatic formatting of HLA data for searching within a GL String; truncation of molecular HLA data to a specific number of fields; and reading HLA genotypes in HML files and extracting the GL String. This library is intended for research use. Any application making use of this package in a clinical setting will need to be independently validated according to local regulations.

Immunotherapy has revolutionized cancer treatment, but predicting patient response remains challenging. Here, we presented Intelligent Predicting Response to cancer Immunotherapy through Systematic Modeling (iPRISM), a novel network-based model that integrates multiple data types to predict immunotherapy outcomes. It incorporates gene expression, biological functional network, tumor microenvironment characteristics, immune-related pathways, and clinical data to provide a comprehensive view of factors influencing immunotherapy efficacy. By identifying key genetic and immunological factors, it provides an insight for more personalized treatment strategies and combination therapies to overcome resistance mechanisms.

Flexibly implements Integral Projection Models using a mathematical(ish) syntax. This package will not help with the vital rate modeling process, but will help convert those regression models into an IPM. ipmr handles density dependence and environmental stochasticity, with a couple of options for implementing the latter. In addition, provides functions to avoid unintentional eviction of individuals from models. Additionally, provides model diagnostic tools, plotting functionality, stochastic/deterministic simulations, and analysis tools. Integral projection models are described in depth by Easterling et al. (2000) <doi:10.1890/0012-9658(2000)081[0694:SSSAAN]2.0.CO;2>, Merow et al. (2013) <doi:10.1111/2041-210X.12146>, Rees et al. (2014) <doi:10.1111/1365-2656.12178>, and Metcalf et al. (2015) <doi:10.1111/2041-210X.12405>. Williams et al. (2012) <doi:10.1890/11-2147.1> discuss the problem of unintentional eviction.

This function predicts item response probabilities and item responses using the item-focused tree model. The item-focused tree model combines logistic regression with recursive partitioning to detect Differential Item Functioning in dichotomous items. The model applies partitioning rules to the data, splitting it into homogeneous subgroups, and uses logistic regression within each subgroup to explain the data. Differential Item Functioning detection is achieved by examining potential group differences in item response patterns. This method is useful for understanding how different predictors, such as demographic or psychological factors, influence item responses across subgroups.

Various functions and a Shiny app to enrich the results of Multiple Correspondence Analysis with interpretive axes and planes (see Moschidis, Markos, and Thanopoulos, 2022; <doi:10.1108/ACI-07-2022-0191>).

Offers modeling the association between gene-expression and bioassay data, taking care of the effect due to a fingerprint feature and helps with several plots to better understand the analysis.

This package provides a multivariate Gaussian mixture model framework to integrate multiple types of genomic data and allow modeling of inter-data-type correlations for association analysis. IMIX can be implemented to test whether a disease is associated with genes in multiple genomic data types, such as DNA methylation, copy number variation, gene expression, etc. It can also study the integration of multiple pathways. IMIX uses the summary statistics of association test outputs and conduct integration analysis for two or three types of genomics data. IMIX features statistically-principled model selection, global FDR control and computational efficiency. Details are described in Ziqiao Wang and Peng Wei (2020) <doi:10.1093/bioinformatics/btaa1001>.

This package provides tools for passing messages between R processes. Shiny examples are provided showing how to perform useful tasks such as: updating reactive values from within a future, progress bars for long running async tasks, and interrupting async tasks based on user input.

An implementation of the MaxLFQ algorithm by Cox et al. (2014) <doi:10.1074/mcp.M113.031591> in a comprehensive pipeline for processing proteomics data in data-independent acquisition mode (Pham et al. 2020 <doi:10.1093/bioinformatics/btz961>; Pham et al. 2026 <doi:10.1021/acs.jproteome.5c01038>). It offers additional options for protein quantification using the N most intense fragment ions, using all fragment ions, the median polish algorithm by Tukey (1977, ISBN:0201076160), and a robust linear model. In general, the tool can be used to integrate multiple proportional observations into a single quantitative value.

Interpreting the differences between mean scale scores across various forms of an assessment can be challenging. This difficulty arises from different mappings between raw scores and scale scores, complex mathematical relationships, adjustments based on judgmental procedures, and diverse equating functions applied to different assessment forms. An alternative method involves running simulations to explore the effect of incrementing raw scores on mean scale scores. The idmact package provides an implementation of this approach based on the algorithm detailed in Schiel (1998) <https://www.act.org/content/dam/act/unsecured/documents/ACT_RR98-01.pdf> which was developed to help interpret differences between mean scale scores on the American College Testing (ACT) assessment. The function idmact_subj() within the package offers a framework for running simulations on subject-level scores. In contrast, the idmact_comp() function provides a framework for conducting simulations on composite scores.

This package provides function to read data from the Igor Pro data analysis program by Wavemetrics'. The data formats supported are Igor packed experiment format ('pxp') and Igor binary wave ('ibw'). See: <https://www.wavemetrics.com/> for details. Also includes functions to load special pxp files produced by the Igor Pro Neuromatic and Nclamp packages for recording and analysing neuronal data. See <https://github.com/SilverLabUCL/NeuroMatic> for details.

Training datasets for iC10; which implements the classifier described in the paper Genome-driven integrated classification of breast cancer validated in over 7,500 samples (Ali HR et al., Genome Biology 2014). It uses copy number and/or expression form breast cancer data, trains a pamr classifier (Tibshirani et al.) with the features available and predicts the iC10 group. Genomic annotation for the training dataset has been obtained from Mark Dunning's lluminaHumanv3.db package.

Fits large-scale regression models with a penalty that restricts the maximum number of non-zero regression coefficients to a prespecified value. While Chu et al (2020) <doi:10.1093/gigascience/giaa044> describe the basic algorithm, this package uses Cyclops for an efficient implementation.

Empirical Bayes variable selection via ICM/M algorithm for normal, binary logistic, and Cox's regression. The basic problem is to fit high-dimensional regression which sparse coefficients. This package allows incorporating the Ising prior to capture structure of predictors in the modeling process. More information can be found in the papers listed in the URL below.

Sample states from the Ising model and compute the probability of states. Sampling can be done for any number of nodes, but due to the intractability of the Ising model the distribution can only be computed up to roughly 10 nodes. The Blume-Capel model, an Ising model with an additional on-site quadratic (crystal-field) term, is also supported.

Implementation of functions to assign corresponding common job prestige scores (SIOPS, ISEI), the official job or group title and the ISCO-88 code to given ISCO-08 codes. ISCO-08 is the latest version of the International Standard Classification of Occupations which is used to organise information on labour and jobs.

Calculates the RMS intrinsic and parameter-effects curvatures of a nonlinear regression model. The curvatures are global measures of assessing whether a model/data set combination is close-to-linear or not. See Bates and Watts (1980) <doi:10.1002/9780470316757> and Ratkowsky and Reddy (2017) <doi:10.1093/aesa/saw098> for details.

This package provides functions to simulate baseline characteristics, reconstruct overall survival data from published Kaplan-Meier curves, and generate publication-ready tables and forest plots reproducing the IMpower133 clinical trial results (Horn et al., 2018, <doi:10.1056/NEJMoa1809064>). The IPD reconstruction method is based on Liu et al.(2021, <doi:10.1186/s12874-021-01308-8>).

This package implements an S7 class for estimates based on influence functions, with forward mode automatic differentiation defined for standard arithmetic operations.

This package provides a collection of useful functions and datasets for the Data Science Course at IBAW.

Data sets, functions and scripts with examples to implement autoregressive models for irregularly observed time series. The models available in this package are the irregular autoregressive model (Eyheramendy et al.(2018) <doi:10.1093/mnras/sty2487>), the complex irregular autoregressive model (Elorrieta et al.(2019) <doi:10.1051/0004-6361/201935560>) and the bivariate irregular autoregressive model (Elorrieta et al.(2021) <doi:10.1093/mnras/stab1216>).