Perform two linear combination methods for biomarkers: (1) Empirical performance optimization for specificity (or sensitivity) at a controlled sensitivity (or specificity) level of Huang and Sanda (2022) <doi:10.1214/22-aos2210>, and (2) weighted maximum score estimator with empirical minimization of averaged false positive rate and false negative rate. Both adopt the algorithms of Huang and Sanda (2022) <doi:10.1214/22-aos2210>. MOSEK solver is used and needs to be installed; an academic license for MOSEK is free.

This package performs variety of viral quasispecies diversity analyses [see Pamornchainavakul et al. (2024) <doi:10.21203/rs.3.rs-4637890/v1>] based on long-read sequence alignment. Main functions include 1) sequencing error and other noise minimization and read sampling, 2) Single nucleotide variant (SNV) profiles comparison, and 3) viral quasispecies profiles comparison and visualization.

Locally sparse estimator of generalized varying coefficient model for asynchronous longitudinal data by kernel-weighted estimating equation.

This package provides a shiny application to automate forward and back survey translation with optional reconciliation using large language models (LLMs). Supports both item-by-item and batch translation modes for optimal performance and context-aware translations. Handles multi-sheet Excel files and supports OpenAI (GPT), Google Gemini, and Anthropic Claude models. Follows the TRAPD (Translation, Review, Adjudication, Pretesting, Documentation) framework and ISPOR (International Society for Pharmacoeconomics and Outcomes Research) recommendations. See Harkness et al. (2010) <doi:10.1002/9780470609927.ch7> and Wild et al. (2005) <doi:10.1111/j.1524-4733.2005.04054.x>.

Implementation of the drift-diffusion mixed model for category learning as described in Paulon et al. (2021) <doi:10.1080/01621459.2020.1801448>.

This package provides functions to estimate survival and a treatment effect using a landmark estimation approach.

Package shiny provides interactive web applications in R. Package loon is an interactive toolkit engaged in open-ended, creative and unscripted data exploration. The loon.shiny package can take loon widgets and display a selfsame shiny app.

The LIC criterion is to determine the most informative subsets so that the subset can retain most of the information contained in the complete data. The philosophy of the package is described in Guo G. (2022) <doi:10.1080/02664763.2022.2053949>.

An interface for NetLogo <https://www.netlogo.org> that enables programmatic setup and execution of simulations. Designed to facilitate integrating NetLogo models into reproducible workflows by creating and running BehaviorSpace experiments and retrieving their results.

Targeted Maximum Likelihood Estimation ('TMLE') of treatment/censoring specific mean outcome or marginal structural model for point-treatment and longitudinal data.

Kernel regression smoothing with adaptive local or global plug-in bandwidth selection.

The solution of equality constrained least squares problem (LSE) is given through four analytics methods (Generalized QR Factorization, Lagrange Multipliers, Direct Elimination and Null Space method). We expose the orthogonal decomposition called Generalized QR Factorization (GQR) and also RQ factorization. Finally some codes for the solution of LSE applied in quaternions.

Calculate mean statistics and leaf angle distribution type from measured leaf inclination angles. LAD distribution is fitted using a two-parameters (mu, nu) Beta distribution and compared with six theoretical LAD distributions. Additional information is provided in Chianucci and Cesaretti (2022) <doi:10.1101/2022.10.28.513998>.

This package provides functions for computing the r and r* statistics for inference on an arbitrary scalar function of model parameters, plus some code for the (modified) profile likelihood.

Compute power and sample size for linear models of longitudinal data. Supported models include mixed-effects models and models fit by generalized least squares and generalized estimating equations. The package is described in Iddi and Donohue (2022) <DOI:10.32614/RJ-2022-022>. Relevant formulas are derived by Liu and Liang (1997) <DOI:10.2307/2533554>, Diggle et al (2002) <ISBN:9780199676750>, and Lu, Luo, and Chen (2008) <DOI:10.2202/1557-4679.1098>.

This package provides S3 classes to represent low rank matrix decompositions.

Designed to query Longitudinal Employer-Household Dynamics (LEHD) workplace/residential association and origin-destination flat files and optionally aggregate Census block-level data to block group, tract, county, or state. Data comes from the LODES FTP server <https://lehd.ces.census.gov/data/lodes/LODES8/>.

Runtime for serving containers that can execute R code on the AWS Lambda serverless compute service <https://aws.amazon.com/lambda/>. Provides the necessary functionality for handling the various endpoints required for accepting new input and sending responses.

Density, distribution, quantile and random generation function for the logitnormal distribution. Estimation of the mode and the first two moments. Estimation of distribution parameters.

This package provides instrumental variable estimation of treatment effects when both the endogenous treatment and its instrument are binary. Applicable to both binary and continuous outcomes.

This package implements methods for analyzing latent variable models with measurement error correction, including Item Response Theory (IRT) models. Provides tools for various correction methods such as Bayesian Markov Chain Monte Carlo (MCMC), over-imputation, bootstrapping for robust standard errors, Ordinary Least Squares (OLS), and Instrumental Variables (IV) based approaches. Supports flexible specification of observable indicators and groupings for latent variable analyses in social sciences and other fields. Methods are described in a working paper (2025) <doi:10.48550/arXiv.2507.22218>.

Non-parametric estimators for casual effects based on longitudinal modified treatment policies as described in Diaz, Williams, Hoffman, and Schenck <doi:10.1080/01621459.2021.1955691>, traditional point treatment, and traditional longitudinal effects. Continuous, binary, categorical treatments, and multivariate treatments are allowed as well are censored outcomes. The treatment mechanism is estimated via a density ratio classification procedure irrespective of treatment variable type. For both continuous and binary outcomes, additive treatment effects can be calculated and relative risks and odds ratios may be calculated for binary outcomes. Supports survival outcomes with competing risks (Diaz, Hoffman, and Hejazi; <doi:10.1007/s10985-023-09606-7>).

This package provides a framework to load text and excel files through a shiny graphical interface. It allows renaming, transforming, ordering and removing variables. It includes basic exploratory methods such as the mean, median, mode, normality test, histogram and correlation.

This package provides a framework that allows for easy logging of changes in data. Main features: start tracking changes by adding a single line of code to an existing script. Track changes in multiple datasets, using multiple loggers. Add custom-built loggers or use loggers offered by other packages. <doi:10.18637/jss.v098.i01>.