Nuclear magnetic resonance (NMR) is a highly versatile analytical technique for studying molecular configuration, conformation, and dynamics, especially those of biomacromolecules such as proteins. Biological Magnetic Resonance Data Bank ('BMRB') is a repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules. Currently, BMRB offers an R package RBMRB to fetch data, however, it doesn't easily offer individual data file downloading and storing in a local directory. When using RBMRB', the data will stored as an R object, which fundamentally hinders the NMR researches to access the rich information from raw data, for example, the metadata. Here, BMRBr File Downloader ('BMRBr') offers a more fundamental, low level downloader, which will download original deposited .str format file. This type of file contains information such as entry title, authors, citation, protein sequences, and so on. Many factors affect NMR experiment outputs, such as temperature, resonance sensitivity and etc., approximately 40% of the entries in the BMRB have chemical shift accuracy problems [1,2] Unfortunately, current reference correction methods are heavily dependent on the availability of assigned protein chemical shifts or protein structure. This is my current research project is going to solve, which will be included in the future release of the package. The current version of the package is sufficient and robust enough for downloading individual BMRB data file from the BMRB database <http://www.bmrb.wisc.edu>. The functionalities of this package includes but not limited: * To simplifies NMR researches by combine data downloading and results analysis together. * To allows NMR data reaches a broader audience that could utilize more than just chemical shifts but also metadata. * To offer reference corrected data for entries without assignment or structure information (future release). Reference: [1] E.L. Ulrich, H. Akutsu, J.F. Doreleijers, Y. Harano, Y.E. Ioannidis, J. Lin, et al., BioMagResBank, Nucl. Acids Res. 36 (2008) D402â 8. <doi:10.1093/nar/gkm957>. [2] L. Wang, H.R. Eghbalnia, A. Bahrami, J.L. Markley, Linear analysis of carbon-13 chemical shift differences and its application to the detection and correction of errors in referencing and spin system identifications, J. Biomol. NMR. 32 (2005) 13â 22. <doi:10.1007/s10858-005-1717-0>.

Facilitates many of the analyses performed in studies of behavioral economic demand. The package supports commonly-used options for modeling operant demand including (1) data screening proposed by Stein, Koffarnus, Snider, Quisenberry, & Bickel (2015; <doi:10.1037/pha0000020>), (2) fitting models of demand such as linear (Hursh, Raslear, Bauman, & Black, 1989, <doi:10.1007/978-94-009-2470-3_22>), exponential (Hursh & Silberberg, 2008, <doi:10.1037/0033-295X.115.1.186>) and modified exponential (Koffarnus, Franck, Stein, & Bickel, 2015, <doi:10.1037/pha0000045>), and (3) calculating numerous measures relevant to applied behavioral economists (Intensity, Pmax, Omax). Also supports plotting and comparing data.

This package provides functions to create side-by-side boxplots for a continuous variable grouped by a two-level categorical variable, check normality assumptions using the Shapiro-Wilk test (Shapiro and Wilk (1965) <doi:10.2307/2333709>), and perform appropriate statistical tests such as the independent two-sample t-test (Student (1908) <doi:10.1093/biomet/6.1.1>) or the Mannâ Whitney U test ( Mannâ Whitney (1947) <doi:10.1214/aoms/1177730491>). Returns a publication-ready plot and test statistics including test statistic, degrees of freedom, and p-value.

The main purpose of this package is to propose a transparent methodological framework to compare bioregionalization methods based on hierarchical and non-hierarchical clustering algorithms (Kreft & Jetz (2010) <doi:10.1111/j.1365-2699.2010.02375.x>) and network algorithms (Lenormand et al. (2019) <doi:10.1002/ece3.4718> and Leroy et al. (2019) <doi:10.1111/jbi.13674>).

This package implements likelihood inference for early epidemic analysis. BETS is short for the four key epidemiological events being modeled: Begin of exposure, End of exposure, time of Transmission, and time of Symptom onset. The package contains a dataset of the trajectory of confirmed cases during the coronavirus disease (COVID-19) early outbreak. More detail of the statistical methods can be found in Zhao et al. (2020) <arXiv:2004.07743>.

Bell regression models for count data with overdispersion. The implemented models account for ordinary and zero-inflated regression models under both frequentist and Bayesian approaches. Theoretical details regarding the models implemented in the package can be found in Castellares et al. (2018) <doi:10.1016/j.apm.2017.12.014> and Lemonte et al. (2020) <doi:10.1080/02664763.2019.1636940>.

Fast and accurate calculation of Blaker's binomial and Poisson confidence limits (and some related stuff).

Propagate uncertainty from several estimates when combining these estimates via a function. This is done by using the parametric bootstrap to simulate values from the distribution of each estimate to build up an empirical distribution of the combined parameter. Finally either the percentile method is used or the highest density interval is chosen to derive a confidence interval for the combined parameter with the desired coverage. Gaussian copulas are used for when parameters are assumed to be dependent / correlated. References: Davison and Hinkley (1997,ISBN:0-521-57471-4) for the parametric bootstrap and percentile method, Gelman et al. (2014,ISBN:978-1-4398-4095-5) for the highest density interval, Stockdale et al. (2020)<doi:10.1016/j.jhep.2020.04.008> for an example of combining conditional prevalences.

The BioTIME database was first published in 2018 and inspired ideas, questions, project and research article. To make it even more accessible, an R package was created. The BioTIMEr package provides tools designed to interact with the BioTIME database. The functions provided include the BioTIME recommended methods for preparing (gridding and rarefaction) time series data, a selection of standard biodiversity metrics (including species richness, numerical abundance and exponential Shannon) alongside examples on how to display change over time. It also includes a sample subset of both the query and meta data, the full versions of which are freely available on the BioTIME website <https://biotime.st-andrews.ac.uk/home.php>.

This package performs Bayesian estimation of the additive main effects and multiplicative interaction (AMMI) model. The method is explained in Crossa, J., Perez-Elizalde, S., Jarquin, D., Cotes, J.M., Viele, K., Liu, G. and Cornelius, P.L. (2011) (<doi:10.2135/cropsci2010.06.0343>).

An implementation of sensitivity and robustness methods in Bayesian networks in R. It includes methods to perform parameter variations via a variety of co-variation schemes, to compute sensitivity functions and to quantify the dissimilarity of two Bayesian networks via distances and divergences. It further includes diagnostic methods to assess the goodness of fit of a Bayesian networks to data, including global, node and parent-child monitors. Reference: M. Leonelli, R. Ramanathan, R.L. Wilkerson (2022) <doi:10.1016/j.knosys.2023.110882>.

This package provides high-level modeling functions to define and train models using the torch R package. Models include linear, logistic, and multinomial regression as well as multilayer perceptrons.

This package provides tools to process the information obtained from experiments conducted in the Barnes Maze. These tools enable the detection of trajectories generated by subjects during trials, as well as the acquisition of precise coordinates and relevant statistical data regarding the results. Through this approach, it aims to facilitate the analysis and interpretation of observed behaviors, thereby contributing to a deeper understanding of learning and memory processes in such experiments.

Utility functions, datasets and extended examples for survival analysis. This extends a range of other packages, some simple wrappers for time-to-event analyses, datasets, and extensive examples in HTML with R scripts. The package also supports the course Biostatistics III entitled "Survival analysis for epidemiologists in R".

An implementation of Bayesian survival models with graph-structured selection priors for sparse identification of omics features predictive of survival (Madjar et al., 2021 <doi:10.1186/s12859-021-04483-z>) and its extension to use a fixed graph via a Markov Random Field (MRF) prior for capturing known structure of omics features, e.g. disease-specific pathways from the Kyoto Encyclopedia of Genes and Genomes database (Hermansen et al., 2025 <doi:10.48550/arXiv.2503.13078>).

Multivariate tool for analyzing genome-wide association study results in the form of univariate summary statistics. The goal of bmass is to comprehensively test all possible multivariate models given the phenotypes and datasets provided. Multivariate models are determined by assigning each phenotype to being either Unassociated (U), Directly associated (D) or Indirectly associated (I) with the genetic variant of interest. Test results for each model are presented in the form of Bayes factors, thereby allowing direct comparisons between models. The underlying framework implemented here is based on the modeling developed in "A Unified Framework for Association Analysis with Multiple Related Phenotypes", M. Stephens (2013) <doi:10.1371/journal.pone.0065245>.

Propose a parametric fit for censored linear regression models based on SMSN distributions, from a Bayesian perspective. Also, generates SMSN random variables.

This package provides functions for performing the Bayesian bootstrap as introduced by Rubin (1981) <doi:10.1214/aos/1176345338> and for summarizing the result. The implementation can handle both summary statistics that works on a weighted version of the data and summary statistics that works on a resampled data set.

Create a blended curve from two survival curves, which is particularly useful for survival extrapolation in health technology assessment. The main idea is to mix a flexible model that fits the observed data well with a parametric model that encodes assumptions about long-term survival. The two curves are blended into a single survival curve that is identical to the first model over the range of observed times and gradually approaches the parametric model over the extrapolation period based on a given weight function. This approach allows for the inclusion of external information, such as data from registries or expert opinion, to guide long-term extrapolations, especially when dealing with immature trial data. See Che et al. (2022) <doi:10.1177/0272989X221134545>.

The function \codebarcode() produces a histogram-like plot of a distribution that shows granularity in the data.

Efficient Markov Chain Monte Carlo (MCMC) algorithms for the fully Bayesian estimation of vectorautoregressions (VARs) featuring stochastic volatility (SV). Implements state-of-the-art shrinkage priors following Gruber & Kastner (2025) <doi:10.1016/j.ijforecast.2025.02.001>. Efficient equation-per-equation estimation following Kastner & Huber (2020) <doi:10.1002/for.2680> and Carrerio et al. (2021) <doi:10.1016/j.jeconom.2021.11.010>.

This package provides tools to visualize ordination results in R by adding covariance-based ellipses, centroids, vectors, and confidence regions to plots created with ggplot2'. The package extends the vegan framework and supports Principal Component Analysis (PCA), Redundancy Analysis (RDA), and Non-metric Multidimensional Scaling (NMDS). Ellipses can represent either group dispersion (standard deviation, SD) or centroid precision (standard error, SE), following Wang et al. (2015) <doi:10.1371/journal.pone.0118537>. Robust estimators of covariance are implemented, including the Minimum Covariance Determinant (MCD) method of Hubert et al. (2018) <doi:10.1002/wics.1421>. This approach reduces the influence of outliers. barrel is particularly useful for multivariate ecological datasets, promoting reproducible, publication-quality ordination graphics with minimal effort.

The kernelSmoothing() function allows you to square and smooth geolocated data. It calculates a classical kernel smoothing (conservative) or a geographically weighted median. There are four major call modes of the function. The first call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth) for a classical kernel smoothing and automatic grid. The second call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth, quantiles) for a geographically weighted median and automatic grid. The third call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth, centroids) for a classical kernel smoothing and user grid. The fourth call mode is kernelSmoothing(obs, epsg, cellsize, bandwidth, quantiles, centroids) for a geographically weighted median and user grid. Geographically weighted summary statistics : a framework for localised exploratory data analysis, C.Brunsdon & al., in Computers, Environment and Urban Systems C.Brunsdon & al. (2002) <doi:10.1016/S0198-9715(01)00009-6>, Statistical Analysis of Spatial and Spatio-Temporal Point Patterns, Third Edition, Diggle, pp. 83-86, (2003) <doi:10.1080/13658816.2014.937718>.

This package provides a method to filter correlation and covariance matrices by averaging bootstrapped filtered hierarchical clustering and boosting. See Ch. Bongiorno and D. Challet, Covariance matrix filtering with bootstrapped hierarchies (2020) <arXiv:2003.05807> and Ch. Bongiorno and D. Challet, Reactive Global Minimum Variance Portfolios with k-BAHC covariance cleaning (2020) <arXiv:2005.08703>.