It contains six common multi-category classification accuracy evaluation measures. All of these measures could be found in Li and Ming (2019) <doi:10.1002/sim.8103>. Specifically, Hypervolume Under Manifold (HUM), described in Li and Fine (2008) <doi:10.1093/biostatistics/kxm050>. Correct Classification Percentage (CCP), Integrated Discrimination Improvement (IDI), Net Reclassification Improvement (NRI), R-Squared Value (RSQ), described in Li, Jiang and Fine (2013) <doi:10.1093/biostatistics/kxs047>. Polytomous Discrimination Index (PDI), described in Van Calster et al. (2012) <doi:10.1007/s10654-012-9733-3>. Li et al. (2018) <doi:10.1177/0962280217692830>. PDI with variance estimation using Dover et al. (2021) <doi:10.1002/sim.9187>. We described all these above measures and our mcca package in Li, Gao and D'Agostino (2019) <doi:10.1002/sim.8103>.

This package provides access to well-documented medical datasets for teaching. Featuring several from the Teaching of Statistics in the Health Sciences website <https://www.causeweb.org/tshs/category/dataset/>, a few reconstructed datasets of historical significance in medical research, some reformatted and extended from existing R packages, and some data donations.

MHCnuggets (<https://github.com/KarchinLab/mhcnuggets>) is a Python tool to predict MHC class I and MHC class II epitopes. This package allows one to call MHCnuggets from R.

This package provides new functions info(), warn() and error(), similar to message(), warning() and stop() respectively. However, the new functions can have a level associated with them, so that when executed the global level option determines whether they are shown or not. This allows debug modes, outputting more information. The can also output all messages to a log file.

BEAST2 (<https://www.beast2.org>) is a widely used Bayesian phylogenetic tool, that uses DNA/RNA/protein data and many model priors to create a posterior of jointly estimated phylogenies and parameters. mcbette allows to do a Bayesian model comparison over some site and clock models, using babette (<https://github.com/ropensci/babette/>).

Two method new of multigroup and simulation of data. The first technique called multigroup PCA (mgPCA) this multivariate exploration approach that has the idea of considering the structure of groups and / or different types of variables. On the other hand, the second multivariate technique called Multigroup Dimensionality Reduction (MDR) it is another multivariate exploration method that is based on projections. In addition, a method called Single Dimension Exploration (SDE) was incorporated for to analyze the exploration of the data. It could help us in a better way to observe the behavior of the multigroup data with certain variables of interest.

Distributions that are typically used for exposure rating in general insurance, in particular to price reinsurance contracts. The vignette shows code snippets to fit the distribution to empirical data. See, e.g., Bernegger (1997) <doi:10.2143/AST.27.1.563208> freely available on-line.

The latest guidelines proposed by International Expert Consensus are used for the clinical diagnosis of Metabolic Associated Fatty Liver Disease (MAFLD). The new definition takes hepatic steatosis (determined by elastography or histology or biomarker-based fatty liver index) as a major criterion. In addition, race, gender, body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), homeostatic model assessment of insulin resistance (HOMAIR), high sensitive c-reactive protein (HsCRP) for the diagnosis of MAFLD. Each parameter has to be interpreted based on the proposed cut-offs, making the diagnosis slightly complex and error-prone. This package is developed by incorporating the latest international expert consensus guidelines, and it will aid in the easy and quick diagnosis of MAFLD based on FibroScan in busy healthcare settings and also for research purposes. The new definition for MAFLD as per the International Consensus Statement is described by Eslam M et al (2020). <doi:10.1016/j.jhep.2020.03.039>.

This package contains functions intended to facilitate the production of plant taxonomic monographs. The package includes functions to convert tables into taxonomic descriptions, lists of collectors, examined specimens, identification keys (dichotomous and interactive), and can generate a monograph skeleton. Additionally, wrapper functions to batch the production of phenology histograms and distributional and diversity maps are also available.

Effect sizes, diagnostics and performance metrics for multilevel and mixed effects models. Includes marginal and conditional R2 estimates for linear mixed effects models based on Johnson (2014) <doi:10.1111/2041-210X.12225>.

The Mapper algorithm from Topological Data Analysis, the steps are as follows 1. Define a filter (lens) function on the data. 2. Perform clustering within each level set. 3. Generate a complex from the clustering results.

Topological data analysis (TDA) is a method of data analysis that uses techniques from topology to analyze high-dimensional data. Here we implement Mapper, an algorithm from this area developed by Singh, Mémoli and Carlsson (2007) which generalizes the concept of a Reeb graph <https://en.wikipedia.org/wiki/Reeb_graph>.

This package implements Multivariable Functional Mendelian Randomization (MV-FMR) to estimate time-varying causal effects of multiple longitudinal exposures on health outcomes. Extends univariable functional Mendelian Randomisation (MR) (Tian et al., 2024 <doi:10.1002/sim.10222>) to the multivariable setting, enabling joint estimation of multiple time-varying exposures with pleiotropy and mediation scenarios. Key features include: (1) data-driven cross-validation for basis component selection, (2) handling of mediation pathways between exposures, (3) support for both continuous and binary outcomes using Generalized Method of Moments (GMM) and control function approaches, (4) one-sample and two-sample MR designs, (5) bootstrap inference and instrument diagnostics including Q-statistics for overidentification testing. Methods are described in Fontana et al. (2025) <doi:10.48550/arXiv.2512.19064>.

Simulation, analysis and sampling of spatial biodiversity data (May, Gerstner, McGlinn, Xiao & Chase 2017) <doi:10.1111/2041-210x.12986>. In the simulation tools user define the numbers of species and individuals, the species abundance distribution and species aggregation. Functions for analysis include species rarefaction and accumulation curves, species-area relationships and the distance decay of similarity.

Function multiroc() can be used for computing and visualizing Receiver Operating Characteristics (ROC) and Area Under the Curve (AUC) for multi-class classification problems. It supports both One-vs-One approach by M.Bishop, C. (2006, ISBN:978-0-387-31073-2) and One-vs-All approach by Murphy P., K. (2012, ISBN:9780262018029).

Facilitates tidy calculation of popular quantitative marketing metrics. It also includes functions for doing analysis that will help marketers and data analysts better understand the drivers and/or trends of these metrics. These metrics include Customer Experience Index <https://go.forrester.com/analytics/cx-index/> and Net Promoter Score <https://www.netpromoter.com/know/>.

Visualizes multiple sequence alignments dynamically within the Shiny web application framework.

This package provides a simple way to construct and maintain functions that keep state i.e. remember their argument lists. This can be useful when one needs to repeatedly invoke the same function with only a small number of argument changes at each invocation.

This package provides a system for Analysis of LSD when there is one missing observation. Methods for this process is described in A.M.Gun,M.K.Gupta,B.Dasgupta(2019,ISBN:81-87567-81-3).

Core functions as well as diagnostic and calibration tools for combining matching and linear regression for causal inference in observational studies.

Agricultural data for 1888-2021 from the Morrow Plots at the University of Illinois. The world's second oldest ongoing agricultural experiment, the Morrow Plots measure the impact of crop rotation and fertility treatments on corn yields. The data includes planting information and annual yield measures for corn grown continuously and in rotation with other crops, in treated and untreated soil.

This package provides tools specifically designed for analyzing longitudinal microbiome data. This tool integrates seven functional modules, providing a systematic framework for microbiome time-series analysis. For more details on inferences involving interspecies interactions see Fisher (2014) <doi:10.1371/journal.pone.0102451>. Details on this package are also described in an unpublished manuscript.

Computes the maximum matching for unweighted graph and maximum matching for (un)weighted bipartite graph efficiently.

It contains the function to apply MARMoT balancing technique discussed in: Silan, Boccuzzo, Arpino (2021) <DOI:10.1002/sim.9192>, Silan, Belloni, Boccuzzo, (2023) <DOI:10.1007/s10260-023-00695-0>; furthermore it contains a function for computing the Deloof's approximation of the average rank (and also a parallelized version) and a function to compute the Absolute Standardized Bias.