This package implements the nonparametric trend test for one or several samples as proposed by Bathke (2009) <doi:10.1007/s00184-008-0171-x>. The method provides a unified framework for analyzing trends in both independent and dependent data samples, making it a versatile tool for various study designs. The package allows for the evaluation of different trend alternatives, including two-sided (general trend), monotonic increasing, and monotonic decreasing trends. As a nonparametric procedure, it does not require the assumption of data normality, offering a robust alternative to parametric tests.

Download data from the Northern Ireland Statistics and Research Agency (NISRA) data portal, accessed at <https://data.nisra.gov.uk>. NISRA is a government agency and the principal source of official statistics and social research on Northern Ireland.

Three distinct methods are implemented for evaluating the sums of arbitrary negative binomial distributions. These methods are: Furman's exact probability mass function (Furman (2007) <doi:10.1016/j.spl.2006.06.007>), saddlepoint approximation, and a method of moments approximation. Functions are provided to calculate the density function, the distribution function and the quantile function of the convolutions in question given said evaluation methods. Functions for generating random deviates from negative binomial convolutions and for directly calculating the mean, variance, skewness, and excess kurtosis of said convolutions are also provided.

Replacement for nls() tools for working with nonlinear least squares problems. The calling structure is similar to, but much simpler than, that of the nls() function. Moreover, where nls() specifically does NOT deal with small or zero residual problems, nlmrt is quite happy to solve them. It also attempts to be more robust in finding solutions, thereby avoiding singular gradient messages that arise in the Gauss-Newton method within nls(). The Marquardt-Nash approach in nlmrt generally works more reliably to get a solution, though this may be one of a set of possibilities, and may also be statistically unsatisfactory. Added print and summary as of August 28, 2012.

Access the United States National Provider Identifier Registry API <https://npiregistry.cms.hhs.gov/api/>. Obtain and transform administrative data linked to a specific individual or organizational healthcare provider, or perform advanced searches based on provider name, location, type of service, credentials, and other attributes exposed by the API.

NanoString nCounter data are gene expression assays where there is no need for the use of enzymes or amplification protocols and work with fluorescent barcodes (Geiss et al. (2018) <doi:10.1038/nbt1385>). Each barcode is assigned a messenger-RNA/micro-RNA (mRNA/miRNA) which after bonding with its target can be counted. As a result each count of a specific barcode represents the presence of its target mRNA/miRNA. NACHO (NAnoString quality Control dasHbOard) is able to analyse the exported NanoString nCounter data and facilitates the user in performing a quality control. NACHO does this by visualising quality control metrics, expression of control genes, principal components and sample specific size factors in an interactive web application.

This package provides tools for non-parametric Fourier deconvolution using the N-Power Fourier Deconvolution (NPFD) method. This package includes methods for density estimation (densprf()) and sample generation (createSample()), enabling users to perform statistical analyses on mixed or replicated data sets.

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.

This package provides functions to flash your hue lights, or text yourself, from R. Designed to be used with long running scripts.

In shotgun proteomics, shared peptides (i.e., peptides that might originate from different proteins sharing homology, from different proteoforms due to alternative mRNA splicing, post-translational modifications, proteolytic cleavages, and/or allelic variants) represent a major source of ambiguity in protein identifications. The net4pg package allows to assess and handle ambiguity of protein identifications. It implements methods for two main applications. First, it allows to represent and quantify ambiguity of protein identifications by means of graph connected components (CCs). In graph theory, CCs are defined as the largest subgraphs in which any two vertices are connected to each other by a path and not connected to any other of the vertices in the supergraph. Here, proteins sharing one or more peptides are thus gathered in the same CC (multi-protein CC), while unambiguous protein identifications constitute CCs with a single protein vertex (single-protein CCs). Therefore, the proportion of single-protein CCs and the size of multi-protein CCs can be used to measure the level of ambiguity of protein identifications. The package implements a strategy to efficiently calculate graph connected components on large datasets and allows to visually inspect them. Secondly, the net4pg package allows to exploit the increasing availability of matched transcriptomic and proteomic datasets to reduce ambiguity of protein identifications. More precisely, it implement a transcriptome-based filtering strategy fundamentally consisting in the removal of those proteins whose corresponding transcript is not expressed in the sample-matched transcriptome. The underlying assumption is that, according to the central dogma of biology, there can be no proteins without the corresponding transcript. Most importantly, the package allows to visually inspect the effect of the filtering on protein identifications and quantify ambiguity before and after filtering by means of graph connected components. As such, it constitutes a reproducible and transparent method to exploit transcriptome information to enhance protein identifications. All methods implemented in the net4pg package are fully described in Fancello and Burger (2022) <doi:10.1186/s13059-022-02701-2>.

Given a failure type, the function computes covariate-specific probability of failure over time and covariate-specific conditional hazard rate based on possibly right-censored competing risk data. Specifically, it computes the non-parametric maximum-likelihood estimates of these quantities and their asymptotic variances in a semi-parametric mixture model for competing-risks data, as described in Chang et al. (2007a).

This package provides an htmlwidgets <https://www.htmlwidgets.org/> interface to NGL.js <http://nglviewer.org/ngl/api/>. NGLvieweR can be used to visualize and interact with protein databank ('PDB') and structural files in R and Shiny applications. It includes a set of API functions to manipulate the viewer after creation in Shiny.

Create interactive analytic networks. It joins the data analysis power of R to obtain coincidences, co-occurrences and correlations, and the visualization libraries of JavaScript in one package.

Annotated neuroblastoma copy number profiles, a benchmark data set for change-point detection algorithms, as described by Hocking et al. <doi:10.1186/1471-2105-14-164>.

Network trees recursively partition the data with respect to covariates. Two network tree algorithms are available: model-based trees based on a multivariate normal model and nonparametric trees based on covariance structures. After partitioning, correlation-based networks (psychometric networks) can be fit on the partitioned data. For details see Jones, Mair, Simon, & Zeileis (2020) <doi:10.1007/s11336-020-09731-4>.

Nonnegative matrix factorization (NMF) is a technique to factorize a matrix with nonnegative values into the product of two matrices. Covariates are also allowed. Parallel computing is an option to enhance the speed and high-dimensional and large scale (and/or sparse) data are allowed. Relevant papers include: Wang Y. X. and Zhang Y. J. (2012). Nonnegative matrix factorization: A comprehensive review. IEEE Transactions on Knowledge and Data Engineering, 25(6), 1336-1353 <doi:10.1109/TKDE.2012.51> and Kim H. and Park H. (2008). Nonnegative matrix factorization based on alternating nonnegativity constrained least squares and active set method. SIAM Journal on Matrix Analysis and Applications, 30(2), 713-730 <doi:10.1137/07069239X>.

Segregation is a network-level property such that edges between predefined groups of vertices are relatively less likely. Network homophily is a individual-level tendency to form relations with people who are similar on some attribute (e.g. gender, music taste, social status, etc.). In general homophily leads to segregation, but segregation might arise without homophily. This package implements descriptive indices measuring homophily/segregation. It is a computational companion to Bojanowski & Corten (2014) <doi:10.1016/j.socnet.2014.04.001>.

Build and run spatially explicit agent-based models using only the R platform. NetLogoR follows the same framework as the NetLogo software (Wilensky (1999) <https://www.netlogo.org>) and is a translation in R of the structure and functions of NetLogo'. NetLogoR provides new R classes to define model agents and functions to implement spatially explicit agent-based models in the R environment. This package allows benefiting of the fast and easy coding phase from the highly developed NetLogo framework, coupled with the versatility, power and massive resources of the R software. Examples of two models from the NetLogo software repository (Ants <https://ccl.northwestern.edu/netlogo/models/Ants>) and Wolf-Sheep-Predation (<https://ccl.northwestern.edu/netlogo/models/WolfSheepPredation>), and a third, Butterfly, from Railsback and Grimm (2012) <https://www.railsback-grimm-abm-book.com/>, all written using NetLogoR are available. The NetLogo code of the original version of these models is provided alongside. A programming guide inspired from the NetLogo Programming Guide (<https://docs.netlogo.org/programming.html>) and a dictionary of NetLogo primitives (<https://docs.netlogo.org/dictionary.html>) equivalences are also available. NOTE: To increment time', these functions can use a for loop or can be integrated with a discrete event simulator, such as SpaDES (<https://cran.r-project.org/package=SpaDES>).

Nonparametric tests for clustered data in pre-post intervention design documented in Cui and Harrar (2021) <doi:10.1002/bimj.201900310> and Harrar and Cui (2022) <doi:10.1016/j.jspi.2022.05.009>. Other than the main test results mentioned in the reference paper, this package also provides a function to calculate the sample size allocations for the input long format data set, and also a function for adjusted/unadjusted confidence intervals calculations. There are also functions to visualize the distribution of data across different intervention groups over time, and also the adjusted/unadjusted confidence intervals.

Predicting the structure of a graph including new nodes and edges using a time series of graphs. Flux balance analysis, a linear and integer programming technique used in biochemistry is used with time series prediction methods to predict the graph structure at a future time point Kandanaarachchi (2025) <doi:10.48550/arXiv.2507.05806>.

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the rxode2 package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

This package provides a set of functions to simulate National Football League seasons including the sophisticated tie-breaking procedures.

Similarity measures for hierarchical clustering of objects characterized by nominal (categorical) variables. Evaluation criteria for nominal data clustering.

This package provides functions to calculate estimates of intrinsic and extrinsic noise from the two-reporter single-cell experiment, as in Elowitz, M. B., A. J. Levine, E. D. Siggia, and P. S. Swain (2002) Stochastic gene expression in a single cell. Science, 297, 1183-1186. Functions implement multiple estimators developed for unbiasedness or min Mean Squared Error (MSE) in Fu, A. Q. and Pachter, L. (2016). Estimating intrinsic and extrinsic noise from single-cell gene expression measurements. Statistical Applications in Genetics and Molecular Biology, 15(6), 447-471.