This comprehensive toolkit provide a consistent and extensible framework for working with missing values in vectors. The companion package tidyimpute provides similar functionality for list-like and table-like structures). Functions exist for detection, removal, replacement, imputation, recollection, etc. of NAs'.

An R interface to the Julia package NeuralEstimators.jl'. The package facilitates the user-friendly development of neural Bayes estimators, which are neural networks that map data to a point summary of the posterior distribution (Sainsbury-Dale et al., 2024, <doi:10.1080/00031305.2023.2249522>). These estimators are likelihood-free and amortised, in the sense that, once the neural networks are trained on simulated data, inference from observed data can be made in a fraction of the time required by conventional approaches. The package also supports amortised Bayesian or frequentist inference using neural networks that approximate the posterior or likelihood-to-evidence ratio (Zammit-Mangion et al., 2025, Sec. 3.2, 5.2, <doi:10.48550/arXiv.2404.12484>). The package accommodates any model for which simulation is feasible by allowing users to define models implicitly through simulated data.

Similarity measures for hierarchical clustering of objects characterized by nominal (categorical) variables. Evaluation criteria for nominal data clustering.

This package provides customized forest plots for network meta-analysis incorporating direct, indirect, and NMA effects. Includes visualizations of evidence contributions through proportion bars based on the hat matrix and evidence flow decomposition.

Fits regularization paths for linear regression, GLM, and Cox regression models using lasso or nonconvex penalties, in particular the minimax concave penalty (MCP) and smoothly clipped absolute deviation (SCAD) penalty, with options for additional L2 penalties (the "elastic net" idea). Utilities for carrying out cross-validation as well as post-fitting visualization, summarization, inference, and prediction are also provided. For more information, see Breheny and Huang (2011) <doi:10.1214/10-AOAS388> or visit the ncvreg homepage <https://pbreheny.github.io/ncvreg/>.

This package provides a complete and seamless Nonmem simulation interface within R. Turns Nonmem control streams into simulation control streams, executes them with specified simulation input data and returns the results. The simulation is performed by Nonmem', eliminating manual work and risks of re-implementation of models in other tools.

This package contains data, code, and figures from Hill et al. 2018a (Journal of Experimental Marine Biology and Ecology; <DOI: 10.1016/j.jembe.2018.07.006>) and Hill et al. 2018b (Data In Brief <DOI: 10.1016/j.dib.2018.09.133>). Datasets document plant allometry, stem heights, nutrient and stable isotope content, and sediment denitrification enzyme assays. The data and analysis offer an examination of nitrogen uptake and allocation in two salt marsh plant species.

Estimating the first and second derivatives of a regression function by the method of Wang and Lin (2015) <http://www.jmlr.org/papers/v16/wang15b.html>.

Allows users to download and analyze official data on Brazil's federal budget through the SPARQL endpoint provided by the Integrated Budget and Planning System ('SIOP'). This package enables access to detailed information on budget allocations and expenditures of the federal government, making it easier to analyze and visualize these data. Technical information on the Brazilian federal budget is available (Portuguese only) at <https://www1.siop.planejamento.gov.br/mto/>. The SIOP endpoint is available at <https://www1.siop.planejamento.gov.br/sparql/>.

Sequential outlier identification for Gaussian mixture models using the distribution of Mahalanobis distances. The optimal number of outliers is chosen based on the dissimilarity between the theoretical and observed distributions of the scaled squared sample Mahalanobis distances. Also includes an extension for Gaussian linear cluster-weighted models using the distribution of studentized residuals. Doherty, McNicholas, and White (2025) <doi:10.48550/arXiv.2505.11668>.

Optimal Subset Cardinality Regression (OSCAR) models offer regularized linear regression using the L0-pseudonorm, conventionally known as the number of non-zero coefficients. The package estimates an optimal subset of features using the L0-penalization via cross-validation, bootstrapping and visual diagnostics. Effective Fortran implementations are offered along the package for finding optima for the DC-decomposition, which is used for transforming the discrete L0-regularized optimization problem into a continuous non-convex optimization task. These optimization modules include DBDC ('Double Bundle method for nonsmooth DC optimization as described in Joki et al. (2018) <doi:10.1137/16M1115733>) and LMBM ('Limited Memory Bundle Method for large-scale nonsmooth optimization as in Haarala et al. (2004) <doi:10.1080/10556780410001689225>). The OSCAR models are comprehensively exemplified in Halkola et al. (2023) <doi:10.1371/journal.pcbi.1010333>). Multiple regression model families are supported: Cox, logistic, and Gaussian.

This ONEST software implements the method of assessing the pathologist agreement in reading PD-L1 assays (Reisenbichler et al. (2020 <doi:10.1038/s41379-020-0544-x>)), to determine the minimum number of evaluators needed to estimate agreement involving a large number of raters. Input to the program should be binary(1/0) pathology data, where â 0â may stand for negative and â 1â for positive. Additional examples were given using the data from Rimm et al. (2017 <doi:10.1001/jamaoncol.2017.0013>).

This package provides a framework for organizing R projects with a standardized structure. Most analyses consist of three main components: code, results, and data, each with different requirements such as version control, sharing, and encryption. This package provides tools to set up and manage project directories, handle file paths consistently across operating systems, organize results using date-based structures, source code from specified directories, create and manage Quarto documents, and perform file operations safely. It ensures consistency across projects while accommodating different requirements for various types of content.

This package provides a method that analyzes quality control metrics from multi-sample genomic sequencing studies and nominates poor quality samples for exclusion. Per sample quality control data are transformed into z-scores and aggregated. The distribution of aggregated z-scores are modelled using parametric distributions. The parameters of the optimal model, selected either by goodness-of-fit statistics or user-designation, are used for outlier nomination. Two implementations of the Cosine Similarity Outlier Detection algorithm are provided with flexible parameters for dataset customization.

This package provides a general framework for the application of cross-validation schemes to particular functions. By allowing arbitrary lists of results, origami accommodates a range of cross-validation applications. This implementation was first described by Coyle and Hejazi (2018) <doi:10.21105/joss.00512>.

It is a computer tool to estimate the item-sum score's reliability (composite reliability, CR) in multidimensional scales with overlapping items. An item that measures more than one domain construct is called an overlapping item. The estimation is based on factor models allowing unlimited cross-factor loadings such as exploratory structural equation modeling (ESEM) and Bayesian structural equation modeling (BSEM). The factor models include correlated-factor models and bi-factor models. Specifically for bi-factor models, a type of hierarchical factor model, the package estimates the CR hierarchical subscale/hierarchy and CR subscale/scale total. The CR estimator Omega-generic was proposed by Mai, Srivastava, and Krull (2021) <https://whova.com/embedded/subsession/enars_202103/1450751/1452993/>. The current version can only handle continuous data. Yujiao Mai contributes to the algorithms, R programming, and application example. Deo Kumar Srivastava contributes to the algorithms and the application example. Kevin R. Krull contributes to the application example. The package OmegaG was sponsored by American Lebanese Syrian Associated Charities (ALSAC). However, the contents of OmegaG do not necessarily represent the policy of the ALSAC.

The oblique decision tree (ODT) uses linear combinations of predictors as partitioning variables in a decision tree. Oblique Decision Random Forest (ODRF) is an ensemble of multiple ODTs generated by feature bagging. Oblique Decision Boosting Tree (ODBT) applies feature bagging during the training process of ODT-based boosting trees to ensemble multiple boosting trees. All three methods can be used for classification and regression, and ODT and ODRF serve as supplements to the classical CART of Breiman (1984) <DOI:10.1201/9781315139470> and Random Forest of Breiman (2001) <DOI:10.1023/A:1010933404324> respectively.

Detection of overdispersion in count data for multiple regression analysis. Log-linear count data regression is one of the most popular techniques for predictive modeling where there is a non-negative discrete quantitative dependent variable. In order to ensure the inferences from the use of count data models are appropriate, researchers may choose between the estimation of a Poisson model and a negative binomial model, and the correct decision for prediction from a count data estimation is directly linked to the existence of overdispersion of the dependent variable, conditional to the explanatory variables. Based on the studies of Cameron and Trivedi (1990) <doi:10.1016/0304-4076(90)90014-K> and Cameron and Trivedi (2013, ISBN:978-1107667273), the overdisp() command is a contribution to researchers, providing a fast and secure solution for the detection of overdispersion in count data. Another advantage is that the installation of other packages is unnecessary, since the command runs in the basic R language.

It provides functions to generate a correlation matrix from a genetic dataset and to use this matrix to predict the phenotype of an individual by using the phenotypes of the remaining individuals through kriging. Kriging is a geostatistical method for optimal prediction or best unbiased linear prediction. It consists of predicting the value of a variable at an unobserved location as a weighted sum of the variable at observed locations. Intuitively, it works as a reverse linear regression: instead of computing correlation (univariate regression coefficients are simply scaled correlation) between a dependent variable Y and independent variables X, it uses known correlation between X and Y to predict Y.

The separate p-values of SNPs, RNA expressions and DNA methylations are calculated by KM regression. The correlation between different omics data are taken into account. This method can be applied to either samples with all three types of omics data or samples with two types.

Bayesian logistic regression model with optional EXchangeability-NonEXchangeability parameter modelling for flexible borrowing from historical or concurrent data-sources. The safety model can guide dose-escalation decisions for adaptive oncology Phase I dose-escalation trials which involve an arbitrary number of drugs. Please refer to Neuenschwander et al. (2008) <doi:10.1002/sim.3230> and Neuenschwander et al. (2016) <doi:10.1080/19466315.2016.1174149> for details on the methodology.

An interface to easily run local language models with Ollama <https://ollama.com> server and API endpoints (see <https://github.com/ollama/ollama/blob/main/docs/api.md> for details). It lets you run open-source large language models locally on your machine.

This package provides implementations of some of the most important outlier detection algorithms. Includes a tutorial mode option that shows a description of each algorithm and provides a step-by-step execution explanation of how it identifies outliers from the given data with the specified input parameters. References include the works of Azzedine Boukerche, Lining Zheng, and Omar Alfandi (2020) <doi:10.1145/3381028>, Abir Smiti (2020) <doi:10.1016/j.cosrev.2020.100306>, and Xiaogang Su, Chih-Ling Tsai (2011) <doi:10.1002/widm.19>.

This package provides tools to build and work with an ontology of linked (open) data in a tidy workflow. It is inspired by the Food and Agrilculture Organizations (FAO) caliper platform <https://www.fao.org/statistics/caliper/web/> and makes use of the Simple Knowledge Organisation System (SKOS).