This package provides routines to compute normalised prediction distribution errors, a metric designed to evaluate non-linear mixed effect models such as those used in pharmacokinetics and pharmacodynamics.

Closed testing has been proved powerful for true discovery guarantee. The computation of closed testing is, however, quite burdensome. A general way to reduce computational complexity is to combine partial closed testings for some prespecified feature sets of interest. Partial closed testings are performed at Bonferroni-corrected alpha level to guarantee the lower bounds for the number of true discoveries in prespecified sets are simultaneously valid. For any post hoc chosen sets of interest, coherence property is used to get the lower bound. In this package, we implement closed testing with globaltest to calculate the lower bound for number of true discoveries, see Ningning Xu et.al (2021) <arXiv:2001.01541> for detailed description.

This package provides tools for working with the National Hydrography Dataset, with functions for querying, downloading, and networking both the NHD <https://www.usgs.gov/national-hydrography> and NHDPlus <https://www.epa.gov/waterdata/nhdplus-national-hydrography-dataset-plus> datasets.

Assists actuaries and other insurance modellers in pricing, reserving and capital modelling for non-life insurance and reinsurance modelling. Provides functions that help model excess levels, capping and pure Incurred but not reported claims (pure IBNR). Includes capped mean, exposure curves and increased limit factor curves (ILFs) for LogNormal, Gamma, Pareto, Sliced LogNormal-Pareto and Sliced Gamma-Pareto distributions. Includes mean, probability density function (pdf), cumulative probability function (cdf) and inverse cumulative probability function for Sliced LogNormal-Pareto and Sliced Gamma-Pareto distributions. Includes calculating pure IBNR exposure with LogNormal and Gamma distribution for reporting delay. Includes three shiny tools, one to simulate insurance claims applying reinsurance structures, fit generalised linear models and fit claims frequency or severity distributions. Methods used in the package refer to Free for All by Yiannis Parizas (2023) <https://www.theactuary.com/2023/03/02/free-all>; Escaping the triangle by Yiannis Parizas (2019) <https://www.theactuary.com/features/2019/06/2019/06/05/escaping-triangle>; Take to excess by Yiannis Parizas (2019) <https://www.theactuary.com/features/2019/03/2019/03/06/taken-excess>.

Estimating the first and second derivatives of a regression function by the method of Wang and Lin (2015) <http://www.jmlr.org/papers/v16/wang15b.html>.

This package performs nonparametric analysis of longitudinal data in factorial experiments. Longitudinal data are those which are collected from the same subjects over time, and they frequently arise in biological sciences. Nonparametric methods do not require distributional assumptions, and are applicable to a variety of data types (continuous, discrete, purely ordinal, and dichotomous). Such methods are also robust with respect to outliers and for small sample sizes.

Datasets of driving offences and fines in New Zealand between 2009 and 2017. Originally published by the New Zealand Police at <http://www.police.govt.nz/about-us/publication/road-policing-driver-offence-data-january-2009-december-2017>.

This package provides a small multilayer perceptron implementation for R'. It supports regression and classification, multiple hidden layers, mini-batch training, Adam, SGD, momentum, Nesterov, RPROP, GRPROP and L-BFGS optimizers, dropout, L2 regularization, early stopping, convergence thresholds, gradient clipping, sample and class weights, callback hooks, target scaling and robust Huber loss for regression, Rcpp forward-pass kernels, formula interfaces, model evaluation with balanced classification metrics, cross-validation, compact tuning, permutation importance, model persistence helpers, and S3 prediction methods. Methods follow Rumelhart, Hinton and Williams (1986) <doi:10.1038/323533a0>, with optimizers including Riedmiller and Braun (1993) <doi:10.1109/ICNN.1993.298623>, Nocedal (1980) <doi:10.1090/S0025-5718-1980-0572855-7>, and Kingma and Ba (2014) <doi:10.48550/arXiv.1412.6980>.

Utilities for unambiguous, neat and legible representation of data (date, time stamp, numbers, percentages and strings) for presentation of analysis , aiming for elegance and consistency. The purpose of this package is to format data, that is better for presentation and any automation jobs that reports numbers.

Calculate various functions needed for design and monitoring clinical trials with negative binomial endpoint with variable follow-up. This version has a few changes compared to the previous version 1.0.0, including (1) correct a typo in Type 1 censoring, mtbnull=bnull and (2) restructure the code to account for shape parameter equal to zero, i.e. Poisson scenario.

Replacement for nls() tools for working with nonlinear least squares problems. The calling structure is similar to, but much simpler than, that of the nls() function. Moreover, where nls() specifically does NOT deal with small or zero residual problems, nlmrt is quite happy to solve them. It also attempts to be more robust in finding solutions, thereby avoiding singular gradient messages that arise in the Gauss-Newton method within nls(). The Marquardt-Nash approach in nlmrt generally works more reliably to get a solution, though this may be one of a set of possibilities, and may also be statistically unsatisfactory. Added print and summary as of August 28, 2012.

Collection of functions for fast manipulation, handling, and analysis of large-scale networks based on family and social data. Functions are utility functions used to manipulate data in three "formats": sparse adjacency matrices, pedigree trio family data, and pedigree family data. When possible, the functions should be able to handle millions of data points quickly for use in combination with data from large public national registers and databases. Kenneth Lange (2003, ISBN:978-8181281135).

Interface to the open location server API of Publieke Diensten Op de Kaart (<http://www.pdok.nl>). It offers geocoding, address suggestions and lookup of geographical objects. Included is an utility function for displaying leaflet tiles restricted to the Netherlands.

Clinical reporting figures require to use consistent colors and configurations. As a part of the Roche open-source clinical reporting project, namely the NEST project, the nestcolor package specifies the color code and default theme with specifying ggplot2 theme parameters. Users can easily customize color and theme settings before using the reset of NEST packages to ensure consistent settings in both static and interactive output at the downstream.

This package provides a toolkit for assessing data normality using a comprehensive collection of statistical methods. It includes descriptive measures and formal hypothesis tests, such as skewness and kurtosis tests, the Andersonâ Darling test, the Shapiroâ Wilk test, and the D'Agostinoâ Pearson K2 omnibus test.

NEON observational data are provided via the NEON Data Portal <https://www.neonscience.org> and NEON API, and can be downloaded and reformatted by the neonUtilities package. NEON observational data (human-observed measurements, and analyses derived from human-collected samples, such as tree diameters and algal chemistry) are published in a format consisting of one or more tabular data files. This package provides tools for performing common operations on NEON observational data, including checking for duplicates and joining tables.

Non-linear least squares regression with the Levenberg-Marquardt algorithm using multiple starting values for increasing the chance that the minimum found is the global minimum.

Calculating the net reclassification improvement (NRI) for risk prediction models with time to event and binary data.

Fits nonlinear Bayesian extensions of the Fay-Herriot model for small area estimation using area-level direct estimates and corresponding sampling variances. The package provides model fitting, prediction, uncertainty summaries, and diagnostic tools for nonlinear small area estimation workflows.

Implement and enhance the performance of spatial fuzzy clustering using Fuzzy Geographically Weighted Clustering with various optimization algorithms, mainly from Xin She Yang (2014) <ISBN:9780124167438> with book entitled Nature-Inspired Optimization Algorithms. The optimization algorithm is useful to tackle the disadvantages of clustering inconsistency when using the traditional approach. The distance measurements option is also provided in order to increase the quality of clustering results. The Fuzzy Geographically Weighted Clustering with nature inspired optimisation algorithm was firstly developed by Arie Wahyu Wijayanto and Ayu Purwarianti (2014) <doi:10.1109/CITSM.2014.7042178> using Artificial Bee Colony algorithm.

Model-based clustering of high-dimensional non-negative data that follow Generalized Negative Binomial distribution. All functions in this package applies to either continuous or integer data. Correlation between variables are allowed, while samples are assumed to be independent.

This package provides a cross-platform interface to prevent the operating system from going to sleep while long-running R tasks are executing.

The n-vector framework uses the normal vector to the Earth ellipsoid (called n-vector) as a non-singular position representation that turns out to be very convenient for practical position calculations. The n-vector is simple to use and gives exact answers for all global positions, and all distances, for both ellipsoidal and spherical Earth models. This package is a translation of the Matlab library from FFI, the Norwegian Defence Research Establishment, as described in Gade (2010) <doi:10.1017/S0373463309990415>.

Implementation of Narrowest Significance Pursuit, a general and flexible methodology for automatically detecting localised regions in data sequences which each must contain a change-point (understood as an abrupt change in the parameters of an underlying linear model), at a prescribed global significance level. Narrowest Significance Pursuit works with a wide range of distributional assumptions on the errors, and yields exact desired finite-sample coverage probabilities, regardless of the form or number of the covariates. For details, see P. Fryzlewicz (2021) <https://stats.lse.ac.uk/fryzlewicz/nsp/nsp.pdf>.