Data integration Web application for biobanks by OBiBa'. Opal is the core database application for biobanks. Participant data, once collected from any data source, must be integrated and stored in a central data repository under a uniform model. Opal is such a central repository. It can import, process, validate, query, analyze, report, and export data. Opal is typically used in a research center to analyze the data acquired at assessment centres. Its ultimate purpose is to achieve seamless data-sharing among biobanks. This Opal client allows to interact with Opal web services and to perform operations on the R server side. DataSHIELD administration tools are also provided.

This package provides a mutable Signal object can report changes to its state, clients could register functions so that they are called whenever the signal is emitted. The signal could be emitted, disconnected, blocked, unblocked, and buffered.

This package provides tools to process raster data and apply Otsu-based thresholding for burned area mapping and other image segmentation tasks. Implements the method described by Otsu (1979) <doi:10.1109/TSMC.1979.4310076>, a data-driven technique that determines an optimal threshold by maximizing the inter-class variance of pixel intensities. It includes validation functions to assess segmentation accuracy against reference data using standard accuracy metrics such as precision, recall, and F1-score.

Evaluates the Owen Q-function for an integer value of the degrees of freedom, by applying Owen's algorithm (1965) <doi:10.1093/biomet/52.3-4.437>. It is useful for the calculation of the power of equivalence tests.

Visualise results obtained from analysing data mapped to the Observational Medical Outcomes Partnership (OMOP) common data model using shiny applications.

The ordinal forest (OF) method allows ordinal regression with high-dimensional and low-dimensional data. After having constructed an OF prediction rule using a training dataset, it can be used to predict the values of the ordinal target variable for new observations. Moreover, by means of the (permutation-based) variable importance measure of OF, it is also possible to rank the covariates with respect to their importance in the prediction of the values of the ordinal target variable. OF is presented in Hornung (2020). NOTE: Starting with package version 2.4, it is also possible to obtain class probability predictions in addition to the class point predictions. Moreover, the variable importance values can also be based on the class probability predictions. Preliminary results indicate that this might lead to a better discrimination between influential and non-influential covariates. The main functions of the package are: ordfor() (construction of OF) and predict.ordfor() (prediction of the target variable values of new observations). References: Hornung R. (2020) Ordinal Forests. Journal of Classification 37, 4â 17. <doi:10.1007/s00357-018-9302-x>.

Picks the suitable cell types in spatial and scRNA-seq data using shrinkage methods. The package includes curated reference gene expression profiles for human and mouse cell types, facilitating immediate application to common spatial transcriptomics or scRNA datasets. Additionally, users can input custom reference data to support tissue- or experiment-specific analyses.

Makes it easy to display descriptive information on a data set. Getting an easy overview of a data set by displaying and visualizing sample information in different tables (e.g., time and scope conditions). The package also provides publishable LaTeX code to present the sample information.

Algorithms for D-, A-, I-, and c-optimal designs. For more details, see the package description. Some of the functions in this package require the gurobi software and its accompanying R package. For their installation, please follow the instructions at <https://www.gurobi.com> and the file gurobi_inst.txt, respectively.

Generate 2, 3 or 4-dimensional gradient noise. The noise function is comparable to classic Perlin noise, but with less directional artefacts and lower computational overhead. It can have applications in procedural generation or (flow fields) simulations.

An integrated R interface to the Overture API (<https://docs.overturemaps.org/>). Allows R users to return Overture data as dbplyr data frames or materialized sf spatial data frames.

Generalise the starting point of the array index.

Creativity research involves the need to score open-ended problems. Usually done by humans, automatic scoring using AI becomes more and more accurate. This package provides a simple interface to the Open Scoring API <https://openscoring.du.edu/docs>, leading creativity scoring technology by Organiscak et al. (2023) <doi:10.1016/j.tsc.2023.101356>. With it, you can score your own data directly from an R script.

Automated reporting in Word and PowerPoint can require customization for each organizational template. This package works around this by adding standard reporting functions and an abstraction layer to facilitate automated reporting workflows that can be replicated across different organizational templates.

Use health data in the Observational Medical Outcomes Partnership Common Data Model format in Spark'. Functionality includes creating all required tables and fields and creation of a single reference to the data. Native Spark functionality is supported.

Access data and processing functionalities of openEO compliant back-ends in R.

The online principal component regression method can process the online data set. OPCreg implements the online principal component regression method, which is specifically designed to process online datasets efficiently. This method is particularly useful for handling large-scale, streaming data where traditional batch processing methods may be computationally infeasible.The philosophy of the package is described in Guo (2025) <doi:10.1016/j.physa.2024.130308>.

This package provides tools for managing nested, multi-level configuration systems with runtime mutability, type validation, and default value management. Supports creating hierarchical options managers with customizable validators for scalar and vector types (numeric, character, logical), enumerated values, bounded ranges, and complex structures like XY pairs. Options can be dynamically modified at runtime while maintaining type safety through validator functions, and easily reset to their default values when needed.

This package provides an R interface to the OMOPHub API for accessing OHDSI ATHENA standardized medical vocabularies. Supports concept search, semantic search using neural embeddings, concept similarity, vocabulary exploration, hierarchy navigation, relationship queries, and concept mappings with automatic pagination and rate limiting.

This package provides a novel method to implement cancer subtyping and subtype specific drug targets identification via non-negative matrix tri-factorization. To improve the interpretability, we introduce orthogonal constraint to the row coefficient matrix and column coefficient matrix. To meet the prior knowledge that each subtype should be strongly associated with few gene sets, we introduce sparsity constraint to the association sub-matrix. The average residue was introduced to evaluate the row and column cluster numbers. This is part of the work "Liver Cancer Analysis via Orthogonal Sparse Non-Negative Matrix Tri- Factorization" which will be submitted to BBRC.

Necessary functions for optimized automated evaluation of the number and parameters of Gaussian mixtures in one-dimensional data. Various methods are available for parameter estimation and for determining the number of modes in the mixture. A detailed description of the methods ca ben found in Lotsch, J., Malkusch, S. and A. Ultsch. (2022) <doi:10.1016/j.imu.2022.101113>.

This package provides a modified version of alternating logistic regressions (ALR) with estimation based on orthogonalized residuals (ORTH) is implemented, which use paired estimating equations to jointly estimate parameters in marginal mean and within-association models. The within-cluster association between ordinal responses is modeled by global pairwise odds ratios (POR). A finite-sample bias correction is provided to POR parameter estimates based on matrix multiplicative adjusted orthogonalized residuals (MMORTH) for correcting estimating equations, and different bias-corrected variance estimators such as BC1, BC2, and BC3.

The aim of od is to provide tools and example datasets for working with origin-destination ('OD') datasets of the type used to describe aggregate urban mobility patterns (Carey et al. 1981) <doi:10.1287/trsc.15.1.32>. The package builds on functions for working with OD data in the package stplanr', (Lovelace and Ellison 2018) <doi:10.32614/RJ-2018-053> with a focus on computational efficiency and support for the sf class system (Pebesma 2018) <doi:10.32614/RJ-2018-009>. With few dependencies and a simple class system based on data frames, the package is intended to facilitate efficient analysis of OD datasets and to provide a place for developing new functions. The package enables the creation and analysis of geographic entities representing large scale mobility patterns, from daily travel between zones in cities to migration between countries.

This package provides functions to download and tidy statistical data published by the Office for National Statistics <https://www.ons.gov.uk>. Covers GDP, inflation (CPI, CPIH, RPI), unemployment, employment, wages, trade, retail sales, house prices, productivity, population, and public sector finances. Most series are fetched from the ONS website using its CSV time series endpoint. House price data is sourced from HM Land Registry <https://www.gov.uk/government/organisations/land-registry>. Data is cached locally between sessions.