This package provides functions and methods for manipulating SNOMED CT concepts. The package contains functions for loading the SNOMED CT release into a convenient R environment, selecting SNOMED CT concepts using regular expressions, and navigating the SNOMED CT ontology. It provides the SNOMEDconcept S3 class for a vector of SNOMED CT concepts (stored as 64-bit integers) and the SNOMEDcodelist S3 class for a table of concepts IDs with descriptions. The package can be used to construct sets of SNOMED CT concepts for research (<doi:10.1093/jamia/ocac158>). For more information about SNOMED CT visit <https://www.snomed.org/>.

In repeated measures studies with extreme large or small values it is common that the subjects measurements on average are closer to the mean of the basic population. Interpreting possible changes in the mean in such situations can lead to biased results since the values were not randomly selected, they come from truncated sampling. This method allows to estimate the range of means where treatment effects are likely to occur when regression toward the mean is present. Ostermann, T., Willich, Stefan N. & Luedtke, Rainer. (2008). Regression toward the mean - a detection method for unknown population mean based on Mee and Chua's algorithm. BMC Medical Research Methodology.<doi:10.1186/1471-2288-8-52>. Acknowledgments: We would like to acknowledge "Lena Roth" and "Nico Steckhan" for the package's initial updates (Q3 2024) and continued supervision and guidance. Both have contributed to discussing and integrating these methods into the package, ensuring they are up-to-date and contextually relevant.

Jade is a high performance template engine heavily influenced by Haml and implemented with JavaScript for node and browsers.

Compute time-dependent Incident/dynamic accuracy measures (ROC curve, AUC, integrated AUC )from censored survival data under proportional or non-proportional hazard assumption of Heagerty & Zheng (Biometrics, Vol 61 No 1, 2005, PP 92-105).

This package provides a reliable and validated tool that captures detailed risk metrics such as R CMD check, test coverage, traceability matrix, documentation, dependencies, reverse dependencies, suggested dependency analysis, repository data, and enhanced reporting for R packages that are local or stored on remote repositories such as GitHub, CRAN, and Bioconductor.

This package provides a set of tools to explore the behaviour statistics used for forensic DNA interpretation when close relatives are involved. The package also offers some useful tools for exploring other forensic DNA situations.

Three robust marginal integration procedures for additive models based on local polynomial kernel smoothers. As a preliminary estimator of the multivariate function for the marginal integration procedure, a first approach uses local constant M-estimators, a second one uses local polynomials of order 1 over all the components of covariates, and the third one uses M-estimators based on local polynomials but only in the direction of interest. For this last approach, estimators of the derivatives of the additive functions can be obtained. All three procedures can compute predictions for points outside the training set if desired. See Boente and Martinez (2017) <doi:10.1007/s11749-016-0508-0> for details.

Rapid7 collects cybersecurity data and makes it available via their Open Data <http://opendata.rapid7.com> portal which has an API. Tools are provided to assist in querying for available data sets and downloading any data set authorized to a free, registered account.

Queries data from WHOIS servers.

This package provides access to a suite of geospatial data layers for wildfire management, fuel modeling, ecology, natural resource management, climate, conservation, etc., via the LANDFIRE (<https://www.landfire.gov/>) Product Service ('LFPS') API.

Adaptation of the Matlab tsEVA toolbox developed by Lorenzo Mentaschi available here: <https://github.com/menta78/tsEva>. It contains an implementation of the Transformed-Stationary (TS) methodology for non-stationary extreme value Analysis (EVA) as described in Mentaschi et al. (2016) <doi:10.5194/hess-20-3527-2016>. In synthesis this approach consists in: (i) transforming a non-stationary time series into a stationary one to which the stationary extreme value theory can be applied; and (ii) reverse-transforming the result into a non-stationary extreme value distribution. RtsEva offers several options for trend estimation (mean, extremes, seasonal) and contains multiple plotting functions displaying different aspects of the non-stationarity of extremes.

Rolling Window Multiple Correlation ('RolWinMulCor') estimates the rolling (running) window correlation for the bi- and multi-variate cases between regular (sampled on identical time points) time series, with especial emphasis to ecological data although this can be applied to other kinds of data sets. RolWinMulCor is based on the concept of rolling, running or sliding window and is useful to evaluate the evolution of correlation through time and time-scales. RolWinMulCor contains six functions. The first two focus on the bi-variate case: (1) rolwincor_1win() and (2) rolwincor_heatmap(), which estimate the correlation coefficients and the their respective p-values for only one window-length (time-scale) and considering all possible window-lengths or a band of window-lengths, respectively. The second two functions: (3) rolwinmulcor_1win() and (4) rolwinmulcor_heatmap() are designed to analyze the multi-variate case, following the bi-variate case to visually display the results, but these two approaches are methodologically different. That is, the multi-variate case estimates the adjusted coefficients of determination instead of the correlation coefficients. The last two functions: (5) plot_1win() and (6) plot_heatmap() are used to represent graphically the outputs of the four aforementioned functions as simple plots or as heat maps. The functions contained in RolWinMulCor are highly flexible since these contains several parameters to control the estimation of correlation and the features of the plot output, e.g. to remove the (linear) trend contained in the time series under analysis, to choose different p-value correction methods (which are used to address the multiple comparison problem) or to personalise the plot outputs. The RolWinMulCor package also provides examples with synthetic and real-life ecological time series to exemplify its use. Methods derived from H. Abdi. (2007) <https://personal.utdallas.edu/~herve/Abdi-MCC2007-pretty.pdf>, R. Telford (2013) <https://quantpalaeo.wordpress.com/2013/01/04/, J. M. Polanco-Martinez (2019) <doi:10.1007/s11071-019-04974-y>, and J. M. Polanco-Martinez (2020) <doi:10.1016/j.ecoinf.2020.101163>.

Non-parametric clustering of joint pattern multi-genetic/epigenetic factors. This package contains functions designed to cluster subjects based on gene features including single nucleotide polymorphisms (SNPs), DNA methylation (CPG), gene expression (GE), and covariate data. The novel concept follows the general K-means (Hartigan and Wong (1979) <doi:10.2307/2346830> framework but uses weighted Euclidean distances across the gene features to cluster subjects. This approach is unique in that it attempts to capture all pairwise interactions in an effort to cluster based on their complex biological interactions.

Implementation of the Robust Exponential Decreasing Index (REDI), proposed in the article by Issa Moussa, Arthur Leroy et al. (2019) <https://bmjopensem.bmj.com/content/bmjosem/5/1/e000573.full.pdf>. The REDI represents a measure of cumulated workload, robust to missing data, providing control of the decreasing influence of workload over time. Various functions are provided to format data, compute REDI, and visualise results in a simple and convenient way.

Data Envelopment Analysis for R, estimating robust DEA scores without and with environmental variables and doing returns-to-scale tests.

Quantitative Structure-Activity Relationship (QSAR) modeling is a valuable tool in computational chemistry and drug design, where it aims to predict the activity or property of chemical compounds based on their molecular structure. In this vignette, we present the rQSAR package, which provides functions for variable selection and QSAR modeling using Multiple Linear Regression (MLR), Partial Least Squares (PLS), and Random Forest algorithms.

This package contains functions to retrieve, organize, and visualize weather data from the NCEP/NCAR Reanalysis (<https://psl.noaa.gov/data/gridded/data.ncep.reanalysis.html>) and NCEP/DOE Reanalysis II (<https://psl.noaa.gov/data/gridded/data.ncep.reanalysis2.html>) datasets. Data are queried via the Internet and may be obtained for a specified spatial and temporal extent or interpolated to a point in space and time. We also provide functions to visualize these weather data on a map. There are also functions to simulate flight trajectories according to specified behavior using either NCEP wind data or data specified by the user.

This package provides a computational resource designed to accurately detect microbial nucleic acids while filtering out contaminants and false-positive taxonomic assignments from standard transcriptomic sequencing of mammalian tissues. For more details, see Ghaddar (2023) <doi:10.1038/s43588-023-00507-1>. This implementation leverages the polars package for fast and systematic microbial signal recovery and denoising from host tissue genomic sequencing.

Perform mediation analysis via the fast-and-robust bootstrap test ROBMED (Alfons, Ates & Groenen, 2022a; <doi:10.1177/1094428121999096>), as well as various other methods. Details on the implementation and code examples can be found in Alfons, Ates, and Groenen (2022b) <doi:10.18637/jss.v103.i13>. Further discussion on robust mediation analysis can be found in Alfons & Schley (2025) <doi:10.1002/wics.70051>.

Generates graphs, CSV files, and coordinates related to river valleys when calling the riverbuilder() function.

Provide color schemes for maps (and other graphics) based on the color palettes of several Microsoft(r) products. Forked from RColorBrewer v1.1-2.

Data driven approach for robust regression estimation in homoscedastic and heteroscedastic context. See Wang et al. (2007), <doi:10.1198/106186007X180156> regarding homoscedastic framework.

Exchange rate for Kenya Shilling against other currencies, US DOLLAR, EURO, STERLING POUND, Tanzania Shilling, Uganda Shilling.

Build regular expressions piece by piece using human readable code. This package contains core functionality, and is primarily intended to be used by package developers.