This package provides functionality of a statistical testing implementation whether a dataset comes from a symmetric distribution when the center of symmetry is unknown, including Wilcoxon test and sign test procedure. In addition, sample size determination for both tests is provided. The Wilcoxon test procedure is described in Vexler et al. (2023) <https://www.sciencedirect.com/science/article/abs/pii/S0167947323000579>, and the sign test is outlined in Gastwirth (1971) <https://www.jstor.org/stable/2284233>.

Simulate genotypes for case-parent triads, case-control, and quantitative trait samples with realistic linkage diequilibrium structure and allele frequency distribution. For studies of epistasis one can simulate models that involve specific SNPs at specific sets of loci, which we will refer to as "pathways". TriadSim generates genotype data by resampling triad genotypes from existing data. The details of the method is described in the manuscript under preparation "Simulating Autosomal Genotypes with Realistic Linkage Disequilibrium and a Spiked in Genetic Effect" Shi, M., Umbach, D.M., Wise A.S., Weinberg, C.R.

Interfaces with the Hugging Face tokenizers library to provide implementations of today's most used tokenizers such as the Byte-Pair Encoding algorithm <https://huggingface.co/docs/tokenizers/index>. It's extremely fast for both training new vocabularies and tokenizing texts.

This package provides a kernel of functions for programming time series methods in a way that is relatively independently of the representation of time. Also provides plotting, time windowing, and some other utility functions which are specifically intended for time series. See the Guide distributed as a vignette, or ?tframe.Intro for more details. (User utilities are in package tfplot.).

Themes for ggplot2 are a convenient way to style plots. The hrbrthemes package contains a particularly nice one, but brings along a significant tail of dependencies. So this (currently experimental) package brings along just the theme_ipsum_rc theme using the Roboto Condensed font. Should the font not be installed on your system, see the help in the package hrbrthemes on how to install Roboto Condensed'. Note that hrbrthemes is now archived at CRAN.

Hospitals, hospital systems, and even trauma systems that provide care to injured patients may not be aware of robust metrics that can help gauge the efficacy of their programs in saving the lives of injured patients. traumar provides robust functions driven by the academic literature to automate the calculation of relevant metrics to individuals desiring to measure the performance of their trauma center or even a trauma system. traumar also provides some helper functions for the data analysis journey. Users can refer to the following publications for descriptions of the methods used in traumar'. TRISS methodology, including probability of survival, and the W, M, and Z Scores - Flora (1978) <doi:10.1097/00005373-197810000-00003>, Boyd et al. (1987, PMID:3106646), Llullaku et al. (2009) <doi:10.1186/1749-7922-4-2>, Singh et al. (2011) <doi:10.4103/0974-2700.86626>, Baker et al. (1974, PMID:4814394), and Champion et al. (1989) <doi:10.1097/00005373-198905000-00017>. For the Relative Mortality Metric, see Napoli et al. (2017) <doi:10.1080/24725579.2017.1325948>, Schroeder et al. (2019) <doi:10.1080/10903127.2018.1489021>, and Kassar et al. (2016) <doi:10.1177/00031348221093563>. For more information about methods to calculate over- and under-triage in trauma hospital populations and samples, please see the following publications - Peng & Xiang (2016) <doi:10.1016/j.ajem.2016.08.061>, Beam et al. (2022) <doi:10.23937/2474-3674/1510136>, Roden-Foreman et al. (2017) <doi:10.1097/JTN.0000000000000283>.

This package performs maximum likelihood based estimation and inference on time to event data, possibly subject to non-informative right censoring. FitParaSurv() provides maximum likelihood estimates of model parameters and distributional characteristics, including the mean, median, variance, and restricted mean. CompParaSurv() compares the mean, median, and restricted mean survival experiences of two treatment groups. Candidate distributions include the exponential, gamma, generalized gamma, log-normal, and Weibull.

This package implements a semiparametric estimator for the odds ratio model with censored, time-lagged, ordered categorical outcome in a randomized clinical trial that incorporates baseline and time-dependent information. Tsiatis AA, Davidian M, Holloway ST (2023) <doi:10.1111/biom.13603>.

Handle genomic data within data frames just as you would with GRanges'. This packages provides method to deal with genomic intervals the "tidy-way" which makes it simpler to integrate in the the general data munging process. The API is inspired by the popular bedtools and the genome_join() method from the fuzzyjoin package.

This package provides a calculator for the two-dimensional clinical Disease Activity index for Psoriatic Arthritis (TwoDcDAPSA), a principal component-derived measure that complements the conventional clinical DAPSA score. The TwoDcDAPSA captures residual variation in patient-reported outcomes (pain and patient global assessment) and joint counts (swollen and tender) after adjusting for standardized cDAPSA using natural spline coefficients derived from published models. Residuals are standardized and combined with fixed principal component loadings to yield a continuous PROs-Joint Contrast (PJC) score and quartile groupings. The package applies pre-specified coefficients and loadings to new datasets but does not estimate spline models or principal components itself.

Compile Typst files using the typst-cli (<https://typst.app>) command line tool. Automatically falls back to rendering via embedded Typst from Quarto (<https://quarto.org>) if Typst is not installed. Includes utilities to check for typst-cli availability and run Typst commands.

Bayesian trophic position models using stan by leveraging brms for stable isotope data. Trophic position models are derived by using equations from Post (2002) <doi:10.1890/0012-9658(2002)083[0703:USITET]2.0.CO;2>, Vander Zanden and Vadeboncoeur (2002) <doi:10.1890/0012-9658(2002)083[2152:FAIOBA]2.0.CO;2>, and Heuvel et al. (2024) <doi:10.1139/cjfas-2024-0028>.

Fits 2D and 3D geometric transformations via Stan probabilistic programming engine ( Stan Development Team (2021) <https://mc-stan.org>). Returns posterior distribution for individual parameters of the fitted distribution. Allows for computation of LOO and WAIC information criteria (Vehtari A, Gelman A, Gabry J (2017) <doi:10.1007/s11222-016-9696-4>) as well as Bayesian R-squared (Gelman A, Goodrich B, Gabry J, and Vehtari A (2018) <doi:10.1080/00031305.2018.1549100>).

This package creates a local Lightning Memory-Mapped Database ('LMDB') of many commonly used taxonomic authorities and provides functions that can quickly query this data. Supported taxonomic authorities include the Integrated Taxonomic Information System ('ITIS'), National Center for Biotechnology Information ('NCBI'), Global Biodiversity Information Facility ('GBIF'), Catalogue of Life ('COL'), and Open Tree Taxonomy ('OTT'). Name and identifier resolution using LMDB can be hundreds of times faster than either relational databases or internet-based queries. Precise data provenance information for data derived from naming providers is also included.

Tautulli (<http://tautulli.com>) is a monitoring application for Plex Media Servers (<https://www.plex.tv>) which collects a lot of data about media items and server usage such as play counts. This package interacts with the Tautulli API of any specified server to get said data into R. The Tautulli API documentation is available at <https://github.com/Tautulli/Tautulli/blob/master/API.md>.

This package provides a set of tools for managing time-series data, with a particular emphasis on defining various frequency types such as daily and weekly. It also includes functionality for converting data between different frequencies.

Flexible simulation of time series using time series components, including seasonal, calendar and outlier effects. Main algorithm described in Ollech, D. (2021) <doi:10.1515/jtse-2020-0028>.

Propensity score matching for non-binary treatments.

This package implements target trial emulation methods to apply randomized clinical trial design and analysis in an observational setting. Using marginal structural models, it can estimate intention-to-treat and per-protocol effects in emulated trials using electronic health records. A description and application of the method can be found in Danaei et al (2013) <doi:10.1177/0962280211403603>.

The goal of trainR is to provide a simple interface to the National Rail Enquiries (NRE) systems. There are few data feeds available, the simplest of them is Darwin, which provides real-time arrival and departure predictions, platform numbers, delay estimates, schedule changes and cancellations. Other data feeds provide historical data, Historic Service Performance (HSP), and much more. trainR simplifies the data retrieval, so that the users can focus on their analyses. For more details visit <https://www.nationalrail.co.uk/46391.aspx>.

Data analysis package for estimating potential biological effects from chemical concentrations in environmental samples. Included are a set of functions to analyze, visualize, and organize measured concentration data as it relates to user-selected chemical-biological interaction benchmark data such as water quality criteria. The intent of these analyses is to develop a better understanding of the potential biological relevance of environmental chemistry data. Results can be used to prioritize which chemicals at which sites may be of greatest concern. These methods are meant to be used as a screening technique to predict potential for biological influence from chemicals that ultimately need to be validated with direct biological assays. A description of the analysis can be found in Blackwell (2017) <doi:10.1021/acs.est.7b01613>.

Simulation of random vectors from truncated multivariate normal and t distributions based on the algorithms proposed by Yifang Li and Sujit K. Ghosh (2015) <doi:10.1080/15598608.2014.996690>.

This package provides a universal non-uniform random number generator for quite arbitrary distributions with piecewise twice differentiable densities.

This package provides a simple interface to search available data provided by Theia (<https://theia.cnes.fr>), download it, and manage it. Data can be downloaded based on a search result or from a cart file downloaded from Theia website.