In some phase I trials, the design goal is to find the dose associated with a certain target toxicity rate or the dose with a certain weighted sum of rates of various toxicity grades. TITEgBOIN provides the set up and calculations needed to run a dose-finding trial using bayesian optimal interval (BOIN) (Yuan et al. (2016) <doi:10.1158/1078-0432.CCR-16-0592>), generalized bayesian optimal interval (gBOIN) (Mu et al. (2019) <doi:10.1111/rssc.12263>), time-to-event bayesian optimal interval (TITEBOIN) (Lin et al. (2020) <doi:10.1093/biostatistics/kxz007>) and time-to-event generalized bayesian optimal interval (TITEgBOIN) (Takeda et al. (2022) <doi:10.1002/pst.2182>) designs. TITEgBOIN can conduct tasks: run simulations and get operating characteristics; determine the dose for the next cohort; select maximum tolerated dose (MTD). These functions allow customization of design characteristics to vary sample size, cohort sizes, target dose limiting toxicity (DLT) rates or target normalized equivalent toxicity score (ETS) rates to account for discrete toxicity score, and incorporate safety and/or stopping rules.

Tautulli (<http://tautulli.com>) is a monitoring application for Plex Media Servers (<https://www.plex.tv>) which collects a lot of data about media items and server usage such as play counts. This package interacts with the Tautulli API of any specified server to get said data into R. The Tautulli API documentation is available at <https://github.com/Tautulli/Tautulli/blob/master/API.md>.

This package provides a clinically meaningful measures of treatment effects for right-censored data are provided, based on the concept of Kendall's tau, along with the corresponding inference procedures. Two plots of tau processes, with the option to account for the cure fraction or not, are available. The plots of tau processes serve as useful graphical tools for monitoring the relative performances over time.

The Cancer Genome Atlas (TCGA) is a program aimed at improving our understanding of Cancer Biology. Several TCGA Datasets are available online. TCGAretriever helps accessing and downloading TCGA data hosted on cBioPortal via its Web Interface (see <https://www.cbioportal.org/> for more information).

Download daily interest rates from the US Treasury XML feed. Leveraging <https://home.treasury.gov/treasury-daily-interest-rate-xml-feed>, this package serves as a wrapper, facilitating the retrieval of daily treasury rates across various categories, including par yield curves, treasury bills, long-term rates, and real yield curves.

Computation of stopping boundaries for a single-arm trial using a Bayesian criterion. For each m<=n (n=total patient number of the trial) the smallest number of observed toxicities is calculated leading to the termination of the trial/accrual according to the specified criteria. The probabilities of stopping the trial/accrual at and up until (resp.) the m-th patient (m<=n) is also calculated. This design is more conservative than the frequentist approach (using Clopper Pearson CIs) which might be preferred as it concerns safety. See also Aamot et al. (2010) "Continuous monitoring of toxicity in clinical Trials - simulating the risk of stopping prematurely" <doi:10.5414/cpp48476>.

This package performs the detection of linear trend changes for univariate time series by implementing the bottom-up unbalanced wavelet transformation proposed by H. Maeng and P. Fryzlewicz (2023). The estimated number and locations of the change-points are returned with the piecewise-linear estimator for signal.

An implementation of turtle graphics <http://en.wikipedia.org/wiki/Turtle_graphics>. Turtle graphics comes from Papert's language Logo and has been used to teach concepts of computer programming.

ARIMA-model-based decomposition of quarterly and monthly time series data. The methodology is developed and described, among others, in Burman (1980) <DOI:10.2307/2982132> and Hillmer and Tiao (1982) <DOI:10.2307/2287770>.

The ESTIMATE package infers tumor purity from expression data as a function of immune and stromal infiltrate, but requires writing of intermediate files, is un-pipeable, and performs poorly when presented with modern datasets with current gene symbols. tidyestimate a fast, tidy, modern reimagination of ESTIMATE (2013) <doi:10.1038/ncomms3612>.

Estimation of transition probabilities for the illness-death model and or the three-state progressive model.

This package provides functions for preparing and analyzing animal tracking data, with the intention of identifying areas which are potentially important at the population level and therefore of conservation interest. Areas identified using this package may be checked against global or regionally-defined criteria, such as those set by the Key Biodiversity Area program. The method published herein is described in full in Beal et al. 2021 <doi:10.1111/2041-210X.13713>.

This package provides access to the Taxonomic Name Resolution Service <https://github.com/ojalaquellueva/tnrsapi> through R. The user supplies plant taxonomic names and the package returns resolved taxonomic names along with information on decisions. Optionally, the package can also be used to parse taxonomic names.

The textrank algorithm is an extension of the Pagerank algorithm for text. The algorithm allows to summarize text by calculating how sentences are related to one another. This is done by looking at overlapping terminology used in sentences in order to set up links between sentences. The resulting sentence network is next plugged into the Pagerank algorithm which identifies the most important sentences in your text and ranks them. In a similar way textrank can also be used to extract keywords. A word network is constructed by looking if words are following one another. On top of that network the Pagerank algorithm is applied to extract relevant words after which relevant words which are following one another are combined to get keywords. More information can be found in the paper from Mihalcea, Rada & Tarau, Paul (2004) <https://www.aclweb.org/anthology/W04-3252/>.

Approaches for incorporating time into network analysis. Methods include: construction of time-ordered networks (temporal graphs); shortest-time and shortest-path-length analyses; resource spread calculations; data resampling and rarefaction for null model construction; reduction to time-aggregated networks with variable window sizes; application of common descriptive statistics to these networks; vector clock latencies; and plotting functionalities. The package supports <doi:10.1371/journal.pone.0020298>.

Generating Tag and Word Clouds.

Perform a Visual Predictive Check (VPC), while accounting for stratification, censoring, and prediction correction. Using piping from magrittr', the intuitive syntax gives users a flexible and powerful method to generate VPCs using both traditional binning and a new binless approach Jamsen et al. (2018) <doi:10.1002/psp4.12319> with Additive Quantile Regression (AQR) and Locally Estimated Scatterplot Smoothing (LOESS) prediction correction.

This package provides a novel feature-wise normalization method based on a zero-inflated negative binomial model. This method assumes that the effects of sequencing depth vary for each taxon on their mean and also incorporates a rational link of zero probability and taxon dispersion as a function of sequencing depth. Ziyue Wang, Dillon Lloyd, Shanshan Zhao, Alison Motsinger-Reif (2023) <doi:10.1101/2023.10.31.563648>.

Base R sometimes requires verbose statements for simple, often recurring tasks, such as printing text without trailing space, ending with newline. This package aims at providing shorthands for such tasks.

Interface to the API for TreeBASE <http://treebase.org> from R. TreeBASE is a repository of user-submitted phylogenetic trees (of species, population, or genes) and the data used to create them.

Temporal disaggregation methods are used to disaggregate and interpolate a low frequency time series to a higher frequency series, where either the sum, the mean, the first or the last value of the resulting high frequency series is consistent with the low frequency series. Temporal disaggregation can be performed with or without one or more high frequency indicator series. Contains the methods of Chow-Lin, Santos-Silva-Cardoso, Fernandez, Litterman, Denton and Denton-Cholette, summarized in Sax and Steiner (2013) <doi:10.32614/RJ-2013-028>. Supports most R time series classes.

Data handling and estimation functions for animal movement estimation from archival or satellite tags. Helper functions are included for making image summaries binned by time interval from Markov Chain Monte Carlo simulations.

Generate tables, listings, and graphs (TLG) using tidyverse'. Tables can be created functionally, using a standard TLG process, or by specifying table and column metadata to create generic analysis summaries. The envsetup package can also be leveraged to create environments for table creation.

Providing new german-wide TapeR Models and functions for their evaluation. Included are the most common tree species in Germany (Norway spruce, Scots pine, European larch, Douglas fir, Silver fir as well as European beech, Common/Sessile oak and Red oak). Many other species are mapped to them so that 36 tree species / groups can be processed. Single trees are defined by species code, one or multiple diameters in arbitrary measuring height and tree height. The functions then provide information on diameters along the stem, bark thickness, height of diameters, volume of the total or parts of the trunk and total and component above-ground biomass. It is also possible to calculate assortments from the taper curves. Uncertainty information is provided for diameter, volume and component biomass estimation.