This package implements methods for inference on potential waning of vaccine efficacy and for estimation of vaccine efficacy at a user-specified time after vaccination based on data from a randomized, double-blind, placebo-controlled vaccine trial in which participants may be unblinded and placebo subjects may be crossed over to the study vaccine. The methods also for variant stratification and allow adjustment for possible confounding via inverse probability weighting through specification of models for the trial entry process, unblinding mechanisms, and the probability an unblinded placebo participant accepts study vaccine.

An implementation of Vasicek and Song goodness-of-fit tests. Several functions are provided to estimate differential Shannon entropy, i.e., estimate Shannon entropy of real random variables with density, and test the goodness-of-fit of some family of distributions, including uniform, Gaussian, log-normal, exponential, gamma, Weibull, Pareto, Fisher, Laplace and beta distributions; see Lequesne and Regnault (2020) <doi:10.18637/jss.v096.c01>.

The algorithm implemented in this package was designed to quickly estimates the distribution of the log-rank especially for heavy unbalanced groups. VALORATE estimates the null distribution and the p-value of the log-rank test based on a recent formulation. For a given number of alterations that define the size of survival groups, the estimation involves a weighted sum of distributions that are conditional on a co-occurrence term where mutations and events are both present. The estimation of conditional distributions is quite fast allowing the analysis of large datasets in few minutes <https://bioinformatics.mx/index.php/bioinfo-tools/>.

Uses large language models to create poems about R packages. Currently contains the roses() function to make "roses are red, ..." style poems and the prompt() function to only assemble the prompt without submitting it to the model.

This package provides a dedicated viral-explainer model tool designed to empower researchers in the field of HIV research, particularly in viral load and CD4 (Cluster of Differentiation 4) lymphocytes regression modeling. Drawing inspiration from the tidymodels framework for rigorous model building of Max Kuhn and Hadley Wickham (2020) <https://www.tidymodels.org>, and the DALEXtra tool for explainability by Przemyslaw Biecek (2020) <doi:10.48550/arXiv.2009.13248>. It aims to facilitate interpretable and reproducible research in biostatistics and computational biology for the benefit of understanding HIV dynamics.

Using frequency matrices, very low frequency variants (VLFs) are assessed for amino acid and nucleotide sequences. The VLFs are then compared to see if they occur in only one member of a species, singleton VLFs, or if they occur in multiple members of a species, shared VLFs. The amino acid and nucleotide VLFs are then compared to see if they are concordant with one another. Amino acid VLFs are also assessed to determine if they lead to a change in amino acid residue type, and potential changes to protein structures. Based on Stoeckle and Kerr (2012) <doi:10.1371/journal.pone.0043992> and Phillips et al. (2023) <doi:10.3897/BDJ.11.e96480>.

This package provides a collection of tools for downstream analysis of VirusHunterGatherer output. Processing of hittables and plotting of results, enabling better interpretation, is made easier with the provided functions.

Vector binary tree provides a new data structure, to make your data visiting and management more efficient. If the data has structured column names, it can read these names and factorize them through specific split pattern, then build the mappings within double list, vector binary tree, array and tensor mutually, through which the batched data processing is achievable easily. The methods of array and tensor are also applicable. Detailed methods are described in Chen Zhang et al. (2020) <doi:10.35566/isdsa2019c8>.

This package provides methods for calculating the variance scale exponent to identify memory patterns in time series data. Includes tests for white noise, short memory, and long memory. See Fu, H. et al. (2018) <doi:10.1016/j.physa.2018.06.092>.

Visual contour and 2D point and contour plots for binary classification modeling under algorithms such as glm', rf', gbm', nnet and svm', presented over two dimensions generated by famd and mca methods. Package FactoMineR for multivariate reduction functions and package MBA for interpolation functions are used. The package can be used to visualize the discriminant power of input variables and algorithmic modeling, explore outliers, compare algorithm behaviour, etc. It has been created initially for teaching purposes, but it has also many practical uses under the XAI paradigm.

This package performs clustering of quantitative variables, assuming that clusters lie in low-dimensional subspaces. Segmentation of variables, number of clusters and their dimensions are selected based on BIC. Candidate models are identified based on many runs of K-means algorithm with different random initializations of cluster centers.

Computes the random forest variable importance (VIMP) for the conditional inference random forest (cforest) of the party package. Includes a function (varImp) that computes the VIMP for arbitrary measures from the measures package. For calculating the VIMP regarding the measures accuracy and AUC two extra functions exist (varImpACC and varImpAUC).

This package provides methods to calculate the expected value of information from a decision-analytic model. This includes the expected value of perfect information (EVPI), partial perfect information (EVPPI) and sample information (EVSI), and the expected net benefit of sampling (ENBS). A range of alternative computational methods are provided under the same user interface. See Heath et al. (2024) <doi:10.1201/9781003156109>, Jackson et al. (2022) <doi:10.1146/annurev-statistics-040120-010730>.

This package contains functions for a variational Bayesian method for sparse PCA proposed by Ning (2020) <arXiv:2102.00305>. There are two algorithms: the PX-CAVI algorithm (if assuming the loadings matrix is jointly row-sparse) and the batch PX-CAVI algorithm (if without this assumption). The outputs of the main function, VBsparsePCA(), include the mean and covariance of the loadings matrix, the score functions, the variable selection results, and the estimated variance of the random noise.

This package provides R functions to draw lines and curves with the width of the curve allowed to vary along the length of the curve.

Streams and parses variant call format file headers without reading full files. Provides structured metadata, validation, inference, and HTML reporting. For details on the specifications used see Danecek et al. (2021) <doi:10.1093/gigascience/giab008>.

This package creates Vertex Similarity matrix of an undirected graph based on the method stated by E. A. Leicht, Petter Holme, AND M. E. J. Newman in their paper <DOI:10.1103/PhysRevE.73.026120>.

This is a sparklyr extension integrating VariantSpark and R. VariantSpark is a framework based on scala and spark to analyze genome datasets, see <https://bioinformatics.csiro.au/>. It was tested on datasets with 3000 samples each one containing 80 million features in either unsupervised clustering approaches and supervised applications, like classification and regression. The genome datasets are usually writing in VCF, a specific text file format used in bioinformatics for storing gene sequence variations. So, VariantSpark is a great tool for genome research, because it is able to read VCF files, run analyses and return the output in a spark data frame.

If f <- function(x)x^2 and g <- function(x)x+1 it is a constant source of annoyance that "f+g" is not defined. Package vfunc allows you to do this, and we have (f+g)(2) returning 5. The other arithmetic operators are similarly implemented. A wide class of coding bugs is eliminated.

Collection of functions to evaluate presence-absence models. It comprises functions to adjust discrimination statistics for the representativeness effect through case-weighting, along with functions for visualizing the outcomes. Originally outlined in: Jiménez-Valverde (2022) The uniform AUC: dealing with the representativeness effect in presence-absence models. Methods Ecol. Evol, 13, 1224-1236.

This package provides a Shiny application and functions for visual exploration of hierarchical clustering with numeric datasets. Allows users to iterative set hyperparameters, select features and evaluate results through various plots and computation of evaluation criteria.

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This package provides tools for estimating vaccine effectiveness and related metrics. The vaccineff_data class manages key features for preparing, visualizing, and organizing cohort data, as well as estimating vaccine effectiveness. The results and model performance are assessed using the vaccineff class.

This package provides a wrapped LASSO approach by integrating an ensemble learning strategy to help select efficient, stable, and high confidential variables from omics-based data. Using a bagging strategy in combination of a parametric method or inflection point search method for cut-off threshold determination. This package can integrate and vote variables generated from multiple LASSO models to determine the optimal candidates. Luo H, Zhao Q, et al (2020) <doi:10.1126/scitranslmed.aax7533> for more details.