PAST takes GWAS output and assigns SNPs to genes, uses those genes to find pathways associated with the genes, and plots pathways based on significance. Implements methods for reading GWAS input data, finding genes associated with SNPs, calculating enrichment score and significance of pathways, and plotting pathways.

This package provides convenience functions for programming with magrittr pipes. Conditional pipes, a string prefixer and a function to pipe the given object into a specific argument given by character name are currently supported. It is named after the dadaist Hans Arp, a friend of Rene Magritte.

Cohort plAtform Trial Simulation whereby every cohort consists of two arms, control and experimental treatment. Endpoints are co-primary binary endpoints and decisions are made using either Bayesian or frequentist decision rules. Realistic trial trajectories are simulated and the operating characteristics of the designs are calculated.

Get insight into a forest of classification trees, by calculating similarities between the trees, and subsequently clustering them. Each cluster is represented by it's most central cluster member. The package implements the methodology described in Sies & Van Mechelen (2020) <doi:10.1007/s00357-019-09350-4>.

This package provides information on drug names (brand, generic and street) for drugs tracked by the DEA. There are functions that will search synonyms and return the drug names and types. The vignettes have extensive information on the work done to create the data for the package.

This package provides simple, fast, and stable functions to fit the normal means model using empirical Bayes. For available models and details, see function ebnm(). Our JSS article, Willwerscheid, Carbonetto, and Stephens (2025) <doi:10.18637/jss.v114.i03>, provides a detailed introduction to the package.

Proposes non-parametric estimates of the Fisher information measure and the Shannon entropy power. More theoretical and implementation details can be found in Guignard et al. <doi:10.3389/feart.2020.00255>. A python version of this work is available on github and PyPi ('FiShPy').

This package provides a ggplot2 extension that enables visualization of IP (Internet Protocol) addresses and networks. The address space is mapped onto the Cartesian coordinate system using a space-filling curve. Offers full support for both IPv4 and IPv6 (Internet Protocol versions 4 and 6) address spaces.

Estimation and analysis of group-based multivariate trajectory models (Nagin, 2018 <doi:10.1177/0962280216673085>; Magrini, 2022 <doi:10.1007/s10182-022-00437-9>). The package implements an Expectation-Maximization (EM) algorithm allowing unbalanced panel and missing values, and provides several functionalities for prediction and graphical representation.

Focuses on data collecting, analyzing and visualization in green finance and environmental risk research and analysis. Main function includes environmental data collecting from official websites such as MEP (Ministry of Environmental Protection of China, <https://www.mee.gov.cn>), water related projects identification and environmental data visualization.

Functionalities to compute model based genetic components i.e. genotypic variance, phenotypic variance and heritability for given traits of different genotypes from replicated data using methodology explained by Burton, G. W. & Devane, E. H. (1953) (<doi:10.2134/agronj1953.00021962004500100005x>) and Allard, R.W. (2010, ISBN:8126524154).

Implementation of the classifier described in the paper Ali HR et al (2014) <doi:10.1186/s13059-014-0431-1>. It uses copy number and/or expression form breast cancer data, trains a Tibshirani's pamr classifier with the features available and predicts the iC10 group.

This package provides a unified software package simultaneously implemented in Python', R', and Matlab providing a uniform and internally-consistent way of calculating stoichiometric equilibrium constants in modern and palaeo seawater as a function of temperature, salinity, pressure and the concentration of magnesium, calcium, sulphate, and fluorine.

Bandwidth selection for kernel density estimators of 2-d level sets and highest density regions. It applies a plug-in strategy to estimate the asymptotic risk function and minimize to get the optimal bandwidth matrix. See Doss and Weng (2018) <arXiv:1806.00731> for more detail.

"Learning with Subset Stacking" is a supervised learning algorithm that is based on training many local estimators on subsets of a given dataset, and then passing their predictions to a global estimator. You can find the details about LESS in our manuscript at <arXiv:2112.06251>.

Estimates multivariate subgaussian stable densities and probabilities as well as generates random variates using product distribution theory. A function for estimating the parameters from data to fit a distribution to data is also provided, using the method from Nolan (2013) <doi:10.1007/s00180-013-0396-7>.

Count the occurrence of sequences of values in a vector that meets certain conditions of length and magnitude. The method is based on the Run Length Encoding algorithm, available with base R, inspired by A. H. Robinson and C. Cherry (1967) <doi:10.1109/PROC.1967.5493>.

An implementation for computing Optimal B-Robust Estimators of two-parameter distribution. The procedure is composed of some equations that are evaluated alternatively until the solution is reached. Some tools for analyzing the estimates are included. The most relevant is covariance matrix computation using a closed formula.

Recursive algorithms for computing various relatedness coefficients, including pairwise kinship, kappa and identity coefficients. Both autosomal and X-linked coefficients are computed. Founders are allowed to be inbred, which enables construction of any given kappa coefficients, as described in Vigeland (2020) <doi:10.1007/s00285-020-01505-x>. In addition to the standard coefficients, ribd also computes a range of lesser-known coefficients, including generalised kinship coefficients, multi-person coefficients and two-locus coefficients (Vigeland, 2023, <doi:10.1093/g3journal/jkac326>). Many features of ribd are available through the online app QuickPed at <https://magnusdv.shinyapps.io/quickped>; see Vigeland (2022) <doi:10.1186/s12859-022-04759-y>.

This package contains implementations of recurrent event data analysis routines including (1) survival and recurrent event data simulation from stochastic process point of view by the thinning method proposed by Lewis and Shedler (1979) <doi:10.1002/nav.3800260304> and the inversion method introduced in Cinlar (1975, ISBN:978-0486497976), (2) the mean cumulative function (MCF) estimation by the Nelson-Aalen estimator of the cumulative hazard rate function, (3) two-sample recurrent event responses comparison with the pseudo-score tests proposed by Lawless and Nadeau (1995) <doi:10.2307/1269617>, (4) gamma frailty model with spline rate function following Fu, et al. (2016) <doi:10.1080/10543406.2014.992524>.

This package implements five methods proposed by Resnik, Schlicker, Jiang, Lin and Wang, respectively, for measuring semantic similarities among Disease ontology (DO) terms and gene products. Enrichment analyses including hypergeometric model and gene set enrichment analysis are also implemented for discovering disease associations of high-throughput biological data.

This package contains an implementation of AIMS -- Absolute Intrinsic Molecular Subtyping. It contains necessary functions to assign the five intrinsic molecular subtypes (Luminal A, Luminal B, Her2-enriched, Basal-like, Normal-like). Assignments could be done on individual samples as well as on dataset of gene expression data.

Remind allows you to remind yourself of upcoming events and appointments. Each reminder or alarm can consist of a message sent to standard output, or a program to be executed. It also features: sophisticated date calculation, moon phases, sunrise/sunset, Hebrew calendar, alarms, PostScript output and proper handling of holidays.

This package provides an implementation of the Uniform Manifold Approximation and Projection dimensionality reduction by McInnes et al. (2018). It also provides means to transform new data and to carry out supervised dimensionality reduction. An implementation of the related LargeVis method of Tang et al. (2016) is also provided.