This package provides a collection of tools for the calculation of freewater metabolism from in situ time series of dissolved oxygen, water temperature, and, optionally, additional environmental variables. LakeMetabolizer implements 5 different metabolism models with diverse statistical underpinnings: bookkeeping, ordinary least squares, maximum likelihood, Kalman filter, and Bayesian. Each of these 5 metabolism models can be combined with 1 of 7 models for computing the coefficient of gas exchange across the airâ water interface (k). LakeMetabolizer also features a variety of supporting functions that compute conversions and implement calculations commonly applied to raw data prior to estimating metabolism (e.g., oxygen saturation and optical conversion models).

This package provides functions to analyze coarse data. Specifically, it contains functions to (1) fit parametric accelerated failure time models to interval-censored survival time data, and (2) estimate the case-fatality ratio in scenarios with under-reporting. This package's development was motivated by applications to infectious disease: in particular, problems with estimating the incubation period and the case fatality ratio of a given disease. Sample data files are included in the package. See Reich et al. (2009) <doi:10.1002/sim.3659>, Reich et al. (2012) <doi:10.1111/j.1541-0420.2011.01709.x>, and Lessler et al. (2009) <doi:10.1016/S1473-3099(09)70069-6>.

This package provides a library of density, distribution function, quantile function, (bounded) raw moments and random generation for a collection of distributions relevant for the firm size literature. Additionally, the package contains tools to fit these distributions using maximum likelihood and evaluate these distributions based on (i) log-likelihood ratio and (ii) deviations between the empirical and parametrically implied moments of the distributions. We add flexibility by allowing the considered distributions to be combined into piecewise composite or finite mixture distributions, as well as to be used when truncated. See Dewitte (2020) <https://hdl.handle.net/1854/LU-8644700> for a description and application of methods available in this package.

This package defines a BigMatrix ReferenceClass which adds safety and convenience features to the filebacked.big.matrix class from the bigmemory package. BigMatrix protects against segfaults by monitoring and gracefully restoring the connection to on-disk data and it also protects against accidental data modification with a file-system-based permissions system. Utilities are provided for using BigMatrix-derived classes as assayData matrices within the Biobase package's eSet family of classes. BigMatrix provides some optimizations related to attaching to, and indexing into, file-backed matrices with dimnames. Additionally, the package provides a BigMatrixFactor class, a file-backed matrix with factor properties.

The Core Microbiome refers to the group of microorganisms that are consistently present in a particular environment, habitat, or host species. These microorganisms play a crucial role in the functioning and stability of that ecosystem. Identifying these microorganisms can contribute to the emerging field of personalized medicine. The CoreMicrobiomeR is designed to facilitate the identification, statistical testing, and visualization of this group of microorganisms.This package offers three key functions to analyze and visualize microbial community data. This package has been developed based on the research papers published by Pereira et al.(2018) <doi:10.1186/s12864-018-4637-6> and Beule L, Karlovsky P. (2020) <doi:10.7717/peerj.9593>.

As different antipsychotic medications have different potencies, the doses of different medications cannot be directly compared. Various strategies are used to convert doses into a common reference so that comparison is meaningful. Chlorpromazine (CPZ) has historically been used as a reference medication into which other antipsychotic doses can be converted, as "chlorpromazine-equivalent doses". Using conversion keys generated from widely-cited scientific papers, e.g. Gardner et. al 2010 <doi:10.1176/appi.ajp.2009.09060802> and Leucht et al. 2016 <doi:10.1093/schbul/sbv167>, antipsychotic doses are converted to CPZ (or any specified antipsychotic) equivalents. The use of the package is described in the included vignette. Not for clinical use.

The komacv-rg bundle provides packages that aid in creating CVs based on the komacv class and creating related documents, such as cover letters and cover sheets for job applications.

Concretely, the bundle consists of three packages: komacv-addons, komacv-lco, and komacv-multilang. komacv-addons is a small collection of add-ons and fixes for the komacv class; komacv-lco enables the use of letter class options from scrlttr2 also in komacv-based and other non-scrlttr2-based documents; komacv-multilang enables the provisioning of CVs in multiple languages and the selection of a language via Babel or Polyglossia.

This package provides a fast implementation with additional experimental features for testing, monitoring and dating structural changes in (linear) regression models. strucchangeRcpp features tests/methods from the generalized fluctuation test framework as well as from the F test (Chow test) framework. This includes methods to fit, plot and test fluctuation processes (e.g. cumulative/moving sum, recursive/moving estimates) and F statistics, respectively. These methods are described in Zeileis et al. (2002) <doi:10.18637/jss.v007.i02>. Finally, the breakpoints in regression models with structural changes can be estimated together with confidence intervals, and their magnitude as well as the model fit can be evaluated using a variety of statistical measures.

multiHiCcompare provides functions for joint normalization and difference detection in multiple Hi-C datasets. This extension of the original HiCcompare package now allows for Hi-C experiments with more than 2 groups and multiple samples per group. multiHiCcompare operates on processed Hi-C data in the form of sparse upper triangular matrices. It accepts four column (chromosome, region1, region2, IF) tab-separated text files storing chromatin interaction matrices. multiHiCcompare provides cyclic loess and fast loess (fastlo) methods adapted to jointly normalizing Hi-C data. Additionally, it provides a general linear model (GLM) framework adapting the edgeR package to detect differences in Hi-C data in a distance dependent manner.

Total Time on Test plot and routines for parameter estimation of any lifetime distribution implemented in R via maximum likelihood (ML) given a data set. It is implemented thinking on parametric survival analysis, but it feasible to use in parameter estimation of probability density or mass functions in any field. The main routines maxlogL and maxlogLreg are wrapper functions specifically developed for ML estimation. There are included optimization procedures such as nlminb and optim from base package, and DEoptim Mullen (2011) <doi:10.18637/jss.v040.i06>. Standard errors are estimated with numDeriv Gilbert (2011) <https://CRAN.R-project.org/package=numDeriv> or the option Hessian = TRUE of optim function.

This package provides functions for working with primary event censored distributions and Stan implementations for use in Bayesian modeling. Primary event censored distributions are useful for modeling delayed reporting scenarios in epidemiology and other fields (Charniga et al. (2024) <doi:10.48550/arXiv.2405.08841>). It also provides support for arbitrary delay distributions, a range of common primary distributions, and allows for truncation and secondary event censoring to be accounted for (Park et al. (2024) <doi:10.1101/2024.01.12.24301247>). A subset of common distributions also have analytical solutions implemented, allowing for faster computation. In addition, it provides multiple methods for fitting primary event censored distributions to data via optional dependencies.

The trigger strategy is a general framework for a multistage statistical design with multiple hypotheses, allowing an adaptive selection of interim analyses. The selection of interim stages can be associated with some prespecified endpoints which serve as the trigger. This selection allows us to refine the critical boundaries in hypotheses testing procedures, and potentially increase the statistical power. This package includes several trial designs using the trigger strategy. See Gou, J. (2023), "Trigger strategy in repeated tests on multiple hypotheses", Statistics in Biopharmaceutical Research, 15(1), 133-140, and Gou, J. (2022), "Sample size optimization and initial allocation of the significance levels in group sequential trials with multiple endpoints", Biometrical Journal, 64(2), 301-311.

git-remote-gcrypt is a Git remote helper to push and pull from repositories encrypted with GnuPG. It works with the standard Git transports, including repository hosting services like GitLab.

Remote helper programs are invoked by Git to handle network transport. This helper handles gcrypt: URLs that access a remote repository encrypted with GPG, using our custom format.

Supported locations are local, rsync:// and sftp://, where the repository is stored as a set of files, or instead any Git URL where gcrypt will store the same representation in a Git repository, bridged over arbitrary Git transport.

The aim is to provide confidential, authenticated Git storage and collaboration using typical untrusted file hosts or services.

This package provides hardware-accelerated tools for performing rerandomization and randomization testing in experimental research. Using a JAX backend, the package enables exact rerandomization inference even for large experiments with hundreds of billions of possible randomizations. Key functionalities include generating pools of acceptable rerandomizations based on covariate balance, conducting exact randomization tests, and performing pre-analysis evaluations to determine optimal rerandomization acceptance thresholds. The package supports various hardware acceleration frameworks including CPU', CUDA', and METAL', making it versatile across accelerated computing environments. This allows researchers to efficiently implement stringent rerandomization designs and conduct valid inference even with large sample sizes. The package is partly based on Jerzak and Goldstein (2023) <doi:10.48550/arXiv.2310.00861>.

This package implements structural estimators to estimate preferences and correct for the sample selection bias of observed outcomes in matching markets. This includes one-sided matching of agents into groups (Klein, 2015) <doi:10.17863/CAM.5812> as well as two-sided matching of students to schools (Klein et al., 2024) <doi:10.1016/j.geb.2024.07.003>. The package also contains algorithms to find stable matchings in the three most common matching problems: the stable roommates problem (Irving, 1985) <doi:10.1016/0196-6774(85)90033-1>, the college admissions problem (Gale and Shapley, 1962) <doi:10.2307/2312726>, and the house allocation problem (Shapley and Scarf, 1974) <doi:10.1016/0304-4068(74)90033-0>.

Copula based Cox proportional hazards models for survival data subject to dependent censoring. This approach does not assume that the parameter defining the copula is known. The dependency parameter is estimated with other finite model parameters by maximizing a Pseudo likelihood function. The cumulative hazard function is estimated via estimating equations derived based on martingale ideas. Available copula functions include Frank, Gumbel and Normal copulas. Only Weibull and lognormal models are allowed for the censoring model, even though any parametric model that satisfies certain identifiability conditions could be used. Implemented methods are described in the article "Copula based Cox proportional hazards models for dependent censoring" by Deresa and Van Keilegom (2024) <doi:10.1080/01621459.2022.2161387>.

The extended neighbourhood rule for the k nearest neighbour ensemble where the neighbours are determined in k steps. Starting from the first nearest observation of the test point, the algorithm identifies a single observation that is closest to the observation at the previous step. At each base learner in the ensemble, this search is extended to k steps on a random bootstrap sample with a random subset of features selected from the feature space. The final predicted class of the test point is determined by using a majority vote in the predicted classes given by all base models. Amjad Ali, Muhammad Hamraz, Naz Gul, Dost Muhammad Khan, Saeed Aldahmani, Zardad Khan (2022) <doi:10.48550/arXiv.2205.15111>.

Fits up to 20 nonlinear lactation curve models to dairy animal milk yield data. Models fitted include exponential, polynomial, mixed logarithmic, inverse polynomial, and sigmoid families published between 1923 and 2000. Supports batch processing of multiple animals from a single CSV file, with flexible selection of animals and models. Produces per-animal parameter tables, goodness-of-fit metrics including R-squared (R2), Root Mean Square Error (RMSE), Akaike Information Criterion (AIC), Bayesian Information Criterion (BIC), and a serial autocorrelation statistic, 15 diagnostic figures, and combined cross-animal comparison outputs. References: <doi:10.1085/jgp.5.4.441>, <doi:10.1038/216164a0>, <doi:10.1016/0301-6226(87)90003-0>, <doi:10.4141/cjas87-067>, <doi:10.3168/jds.S0022-0302(00)75136-8>.

Non-proportional hazard (NPH) is commonly observed in immuno-oncology studies, where the survival curves of the treatment and control groups show delayed separation. To properly account for NPH, several statistical methods have been developed. One such method is Max-Combo test, which is a straightforward and flexible hypothesis testing method that can simultaneously test for constant, early, middle, and late treatment effects. However, the majority of the Max-Combo test performed in clinical studies are unstratified, ignoring the important prognostic stratification factors. To fill this gap, we have developed an R package for stratified Max-Combo testing that accounts for stratified baseline factors. Our package explores various methods for calculating combined test statistics, estimating joint distributions, and determining the p-values.

This package provides a nomogram, which can be carried out in rms package, provides a graphical explanation of a prediction process. However, it is not very easy to draw straight lines, read points and probabilities accurately. Even, it is hard for users to calculate total points and probabilities for all subjects. This package provides formula_rd() and formula_lp() functions to fit the formula of total points with raw data and linear predictors respectively by polynomial regression. Function points_cal() will help you calculate the total points. prob_cal() can be used to calculate the probabilities after lrm(), cph() or psm() regression. For more complex condition, interaction or restricted cubic spine, TotalPoints.rms() can be used.

This package implements two iterative techniques called T3Clus and 3Fkmeans, aimed at simultaneously clustering objects and a factorial dimensionality reduction of variables and occasions on three-mode datasets developed by Vichi et al. (2007) <doi:10.1007/s00357-007-0006-x>. Also, we provide a convex combination of these two simultaneous procedures called CT3Clus and based on a hyperparameter alpha (alpha in [0,1], with 3FKMeans for alpha=0 and T3Clus for alpha= 1) also developed by Vichi et al. (2007) <doi:10.1007/s00357-007-0006-x>. Furthermore, we implemented the traditional tandem procedures of T3Clus (TWCFTA) and 3FKMeans (TWFCTA) for sequential clustering-factorial decomposition (TWCFTA), and vice-versa (TWFCTA) proposed by P. Arabie and L. Hubert (1996) <doi:10.1007/978-3-642-79999-0_1>.

Facilitates some of the analyses performed in studies of behavioral economic discounting. The package supports scoring of the 27-Item Monetary Choice Questionnaire (see Kaplan et al., 2016; <doi:10.1007/s40614-016-0070-9>), calculating k values (Mazur's simple hyperbolic and exponential) using nonlinear regression, calculating various Area Under the Curve (AUC) measures, plotting regression curves for both fit-to-group and two-stage approaches, checking for unsystematic discounting (Johnson & Bickel, 2008; <doi:10.1037/1064-1297.16.3.264>) and scoring of the minute discounting task (see Koffarnus & Bickel, 2014; <doi:10.1037/a0035973>) using the Qualtrics 5-trial discounting template (see the Qualtrics Minute Discounting User Guide; <doi:10.13140/RG.2.2.26495.79527>), which is also available as a .qsf file in this package.

Supporting the quantitative analysis of binary welfare based decision making processes using Monte Carlo simulations. Decision support is given on two levels: (i) The actual decision level is to choose between two alternatives under probabilistic uncertainty. This package calculates the optimal decision based on maximizing expected welfare. (ii) The meta decision level is to allocate resources to reduce the uncertainty in the underlying decision problem, i.e to increase the current information to improve the actual decision making process. This problem is dealt with using the Value of Information Analysis. The Expected Value of Information for arbitrary prospective estimates can be calculated as well as Individual Expected Value of Perfect Information. The probabilistic calculations are done via Monte Carlo simulations. This Monte Carlo functionality can be used on its own.

Package graphicx provides a useful keyword viewport which allows to show just a part of an image. However, one needs to put there the actual coordinates of the viewport window. Sometimes it is useful to have relative coordinates as fractions of natural size. For example, one may want to print a large image on a spread, putting a half on a verso page, and another half on the next recto page. For this one would need a viewport occupying exactly one half of the file's bounding box, whatever the actual width of the image may be. This package adds a new keyword rviewport to the graphicx package specifying relative viewport for graphics inclusion: a window defined by the given fractions of the natural width and height of the image.