Design dose escalation using Bayesian logistic regression modeling in Phase I oncology trial.

Bayesian methods for predicting the calendar time at which a target number of events is reached in clinical trials. The methodology applies to both blinded and unblinded settings and jointly models enrollment, event-time, and censoring processes. The package provides tools for trial data simulation, model fitting using Stan via the rstan interface, and event time prediction under a wide range of trial designs, including varying sample sizes, enrollment patterns, treatment effects, and event or censoring time distributions. The package is intended to support interim monitoring, operational planning, and decision-making in clinical trial development. Methods are described in Fu et al. (2025) <doi:10.1002/sim.70310>.

This package provides tools to design best-worst scaling designs (i.e., balanced incomplete block designs) and to analyze data from these designs, using aggregate and individual methods such as: difference scores, Louviere, Lings, Islam, Gudergan, & Flynn (2013) <doi:10.1016/j.ijresmar.2012.10.002>; analytical estimation, Lipovetsky & Conklin (2014) <doi:10.1016/j.jocm.2014.02.001>; empirical Bayes, Lipovetsky & Conklin (2015) <doi:10.1142/S1793536915500028>; Elo, Hollis (2018) <doi:10.3758/s13428-017-0898-2>; and network-based measures.

Analysis of relative cell type proportions in bulk gene expression data. Provides a well-validated set of brain cell type-specific marker genes derived from multiple types of experiments, as described in McKenzie (2018) <doi:10.1038/s41598-018-27293-5>. For brain tissue data sets, there are marker genes available for astrocytes, endothelial cells, microglia, neurons, oligodendrocytes, and oligodendrocyte precursor cells, derived from each of human, mice, and combination human/mouse data sets. However, if you have access to your own marker genes, the functions can be applied to bulk gene expression data from any tissue. Also implements multiple options for relative cell type proportion estimation using these marker genes, adapting and expanding on approaches from the CellCODE R package described in Chikina (2015) <doi:10.1093/bioinformatics/btv015>. The number of cell type marker genes used in a given analysis can be increased or decreased based on your preferences and the data set. Finally, provides functions to use the estimates to adjust for variability in the relative proportion of cell types across samples prior to downstream analyses.

Bayesian approach to multidimensional scaling. The package consists of implementations of the methods of Oh and Raftery (2001) <doi:10.1198/016214501753208690>.

Collection of tools to work with European basketball data. Functions available are related to friendly web scraping, data management and visualization. Data were obtained from <https://www.euroleaguebasketball.net/euroleague/>, <https://www.euroleaguebasketball.net/eurocup/> and <https://www.acb.com/>, following the instructions of their respectives robots.txt files, when available. Box score data are available for the three leagues. Play-by-play and spatial shooting data are also available for the Spanish league. Methods for analysis include a population pyramid, 2D plots, circular plots of players percentiles, plots of players monthly/yearly stats, team heatmaps, team shooting plots, team four factors plots, cross-tables with the results of regular season games, maps of nationalities, combinations of lineups, possessions-related variables, timeouts, performance by periods, personal fouls, offensive rebounds and different types of shooting charts. Please see Vinue (2020) <doi:10.1089/big.2018.0124> and Vinue (2024) <doi:10.1089/big.2023.0177>.

Noise filter based on determining the proportion of neighboring points. A false point will be rejected if it has only few neighbors, but accepted if the proportion of neighbors in a rectangular frame is high. The size of the rectangular frame as well as the cut-off value, i.e. of a minimum proportion of neighbor-points, may be supplied or can be calculated automatically. Originally designed for the cleaning of heart rates, but suitable for filtering any slowly-changing physiological variable.For more information see Signer (2010)<doi:10.1111/j.2041-210X.2009.00010.x>.

Specify and fit the Bradley-Terry model, including structured versions in which the parameters are related to explanatory variables through a linear predictor and versions with contest-specific effects, such as a home advantage.

Bagging bandwidth selection methods for the Parzen-Rosenblatt and Nadaraya-Watson estimators. These bandwidth selectors can achieve greater statistical precision than their non-bagged counterparts while being computationally fast. See Barreiro-Ures et al. (2020) <doi:10.1093/biomet/asaa092> and Barreiro-Ures et al. (2021) <doi:10.48550/arXiv.2105.04134>.

This package contains a split population survival estimator that models the misclassification probability of failure versus right-censored events. The split population survival estimator is described in Bagozzi et al. (2019) <doi:10.1017/pan.2019.6>.

For a series of binary responses, create stopping boundary with exact results after stopping, allowing updating for missing assessments.

Decision tree algorithm with a major feature added. Allows for users to define an ordering on the partitioning process. Resulting in Branch-Exclusive Splits Trees (BEST). Cedric Beaulac and Jeffrey S. Rosentahl (2019) <arXiv:1804.10168>.

Enables off-the-shelf functionality for fully Bayesian, nonstationary Gaussian process modeling. The approach to nonstationary modeling involves a closed-form, convolution-based covariance function with spatially-varying parameters; these parameter processes can be specified either deterministically (using covariates or basis functions) or stochastically (using approximate Gaussian processes). Stationary Gaussian processes are a special case of our methodology, and we furthermore implement approximate Gaussian process inference to account for very large spatial data sets (Finley, et al (2017) <doi:10.48550/arXiv.1702.00434>). Bayesian inference is carried out using Markov chain Monte Carlo methods via the "nimble" package, and posterior prediction for the Gaussian process at unobserved locations is provided as a post-processing step.

US baby names provided by the SSA. This package contains all names used for at least 5 children of either sex.

Calculates nonparametric pointwise confidence intervals for the survival distribution for right censored data, and for medians [Fay and Brittain <DOI:10.1002/sim.6905>]. Has two-sample tests for dissimilarity (e.g., difference, ratio or odds ratio) in survival at a fixed time, and differences in medians [Fay, Proschan, and Brittain <DOI:10.1111/biom.12231>]. Basically, the package gives exact inference methods for one- and two-sample exact inferences for Kaplan-Meier curves (e.g., generalizing Fisher's exact test to allow for right censoring), which are especially important for latter parts of the survival curve, small sample sizes or heavily censored data. Includes mid-p options.

The backfill Bayesian optimal interval design using efficacy and toxicity outcomes for dose optimization (BF-BOIN-ET) design is a novel clinical trial design to allow patients to be backfilled at lower doses during a dose-finding trial while prioritizing the dose-escalation cohort to explore a higher dose. The advantages compared to the other designs in terms of the percentage of correct optimal dose (OD) selection, reducing the sample size, and shortening the duration of the trial, in various realistic setting.

This package provides a Bayesian data modeling scheme that performs four interconnected tasks: (i) characterizes the uncertainty of the elicited parametric prior; (ii) provides exploratory diagnostic for checking prior-data conflict; (iii) computes the final statistical prior density estimate; and (iv) executes macro- and micro-inference. Primary reference is Mukhopadhyay, S. and Fletcher, D. 2018 paper "Generalized Empirical Bayes via Frequentist Goodness of Fit" (<https://www.nature.com/articles/s41598-018-28130-5 >).

This package provides a fast and intuitive batch effect removal tool for single-cell data. BBKNN is originally used in the scanpy python package, and now can be used with Seurat seamlessly.

This package provides users with its associated functions for pedagogical purposes in visually learning Bayesian networks and Markov chain Monte Carlo (MCMC) computations. It enables users to: a) Create and examine the (starting) graphical structure of Bayesian networks; b) Create random Bayesian networks using a dataset with customized constraints; c) Generate Stan code for structures of Bayesian networks for sampling the data and learning parameters; d) Plot the network graphs; e) Perform Markov chain Monte Carlo computations and produce graphs for posteriors checks. The package refers to one reference item, which describes the methods and algorithms: Vuong, Quan-Hoang and La, Viet-Phuong (2019) <doi:10.31219/osf.io/w5dx6> The bayesvl R package. Open Science Framework (May 18).

Create a blended curve from two survival curves, which is particularly useful for survival extrapolation in health technology assessment. The main idea is to mix a flexible model that fits the observed data well with a parametric model that encodes assumptions about long-term survival. The two curves are blended into a single survival curve that is identical to the first model over the range of observed times and gradually approaches the parametric model over the extrapolation period based on a given weight function. This approach allows for the inclusion of external information, such as data from registries or expert opinion, to guide long-term extrapolations, especially when dealing with immature trial data. See Che et al. (2022) <doi:10.1177/0272989X221134545>.

Code for backShift', an algorithm to estimate the connectivity matrix of a directed (possibly cyclic) graph with hidden variables. The underlying system is required to be linear and we assume that observations under different shift interventions are available. For more details, see <arXiv:1506.02494>.

This package provides functions to create side-by-side boxplots for a continuous variable grouped by a two-level categorical variable, check normality assumptions using the Shapiro-Wilk test (Shapiro and Wilk (1965) <doi:10.2307/2333709>), and perform appropriate statistical tests such as the independent two-sample t-test (Student (1908) <doi:10.1093/biomet/6.1.1>) or the Mannâ Whitney U test ( Mannâ Whitney (1947) <doi:10.1214/aoms/1177730491>). Returns a publication-ready plot and test statistics including test statistic, degrees of freedom, and p-value.

Typically, models in R exist in memory and can be saved via regular R serialization. However, some models store information in locations that cannot be saved using R serialization alone. The goal of bundle is to provide a common interface to capture this information, situate it within a portable object, and restore it for use in new settings.

This package implements regression models for binary data on the absolute risk scale. These models are applicable to cohort and population-based case-control data.