Generate continuous (normal, non-normal, or mixture distributions), binary, ordinal, and count (regular or zero-inflated, Poisson or Negative Binomial) variables with a specified correlation matrix, or one continuous variable with a mixture distribution. This package can be used to simulate data sets that mimic real-world clinical or genetic data sets (i.e., plasmodes, as in Vaughan et al., 2009 <DOI:10.1016/j.csda.2008.02.032>). The methods extend those found in the SimMultiCorrData R package. Standard normal variables with an imposed intermediate correlation matrix are transformed to generate the desired distributions. Continuous variables are simulated using either Fleishman (1978)'s third order <DOI:10.1007/BF02293811> or Headrick (2002)'s fifth order <DOI:10.1016/S0167-9473(02)00072-5> polynomial transformation method (the power method transformation, PMT). Non-mixture distributions require the user to specify mean, variance, skewness, standardized kurtosis, and standardized fifth and sixth cumulants. Mixture distributions require these inputs for the component distributions plus the mixing probabilities. Simulation occurs at the component level for continuous mixture distributions. The target correlation matrix is specified in terms of correlations with components of continuous mixture variables. These components are transformed into the desired mixture variables using random multinomial variables based on the mixing probabilities. However, the package provides functions to approximate expected correlations with continuous mixture variables given target correlations with the components. Binary and ordinal variables are simulated using a modification of ordsample() in package GenOrd'. Count variables are simulated using the inverse CDF method. There are two simulation pathways which calculate intermediate correlations involving count variables differently. Correlation Method 1 adapts Yahav and Shmueli's 2012 method <DOI:10.1002/asmb.901> and performs best with large count variable means and positive correlations or small means and negative correlations. Correlation Method 2 adapts Barbiero and Ferrari's 2015 modification of the GenOrd package <DOI:10.1002/asmb.2072> and performs best under the opposite scenarios. The optional error loop may be used to improve the accuracy of the final correlation matrix. The package also contains functions to calculate the standardized cumulants of continuous mixture distributions, check parameter inputs, calculate feasible correlation boundaries, and summarize and plot simulated variables.

Publication bias, the fact that studies identified for inclusion in a meta analysis do not represent all studies on the topic of interest, is commonly recognized as a threat to the validity of the results of a meta analysis. One way to explicitly model publication bias is via selection models or weighted probability distributions. In this package we provide implementations of several parametric and nonparametric weight functions. The novelty in Rufibach (2011) is the proposal of a non-increasing variant of the nonparametric weight function of Dear & Begg (1992). The new approach potentially offers more insight in the selection process than other methods, but is more flexible than parametric approaches. To maximize the log-likelihood function proposed by Dear & Begg (1992) under a monotonicity constraint we use a differential evolution algorithm proposed by Ardia et al (2010a, b) and implemented in Mullen et al (2009). In addition, we offer a method to compute a confidence interval for the overall effect size theta, adjusted for selection bias as well as a function that computes the simulation-based p-value to assess the null hypothesis of no selection as described in Rufibach (2011, Section 6).

Evaluating the consistency assumption of Network Meta-Analysis both globally and locally in the Bayesian framework. Inconsistencies are located by applying Bayesian variable selection to the inconsistency factors. The implementation of the method is described by Seitidis et al. (2023) <doi:10.1002/sim.9891>.

Efficient Markov chain Monte Carlo (MCMC) algorithms for fully Bayesian estimation of time-varying parameter models with shrinkage priors, both dynamic and static. Details on the algorithms used are provided in Bitto and Frühwirth-Schnatter (2019) <doi:10.1016/j.jeconom.2018.11.006> and Cadonna et al. (2020) <doi:10.3390/econometrics8020020> and Knaus and Frühwirth-Schnatter (2023) <doi:10.48550/arXiv.2312.10487>. For details on the package, please see Knaus et al. (2021) <doi:10.18637/jss.v100.i13>. For the multivariate extension, see the shrinkTVPVAR package.

More easy to get intersection, union or complementary set and combinations.

This package implements multi-study learning algorithms such as merging, the study-specific ensemble (trained-on-observed-studies ensemble) the study strap, the covariate-matched study strap, covariate-profile similarity weighting, and stacking weights. Embedded within the caret framework, this package allows for a wide range of single-study learners (e.g., neural networks, lasso, random forests). The package offers over 20 default similarity measures and allows for specification of custom similarity measures for covariate-profile similarity weighting and an accept/reject step. This implements methods described in Loewinger, Kishida, Patil, and Parmigiani. (2019) <doi:10.1101/856385>.

User-friendly functions which parse output of command line programs used to query Slurm. Morris A. Jette and Tim Wickberg (2023) <doi:10.1007/978-3-031-43943-8_1> describe Slurm in detail.

This package creates and fits staged event tree probability models, which are probabilistic graphical models capable of representing asymmetric conditional independence statements for categorical variables. Includes functions to create, plot and fit staged event trees from data, as well as many efficient structure learning algorithms. References: Carli F, Leonelli M, Riccomagno E, Varando G (2022). <doi: 10.18637/jss.v102.i06>. Collazo R. A., Görgen C. and Smith J. Q. (2018, ISBN:9781498729604). Görgen C., Bigatti A., Riccomagno E. and Smith J. Q. (2018) <arXiv:1705.09457>. Thwaites P. A., Smith, J. Q. (2017) <arXiv:1510.00186>. Barclay L. M., Hutton J. L. and Smith J. Q. (2013) <doi:10.1016/j.ijar.2013.05.006>. Smith J. Q. and Anderson P. E. (2008) <doi:10.1016/j.artint.2007.05.004>.

This package performs Stratified Covariate Balancing with Markov blanket feature selection and use of synthetic cases. See Alemi et al. (2016) <DOI:10.1111/1475-6773.12628>.

This package contains functions that fit linear mixed-effects models for high-dimensional data (p>>n) with penalty for both the fixed effects and random effects for variable selection. The details of the algorithm can be found in Luoying Yang PhD thesis (Yang and Wu 2020). The algorithm implementation is based on the R package lmmlasso'. Reference: Yang L, Wu TT (2020). Model-Based Clustering of Longitudinal Data in High-Dimensionality. Unpublished thesis.

Calculates ratings for two-player or multi-player challenges. Methods included in package such as are able to estimate ratings (players strengths) and their evolution in time, also able to predict output of challenge. Algorithms are based on Bayesian Approximation Method, and they don't involve any matrix inversions nor likelihood estimation. Parameters are updated sequentially, and computation doesn't require any additional RAM to make estimation feasible. Additionally, base of the package is written in C++ what makes sport computation even faster. Methods used in the package refer to Mark E. Glickman (1999) <https://www.glicko.net/research/glicko.pdf>; Mark E. Glickman (2001) <doi:10.1080/02664760120059219>; Ruby C. Weng, Chih-Jen Lin (2011) <https://www.jmlr.org/papers/volume12/weng11a/weng11a.pdf>; W. Penny, Stephen J. Roberts (1999) <doi:10.1109/IJCNN.1999.832603>.

Implementation of the boosting procedure with the simulation and extrapolation approach to address variable selection and estimation for high-dimensional data subject to measurement error in predictors. It can be used to address generalized linear models (GLM) in Chen (2023) <doi: 10.1007/s11222-023-10209-3> and the accelerated failure time (AFT) model in Chen and Qiu (2023) <doi: 10.1111/biom.13898>. Some relevant references include Chen and Yi (2021) <doi:10.1111/biom.13331> and Hastie, Tibshirani, and Friedman (2008, ISBN:978-0387848570).

Phenotypic analysis of field trials using mixed models with and without spatial components. One of a series of statistical genetic packages for streamlining the analysis of typical plant breeding experiments developed by Biometris. Some functions have been created to be used in conjunction with the R package asreml for the ASReml software, which can be obtained upon purchase from VSN international (<https://vsni.co.uk/software/asreml-r/>).

Newly developed methods for the estimation of several probabilities in an illness-death model. The package can be used to obtain nonparametric and semiparametric estimates for: transition probabilities, occupation probabilities, cumulative incidence function and the sojourn time distributions. Additionally, it is possible to fit proportional hazards regression models in each transition of the Illness-Death Model. Several auxiliary functions are also provided which can be used for marginal estimation of the survival functions.

Facilitate the evaluation of forecasts in a convenient framework based on data.table. It allows user to to check their forecasts and diagnose issues, to visualise forecasts and missing data, to transform data before scoring, to handle missing forecasts, to aggregate scores, and to visualise the results of the evaluation. The package mostly focuses on the evaluation of probabilistic forecasts and allows evaluating several different forecast types and input formats. Find more information about the package in the Vignettes as well as in the accompanying paper, <doi:10.48550/arXiv.2205.07090>.

Fits semiparametric linear and multilevel models with non-parametric additive Bayesian additive regression tree (BART; Chipman, George, and McCulloch (2010) <doi:10.1214/09-AOAS285>) components and Stan (Stan Development Team (2021) <https://mc-stan.org/>) sampled parametric ones. Multilevel models can be expressed using lme4 syntax (Bates, Maechler, Bolker, and Walker (2015) <doi:10.18637/jss.v067.i01>).

Generates synonyms from a given word drawing from a synonym list from the moby project <http://moby-thesaurus.org/>.

An exact method for computing the Poisson-Binomial Distribution (PBD). The package provides a function for generating a random sample from the PBD, as well as two distinct approaches for computing the density, distribution, and quantile functions of the PBD. The first method uses direct-convolution, or a dynamic-programming approach which is numerically stable but can be slow for a large input due to its quadratic complexity. The second method is much faster on large inputs thanks to its use of Fast Fourier Transform (FFT) based convolutions. Notably in this case the package uses an exponential shift to practically guarantee the relative accuracy of the computation of an arbitrarily small tail of the PBD -- something that FFT-based methods often struggle with. This ShiftConvolvePoiBin method is described in Peres, Lee and Keich (2020) <arXiv:2004.07429> where it is also shown to be competitive with the fastest implementations for exactly computing the entire Poisson-Binomial distribution.

This package provides functions to calculate some point estimators and estimate their variance under unequal probability sampling without replacement. Single and two-stage sampling designs are considered. Some approximations for the second-order inclusion probabilities (joint inclusion probabilities) are available (sample and population based). A variety of Jackknife variance estimators are implemented. Almost every function is written in C (compiled) code for faster results. The functions incorporate some performance improvements for faster results with large datasets.

This package provides a framework for evaluating drug combination effects in preclinical in vivo studies. SynergyLMM provides functions to analyze longitudinal tumor growth experiments using mixed-effects models, perform time-resolved analyses of synergy and antagonism, evaluate model diagnostics and performance, and assess both post-hoc and a priori statistical power. The calculation of drug combination synergy follows the statistical framework provided by Demidenko and Miller (2019, <doi:10.1371/journal.pone.0224137>). The implementation and analysis of linear mixed-effect models is based on the methods described by Pinheiro and Bates (2000, <doi:10.1007/b98882>), and GaÅ ecki and Burzykowski (2013, <doi:10.1007/978-1-4614-3900-4>).

When comparing single cases to control populations and no parameters are known researchers and clinicians must estimate these with a control sample. This is often done when testing a case's abnormality on some variable or testing abnormality of the discrepancy between two variables. Appropriate frequentist and Bayesian methods for doing this are here implemented, including tests allowing for the inclusion of covariates. These have been developed first and foremost by John Crawford and Paul Garthwaite, e.g. in Crawford and Howell (1998) <doi:10.1076/clin.12.4.482.7241>, Crawford and Garthwaite (2005) <doi:10.1037/0894-4105.19.3.318>, Crawford and Garthwaite (2007) <doi:10.1080/02643290701290146> and Crawford, Garthwaite and Ryan (2011) <doi:10.1016/j.cortex.2011.02.017>. The package is also equipped with power calculators for each method.

Interactive visualizations of graphs created with the igraph package using a htmlwidgets wrapper for the sigma.js network visualization v2.4.0 <https://www.sigmajs.org/>, enabling to display several thousands of nodes. While several R packages have been developed to interface sigma.js', all were developed for v1.x.x and none have migrated to v2.4.0 nor are they planning to. This package builds upon the sigmaNet package, and users familiar with it will recognize the similar design approach. Two extensions have been added to the classic sigma.js visualizations by overriding the underlying JavaScript code, enabling to draw a frame around node labels, and to display labels on multiple lines by parsing line breaks. Other additional functionalities that did not require overriding sigma.js code include toggling node visibility when clicked using a node attribute and highlighting specific edges. sigma.js is currently preparing a stable release v3.0.0, and this package plans to update to it when it is available.

Programs for analyzing large-scale time series data. They include functions for automatic specification and estimation of univariate time series, for clustering time series, for multivariate outlier detections, for quantile plotting of many time series, for dynamic factor models and for creating input data for deep learning programs. Examples of using the package can be found in the Wiley book Statistical Learning with Big Dependent Data by Daniel Peña and Ruey S. Tsay (2021). ISBN 9781119417385.

This package performs multiple testing corrections that take specific structure of hypotheses into account, as described in Sankaran & Holmes (2014) <doi:10.18637/jss.v059.i13>.