The Ziggurat pseudo-random number generator (or PRNG) offers a lightweight and very fast PRNG for the normal, exponential, and uniform distributions. It is provided here in a small zero-dependency package. It can be used from R as well as from C/C++ code in other packages as is demonstrated by four included sample packages using four distinct methods to use the PRNG presented here in client package.

Rapidly create a GUI for a function you created by automatically creating widgets for arguments of the function. This package automatically parses help routines for context-sensitive help to these arguments. The interface is essentially a wrapper to some Tcl/Tk routines to both simplify and facilitate GUI creation. More advanced Tcl/Tk routines/GUI objects can be incorporated into the interface for greater customization for the more experienced.

bnem combines the use of indirect measurements of Nested Effects Models (package mnem) with the Boolean networks of CellNOptR. Perturbation experiments of signalling nodes in cells are analysed for their effect on the global gene expression profile. Those profiles give evidence for the Boolean regulation of down-stream nodes in the network, e.g., whether two parents activate their child independently (OR-gate) or jointly (AND-gate).

Network meta-analyses using Bayesian framework following Dias et al. (2013) <DOI:10.1177/0272989X12458724>. Based on the data input, creates prior, model file, and initial values needed to run models in rjags'. Able to handle binomial, normal and multinomial arm-level data. Can handle multi-arm trials and includes methods to incorporate covariate and baseline risk effects. Includes standard diagnostics and visualization tools to evaluate the results.

This package provides a collection of functions for calculating the M2 model fit statistic for diagnostic classification models as described by Liu et al. (2016) <DOI:10.3102/1076998615621293>. These functions provide multiple sources of information for model fit according to the M2 statistic, including the M2 statistic, the *p* value for that M2 statistic, and the Root Mean Square Error of Approximation based on the M2 statistic.

An implementation by Chen, Li, and Zhang (2022) <doi: 10.1093/bioadv/vbac041> of the Depth Importance in Precision Medicine (DIPM) method in Chen and Zhang (2022) <doi:10.1093/biostatistics/kxaa021> and Chen and Zhang (2020) <doi:10.1007/978-3-030-46161-4_16>. The DIPM method is a classification tree that searches for subgroups with especially poor or strong performance in a given treatment group.

The automated clustering and quantification of the digital PCR data is based on the combination of DBSCAN (Hahsler et al. (2019) <doi:10.18637/jss.v091.i01>) and c-means (Bezdek et al. (1981) <doi:10.1007/978-1-4757-0450-1>) algorithms. The analysis is independent of multiplexing geometry, dPCR system, and input amount. The details about input data and parameters are available in the vignette.

An implementation of European Forestry Dynamics Model (EFDM) and an estimation algorithm for the transition probabilities. The EFDM is a large-scale forest model that simulates the development of the forest and estimates volume of wood harvested for any given forested area. This estimate can be broken down by, for example, species, site quality, management regime and ownership category. See Packalen et al. (2015) <doi:10.2788/153990>.

This package provides access to a range of functions for computing and visualizing the Full Bayesian Significance Test (FBST) and the e-value for testing a sharp hypothesis against its alternative, and the Full Bayesian Evidence Test (FBET) and the (generalized) Bayesian evidence value for testing a composite (or interval) hypothesis against its alternative. The methods are widely applicable as long as a posterior MCMC sample is available.

This package provides the following types of models: Models for contingency tables (i.e. log-linear models) Graphical Gaussian models for multivariate normal data (i.e. covariance selection models) Mixed interaction models. Documentation about gRim is provided by vignettes included in this package and the book by Højsgaard, Edwards and Lauritzen (2012, <doi:10.1007/978-1-4614-2299-0>); see citation("gRim") for details.

Two-step modeling with separation of sources of variation through analysis of variance and subsequent multivariate modeling through a range of unsupervised and supervised statistical methods. Separation can focus on removal of interfering effects or isolation of effects of interest. EF Mosleth et al. (2021) <doi:10.1038/s41598-021-82388-w> and EF Mosleth et al. (2020) <doi:10.1016/B978-0-12-409547-2.14882-6>.

Automated General-to-Specific (GETS) modelling of the mean and variance of a regression, and indicator saturation methods for detecting and testing for structural breaks in the mean, see Pretis, Reade and Sucarrat (2018) <doi:10.18637/jss.v086.i03> for an overview of the package. In advanced use, the estimator and diagnostics tests can be fully user-specified, see Sucarrat (2021) <doi:10.32614/RJ-2021-024>.

This package provides functions to implement a hierarchical approach which is designed to perform joint analysis of summary statistics using the framework of Mendelian Randomization or transcriptome analysis. Reference: Lai Jiang, Shujing Xu, Nicholas Mancuso, Paul J. Newcombe, David V. Conti (2020). "A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis." <bioRxiv><doi:10.1101/2020.02.03.924241>.

This package provides seamless access to the WEkEO Harmonised Data Access (HDA) API, enabling users to query, download, and process data efficiently from the HDA platform. With hdar', researchers and data scientists can integrate the extensive HDA datasets into their R workflows, enhancing their data analysis capabilities. Comprehensive information on the API functionality and usage is available at <https://gateway.prod.wekeo2.eu/hda-broker/docs>.

An R package that implements the JICO algorithm [Wang, P., Wang, H., Li, Q., Shen, D., & Liu, Y. (2024). <Journal of Computational and Graphical Statistics, 33(3), 763-773>]. It aims at solving the multi-group regression problem. The algorithm decomposes the responses from multiple groups into shared and group-specific components, which are driven by low-rank approximations of joint and individual structures from the covariates respectively.

Conduct a noncompartmental analysis with industrial strength. Some features are 1) CDISC SDTM terms 2) Automatic or manual slope selection 3) Supporting both linear-up linear-down and linear-up log-down method 4) Interval(partial) AUCs with linear or log interpolation method 5) Produce pdf, rtf, text report files. * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

Fitting of non-parametric production frontiers for use in efficiency analysis. Methods are provided for both a smooth analogue of Data Envelopment Analysis (DEA) and a non-parametric analogue of Stochastic Frontier Analysis (SFA). Frontiers are constructed for multiple inputs and a single output using constrained kernel smoothing as in Racine et al. (2009), which allow for the imposition of monotonicity and concavity constraints on the estimated frontier.

Similarity Weighted Nonnegative Embedding (SWNE) is a method for visualizing high dimensional datasets. SWNE uses Nonnegative Matrix Factorization to decompose datasets into latent factors, projects those factors onto 2 dimensions, and embeds samples and key features in 2 dimensions relative to the factors. SWNE can capture both the local and global dataset structure, and allows relevant features to be embedded directly onto the visualization, facilitating interpretation of the data.

Our approach provides a way to assign continuous cell cycle phase using scRNA-seq data, and consequently, allows to identify cyclic trend of gene expression levels along the cell cycle. This package provides method and training data, which includes scRNA-seq data collected from 6 individual cell lines of induced pluripotent stem cells (iPSCs), and also continuous cell cycle phase derived from FUCCI fluorescence imaging data.

An implementation of best subset selection in generalized linear model and Cox proportional hazard model via the primal dual active set algorithm proposed by Wen, C., Zhang, A., Quan, S. and Wang, X. (2020) <doi:10.18637/jss.v094.i04>. The algorithm formulates coefficient parameters and residuals as primal and dual variables and utilizes efficient active set selection strategies based on the complementarity of the primal and dual variables.

This package provides tools for identifying subgroups within populations based on individual response patterns to specific interventions or treatments. Designed to support researchers and clinicians in exploring heterogeneous treatment effects and developing personalized therapeutic strategies. Offers functionality for analyzing and visualizing the interplay between two variables, thereby enhancing the interpretation of social sustainability metrics. The package focuses on bivariate discriminant analysis and aims to clarify relationships between indicator variables.

This package provides functions to construct efficient block designs for 3-level factorial experiments in block size 3. The designs ensure the estimation of all main effects and two-factor interactions in minimum number of replications. For more details, see Dey and Mukerjee (2012) <doi:10.1016/j.spl.2012.06.014> and Dash, S., Parsad, R. and Gupta, V.K. (2013) <doi:10.1007/s40003-013-0059-5>.

This package provides routines for the generation of response patterns under unidimensional dichotomous and polytomous computerized adaptive testing (CAT) framework. It holds many standard functions to estimate ability, select the first item(s) to administer and optimally select the next item, as well as several stopping rules. Options to control for item exposure and content balancing are also available (Magis and Barrada (2017) <doi:10.18637/jss.v076.c01>).

This package provides several datasets used throughout the book "Sampling and Data Analysis Using R: Theory and Practice" by Islam (2025, ISBN:978-984-35-8644-5). The datasets support teaching and learning of statistical concepts such as sampling methods, descriptive analysis, estimation and basic data handling. These curated data objects allow instructors, students and researchers to reproduce examples, practice data manipulation and perform hands-on analysis using R.