Conduct a noncompartmental analysis with industrial strength. Some features are 1) CDISC SDTM terms 2) Automatic or manual slope selection 3) Supporting both linear-up linear-down and linear-up log-down method 4) Interval(partial) AUCs with linear or log interpolation method 5) Produce pdf, rtf, text report files. * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

Fitting of non-parametric production frontiers for use in efficiency analysis. Methods are provided for both a smooth analogue of Data Envelopment Analysis (DEA) and a non-parametric analogue of Stochastic Frontier Analysis (SFA). Frontiers are constructed for multiple inputs and a single output using constrained kernel smoothing as in Racine et al. (2009), which allow for the imposition of monotonicity and concavity constraints on the estimated frontier.

bnem combines the use of indirect measurements of Nested Effects Models (package mnem) with the Boolean networks of CellNOptR. Perturbation experiments of signalling nodes in cells are analysed for their effect on the global gene expression profile. Those profiles give evidence for the Boolean regulation of down-stream nodes in the network, e.g., whether two parents activate their child independently (OR-gate) or jointly (AND-gate).

Rapidly create a GUI for a function you created by automatically creating widgets for arguments of the function. This package automatically parses help routines for context-sensitive help to these arguments. The interface is essentially a wrapper to some Tcl/Tk routines to both simplify and facilitate GUI creation. More advanced Tcl/Tk routines/GUI objects can be incorporated into the interface for greater customization for the more experienced.

The Ziggurat pseudo-random number generator (or PRNG) offers a lightweight and very fast PRNG for the normal, exponential, and uniform distributions. It is provided here in a small zero-dependency package. It can be used from R as well as from C/C++ code in other packages as is demonstrated by four included sample packages using four distinct methods to use the PRNG presented here in client package.

This package provides functions to construct efficient block designs for 3-level factorial experiments in block size 3. The designs ensure the estimation of all main effects and two-factor interactions in minimum number of replications. For more details, see Dey and Mukerjee (2012) <doi:10.1016/j.spl.2012.06.014> and Dash, S., Parsad, R. and Gupta, V.K. (2013) <doi:10.1007/s40003-013-0059-5>.

This package provides tools for identifying subgroups within populations based on individual response patterns to specific interventions or treatments. Designed to support researchers and clinicians in exploring heterogeneous treatment effects and developing personalized therapeutic strategies. Offers functionality for analyzing and visualizing the interplay between two variables, thereby enhancing the interpretation of social sustainability metrics. The package focuses on bivariate discriminant analysis and aims to clarify relationships between indicator variables.

An implementation of best subset selection in generalized linear model and Cox proportional hazard model via the primal dual active set algorithm proposed by Wen, C., Zhang, A., Quan, S. and Wang, X. (2020) <doi:10.18637/jss.v094.i04>. The algorithm formulates coefficient parameters and residuals as primal and dual variables and utilizes efficient active set selection strategies based on the complementarity of the primal and dual variables.

This package provides routines for the generation of response patterns under unidimensional dichotomous and polytomous computerized adaptive testing (CAT) framework. It holds many standard functions to estimate ability, select the first item(s) to administer and optimally select the next item, as well as several stopping rules. Options to control for item exposure and content balancing are also available (Magis and Barrada (2017) <doi:10.18637/jss.v076.c01>).

Algorithms for classical symmetric and deflation-based FastICA, reloaded deflation-based FastICA algorithm and an algorithm for adaptive deflation-based FastICA using multiple nonlinearities. For details, see Miettinen et al. (2014) <doi:10.1109/TSP.2014.2356442> and Miettinen et al. (2017) <doi:10.1016/j.sigpro.2016.08.028>. The package is described in Miettinen, Nordhausen and Taskinen (2018) <doi:10.32614/RJ-2018-046>.

Simulation of, and fitting models for, Generalised Network Autoregressive (GNAR) time series models which take account of network structure, potentially with exogenous variables. Such models are described in Knight et al. (2020) <doi:10.18637/jss.v096.i05> and Nason and Wei (2021) <doi:10.1111/rssa.12875>. Diagnostic tools for GNAR(X) models can be found in Nason et al. (2023) <doi:10.48550/arXiv.2312.00530>.

An implementation of maximum simulated likelihood method for the estimation of multinomial logit models with random coefficients as presented by Sarrias and Daziano (2017) <doi:10.18637/jss.v079.i02>. Specifically, it allows estimating models with continuous heterogeneity such as the mixed multinomial logit and the generalized multinomial logit. It also allows estimating models with discrete heterogeneity such as the latent class and the mixed-mixed multinomial logit model.

Fits multiple-group latent class analysis (LCA) for exploring differences between populations in the data with a multilevel structure. There are two approaches to reflect group differences in glca: fixed-effect LCA (Bandeen-Roche et al (1997) <doi:10.1080/01621459.1997.10473658>; Clogg and Goodman (1985) <doi:10.2307/270847>) and nonparametric random-effect LCA (Vermunt (2003) <doi:10.1111/j.0081-1750.2003.t01-1-00131.x>).

Computes the probability density, survival function, the hazard rate functions and generates random samples from the GTDL distribution given by Mackenzie, G. (1996) <doi:10.2307/2348408>. The likelihood estimates, the randomized quantile (Louzada, F., et al. (2020) <doi:10.1109/ACCESS.2020.3040525>) residuals and the normally transformed randomized survival probability (Li,L., et al. (2021) <doi:10.1002/sim.8852>) residuals are obtained for the GTDL model.

Implementation of a class of hierarchical item response theory (IRT) models where both the mean and the variance of latent preferences (ability parameters) may depend on observed covariates. The current implementation includes both the two-parameter latent trait model for binary data and the graded response model for ordinal data. Both are fitted via the Expectation-Maximization (EM) algorithm. Asymptotic standard errors are derived from the observed information matrix.

This package implements an efficient algorithm for fitting the entire regularization path of quantile regression models with elastic-net penalties using a generalized coordinate descent scheme. The framework also supports SCAD and MCP penalties. It is designed for high-dimensional datasets and emphasizes numerical accuracy and computational efficiency. This package implements the algorithms proposed in Tang, Q., Zhang, Y., & Wang, B. (2022) <https://openreview.net/pdf?id=RvwMTDYTOb>.

This package provides a novel machine learning method for plant viruses diagnostic using genome sequencing data. This package includes three different machine learning models, random forest, XGBoost, and elastic net, to train and predict mapped genome samples. Mappability profile and unreliable regions are introduced to the algorithm, and users can build a mappability profile from scratch with functions included in the package. Plotting mapped sample coverage information is provided.

Computes the Lomb-Scargle Periodogram and actogram for evenly or unevenly sampled time series. Includes a randomization procedure to obtain exact p-values. Partially based on C original by Press et al. (Numerical Recipes) and the Python module Astropy. For more information see Ruf, T. (1999). The Lomb-Scargle periodogram in biological rhythm research: analysis of incomplete and unequally spaced time-series. Biological Rhythm Research, 30(2), 178-201.

Basic Setup for Projects in R for Monterey County Office of Education. It contains functions often used in the analysis of education data in the county office including seeing if an item is not in a list, rounding in the manner the general public expects, including logos for districts, switching between district names and their county-district-school codes, accessing the local SQL table and making thematically consistent graphs.

Estimates the multivariate skew-t and nested models, as described in the articles Liseo, B., Parisi, A. (2013). Bayesian inference for the multivariate skew-normal model: a population Monte Carlo approach. Comput. Statist. Data Anal. <doi:10.1016/j.csda.2013.02.007> and in Parisi, A., Liseo, B. (2017). Objective Bayesian analysis for the multivariate skew-t model. Statistical Methods & Applications <doi: 10.1007/s10260-017-0404-0>.

Motivated by changing administrative boundaries over time, the nuts package can convert European regional data with NUTS codes between versions (2006, 2010, 2013, 2016 and 2021) and levels (NUTS 1, NUTS 2 and NUTS 3). The package uses spatial interpolation as in Lam (1983) <doi:10.1559/152304083783914958> based on granular (100m x 100m) area, population and land use data provided by the European Commission's Joint Research Center.

Estimation of panel models for glm-like models: this includes binomial models (logit and probit), count models (poisson and negbin) and ordered models (logit and probit), as described in: Baltagi (2013) Econometric Analysis of Panel Data, ISBN-13:978-1-118-67232-7, Hsiao (2014) Analysis of Panel Data <doi:10.1017/CBO9781139839327> and Croissant and Millo (2018), Panel Data Econometrics with R, ISBN:978-1-118-94918-4.

Simulate and run the Gaussian puff forward atmospheric model in sensor (specific sensor coordinates) or grid (across the grid of a full oil and gas operations site) modes, following Jia, M., Fish, R., Daniels, W., Sprinkle, B. and Hammerling, D. (2024) <doi:10.26434/chemrxiv-2023-hc95q-v3>. Numerous visualization options, including static and animated, 2D and 3D, and a site map generator based on sensor and source coordinates.

An efficient implementation of Scalable Bayesian Rule Lists Algorithm, a competitor algorithm for decision tree algorithms; see Hongyu Yang, Cynthia Rudin, Margo Seltzer (2017) <https://proceedings.mlr.press/v70/yang17h.html>. It builds from pre-mined association rules and have a logical structure identical to a decision list or one-sided decision tree. Fully optimized over rule lists, this algorithm strikes practical balance between accuracy, interpretability, and computational speed.