This package provides a user friendly way to create patient level prediction models using the Observational Medical Outcomes Partnership Common Data Model. Given a cohort of interest and an outcome of interest, the package can use data in the Common Data Model to build a large set of features. These features can then be used to fit a predictive model with a number of machine learning algorithms. This is further described in Reps (2017) <doi:10.1093/jamia/ocy032>.

This package provides some tabulated data to be be referred to in a discussion in a vignette accompanying my upcoming R package playWholeHandDriverPassParams'. In addition to that specific purpose, these may also provide data and illustrate some computational approaches that are relevant to card games like hearts or bridge.This package refers to authentic data from Gregory Stoll <https://gregstoll.com/~gregstoll/bridge/math.html>, and details of performing the probability calculations from Jeremy L. Martin <https://jlmartin.ku.edu/~jlmartin/bridge/basics.pdf>.

Simplify your portfolio optimization process by applying a contemporary modeling way to model and solve your portfolio problems. While most approaches and packages are rather complicated this one tries to simplify things and is agnostic regarding risk measures as well as optimization solvers. Some of the methods implemented are described by Konno and Yamazaki (1991) <doi:10.1287/mnsc.37.5.519>, Rockafellar and Uryasev (2001) <doi:10.21314/JOR.2000.038> and Markowitz (1952) <doi:10.1111/j.1540-6261.1952.tb01525.x>.

Analyzes and modifies metabolomics raw data (generated using Gas Chromatography-Atmospheric Pressure Chemical Ionization-Mass Spectrometry) to correct overloaded signals, i.e. ion intensities exceeding detector saturation leading to a cut-off peak. Data in xcmsRaw format are accepted as input and mzXML files can be processed alternatively. Overloaded signals are detected automatically and modified using an Gaussian or an Isotopic-Ratio approach. Quality control plots are generated and corrected data are stored within the original xcmsRaw or mzXML respectively to allow further processing.

This package provides a hypothesis test and variable selection algorithm for use in time-varying, concurrent regression models. The hypothesis test function is also accompanied by a plotting function which will show the estimated beta(s) and confidence band(s) from the hypothesis test. The hypothesis test function helps the user identify significant covariates within the scope of a time-varying concurrent model. The plots will show the amount of area that falls outside the confidence band(s) which is used for the test statistic within the hypothesis test.

This package provides a client library for Vipul's Razor. Vipul's Razor is a distributed, collaborative, spam detection and filtering network. Through user contribution, Razor establishes a distributed and constantly updating catalogue of spam in propagation that is consulted by email clients to filter out known spam. Detection is done with statistical and randomized signatures that efficiently spot mutating spam content. User input is validated through reputation assignments based on consensus on report and revoke assertions which in turn is used for computing confidence values associated with individual signatures.

Supports propensity score-based methodsâ including matching, stratification, and weightingâ for estimating causal treatment effects. It also implements calibration using negative control outcomes to enhance robustness. debiasedTrialEmulation facilitates effect estimation for both binary and time-to-event outcomes, supporting risk ratio (RR), odds ratio (OR), and hazard ratio (HR) as effect measures. It integrates statistical modeling and visualization tools to assess covariate balance, equipoise, and bias calibration. Additional methodsâ including approaches to address immortal time bias, information bias, selection bias, and informative censoringâ are under development. Users interested in these extended features are encouraged to contact the package authors.

This package provides a brotli decompressor that with an interface avoiding the rust stdlib. This makes it suitable for embedded devices and kernels. It is designed with a pluggable allocator so that the standard lib's allocator may be employed. The default build also includes a stdlib allocator and stream interface. Disable this with --features=no-stdlib. Alternatively, --features=unsafe turns off array bounds checks and memory initialization but provides a safe interface for the caller. Without adding the --features=unsafe argument, all included code is safe. For compression in addition to this library, download https://github.com/dropbox/rust-brotli.

This package provides functions for evaluating and visualizing predictive model performance (specifically: binary classifiers) in the field of customer scoring. These metrics include lift, lift index, gain percentage, top-decile lift, F1-score, expected misclassification cost and absolute misclassification cost. See Berry & Linoff (2004, ISBN:0-471-47064-3), Witten and Frank (2005, 0-12-088407-0) and Blattberg, Kim & Neslin (2008, ISBN:978â 0â 387â 72578â 9) for details. Visualization functions are included for lift charts and gain percentage charts. All metrics that require class predictions offer the possibility to dynamically determine cutoff values for transforming real-valued probability predictions into class predictions.

This package implements the calibrated sensitivity analysis approach for matched observational studies. Our sensitivity analysis framework views matched sets as drawn from a super-population. The unmeasured confounder is modeled as a random variable. We combine matching and model-based covariate-adjustment methods to estimate the treatment effect. The hypothesized unmeasured confounder enters the picture as a missing covariate. We adopt a state-of-art Expectation Maximization (EM) algorithm to handle this missing covariate problem in generalized linear models (GLMs). As our method also estimates the effect of each observed covariate on the outcome and treatment assignment, we are able to calibrate the unmeasured confounder to observed covariates. Zhang, B., Small, D. S. (2018). <arXiv:1812.00215>.

Time series forecasting faces challenges due to the non-stationarity, nonlinearity, and chaotic nature of the data. Traditional deep learning models like Recurrent Neural Network (RNN), Long Short-Term Memory (LSTM), and Gated Recurrent Unit (GRU) process data sequentially but are inefficient for long sequences. To overcome the limitations of these models, we proposed a transformer-based deep learning architecture utilizing an attention mechanism for parallel processing, enhancing prediction accuracy and efficiency. This paper presents user-friendly code for the implementation of the proposed transformer-based deep learning architecture utilizing an attention mechanism for parallel processing. References: Nayak et al. (2024) <doi:10.1007/s40808-023-01944-7> and Nayak et al. (2024) <doi:10.1016/j.simpa.2024.100716>.

This package implements a regularized Bayesian estimator that optimizes the estimation of between-group coefficients for multilevel latent variable models by minimizing mean squared error (MSE) and balancing variance and bias. The package provides more reliable estimates in scenarios with limited data, offering a robust solution for accurate parameter estimation in two-level latent variable models. It is designed for researchers in psychology, education, and related fields who face challenges in estimating between-group effects under small sample sizes and low intraclass correlation coefficients. Dashuk et al. (2024) <doi:10.13140/RG.2.2.18148.39048> derived the optimal regularized Bayesian estimator; Dashuk et al. (2024) <doi:10.13140/RG.2.2.34350.01604> extended it to the multivariate case; and Luedtke et al. (2008) <doi:10.1037/a0012869> formalized the two-level latent variable framework.

Sensitivity analysis for case-control studies in which some cases may meet a more narrow definition of being a case compared to other cases which only meet a broad definition. The sensitivity analyses are described in Small, Cheng, Halloran and Rosenbaum (2013, "Case Definition and Sensitivity Analysis", Journal of the American Statistical Association, 1457-1468). The functions sens.analysis.mh and sens.analysis.aberrant.rank provide sensitivity analyses based on the Mantel-Haenszel test statistic and aberrant rank test statistic as described in Rosenbaum (1991, "Sensitivity Analysis for Matched Case Control Studies", Biometrics); see also Section 1 of Small et al. The function adaptive.case.test provides adaptive inferences as described in Section 5 of Small et al. The function adaptive.noether.brown provides a sensitivity analysis for a matched cohort study based on an adaptive test. The other functions in the package are internal functions.

This package provides functions to delineate temporal dataset shifts in Electronic Health Records through the projection and visualization of dissimilarities among data temporal batches. This is done through the estimation of data statistical distributions over time and their projection in non-parametric statistical manifolds, uncovering the patterns of the data latent temporal variability. EHRtemporalVariability is particularly suitable for multi-modal data and categorical variables with a high number of values, common features of biomedical data where traditional statistical process control or time-series methods may not be appropriate. EHRtemporalVariability allows you to explore and identify dataset shifts through visual analytics formats such as Data Temporal heatmaps and Information Geometric Temporal (IGT) plots. An additional EHRtemporalVariability Shiny app can be used to load and explore the package results and even to allow the use of these functions to those users non-experienced in R coding. (Sáez et al. 2020) <doi:10.1093/gigascience/giaa079>.

This package contains functions to implement automated covariate selection using methods described in the high-dimensional propensity score (HDPS) algorithm by Schneeweiss et.al. Covariate adjustment in real-world-observational-data (RWD) is important for for estimating adjusted outcomes and this can be done by using methods such as, but not limited to, propensity score matching, propensity score weighting and regression analysis. While these methods strive to statistically adjust for confounding, the major challenge is in selecting the potential covariates that can bias the outcomes comparison estimates in observational RWD (Real-World-Data). This is where the utility of automated covariate selection comes in. The functions in this package help to implement the three major steps of automated covariate selection as described by Schneeweiss et. al elsewhere. These three functions, in order of the steps required to execute automated covariate selection are, get_candidate_covariates(), get_recurrence_covariates() and get_prioritised_covariates(). In addition to these functions, a sample real-world-data from publicly available de-identified medical claims data is also available for running examples and also for further exploration. The original article where the algorithm is described by Schneeweiss et.al. (2009) <doi:10.1097/EDE.0b013e3181a663cc> .

Determination of rainfall-runoff erosivity factor.

Documentation at https://melpa.org/#/replace-from-region

Documentation at https://melpa.org/#/run-command-recipes

Binary package needed by the iai-callgrind library

This package is a backend crate for signal-hook.

This package provides an ESS-like binding to send lines or regions to a REPL from Racket buffers.