This package contains 3 maps. 1) US States 2) US Counties 3) Countries of the world.

Are you spending too much time fetching and managing clinical trial data? Struggling with complex queries and bulk data extraction? What if you could simplify this process with just a few lines of code? Introducing clintrialx - Fetch clinical trial data from sources like ClinicalTrials.gov <https://clinicaltrials.gov/> and the Clinical Trials Transformation Initiative - Access to Aggregate Content of ClinicalTrials.gov database <https://aact.ctti-clinicaltrials.org/>, supporting pagination and bulk downloads. Also, you can generate HTML reports based on the data obtained from the sources!

This package contains the R functions needed to perform Cluster-Of-Clusters Analysis (COCA) and Consensus Clustering (CC). For further details please see Cabassi and Kirk (2020) <doi:10.1093/bioinformatics/btaa593>.

This package provides functions for the estimation of conditional copulas models, various estimators of conditional Kendall's tau (proposed in Derumigny and Fermanian (2019a, 2019b, 2020) <doi:10.1515/demo-2019-0016>, <doi:10.1016/j.csda.2019.01.013>, <doi:10.1016/j.jmva.2020.104610>), test procedures for the simplifying assumption (proposed in Derumigny and Fermanian (2017) <doi:10.1515/demo-2017-0011> and Derumigny, Fermanian and Min (2022) <doi:10.1002/cjs.11742>), and measures of non-simplifyingness (proposed in Derumigny (2025) <doi:10.48550/arXiv.2504.07704>).

Computer algebra via the SymPy library (<https://www.sympy.org/>). This makes it possible to solve equations symbolically, find symbolic integrals, symbolic sums and other important quantities.

This package implements lasso and ridge regression for dichotomised outcomes (<doi:10.1080/02664763.2023.2233057>), i.e., numerical outcomes that were transformed to binary outcomes. Such artificial binary outcomes indicate whether an underlying measurement is greater than a threshold.

Estimate one or two cutpoints of a metric or ordinal-scaled variable in the multivariable context of survival data or time-to-event data. Visualise the cutpoint estimation process using contour plots, index plots, and spline plots. It is also possible to estimate cutpoints based on the assumption of a U-shaped or inverted U-shaped relationship between the predictor and the hazard ratio. Govindarajulu, U., and Tarpey, T. (2022) <doi:10.1080/02664763.2020.1846690>.

This package provides a verity of summary tables of the Covid19 cases in San Francisco. Data source: San Francisco, Department of Public Health - Population Health Division <https://datasf.org/opendata/>.

Fits a variety of cure models using excess hazard modeling methodology such as the mixture model proposed by Phillips et al. (2002) <doi:10.1002/sim.1101> The Weibull distribution is used to represent the survival function of the uncured patients; Fits also non-mixture cure model such as the time-to-null excess hazard model proposed by Boussari et al. (2020) <doi:10.1111/biom.13361>.

Composite Kernel Machine Regression based on Likelihood Ratio Test (CKLRT): in this package, we develop a kernel machine regression framework to model the overall genetic effect of a SNP-set, considering the possible GE interaction. Specifically, we use a composite kernel to specify the overall genetic effect via a nonparametric function and we model additional covariates parametrically within the regression framework. The composite kernel is constructed as a weighted average of two kernels, one corresponding to the genetic main effect and one corresponding to the GE interaction effect. We propose a likelihood ratio test (LRT) and a restricted likelihood ratio test (RLRT) for statistical significance. We derive a Monte Carlo approach for the finite sample distributions of LRT and RLRT statistics. (N. Zhao, H. Zhang, J. Clark, A. Maity, M. Wu. Composite Kernel Machine Regression based on Likelihood Ratio Test with Application for Combined Genetic and Gene-environment Interaction Effect (Submitted).).

While individual calibrated radiocarbon dates can span several centuries, combining multiple dates together with any chronological constraints can make a chronology much more robust and precise. This package uses Bayesian methods to enforce the chronological ordering of radiocarbon and other dates, for example for trees with multiple radiocarbon dates spaced at exactly known intervals (e.g., 10 annual rings). For methods see Christen 2003 <doi:10.11141/ia.13.2>. Another example is sites where the relative chronological position of the dates is taken into account - the ages of dates further down a site must be older than those of dates further up (Buck, Kenworthy, Litton and Smith 1991 <doi:10.1017/S0003598X00080534>; Nicholls and Jones 2001 <doi:10.1111/1467-9876.00250>). The paper accompanying this R package is Blaauw et al. 2024 <doi:10.1017/RDC.2024.56>.

The implementation of bias-corrected sandwich variance estimators for the analysis of cluster randomized trials with time-to-event outcomes using the marginal Cox model, proposed by Wang et al. (under review).

This package provides a toolkit for making use of credentials mediated by Posit Connect'. It handles the details of communicating with the Connect API correctly, OAuth token caching, and refresh behaviour.

Make fake data that looks realistic, supporting addresses, person names, dates, times, colors, coordinates, currencies, digital object identifiers ('DOIs'), jobs, phone numbers, DNA sequences, doubles and integers from distributions and within a range.

The main objective of the package is to enter a word of at least two letters based on which an Iterated Function System with Probabilities is constructed, and a two-dimensional fractal containing the chosen word infinitely often is generated via the Chaos Game. Additionally, the package allows to project the two-dimensional fractal on several three-dimensional surfaces and to transform the fractal into another fractal with uniform marginals.

This package performs Correspondence Analysis on the given dataframe and plots the results in a scatterplot that emphasizes the geometric interpretation aspect of the analysis, following Borg-Groenen (2005) and Yelland (2010). It is particularly useful for highlighting the relationships between a selected row (or column) category and the column (or row) categories. See Borg-Groenen (2005, ISBN:978-0-387-28981-6); Yelland (2010) <doi:10.3888/tmj.12-4>.

Implementation of the d/p/q/r family of functions for a continuous analog to the standard discrete binomial with continuous size parameter and continuous support with x in [0, size + 1], following Ilienko (2013) <arXiv:1303.5990>.

This package performs copy number variants association analysis with Lasso and Weighted Fusion penalized regression. Creates a "CNV profile curve" to represent an individualâ s CNV events across a genomic region so to capture variations in CNV length and dosage. When evaluating association, the CNV profile curve is directly used as a predictor in the regression model, avoiding the need to predefine CNV loci. CNV profile regression estimates CNV effects at each genome position, making the results comparable across different studies. The penalization encourages sparsity in variable selection with a Lasso penalty and encourages effect smoothness between consecutive CNV events with a weighted fusion penalty, where the weight controls the level of smoothing between adjacent CNVs. For more details, see Si (2024) <doi:10.1101/2024.11.23.624994>.

This package provides a dynamic programming algorithm for optimal clustering multidimensional data with sequential constraint. The algorithm minimizes the sum of squares of within-cluster distances. The sequential constraint allows only subsequent items of the input data to form a cluster. The sequential constraint is typically required in clustering data streams or items with time stamps such as video frames, GPS signals of a vehicle, movement data of a person, e-pen data, etc. The algorithm represents an extension of Ckmeans.1d.dp to multiple dimensional spaces. Similarly to the one-dimensional case, the algorithm guarantees optimality and repeatability of clustering. Method clustering.sc.dp() can find the optimal clustering if the number of clusters is known. Otherwise, methods findwithinss.sc.dp() and backtracking.sc.dp() can be used. See Szkaliczki, T. (2016) "clustering.sc.dp: Optimal Clustering with Sequential Constraint by Using Dynamic Programming" <doi: 10.32614/RJ-2016-022> for more information.

This package provides tools for analyzing performances of cricketers based on stats in ESPN Cricinfo Statsguru. The toolset can be used for analysis of Tests,ODIs and Twenty20 matches of both batsmen and bowlers. The package can also be used to analyze team performances.

Collection of routines for efficient scientific computations in physics and astrophysics. These routines include utility functions, numerical computation tools, as well as visualisation tools. They can be used, for example, for generating random numbers from spherical and custom distributions, information and entropy analysis, special Fourier transforms, two-point correlation estimation (e.g. as in Landy & Szalay (1993) <doi:10.1086/172900>), binning & gridding of point sets, 2D interpolation, Monte Carlo integration, vector arithmetic and coordinate transformations. Also included is a non-exhaustive list of important constants and cosmological conversion functions. The graphics routines can be used to produce and export publication-ready scientific plots and movies, e.g. as used in Obreschkow et al. (2020, MNRAS Vol 493, Issue 3, Pages 4551â 4569). These routines include special color scales, projection functions, and bitmap handling routines.

Implementation of models to analyse compositional microbiome time series taking into account the interaction between groups of bacteria. The models implemented are described in Creus-Martà et al (2018, ISBN:978-84-09-07541-6), Creus-Martà et al (2021) <doi:10.1155/2021/9951817> and Creus-Martà et al (2022) <doi:10.1155/2022/4907527>.

Allows you to conduct robust correlations on your non-normal data set. The robust correlations included in the package are median-absolute-deviation and median-based correlations. Li, J.C.H. (2022) <doi:10.5964/meth.8467>.

Includes binning categorical variables into lesser number of categories based on t-test, converting categorical variables into continuous features using the mean of the response variable for the respective categories, understanding the relationship between the response variable and predictor variables using data transformations.