This package provides functions to combine data.frames in ways that require additional effort in base R, and to add metadata (id, title, ...) that can be used for printing and xlsx export. The Tatoo_report class is provided as a convenient helper to write several such tables to a workbook, one table per worksheet. Tatoo is built on top of openxlsx', but intimate knowledge of that package is not required to use tatoo.

The Time-Delay Correlation algorithm (TDCor) reconstructs the topology of a gene regulatory network (GRN) from time-series transcriptomic data. The algorithm is described in details in Lavenus et al., Plant Cell, 2015. It was initially developed to infer the topology of the GRN controlling lateral root formation in Arabidopsis thaliana. The time-series transcriptomic dataset which was used in this study is included in the package to illustrate how to use it.

artMS provides a set of tools for the analysis of proteomics label-free datasets. It takes as input the MaxQuant search result output (evidence.txt file) and performs quality control, relative quantification using MSstats, downstream analysis and integration. artMS also provides a set of functions to re-format and make it compatible with other analytical tools, including, SAINTq, SAINTexpress, Phosfate, and PHOTON. Check [http://artms.org](http://artms.org) for details.

The purpose of the package is to identify prognostic biomarkers and an optimal numeric cutoff for each biomarker that can be used to stratify a group of test subjects (samples) into two sub-groups with significantly different survival (better vs. worse). The package was developed for the analysis of gene expression data, such as RNA-seq. However, it can be used with any quantitative variable that has a sufficiently large proportion of unique values.

It is an easy-to-use GUI using disease information for detecting tumor/normal sample discriminating gene sets from differentially expressed genes. Our approach is based on an iterative algorithm filtering genes with disease ontology enrichment analysis and wilk and wilks lambda criterion connected to SVM classification model construction. Along with gene set extraction, SVMDO also provides individual prognostic marker detection. The algorithm is designed for FPKM and RPKM normalized RNA-Seq transcriptome datasets.

Analyzes autocorrelation and partial autocorrelation using surrogate methods and bootstrapping, and computes the acceleration constants for the vectorized moving block bootstrap provided by this package. It generates percentile, bias-corrected, and accelerated intervals and estimates partial autocorrelations using Durbin-Levinson. This package calculates the autocorrelation power spectrum, computes cross-correlations between two time series, computes bandwidth for any time series, and performs autocorrelation frequency analysis. It also calculates the periodicity of a time series.

Provide a tool to easily build customized data flows to pre-process large volumes of information from different sources. To this end, bdpar allows to (i) easily use and create new functionalities and (ii) develop new data source extractors according to the user needs. Additionally, the package provides by default a predefined data flow to extract and pre-process the most relevant information (tokens, dates, ... ) from some textual sources (SMS, Email, YouTube comments).

An implementation of the k-means-- algorithm proposed by Chawla and Gionis, 2013 in their paper, "k-means-- : A unified approach to clustering and outlier detection. SIAM International Conference on Data Mining (SDM13)", <doi:10.1137/1.9781611972832.21> and using ordering described by Howe, 2013 in the thesis, Clustering and anomaly detection in tropical cyclones". Useful for creating (potentially) tighter clusters than standard k-means and simultaneously finding outliers inexpensively in multidimensional space.

Algorithms for solving various Maximum Weight Connected Subgraph Problems, including variants with budget constraints, cardinality constraints, weighted edges and signals. The package represents an R interface to high-efficient solvers based on relax-and-cut approach (Ã lvarez-Miranda E., Sinnl M. (2017) <doi:10.1016/j.cor.2017.05.015>) mixed-integer programming (Loboda A., Artyomov M., and Sergushichev A. (2016) <doi:10.1007/978-3-319-43681-4_17>) and simulated annealing.

Convert Markdown ('.md') or R Markdown ('.Rmd') texts, R scripts, directory structures, and other hierarchical structured documents into mind map widgets or Freemind codes or Mermaid mind map codes, and vice versa. Freemind mind map ('.mm') files can be opened by or imported to common mind map software such as Freemind (<https://freemind.sourceforge.io/wiki/index.php/Main_Page>). Mermaid mind map codes (<https://mermaid.js.org/>) can be directly embedded in documents.

Fits many-facet measurement models and returns diagnostics, reporting helpers, and reproducible analysis bundles using a native R implementation. Supports arbitrary facet counts, rating-scale and partial-credit parameterizations ('Andrich (1978) <doi:10.1007/BF02293814>; Masters (1982) <doi:10.1007/BF02296272>), marginal maximum likelihood estimation with Gauss-Hermite quadrature and direct optimization of the marginal log-likelihood, joint maximum likelihood estimation, plus tools for anchor review, interaction screening, linking workflows, and publication-oriented summaries.

Functions, data sets and examples for the book: Yves Croissant (2025) "Microeconometrics with R", Chapman and Hall/CRC The R Series <doi:10.1201/9781003100263>. The package includes a set of estimators for models used in microeconometrics, especially for count data and limited dependent variables. Test functions include score test, Hausman test, Vuong test, Sargan test and conditional moment test. A small subset of the data set used in the book is also included.

An adaptation of Non-dominated Sorting Genetic Algorithm III for multi objective feature selection tasks. Non-dominated Sorting Genetic Algorithm III is a genetic algorithm that solves multiple optimization problems simultaneously by applying a non-dominated sorting technique. It uses a reference points based selection operator to explore solution space and preserve diversity. See the original paper by K. Deb and H. Jain (2014) <DOI:10.1109/TEVC.2013.2281534> for a detailed description.

Do Markov chain Monte Carlo (MCMC) simulation of Potts models (Potts, 1952, <doi:10.1017/S0305004100027419>), which are the multi-color generalization of Ising models (so, as as special case, also simulates Ising models). Use the Swendsen-Wang algorithm (Swendsen and Wang, 1987, <doi:10.1103/PhysRevLett.58.86>) so MCMC is fast. Do maximum composite likelihood estimation of parameters (Besag, 1975, <doi:10.2307/2987782>, Lindsay, 1988, <doi:10.1090/conm/080>).

Calculating Pst values to assess differentiation among populations from a set of quantitative traits is the primary purpose of such a package. The bootstrap method provides confidence intervals and distribution histograms of Pst. Variations of Pst in function of the parameter c/h^2 are studied as well. Finally, the package proposes different transformations especially to eliminate any variation resulting from allometric growth (calculation of residuals from linear regressions, Reist standardizations or Aitchison transformation).

Supervised and unsupervised multivariate methods, supplemented by GUI and some visualizations, to perform various analyses in the field of computational stylistics, authorship attribution, etc. For further reference, see Eder et al. (2016), <https://journal.r-project.org/archive/2016/RJ-2016-007/index.html>. You are also encouraged to visit the Computational Stylistics Group's website <https://computationalstylistics.github.io/>, where a reasonable amount of information about the package and related projects are provided.

This package contains functions that fit linear mixed-effects models for high-dimensional data (p>>n) with penalty for both the fixed effects and random effects for variable selection. The details of the algorithm can be found in Luoying Yang PhD thesis (Yang and Wu 2020). The algorithm implementation is based on the R package lmmlasso'. Reference: Yang L, Wu TT (2020). Model-Based Clustering of Longitudinal Data in High-Dimensionality. Unpublished thesis.

This package provides SAS'-style IF/ELSE chains, independent IF rules, and DELETE logic for data.table', enabling clinical programmers to express Study Data Tabulation Model (SDTM) and Analysis Data Model (ADaM)-style derivations in familiar SAS-like syntax. Methods are informed by clinical data standards described in CDISC SDTM and ADaM implementation guides. See <https://www.cdisc.org/standards/foundational/sdtm> and <https://www.cdisc.org/standards/foundational/adam>.

Allows users to list data structures using path-based navigation. Provides intuitive methods for storing, accessing, and manipulating nested data through simple path strings. Key features include strict mode validation, path existence checking, recursive operations, and automatic parent-level creation. Designed for use cases requiring organized storage of complex nested data while maintaining simple access patterns. Particularly useful for configuration management, nested settings, and any application where data naturally forms a tree-like structure.

This package implements the Variable importance Explainable Elastic Shape Analysis pipeline for explainable machine learning with functional data inputs. Converts training and testing data functional inputs to elastic shape analysis principal components that account for vertical and/or horizontal variability. Computes feature importance to identify important principal components and visualizes variability captured by functional principal components. See Goode et al. (2025) <doi:10.48550/arXiv.2501.07602> for technical details about the methodology.

The dada2 package infers exact amplicon sequence variants (ASVs) from high-throughput amplicon sequencing data, replacing the coarser and less accurate OTU clustering approach. The dada2 pipeline takes as input demultiplexed fastq files, and outputs the sequence variants and their sample-wise abundances after removing substitution and chimera errors. Taxonomic classification is available via a native implementation of the RDP naive Bayesian classifier, and species-level assignment to 16S rRNA gene fragments by exact matching.

This package extracts tandem mass spectrometry (MS/MS) ID data from mzIdentML (leveraging the mzID package) or text files. After collating the search results from multiple datasets it assesses their identification quality and optimize filtering criteria to achieve the maximum number of identifications while not exceeding a specified false discovery rate. It also contains a number of utilities to explore the MS/MS results and assess missed and irregular enzymatic cleavages, mass measurement accuracy, etc.

Pdist computes the euclidean distance between rows of a matrix X and rows of another matrix Y. Previously, this could be done by binding the two matrices together and calling dist, but this creates unnecessary computation by computing the distances between a row of X and another row of X, and likewise for Y. Pdist strictly computes distances across the two matrices, not within the same matrix, making computations significantly faster for certain use cases.

This package performs both stepwise and backward heuristic search for candidate (epi)genetic drivers based on a binary multi-omics dataset. CaDrA's main objective is to identify features which, together, are significantly skewed or enriched pertaining to a given vector of continuous scores (e.g. sample-specific scores representing a phenotypic readout of interest, such as protein expression, pathway activity, etc.), based on the union occurence (i.e. logical OR) of the events.