R implementation of the software tools developed in the H-CUP (Healthcare Cost and Utilization Project) <https://hcup-us.ahrq.gov> and AHRQ (Agency for Healthcare Research and Quality) <https://www.ahrq.gov>. It currently contains functions for mapping ICD-9 codes to the AHRQ comorbidity measures and translating ICD-9 (resp. ICD-10) codes to ICD-10 (resp. ICD-9) codes based on GEM (General Equivalence Mappings) from CMS (Centers for Medicare and Medicaid Services).

BiFET identifies transcription factors (TFs) whose footprints are over-represented in target regions compared to background regions after correcting for the bias arising from the imbalance in read counts and GC contents between the target and background regions. For a given TF k, BiFET tests the null hypothesis that the target regions have the same probability of having footprints for the TF k as the background regions while correcting for the read count and GC content bias.

The package aims to identify miRNA sponge or ceRNA modules in heterogeneous data. It provides several functions to study miRNA sponge modules at single-sample and multi-sample levels, including popular methods for inferring gene modules (candidate miRNA sponge or ceRNA modules), and two functions to identify miRNA sponge modules at single-sample and multi-sample levels, as well as several functions to conduct modular analysis of miRNA sponge modules.

Recreation model that simulates household types, group types, expected visiting duration, and total visits from city zip codes to surrounding destination areas. The methodology is based on the accessibility model described in Bervaes et al. (1996) "Een model voor het gebruik van de groene ruimte in stadslandschappen (Fase I)" <https://www.wur.nl/en/library>, with optimization procedures based on Goldfarb and Idnani (1983) <doi:10.1007/BF02591962> and Vanderbei et al. (1986) <doi:10.1007/BF01840454>.

Predicts survival for patients with severe limb ischaemia using the prognostic model developed from the Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial (Bradbury and others (2010) <doi:10.1016/j.jvs.2010.01.077>). The model is an accelerated failure time Weibull regression. The package is intended for research and audit; it is not a substitute for clinical judgement and its predictions should not be used as the sole basis for clinical decisions.

Efficient procedures for fitting the DD-PCA (Ke et al., 2019, <arXiv:1906.00051>) by decomposing a large covariance matrix into a low-rank matrix plus a diagonally dominant matrix. The implementation of DD-PCA includes the convex approach using the Alternating Direction Method of Multipliers (ADMM) and the non-convex approach using the iterative projection algorithm. Applications of DD-PCA to large covariance matrix estimation and global multiple testing are also included in this package.

Joint dimension reduction and spatial clustering is conducted for Single-cell RNA sequencing and spatial transcriptomics data, and more details can be referred to Wei Liu, Xu Liao, Yi Yang, Huazhen Lin, Joe Yeong, Xiang Zhou, Xingjie Shi and Jin Liu. (2022) <doi:10.1093/nar/gkac219>. It is not only computationally efficient and scalable to the sample size increment, but also is capable of choosing the smoothness parameter and the number of clusters as well.

Simulates cyclic voltammetry, linear-sweep voltammetry (both with and without stirring of the solution), and single-pulse and double-pulse chronoamperometry and chronocoulometry experiments using the implicit finite difference method outlined in Gosser (1993, ISBN: 9781560810261) and in Brown (2015) <doi:10.1021/acs.jchemed.5b00225>. Additional functions provide ways to display and to examine the results of these simulations. The primary purpose of this package is to provide tools for use in courses in analytical chemistry.

This package provides a very flexible framework for building server side logic in R. The framework is unopinionated when it comes to how HTTP requests and WebSocket messages are handled and supports all levels of app complexity; from serving static content to full-blown dynamic web-apps. Fiery does not hold your hand as much as e.g. the shiny package does, but instead sets you free to create your web app the way you want.

Semi-automated analysis of chlorophyll fluorescence images of leaf discs taken with a Walz IMAGING-PAM fluorometer. Provides an R interface to the fvfmPy Python package, which detects leaf discs, assigns them to a grid of rows and columns, and computes the maximum quantum efficiency of photosystem II, Fv/Fm = (Fm - Fo) / Fm, for each disc. The interactive fvfmPy window is launched from R and the results are returned to R as a data frame.

This package provides a novel forward stepwise discriminant analysis framework that integrates Pillai's trace with Uncorrelated Linear Discriminant Analysis (ULDA), providing an improvement over traditional stepwise LDA methods that rely on Wilks Lambda. A stand-alone ULDA implementation is also provided, offering a more general solution than the one available in the MASS package. It automatically handles missing values and provides visualization tools. For more details, see Wang (2024) <doi:10.48550/arXiv.2409.03136>.

This package provides tools to adjust estimates of learning for guessing-related bias in educational and survey research. Implements standard guessing correction methods and latent class models that leverage informative pre-post test transitions to account for guessing behavior. The package helps researchers obtain more accurate estimates of actual learning when respondents may guess on closed-ended knowledge items. For theoretical background and empirical validation, see Cor and Sood (2016) <https://gsood.com/research/papers/guess.pdf>.

Several functions that allow by different methods to infer a piecewise polynomial regression model under regularity constraints, namely continuity or differentiability of the link function. The implemented functions are either specific to data with two regimes, or generic for any number of regimes, which can be given by the user or learned by the algorithm. A paper describing all these methods will be submitted soon. The reference will be added to this file as soon as available.

The Indian Alien Flora Information (ILORA) database contains 14 invasion-relevant variables for 1388 alien plant species in India. The package enables exploration of the database using user-defined criteria. Using this package, users can retrieve variable-specific and species-level data from the database. The package also supports exploratory data analysis and visualization to give users an idea of the variables of interest. Further details about the database are available at <https://iloradb.wixsite.com/alienflora>.

This package provides implementation of various correlation coefficients of common use in Information Retrieval. In particular, it includes Kendall (1970, isbn:0852641990) tau coefficient as well as tau_a and tau_b for the treatment of ties. It also includes Yilmaz et al. (2008) <doi:10.1145/1390334.1390435> tauAP correlation coefficient, and versions tauAP_a and tauAP_b developed by Urbano and Marrero (2017) <doi:10.1145/3121050.3121106> to cope with ties.

These functions take a gene expression value matrix, a primary covariate vector, an additional known covariates matrix. A two stage analysis is applied to counter the effects of latent variables on the rankings of hypotheses. The estimation and adjustment of latent effects are proposed by Sun, Zhang and Owen (2011). "leapp" is developed in the context of microarray experiments, but may be used as a general tool for high throughput data sets where dependence may be involved.

The functions are designed to find the efficient mean-variance frontier or portfolio weights for static portfolio (called Markowitz portfolio) analysis in resource economics or nature conservation. Using the nonlinear programming solver ('Rsolnp'), this package deals with the quadratic minimization of the variance-covariances without shorting (i.e., non-negative portfolio weights) studied in Ando and Mallory (2012) <doi:10.1073/pnas.1114653109>. See the examples, testing versions, and more details from: <https://github.com/ysd2004/portn>.

Robust penalized (adaptive) elastic net S and M estimators for linear regression. The adaptive methods are proposed in Kepplinger, D. (2023) <doi:10.1016/j.csda.2023.107730> and the non-adaptive methods in Cohen Freue, G. V., Kepplinger, D., Salibián-Barrera, M., and Smucler, E. (2019) <doi:10.1214/19-AOAS1269>. The package implements robust hyper-parameter selection with robust information sharing cross-validation according to Kepplinger & Wei (2025) <doi:10.1080/00401706.2025.2540970>.

This is a core implementation of SAS procedures for linear models - GLM, REG, ANOVA, TTEST, FREQ, and UNIVARIATE. Some R packages provide Type II and Type III SS. However, the results of nested and complex designs are often different from those of SAS'. Different results do not necessarily mean incorrectness. However, many want the same results as SAS'. This package aims to achieve that. Reference: Littell RC, Stroup WW, Freund RJ (2002, ISBN:0-471-22174-0).

Simple tabulation should be dead simple. This package is an opinionated approach to easy tabulations while also providing exact numbers and allowing for re-usability. This is achieved by providing tabulations as data.frames with columns for values, optional variable names, frequency counts including and excluding NAs and percentages for counts including and excluding NAs. Also values are automatically sorted by in decreasing order of frequency counts to allow for fast skimming of the most important information.

This package implements the recursively detrended panel unit root tests proposed by Westerlund (2015) <doi:10.1016/j.jeconom.2014.06.015>. Two variants are provided: the basic t-REC test assuming iid errors, and the robust t-RREC test that accounts for serial correlation, cross-sectional dependence, and heteroskedasticity via defactoring and BIC-selected lag augmentation. Both tests have a standard normal null distribution requiring no mean or variance correction. The panel must be strongly balanced.

Computes discrete Fourier transforms (complex, real-to-complex and complex-to-real) and discrete cosine and sine transforms of types one to four over any axes of an array, with the fast Fourier transform (FFT) code of ducc0 (<https://github.com/mreineck/ducc>) bundled in the BSD-licensed subset that SciPy uses. Transforms of any length run in O(n log n) time, real input uses true real transforms, and several threads can share one transform.

Random generation of survival data from a wide range of regression models, including accelerated failure time (AFT), proportional hazards (PH), proportional odds (PO), accelerated hazard (AH), Yang and Prentice (YP), and extended hazard (EH) models. The package rsurv also stands out by its ability to generate survival data from an unlimited number of baseline distributions provided that an implementation of the quantile function of the chosen baseline distribution is available in R. Another nice feature of the package rsurv lies in the fact that linear predictors are specified via a formula-based approach, facilitating the inclusion of categorical variables and interaction terms. The functions implemented in the package rsurv can also be employed to simulate survival data with more complex structures, such as survival data with different types of censoring mechanisms, survival data with cure fraction, survival data with random effects (frailties), multivariate survival data, and competing risks survival data. Details about the R package rsurv can be found in Demarqui (2024) <doi:10.48550/arXiv.2406.01750>.

Expression levels of mRNA molecules are regulated by different processes, comprising inhibition or activation by transcription factors and post-transcriptional degradation by microRNAs. birta (Bayesian Inference of Regulation of Transcriptional Activity) uses the regulatory networks of transcription factors and miRNAs together with mRNA and miRNA expression data to predict switches in regulatory activity between two conditions. A Bayesian network is used to model the regulatory structure and Markov-Chain-Monte-Carlo is applied to sample the activity states.