R package for analysis of transcript and translation features through manipulation of sequence data and NGS data like Ribo-Seq, RNA-Seq, TCP-Seq and CAGE. It is generalized in the sense that any transcript region can be analysed, as the name hints to it was made with investigation of ribosomal patterns over Open Reading Frames (ORFs) as it's primary use case. ORFik is extremely fast through use of C++, data.table and GenomicRanges. Package allows to reassign starts of the transcripts with the use of CAGE-Seq data, automatic shifting of RiboSeq reads, finding of Open Reading Frames for whole genomes and much more.

Partial application is the process of reducing the arity of a function by fixing one or more arguments, thus creating a new function lacking the fixed arguments. The curry package provides three different ways of performing partial function application by fixing arguments from either end of the argument list (currying and tail currying) or by fixing multiple named arguments (partial application). This package provides this functionality through the %<%, %-<%, and %><% operators which allows for a programming style comparable to modern functional languages. Compared to other implementations such a purrr::partial() the operators in curry composes functions with named arguments, aiding in autocomplete etc.

This package provides a robust collection of functions tailored for microbial ecology analysis, encompassing both data analysis and visualization. It introduces an encapsulation feature that streamlines the process into a summary object. With the initial configuration of this summary object, users can execute a wide range of analyses with a single line of code, requiring only two essential parameters for setup. The package delivers comprehensive outputs including analysis objects, statistical outcomes, and visualization-ready data, enhancing the efficiency of research workflows. Designed with user-friendliness in mind, it caters to both novices and seasoned researchers, offering an intuitive interface coupled with adaptable customization options to meet diverse analytical needs.

An implementation of Horn's technique for numerically and graphically evaluating the components or factors retained in a principle components analysis (PCA) or common factor analysis (FA). Horn's method contrasts eigenvalues produced through a PCA or FA on a number of random data sets of uncorrelated variables with the same number of variables and observations as the experimental or observational data set to produce eigenvalues for components or factors that are adjusted for the sample error-induced inflation. Components with adjusted eigenvalues greater than one are retained. paran may also be used to conduct parallel analysis following Glorfeld's (1995) suggestions to reduce the likelihood of over-retention.

Computes scores from Q-sort data, using criteria sorts and derived scales from subsets of items. The qsort package includes descriptions and scoring procedures for four different Q-sets commonly used in developmental psychology research: Attachment Q-set (version 3.0) (Waters, 1995, <doi:10.1111/j.1540-5834.1995.tb00214.x>); California Child Q-set (Block and Block, 1969, <doi:10.1037/0012-1649.21.3.508>); Maternal Behaviour Q-set (version 3.1) (Pederson et al., 1999, <https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=1000&context=psychologypub>); Preschool Q-set (Baumrind, 1968 revised by Wanda Bronson, <doi:10.1111/j.1540-5834.1995.tb00214.x>).

Offers a systematic way for conditional reporting of figures and tables for many (and bivariate combinations of) variables, typically from survey data. Contains interactive ggiraph'-based (<https://CRAN.R-project.org/package=ggiraph>) plotting functions and data frame-based summary tables (bivariate significance tests, frequencies/proportions, unique open ended responses, etc) with many arguments for customization, and extensions possible. Uses a global options() system for neatly reducing redundant code. Also contains tools for immediate saving of objects and returning a hashed link to the object, useful for creating download links to high resolution images upon rendering in Quarto'. Suitable for highly customized reports, primarily intended for survey research.

Multivariate tool for analyzing genome-wide association study results in the form of univariate summary statistics. The goal of bmass is to comprehensively test all possible multivariate models given the phenotypes and datasets provided. Multivariate models are determined by assigning each phenotype to being either Unassociated (U), Directly associated (D) or Indirectly associated (I) with the genetic variant of interest. Test results for each model are presented in the form of Bayes factors, thereby allowing direct comparisons between models. The underlying framework implemented here is based on the modeling developed in "A Unified Framework for Association Analysis with Multiple Related Phenotypes", M. Stephens (2013) <doi:10.1371/journal.pone.0065245>.

Biologically Explainable Machine Learning Framework for Phenotype Prediction using omics data described in Chen and Schwarz (2017) <doi:10.48550/arXiv.1712.00336>.Identifying reproducible and interpretable biological patterns from high-dimensional omics data is a critical factor in understanding the risk mechanism of complex disease. As such, explainable machine learning can offer biological insight in addition to personalized risk scoring.In this process, a feature space of biological pathways will be generated, and the feature space can also be subsequently analyzed using WGCNA (Described in Horvath and Zhang (2005) <doi:10.2202/1544-6115.1128> and Langfelder and Horvath (2008) <doi:10.1186/1471-2105-9-559> ) methods.

Reads EXIF data using ExifTool <https://exiftool.org> and returns results as a data frame. ExifTool is a platform-independent Perl library plus a command-line application for reading, writing and editing meta information in a wide variety of files. ExifTool supports many different metadata formats including EXIF, GPS, IPTC, XMP, JFIF, GeoTIFF, ICC Profile, Photoshop IRB, FlashPix, AFCP and ID3, as well as the maker notes of many digital cameras by Canon, Casio, FLIR, FujiFilm, GE, HP, JVC/Victor, Kodak, Leaf, Minolta/Konica-Minolta, Motorola, Nikon, Nintendo, Olympus/Epson, Panasonic/Leica, Pentax/Asahi, Phase One, Reconyx, Ricoh, Samsung, Sanyo, Sigma/Foveon and Sony.

This software downloads and manages air quality data from the European Environmental Agency (EEA) dataflow (<https://www.eea.europa.eu/data-and-maps/data/aqereporting-9>). See the web page <https://eeadmz1-downloads-webapp.azurewebsites.net/> for details on the EEA's Air Quality Download Service. The package allows dynamically mapping the stations, summarising and time aggregating the measurements and building spatial interpolation maps. See the web page <https://www.eea.europa.eu/en> for further information on EEA activities and history. Further details, as well as, an extended vignette of the main functions included in the package, are available at the GitHub web page dedicated to the project.

Tabacchi et al. (2011) published a very detailed study producing a uniform system of functions to estimate tree volume and phytomass components (stem, branches, stool). The estimates of the 2005 Italian forest inventory (<https://www.inventarioforestale.org/it/>) are based on these functions. The study documents the domain of applicability of each function and the equations to quantify estimates accuracies for individual estimates as well as for aggregated estimates. This package makes the functions available in the R environment. Version 2 exposes two distinct functions for individual and summary estimates. To facilitate access to the functions, tree species identification is now based on EPPO species codes (<https://data.eppo.int/>).

Generate the optimal maximin distance, minimax distance (only for low dimensions), and maximum projection designs within the class of Latin hypercube designs efficiently for computer experiments. Generate Pareto front optimal designs for each two of the three criteria and all the three criteria within the class of Latin hypercube designs efficiently. Provide criterion computing functions. References of this package can be found in Morris, M. D. and Mitchell, T. J. (1995) <doi:10.1016/0378-3758(94)00035-T>, Lu Lu and Christine M. Anderson-CookTimothy J. Robinson (2011) <doi:10.1198/Tech.2011.10087>, Joseph, V. R., Gul, E., and Ba, S. (2015) <doi:10.1093/biomet/asv002>.

Data integration Web application for biobanks by OBiBa'. Opal is the core database application for biobanks. Participant data, once collected from any data source, must be integrated and stored in a central data repository under a uniform model. Opal is such a central repository. It can import, process, validate, query, analyze, report, and export data. Opal is typically used in a research center to analyze the data acquired at assessment centres. Its ultimate purpose is to achieve seamless data-sharing among biobanks. This Opal client allows to interact with Opal web services and to perform operations on the R server side. DataSHIELD administration tools are also provided.

Fast and memory-less computation of the partial distance correlation for vectors and matrices. Permutation-based and asymptotic hypothesis testing for zero partial distance correlation are also performed. References include: Szekely G. J. and Rizzo M. L. (2014). "Partial distance correlation with methods for dissimilarities". The Annals Statistics, 42(6): 2382--2412. <doi:10.1214/14-AOS1255>. Shen C., Panda S. and Vogelstein J. T. (2022). "The Chi-Square Test of Distance Correlation". Journal of Computational and Graphical Statistics, 31(1): 254--262. <doi:10.1080/10618600.2021.1938585>. Szekely G. J. and Rizzo M. L. (2023). "The Energy of Data and Distance Correlation". Chapman and Hall/CRC. <ISBN:9781482242744>.

This package implements Time-Weighted Dynamic Time Warping (TWDTW), a measure for quantifying time series similarity. The TWDTW algorithm, described in Maus et al. (2016) <doi:10.1109/JSTARS.2016.2517118> and Maus et al. (2019) <doi:10.18637/jss.v088.i05>, is applicable to multi-dimensional time series of various resolutions. It is particularly suitable for comparing time series with seasonality for environmental and ecological data analysis, covering domains such as remote sensing imagery, climate data, hydrology, and animal movement. The twdtw package offers a user-friendly R interface, efficient Fortran routines for TWDTW calculations, flexible time weighting definitions, as well as utilities for time series preprocessing and visualization.

In the course of a genome-wide association study, the situation often arises that some phenotypes are known with greater precision than others. It could be that some individuals are known to harbor more micro-environmental variance than others. In the case of inbred strains of model organisms, it could be the case that more organisms were observed from some strains than others, so the strains with more organisms have better-estimated means. Package wISAM handles this situation by allowing for weighting of each observation according to residual variance. Specifically, the weight parameter to the function conduct_scan() takes the precision of each observation (one over the variance).

Famat is made to collect data about lists of genes and metabolites provided by user, and to visualize it through a Shiny app. Information collected is: - Pathways containing some of the user's genes and metabolites (obtained using a pathway enrichment analysis). - Direct interactions between user's elements inside pathways. - Information about elements (their identifiers and descriptions). - Go terms enrichment analysis performed on user's genes. The Shiny app is composed of: - information about genes, metabolites, and direct interactions between them inside pathways. - an heatmap showing which elements from the list are in pathways (pathways are structured in hierarchies). - hierarchies of enriched go terms using Molecular Function and Biological Process.

Biological molecules in a living organism seldom work individually. They usually interact each other in a cooperative way. Biological process is too complicated to understand without considering such interactions. Thus, network-based procedures can be seen as powerful methods for studying complex process. However, many methods are devised for analyzing individual genes. It is said that techniques based on biological networks such as gene co-expression are more precise ways to represent information than those using lists of genes only. This package is aimed to integrate the gene expression and biological network. A biological network is constructed from gene expression data and it is used for Gene Set Enrichment Analysis.

An elaborate molecular evolutionary framework that facilitates straightforward simulation of codon genetic sequences subjected to different degrees and/or patterns of Darwinian selection. The model was built upon the fitness landscape paradigm of Sewall Wright, as popularised by the mutation-selection model of Halpern and Bruno. This enabled realistic evolutionary process of living organisms to be reproduced seamlessly. For example, an Ornstein-Uhlenbeck fitness update algorithm is incorporated herein. Consequently, otherwise complex biological processes, such as the effect of the interplay between genetic drift and mutation on the inference of diversifying selection, may now be investigated with minimal effort. Frequency-dependent and deterministic fitness landscape update techniques are also available.

Analysis of corneal data obtained from a Placido disk corneal topographer with calculation of irregularity indices. This package performs analyses of corneal data obtained from a Placido disk corneal topographer, with the calculation of the Placido irregularity indices and the posterior analysis. The package is intended to be easy to use by a practitioner, providing a simple interface and yielding easily interpretable results. A corneal topographer is an ophthalmic clinical device that obtains measurements in the cornea (the anterior part of the eye). A Placido disk corneal topographer makes use of the Placido disk [Rowsey et al. (1981)]<doi:10.1001/archopht.1981.03930011093022>, which produce a circular pattern of measurement nodes. The raw information measured by such a topographer is used by practitioners to analyze curvatures, to study optical aberrations, or to diagnose specific conditions of the eye (e.g. keratoconus, an important corneal disease). The rPACI package allows the calculation of the corneal irregularity indices described in [Castro-Luna et al. (2020)]<doi:10.1016%2Fj.clae.2019.12.006>, [Ramos-Lopez et al. (2013)]<doi:10.1097%2FOPX.0b013e3182843f2a>, and [Ramos-Lopez et al. (2011)]<doi:10.1097/opx.0b013e3182279ff8>. It provides a simple interface to read corneal topography data files as exported by a typical Placido disk topographer, to compute the irregularity indices mentioned before, and to display summary plots that are easy to interpret for a clinician.

Circadian rhythms are rhythms that oscillate about every 24 h, which has been observed in multiple physiological processes including core body temperature, hormone secretion, heart rate, blood pressure, and many others. Measuring circadian rhythm with wearables is based on a principle that there is increased movement during wake periods and reduced movement during sleep periods, and has been shown to be reliable and valid. This package can be used to extract nonparametric circadian metrics like intradaily variability (IV), interdaily stability (IS), and relative amplitude (RA); and parametric cosinor model and extended cosinor model coefficient. Details can be found in Junrui Di et al (2019) <doi:10.1007/s12561-019-09236-4>.

This package provides functions to calculate the relative crystallinity of starch by X-ray Diffraction (XRD) and Infrared Spectroscopy (FTIR). Starch is biosynthesized by plants in the form of granules semicrystalline. For XRD, the relative crystallinity is obtained by separating the crystalline peaks from the amorphous scattering region. For FTIR, the relative crystallinity is achieved by setting of a Gaussian holocrystalline-peak in the 800-1300 cm-1 region of FTIR spectrum of starch which is divided into amorphous region and crystalline region. The relative crystallinity of native starch granules varies from 14 of 45 percent. This package was supported by FONDECYT 3150630 and CIPA Conicyt-Regional R08C1002 is gratefully acknowledged.

To integrate multiple GSEA studies, we propose a hybrid strategy, iGSEA-AT, for choosing random effects (RE) versus fixed effect (FE) models, with an attempt to achieve the potential maximum statistical efficiency as well as stability in performance in various practical situations. In addition to iGSEA-AT, this package also provides options to perform integrative GSEA with testing based on a FE model (iGSEA-FE) and testing based on a RE model (iGSEA-RE). The approaches account for different set sizes when testing a database of gene sets. The function is easy to use, and the three approaches can be applied to both binary and continuous phenotypes.

This package provides a collection of functions for processing and analyzing metabolite data. The namesake function mrbin() converts 1D or 2D Nuclear Magnetic Resonance data into a matrix of values suitable for further data analysis and performs basic processing steps in a reproducible way. Negative values, a common issue in such data, can be replaced by positive values (<doi:10.1021/acs.jproteome.0c00684>). All used parameters are stored in a readable text file and can be restored from that file to enable exact reproduction of the data at a later time. The function fia() ranks features according to their impact on classifier models, especially artificial neural network models.