Customise Shiny disconnected screens as well as sanitize error messages to make them clearer and friendlier to the user.

Calculate change point based on spectral clustering with the option to automatically calculate the number of clusters if this information is not available.

It allows to rapidly compute, bootstrap and plot up to fourth-order Sobol'-based sensitivity indices using several state-of-the-art first and total-order estimators. Sobol indices can be computed either for models that yield a scalar as a model output or for systems of differential equations. The package also provides a suit of benchmark tests functions and several options to obtain publication-ready figures of the model output uncertainty and sensitivity-related analysis. An overview of the package can be found in Puy et al. (2022) <doi:10.18637/jss.v102.i05>.

Splines are efficiently represented through their Taylor expansion at the knots. The representation accounts for the support sets and is thus suitable for sparse functional data. Two cases of boundary conditions are considered: zero-boundary or periodic-boundary for all derivatives except the last. The periodical splines are represented graphically using polar coordinates. The B-splines and orthogonal bases of splines that reside on small total support are implemented. The orthogonal bases are referred to as splinets and are utilized for functional data analysis. Random spline generator is implemented as well as all fundamental algebraic and calculus operations on splines. The optimal, in the least square sense, functional fit by splinets to data consisting of sampled values of functions as well as splines build over another set of knots is obtained and used for functional data analysis. The S4-version of the object oriented R is used. <doi:10.48550/arXiv.2102.00733>, <doi:10.1016/j.cam.2022.114444>, <doi:10.48550/arXiv.2302.07552>.

Newly developed methods for the estimation of several probabilities in an illness-death model. The package can be used to obtain nonparametric and semiparametric estimates for: transition probabilities, occupation probabilities, cumulative incidence function and the sojourn time distributions. Additionally, it is possible to fit proportional hazards regression models in each transition of the Illness-Death Model. Several auxiliary functions are also provided which can be used for marginal estimation of the survival functions.

Single cell resolution data has been valuable in learning about tissue microenvironments and interactions between cells or spots. This package allows for the simulation of this level of data, be it single cell or â spotsâ , in both a univariate (single metric or cell type) and bivariate (2 or more metrics or cell types) ways. As more technologies come to marker, more methods will be developed to derive spatial metrics from the data which will require a way to benchmark methods against each other. Additionally, as the field currently stands, there is not a gold standard method to be compared against. We set out to develop an R package that will allow users to simulate point patterns that can be biologically informed from different tissue domains, holes, and varying degrees of clustering/colocalization. The data can be exported as spatial files and a summary file (like HALO'). <https://github.com/FridleyLab/scSpatialSIM/>.

Median-of-means is a generic yet powerful framework for scalable and robust estimation. A framework for Bayesian analysis is called M-posterior, which estimates a median of subset posterior measures. For general exposition to the topic, see the paper by Minsker (2015) <doi:10.3150/14-BEJ645>.

Calculate the statistical power to detect clusters using kernel-based spatial relative risk functions that are estimated using the sparr package. Details about the sparr package methods can be found in the tutorial: Davies et al. (2018) <doi:10.1002/sim.7577>. Details about kernel density estimation can be found in J. F. Bithell (1990) <doi:10.1002/sim.4780090616>. More information about relative risk functions using kernel density estimation can be found in J. F. Bithell (1991) <doi:10.1002/sim.4780101112>.

This package contains data files to accompany Smithson & Merkle (2013), Generalized Linear Models for Categorical and Continuous Limited Dependent Variables.

This package performs correlation matrix segmentation and applies a test procedure to detect highly correlated regions in gene expression.

Convert a time series of observations to a time series of standardised indices that can be used to monitor variables on a common and probabilistically interpretable scale. The indices can be aggregated and rescaled to different time scales, visualised using plot capabilities, and calculated using a range of distributions. This includes flexible non-parametric and non-stationary methods.

Import, plot, and diagnose results from statistical catch-at-age models, used in fisheries stock assessment.

Created for population health analytics and monitoring. The functions in this package work best when working with patient level Master Patient Index-like datasets . Built to be used by NHS bodies and other health service providers.

Allows TailwindCSS to be used in Shiny apps with just-in-time compiling, custom css with @apply directive, and custom tailwind configurations.

This package provides a supervised compression method that incorporates the response for reducing big data to a carefully selected subset. Please see Joseph and Mak (2021) <doi:10.1002/sam.11508>. This research is supported by a U.S. National Science Foundation (NSF) grant CMMI-1921646.

It builds dynamic R shiny based dashboards to analyze any CSV files. It provides simple dashboard design to subset the data, perform exploratory data analysis and preliminary machine learning (supervised and unsupervised). It also provides filters based on columns of interest.

This package provides tools for constructing, auditing, and visualizing temporal social interaction networks from event-log data. Supports graph construction from raw user-to-user interaction logs, longitudinal tracking of network structure, community dynamics, user role trajectories, and concentration of engagement over time. Designed for computational social science, platform analytics, and digital community health monitoring. Includes four longitudinal audit indices: the Network Drift Index ('NDI'), Community Fragmentation Index ('CFI'), Visibility Concentration Index ('VCI'), and Role Mobility Index ('RMI'). NDI', CFI', VCI', and RMI are purpose-built composite scores for longitudinal platform auditing.

Data wrangling and cleaning, quality control checks and implementation of machine learning classification algorithm.

Implementations of stochastic, limited-memory quasi-Newton optimizers, similar in spirit to the LBFGS (Limited-memory Broyden-Fletcher-Goldfarb-Shanno) algorithm, for smooth stochastic optimization. Implements the following methods: oLBFGS (online LBFGS) (Schraudolph, N.N., Yu, J. and Guenter, S., 2007 <http://proceedings.mlr.press/v2/schraudolph07a.html>), SQN (stochastic quasi-Newton) (Byrd, R.H., Hansen, S.L., Nocedal, J. and Singer, Y., 2016 <arXiv:1401.7020>), adaQN (adaptive quasi-Newton) (Keskar, N.S., Berahas, A.S., 2016, <arXiv:1511.01169>). Provides functions for easily creating R objects with partial_fit/predict methods from some given objective/gradient/predict functions. Includes an example stochastic logistic regression using these optimizers. Provides header files and registered C routines for using it directly from C/C++.

This package provides an S4 class for representing and interacting with sparse plus rank matrices. At the moment the implementation is quite spare, but the plan is eventually subclass Matrix objects.

Aims to quantify time intensity data by using sigmoidal and double sigmoidal curves. It fits straight lines, sigmoidal, and double sigmoidal curves on to time vs intensity data. Then all the fits are used to make decision on which model best describes the data. This method was first developed in the context of single-cell viral growth analysis (for details, see Caglar et al. (2018) <doi:10.7717/peerj.4251>), and the package name stands for "SIngle CEll Growth Analysis in R".

Enables instrumentation of Shiny apps for tracking user session events such as input changes, browser type, and session duration. These events can be sent to any of the available storage backends and analyzed using the included Shiny app to gain insights about app usage and adoption.

Balancing computational and statistical efficiency, subsampling techniques offer a practical solution for handling large-scale data analysis. Subsampling methods enhance statistical modeling for massive datasets by efficiently drawing representative subsamples from full dataset based on tailored sampling probabilities. These probabilities are optimized for specific goals, such as minimizing the variance of coefficient estimates or reducing prediction error. Based on specified modeling assumptions and subsampling techniques, the package provides functions to draw subsamples from the full data, fit the model on the subsamples, and perform statistical inference.

This package creates SEER (Surveillance, Epidemiology and End Results) and A-bomb data binaries from ASCII sources and provides tools for estimating SEER second cancer risks. Methods are described in <doi:10.1038/leu.2015.258>.