This package is used to detect combination of genomic coordinates falling within a user defined window size along with user defined overlap between identified neighboring clusters. It can be used for genomic data where the clusters are built on a specific chromosome or specific strand. Clustering can be performed with a "greedy" option allowing thus the presence of additional sites within the allowed window size.

satuRn provides a framework for performing differential transcript usage analyses. The package consists of three main functions. The first function, fitDTU, fits quasi-binomial generalized linear models that model transcript usage in different groups of interest. The second function, testDTU, tests for differential usage of transcripts between groups of interest. Finally, plotDTU visualizes the usage profiles of transcripts in groups of interest.

This package provides a graphics device for R that is accessible via network protocols. This package was created to make it easier to embed live R graphics in integrated development environments and other applications. The included HTML/JavaScript client (plot viewer) aims to provide a better overall user experience when dealing with R graphics. The device asynchronously serves graphics via HTTP and WebSockets'.

The R Analytic Tool To Learn Easily (Rattle) provides a collection of utilities functions for the data scientist. A Gnome (RGtk2) based graphical interface is included with the aim to provide a simple and intuitive introduction to R for data science, allowing a user to quickly load data from a CSV file (or via ODBC), transform and explore the data, build and evaluate models, and export models as PMML (predictive modelling markup language) or as scores. A key aspect of the GUI is that all R commands are logged and commented through the log tab. This can be saved as a standalone R script file and as an aid for the user to learn R or to copy-and-paste directly into R itself. Note that RGtk2 and cairoDevice have been archived on CRAN. See <https://rattle.togaware.com> for installation instructions.

To address the violation of the assumption of normally distributed variables, researchers frequently employ bootstrapping. Building upon established packages for R (Sigmann et al. (2024) <doi:10.32614/CRAN.package.afex>, Lenth (2024) <doi:10.32614/CRAN.package.emmeans>), we provide bootstrapping functions to approximate a normal distribution of the parameter estimates for between-subject, within-subject, and mixed one-way and two-way ANOVA.

Epidemiological population dynamics models traditionally define a pathogen's virulence as the increase in the per capita rate of mortality of infected hosts due to infection. This package provides functions allowing virulence to be estimated by maximum likelihood techniques. The approach is based on the analysis of relative survival comparing survival in matching cohorts of infected vs. uninfected hosts (Agnew 2019) <doi:10.1101/530709>.

The functions in this package inspect, read, edit and run files for APSIM "Next Generation" ('JSON') and APSIM "Classic" ('XML'). The files with an apsim extension correspond to APSIM Classic (7.x) - Windows only - and the ones with an apsimx extension correspond to APSIM "Next Generation". For more information about APSIM see (<https://www.apsim.info/>) and for APSIM next generation (<https://apsimnextgeneration.netlify.app/>).

An implementation of intervention effect estimation for DAGs (directed acyclic graphs) learned from binary or continuous data. First, parameters are estimated or sampled for the DAG and then interventions on each node (variable) are propagated through the network (do-calculus). Both exact computation (for continuous data or for binary data up to around 20 variables) and Monte Carlo schemes (for larger binary networks) are implemented.

Procedure for solving the maximin problem for identical design across heterogeneous data groups. Particularly efficient when the design matrix is either orthogonal or has tensor structure. Orthogonal wavelets can be specified for 1d, 2d or 3d data simply by name. For tensor structured design the tensor components (two or three) may be supplied. The package also provides an efficient implementation of the generic magging estimator.

The method aims to identify important factors in screening experiments by aggregation over random models as studied in Singh and Stufken (2022) <doi:10.48550/arXiv.2205.13497>. This package provides functions to run the Gauss-Dantzig selector on screening experiments when interactions may be affecting the response. Currently, all functions require each factor to be at two levels coded as +1 and -1.

Fits unimodal and multimodal gambin distributions to species-abundance distributions from ecological data, as in in Matthews et al. (2014) <DOI:10.1111/ecog.00861>. gambin is short for gamma-binomial'. The main function is fit_abundances(), which estimates the alpha parameter(s) of the gambin distribution using maximum likelihood. Functions are also provided to generate the gambin distribution and for calculating likelihood statistics.

An implementation of the modelling and reporting features described in reference textbook and guidelines (Briggs, Andrew, et al. Decision Modelling for Health Economic Evaluation. Oxford Univ. Press, 2011; Siebert, U. et al. State-Transition Modeling. Medical Decision Making 32, 690-700 (2012).): deterministic and probabilistic sensitivity analysis, heterogeneity analysis, time dependency on state-time and model-time (semi-Markov and non-homogeneous Markov models), etc.

An easy way to work with census, survey, and geographic data provided by IPUMS in R. Generate and download data through the IPUMS API and load IPUMS files into R with their associated metadata to make analysis easier. IPUMS data describing 1.4 billion individuals drawn from over 750 censuses and surveys is available free of charge from the IPUMS website <https://www.ipums.org>.

Vector operations between grapes: An infix-only package! The invctr functions perform common and less common operations on vectors, data frames matrices and list objects: - Extracting a value (range), or, finding the indices of a value (range). - Trimming, or padding a vector with a value of your choice. - Simple polynomial regression. - Set and membership operations. - General check & replace function for NAs, Inf and other values.

This package implements penalised multivariate regression (i.e., for multiple outcomes and many features) by stacked generalisation (<doi:10.1093/bioinformatics/btab576>). For positively correlated outcomes, a single multivariate regression is typically more predictive than multiple univariate regressions. Includes functions for model fitting, extracting coefficients, outcome prediction, and performance measurement. For optional comparisons, install remMap from GitHub (<https://github.com/cran/remMap>).

An R code with a GUI for microclimate time series, with an emphasis on underground environments. KarsTS provides linear and nonlinear methods, including recurrence analysis (Marwan et al. (2007) <doi:10.1016/j.physrep.2006.11.001>) and filling methods (Moffat et al. (2007) <doi:10.1016/j.agrformet.2007.08.011>), as well as tools to manipulate easily time series and gap sets.

This package provides extensions for packages leaflet & mapdeck', many of which are used by package mapview'. Focus is on functionality readily available in Geographic Information Systems such as Quantum GIS'. Includes functions to display coordinates of mouse pointer position, query image values via mouse pointer and zoom-to-layer buttons. Additionally, provides a feature type agnostic function to add points, lines, polygons to a map.

Import bathymetric and hypsometric data from the NOAA (National Oceanic and Atmospheric Administration, <https://www.ncei.noaa.gov/products/etopo-global-relief-model>), GEBCO (General Bathymetric Chart of the Oceans, <https://www.gebco.net>) and other sources, plot xyz data to prepare publication-ready figures, analyze xyz data to extract transects, get depth / altitude based on geographical coordinates, or calculate z-constrained least-cost paths.

Extends the mlr3 package with a backend to transparently work with databases such as SQLite', DuckDB', MySQL', MariaDB', or PostgreSQL'. The package provides three additional backends: DataBackendDplyr relies on the abstraction of package dbplyr to interact with most DBMS. DataBackendDuckDB operates on DuckDB data bases and also on Apache Parquet files. DataBackendPolars operates on Polars data frames.

Robust nonparametric bootstrap and permutation tests for location, correlation, and regression problems, as described in Helwig (2019a) <doi:10.1002/wics.1457> and Helwig (2019b) <doi:10.1016/j.neuroimage.2019.116030>. Univariate and multivariate tests are supported. For each problem, exact tests and Monte Carlo approximations are available. Five different nonparametric bootstrap confidence intervals are implemented. Parallel computing is implemented via the parallel package.

The QRI_func() function performs quantile regression analysis using age and sex as predictors to calculate the Quantile Regression Index (QRI) score for each individualâ s regional brain imaging metrics and then averages across the regional scores to generate an average tissue specific score for each subject. The QRI_plot() is used to plot QRI and generate the normative curves for individual measurements.

Predicts the occurrence times (in day-of-year) of spring phenological events. Three methods, including the accumulated degree days (ADD) method, the accumulated days transferred to a standardized temperature (ADTS) method, and the accumulated developmental progress (ADP) method, were used. See Shi et al. (2017a) <doi:10.1016/j.agrformet.2017.04.001> and Shi et al. (2017b) <doi:10.1093/aesa/sax063> for details.

This package provides models to identify bimodally expressed genes from RNAseq data based on the Bimodality Index. SIBERG models the RNAseq data in the finite mixture modeling framework and incorporates mechanisms for dealing with RNAseq normalization. Three types of mixture models are implemented, namely, the mixture of log normal, negative binomial, or generalized Poisson distribution. See Tong et al. (2013) <doi:10.1093/bioinformatics/bts713>.

Estimate vaccine efficacy (VE) using immunogenicity data. The inclusion of immunogenicity data in regression models can increase precision in VE. The methods are described in the publications "Elucidating vaccine efficacy using a correlate of protection, demographics, and logistic regression" and "Improving precision of vaccine efficacy evaluation using immune correlate data in time-to-event models" by Julie Dudasova, Zdenek Valenta, and Jeffrey R. Sachs (2024).