Multicenter randomized trials involve the collection and analysis of data from numerous study participants across multiple sites. Outliers may be present. To identify outliers, this package examines data at the individual level (univariate and multivariate) and site-level (with and without covariate adjustment). Methods are outlined in further detail in Rigdon et al (to appear).

This package provides a new class of Bayesian meta-analysis models that incorporates a model for internal and external validity bias. In this way, it is possible to combine studies of diverse quality and different types. For example, we can combine the results of randomized control trials (RCTs) with the results of observational studies (OS).

Estimates the directed Kullback-Leibler divergence between two bivariate continuous distributions by numerical integration of kernel density estimates. Also computes pairwise divergences among groups and exact divergences for discrete, bivariate normal, bivariate Pareto type II, and independent bivariate Weibull models. The kernel estimator follows Chackochan, Sankaran and Nair (2026) <doi:10.1080/03610926.2025.2496687>.

Categorize links and nodes from multiple networks in 3 categories: Common links (alpha) specific links (gamma), and different links (beta). Also categorizes the links into sub-categories and groups. The package includes a visualization tool for the networks. More information about the methodology can be found at: Gysi et. al., 2018 <arXiv:1802.00828>.

An implementation of the probability mass function, cumulative density function, quantile function, random number generator, maximum likelihood estimator, and p-value generator from a conditional hypergeometric distribution: the distribution of how many items are in the overlap of all samples when samples of arbitrary size are each taken without replacement from populations of arbitrary size.

This package provides functions for visualizing, animating, solving and analyzing the Rubik's cube. Includes data structures for solvable and unsolvable cubes, random moves and random state scrambles and cubes, 3D displays and animations using OpenGL', patterned cube generation, and lightweight solvers. See Rokicki, T. (2008) <arXiv:0803.3435> for the Kociemba solver.

This package provides a deep neural network model with a monotonic increasing single index function tailored for periodontal disease studies. The residuals are assumed to follow a skewed T distribution, a skewed normal distribution, or a normal distribution. More details can be found at Liu, Wang, Bai and Bandyopadhyay (2026) <doi:10.1093/biostatistics/kxag040>.

Create D3 based SVG ('Scalable Vector Graphics') graphics using a simple R API. The package aims to simplify the creation of many SVG plot types using a straightforward R API. The package relies on the r2d3 R package and the D3 JavaScript library. See <https://rstudio.github.io/r2d3/> and <https://d3js.org/> respectively.

This package provides simple functions to create constraints for small test assembly problems (e.g. van der Linden (2005, ISBN: 978-0-387-29054-6)) using sparse matrices. Currently, GLPK', lpSolve', Symphony', and Gurobi are supported as solvers. The gurobi package is not available from any mainstream repository; see <https://www.gurobi.com/downloads/>.

This package provides efficient methods to compute local and genome wide genetic distances (corresponding to the so called Hudson Fst parameters) through moment method, perform chromosome segmentation into homogeneous Fst genomic regions, and selection sweep detection for multi-population comparison. When multiple profile segmentation is required, the procedure can be parallelized using the future package.

This package provides a set of methods to simulate from and fit computational models of attentional selectivity. The package implements the dual-stage two-phase (DSTP) model of Hübner et al. (2010) <doi:10.1037/a0019471>, and the shrinking spotlight (SSP) model of White et al. (2011) <doi:10.1016/j.cogpsych.2011.08.001>.

Generates efficient designs for discrete choice experiments based on the multinomial logit model, and individually adapted designs for the mixed multinomial logit model. The generated designs can be presented on screen and choice data can be gathered using a shiny application. Traets F, Sanchez G, and Vandebroek M (2020) <doi:10.18637/jss.v096.i03>.

Calculates various intraclass correlation coefficients used to quantify inter-rater and intra-rater reliability. The assumption here is that the raters produced quantitative ratings. Most of the statistical procedures implemented in this package are described in details in Gwet, K.L. (2014, ISBN:978-0970806284): "Handbook of Inter-Rater Reliability," 4th edition, Advanced Analytics, LLC.

This package provides a new class of Bayesian meta-analysis models that incorporates a model for internal and external validity bias. In this way, it is possible to combine studies of diverse quality and different types. For example, we can combine the results of randomized control trials (RCTs) with the results of observational studies (OS).

This package provides a self-guided, weakly supervised learning algorithm for feature extraction from noisy and high-dimensional data. It facilitates the identification of patterns that reflect underlying group structures across all samples in a dataset. The method incorporates a novel strategy to integrate spatial information, improving the clarity of results in spatially resolved data.

This package provides functions for validating and normalizing bibliographic codes such as ISBN, ISSN, and LCCN. Also includes functions to communicate with the WorldCat API, translate Call numbers (Library of Congress and Dewey Decimal) to their subject classifications or subclassifications, and provides various loadable data files such call number / subject crosswalks and code tables.

Compute lifetime attributable risk of radiation-induced cancer reveals that it can be helpful with enhancement of the flexibility in research with fast calculation and various options. Important reference papers include Berrington de Gonzalez et al. (2012) <doi:10.1088/0952-4746/32/3/205>, National Research Council (2006, ISBN:978-0-309-09156-5).

Package for estimating the parameters of a nonlinear function using iterated linearization via Taylor series. Method is based on KubÃ¡Ä ek (2000) ISBN: 80-244-0093-6. The algorithm is a generalization of the procedure given in Köning, R., Wimmer, G. and Witkovský, V. (2014) <doi:10.1088/0957-0233/25/11/115001>.

The main goal of the psycho package is to provide tools for psychologists, neuropsychologists and neuroscientists, to facilitate and speed up the time spent on data analysis. It aims at supporting best practices and tools to format the output of statistical methods to directly paste them into a manuscript, ensuring statistical reporting standardization and conformity.

To Simplify the time consuming and error prone task of assembling complex data sets for non-linear mixed effects modeling. Users are able to select from different absorption processes such as zero and first order, or a combination of both. Furthermore, data sets containing data from several entities, responses, and covariates can be simultaneously assembled.

Model selection for penalized graphical models using the Stability Approach to Regularization Selection ('StARS'), with options for speed-ups including Bounded StARS (B-StARS), batch computing, and other stability metrics (e.g., graphlet stability G-StARS). Christian L. Müller, Richard Bonneau, Zachary Kurtz (2016) <doi:10.48550/arXiv.1605.07072>.

This package provides a system that provides a streamlined way of generating publication ready plots for known Single-Cell transcriptomics data in a â publication readyâ format. This is, the goal is to automatically generate plots with the highest quality possible, that can be used right away or with minimal modifications for a research article.

This package provides a meta-package that loads the complete sitrep ecosystem for applied epidemiology analysis. This package provides report templates and automatically loads companion packages, including epitabulate (for epidemiological tables), epidict (for data dictionaries), epikit (for epidemiological utilities), and apyramid (for age-sex pyramids). Simply load sitrep to access all functions from the ecosystem.

To ease the visualization of outputs from Diversity Motif Analyser ('DiMA'; <https://github.com/BVU-BILSAB/DiMA>). vDiveR allows visualization of the diversity motifs (index and its variants â major, minor and unique) for elucidation of the underlying inherent dynamics. Please refer <https://vdiver-manual.readthedocs.io/en/latest/> for more information.