This package provides a complete toolset for methylome-wide association studies (MWAS). It is specifically designed for data from enrichment based methylation assays, but can be applied to other data as well. The analysis pipeline includes seven steps: (1) scanning aligned reads from BAM files, (2) calculation of quality control measures, (3) creation of methylation score (coverage) matrix, (4) principal component analysis for capturing batch effects and detection of outliers, (5) association analysis with respect to phenotypes of interest while correcting for top PCs and known covariates, (6) annotation of significant findings, and (7) multi-marker analysis (methylation risk score) using elastic net. Additionally, RaMWAS include tools for joint analysis of methlyation and genotype data. This work is published in Bioinformatics, Shabalin et al. (2018) <doi:10.1093/bioinformatics/bty069>.

The Resource Description Framework, or RDF is a widely used data representation model that forms the cornerstone of the Semantic Web. RDF represents data as a graph rather than the familiar data table or rectangle of relational databases. The rdflib package provides a friendly and concise user interface for performing common tasks on RDF data, such as reading, writing and converting between the various serializations of RDF data, including rdfxml', turtle', nquads', ntriples', and json-ld'; creating new RDF graphs, and performing graph queries using SPARQL'. This package wraps the low level redland R package which provides direct bindings to the redland C library. Additionally, the package supports the newer and more developer friendly JSON-LD format through the jsonld package. The package interface takes inspiration from the Python rdflib library.

Facilities for running simulations from ordinary differential equation ('ODE') models, such as pharmacometrics and other compartmental models. A compilation manager translates the ODE model into C, compiles it, and dynamically loads the object code into R for improved computational efficiency. An event table object facilitates the specification of complex dosing regimens (optional) and sampling schedules. NB: The use of this package requires both C and Fortran compilers, for details on their use with R please see Section 6.3, Appendix A, and Appendix D in the "R Administration and Installation" manual. Also the code is mostly released under GPL. The VODE and LSODA are in the public domain. The vendored SUNDIALS CVODE sources and headers are released under the BSD-3-Clause license. The information is available in the inst/COPYRIGHTS.

Data exploration and prediction with focus on high dimensional data and chemometrics. The package was initially designed about partial least squares regression and discrimination models and variants, in particular locally weighted PLS models (LWPLS). Then, it has been expanded to many other methods for analyzing high dimensional data. The name rchemo comes from the fact that the package is orientated to chemometrics, but most of the provided methods are fully generic to other domains. Functions such as transform(), predict(), coef() and summary() are available. Tuning the predictive models is facilitated by generic functions gridscore() (validation dataset) and gridcv() (cross-validation). Faster versions are also available for models based on latent variables (LVs) (gridscorelv() and gridcvlv()) and ridge regularization (gridscorelb() and gridcvlb()).

SCUDO (Signature-based Clustering for Diagnostic Purposes) is a rank-based method for the analysis of gene expression profiles for diagnostic and classification purposes. It is based on the identification of sample-specific gene signatures composed of the most up- and down-regulated genes for that sample. Starting from gene expression data, functions in this package identify sample-specific gene signatures and use them to build a graph of samples. In this graph samples are joined by edges if they have a similar expression profile, according to a pre-computed similarity matrix. The similarity between the expression profiles of two samples is computed using a method similar to GSEA. The graph of samples can then be used to perform community clustering or to perform supervised classification of samples in a testing set.

This is an R package to make it easier to import and store phylogenetic trees with associated data; and to link external data from different sources to phylogeny. It also supports exporting phylogenetic trees with heterogeneous associated data to a single tree file and can be served as a platform for merging tree with associated data and converting file formats.

The R package ggplot2 is a plotting system based on the grammar of graphics. GGally extends ggplot2 by adding several functions to reduce the complexity of combining geometric objects with transformed data. Some of these functions include a pairwise plot matrix, a two group pairwise plot matrix, a parallel coordinates plot, a survival plot, and several functions to plot networks.

This package is a flexible and comprehensive R toolbox for model-based optimization. It implements Efficient Global Optimization Algorithm for single- and multi-objective optimization. It supports mixed parameters. The machine learning toolbox mlr offers regression learners. It provides various infill criteria and features batch proposal, parallel execution, visualization, and logging. Its modular implementation allows easy customization by the user.

MEDIPS was developed for analyzing data derived from methylated DNA immunoprecipitation (MeDIP) experiments followed by sequencing (MeDIP-seq). However, MEDIPS provides functionalities for the analysis of any kind of quantitative sequencing data (e.g. ChIP-seq, MBD-seq, CMS-seq and others) including calculation of differential coverage between groups of samples and saturation and correlation analysis.

Specification, review, and scaffolding helpers for AI agent systems. The package standardizes workflow, memory, knowledge, interface, proposal, and review artifacts so humans and coding assistants can infer, inspect, revise, and hand off task designs. It intentionally excludes communication layers, provider-specific model client code, and full runtime execution engines so that design artifacts and implementation transport remain cleanly separated.

This package contains tools for working with data during statistical analysis, promoting flexible, intuitive, and reproducible workflows. There are functions designated for specific statistical tasks such building a custom univariate descriptive table, computing pairwise association statistics, etc. These are built on a collection of data manipulation tools designed for general use that are motivated by the functional programming concept.

Combines multiple functions that automate and simplify methods commonly employed in cross-cultural psychology, providing a unified analysis approach for measurement invariance testing, effect sizes for differential item functioning, factor congruence and multi-group reliability. Methods follow Fischer and Karl (2019) <doi:10.3389/fpsyg.2019.01507> and Gunn, Grimm and Edwards (2020) <doi:10.1080/10705511.2019.1689507>.

This package provides tools for modeling time-to-event data with a cure fraction under correlated destructive negative binomial cure rate models. The models assume multiple latent competing causes with possible dependence and allow for elimination (inactivation) of some initial causes. Estimation is performed via an Expectation-Maximization algorithm, and diagnostic tools based on Cox-Snell residuals are provided.

Interact with Condor from R via SSH connection. Files are first uploaded from user machine to submitter machine, and the job is then submitted from the submitter machine to Condor'. Functions are provided to submit, list, and download Condor jobs from R. Condor is an open source high-throughput computing software framework for distributed parallelization of computationally intensive tasks.

This package implements a kernel-based association test for copy number variation (CNV) aggregate analysis in a certain genomic region (e.g., gene set, chromosome, or genome) that is robust to the within-locus and across-locus etiological heterogeneity, and bypass the need to define a "locus" unit for CNVs. Brucker, A., et al. (2020) <doi:10.1101/666875>.

This package provides utility functions for standardizing economic entity (economy, aggregate, institution, etc.) name and id in economic datasets such as those published by the International Monetary Fund and World Bank. Aims to facilitate consistent data analysis, reporting, and joining across datasets. Used as a foundational building block in the EconDataverse family of packages (<https://www.econdataverse.org>).

This Rcpp'-based package implements highly efficient functions for the calculation of the Jonckheere-Terpstra statistic. It can be used for a variety of applications, including feature selection in machine learning problems, or to conduct genome-wide association studies (GWAS) with multiple quantitative phenotypes. The code leverages OpenMP directives for multi-core computing to reduce overall processing time.

This package contains functions for operations with fuzzy cognitive maps using t-norm and s-norm operators. T-norms and S-norms are described by Dov M. Gabbay and George Metcalfe (2007) <doi:10.1007/s00153-007-0047-1>. System indicators are described by Cox, Earl D. (1995) <isbn:1886801010>. Executable examples are provided in the "inst/examples" folder.

After being given the location of your students submissions and a test file, the function runs each file that is an R script, R Markdown file, or Quarto document, and evaluates the results from all the given tests. Results are neatly returned in a data frame that has a row for each student, and a column for each test.

Extends the capabilities of ggplot2 by providing grammatical elements and plot helpers designed for visualizing temporal patterns. The package implements a grammar of temporal graphics, which leverages calendar structures to highlight changes over time. The package also provides plot helper functions to quickly produce commonly used time series graphics, including time plots, season plots, and seasonal sub-series plots.

An RStudio Addin for Hippie Expand (AKA Hippie Code Completion or Cyclic Expand Word). This type of completion searches for matching tokens within the user's current source editor file, regardless of file type. By searching only within the current source file, hippie offers a fast way to identify and insert completions that appear around the user's cursor.

The goal of HAMMER is to provide factor analytic representation learning and associated determinacy metrics for very-high-dimensional data. It projects high-dimensional data onto low-dimensional generative latent sources and assesses the uncertainty in the projection. The projection is distribution-free, scale-equivariant, and efficient. For details, see Peeters (2026) <doi:10.48550/arXiv.2606.28854>.

This package provides a set of streamlined functions that allow easy generation of linear regression diagnostic plots necessarily for checking linear model assumptions. This package is meant for easy scheming of linear regression diagnostics, while preserving merits of "The Grammar of Graphics" as implemented in ggplot2'. See the ggplot2 website for more information regarding the specific capability of graphics.

Analyses species distribution models and evaluates their performance. It includes functions for variation partitioning, extracting variable importance, computing several metrics of model discrimination and calibration performance, optimizing prediction thresholds based on a number of criteria, performing multivariate environmental similarity surface (MESS) analysis, and displaying various analytical plots. Initially described in Barbosa et al. (2013) <doi:10.1111/ddi.12100>.