Use behavioural variables to score activity and infer sleep from bouts of immobility. It is primarily designed to score sleep in fruit flies from Drosophila Activity Monitor (TriKinetics) and Ethoscope data. It implements sleep scoring using the "five-minute rule" (Hendricks et al. (2000) <DOI:10.1016/S0896-6273(00)80877-6>), activity classification for Ethoscopes (Geissmann et al. (2017) <DOI:10.1371/journal.pbio.2003026>) and a new algorithm to detect when animals are dead.

Efficient R package for latent class analysis of recurrent events, based on the semiparametric multiplicative intensity model by Zhao et al. (2022) <doi:10.1111/rssb.12499>. SLCARE returns estimates for non-functional model parameters along with the associated variance estimates and p-values. Visualization tools are provided to depict the estimated functional model parameters and related functional quantities of interest. SLCARE also delivers a model checking plot to help assess the adequacy of the fitted model.

This package provides a variational mapping approach that reveals and expands future temporal dynamics from folded high-dimensional geometric distance spaces, unfold turns a set of time series into a 4D block of pairwise distances between reframed windows, learns a variational mapper that maps those distances to the next reframed window, and produces horizon-wise predictive functions for each input series. In short: it unfolds the future path of each series from a folded geometric distance representation.

Calculates the minimal sample size for the Wilcoxon-Mann-Whitney test that is needed for a given power and two sided type I error rate. The method works for metric data with and without ties, count data, ordered categorical data, and even dichotomous data. But data is needed for the reference group to generate synthetic data for the treatment group based on a relevant effect. See Happ et al. (2019, <doi:10.1002/sim.7983>) for details.

This package is an R implementation for fully unsupervised deconvolution of complex tissues. DebCAM provides basic functions to perform unsupervised deconvolution on mixture expression profiles by CAM and some auxiliary functions to help understand the subpopulation- specific results. It also implements functions to perform supervised deconvolution based on prior knowledge of molecular markers, S matrix or A matrix. Combining molecular markers from CAM and from prior knowledge can achieve semi-supervised deconvolution of mixtures.

This package provides functions, data sets, analyses and examples from the third edition of the book A Handbook of Statistical Analyses Using R (Torsten Hothorn and Brian S. Everitt, Chapman & Hall/CRC, 2014). The first chapter of the book, which is entitled An Introduction to R, is completely included in this package, for all other chapters, a vignette containing all data analyses is available. In addition, Sweave source code for slides of selected chapters is included in this package.

An R package for integrated differential expression and differential network analysis based on omic data for cancer biomarker discovery. Both correlation and partial correlation can be used to generate differential network to aid the traditional differential expression analysis to identify changes between biomolecules on both their expression and pairwise association levels. A detailed description of the methodology has been published in Methods journal (PMID: 27592383). An interactive visualization feature allows for the exploration and selection of candidate biomarkers.

This packages provides C++ header files for developers wishing to create R packages that processes BAM files. ompBAM automates file access, memory management, and handling of multiple threads behind the scenes', so developers can focus on creating domain-specific functionality. The included vignette contains detailed documentation of this API, including quick-start instructions to create a new ompBAM-based package, and step-by-step explanation of the functionality behind the example packaged included within ompBAM.

Flexible parametric Accelerated Hazards (AH) regression models in overall and relative survival frameworks with 13 distinct Baseline Distributions. The AH Model can also be applied to lifetime data with crossed survival curves. Any user-defined parametric distribution can be fitted, given at least an R function defining the cumulative hazard and hazard rate functions. See Chen and Wang (2000) <doi:10.1080/01621459.2000.10474236>, and Lee (2015) <doi:10.1007/s10985-015-9349-5> for more details.

This package provides simplified access to the data from the Catalog of Theses and Dissertations of the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES, <https://catalogodeteses.capes.gov.br>) for the years 1987 through 2022. The dataset includes variables such as Higher Education Institution (institution), Area of Concentration (area), Graduate Program Name (program_name), Type of Work (type), Language of Work (language), Author Identification (author), Abstract (abstract), Advisor Identification (advisor), Development Region (region), State (state).

This package provides a non-drawing graphic device for benchmarking purpose. In order to properly benchmark graphic drawing code it is necessary to factor out the device implementation itself so that results are not related to the specific graphics device used during benchmarking. The devoid package implements a graphic device that accepts all the required calls from R's graphic engine but performs no action. Apart from benchmarking it is unlikely that this device has any practical use.

This package provides a Bayesian clustering method for replicated time series or replicated measurements from multiple experimental conditions, e.g., time-course gene expression data. It estimates the number of clusters directly from the data using a Dirichlet-process prior. See Fu, A. Q., Russell, S., Bray, S. and Tavare, S. (2013) Bayesian clustering of replicated time-course gene expression data with weak signals. The Annals of Applied Statistics. 7(3) 1334-1361. <doi:10.1214/13-AOAS650>.

Empirical Bayes ranking applicable to parallel-estimation settings where the estimated parameters are asymptotically unbiased and normal, with known standard errors. A mixture normal prior for each parameter is estimated using Empirical Bayes methods, subsequentially ranks for each parameter are simulated from the resulting joint posterior over all parameters (The marginal posterior densities for each parameter are assumed independent). Finally, experiments are ordered by expected posterior rank, although computations minimizing other plausible rank-loss functions are also given.

Allows to calculate the probabilities of occurrences of an event in a great number of repetitions of Bernoulli experiment, through the application of the local and the integral theorem of De Moivre Laplace, and the theorem of Poisson. Gives the possibility to show the results graphically and analytically, and to compare the results obtained by the application of the above theorems with those calculated by the direct application of the Binomial formula. Is basically useful for educational purposes.

This package provides a population genetic simulator, which is able to generate synthetic datasets for single-nucleotide polymorphisms (SNP) for multiple populations. The genetic distances among populations can be set according to the Fixation Index (Fst) as explained in Balding and Nichols (1995) <doi:10.1007/BF01441146>. This tool is able to simulate outlying individuals and missing SNPs can be specified. For Genome-wide association study (GWAS), disease status can be set in desired level according risk ratio.

Quantitative genetics tool supporting the modelling of multivariate genetic variance structures in quantitative data. It allows fitting different models through multivariate genetic-relationship-matrix (GRM) structural equation modelling (SEM) in unrelated individuals, using a maximum likelihood approach. Specifically, it combines genome-wide genotyping information, as captured by GRMs, with twin-research-based SEM techniques, St Pourcain et al. (2017) <doi:10.1016/j.biopsych.2017.09.020>, Shapland et al. (2020) <doi:10.1101/2020.08.14.251199>.

Functions, data sets, analyses and examples from the second edition of the book A Handbook of Statistical Analyses Using R (Brian S. Everitt and Torsten Hothorn, Chapman & Hall/CRC, 2008). The first chapter of the book, which is entitled An Introduction to R'', is completely included in this package, for all other chapters, a vignette containing all data analyses is available. In addition, the package contains Sweave code for producing slides for selected chapters (see HSAUR2/inst/slides).

Linear and logistic regression models penalized with hierarchical shrinkage priors for selection of biomarkers (or more general variable selection), which can be fitted using Stan (Carpenter et al. (2017) <doi:10.18637/jss.v076.i01>). It implements the horseshoe and regularized horseshoe priors (Piironen and Vehtari (2017) <doi:10.1214/17-EJS1337SI>), as well as the projection predictive selection approach to recover a sparse set of predictive biomarkers (Piironen, Paasiniemi and Vehtari (2020) <doi:10.1214/20-EJS1711>).

Short for linear binning', the linbin package provides functions for manipulating, binning, and plotting linearly referenced data. Although developed for data collected on river networks, it can be used with any interval or point data referenced to a 1-dimensional coordinate system. Flexible bin generation and batch processing makes it easy to compute and visualize variables at multiple scales, useful for identifying patterns within and between variables and investigating the influence of scale of observation on data interpretation.

The main function, plot_mm(), is used for (gg)plotting output from mixture models, including both densities and overlaying mixture weight component curves from the fit models in line with the tidy principles. The package includes several additional functions for added plot customization. Supported model objects include: mixtools', EMCluster', and flexmix', with more from each in active dev. Supported mixture model specifications include mixtures of univariate Gaussians, multivariate Gaussians, Gammas, logistic regressions, linear regressions, and Poisson regressions.

Kataegis is a localized hypermutation occurring when a region is enriched in somatic SNVs. Kataegis can result from multiple cytosine deaminations catalyzed by the AID/APOBEC family of proteins. This package contains functions to detect kataegis from SNVs in BED format. This package reports two scores per kataegic event, a hypermutation score and an APOBEC mediated kataegic score. Yousif, F. et al.; The Origins and Consequences of Localized and Global Somatic Hypermutation; Biorxiv 2018 <doi:10.1101/287839>.

An implementation of a phylogenetic comparative method. It can fit univariate among-species Ornstein-Uhlenbeck models of phenotypic trait evolution, where the trait evolves towards a primary optimum. The optimum can be modelled as a single parameter, as multiple discrete regimes on the phylogenetic tree, and/or with continuous covariates. See also Hansen (1997) <doi:10.2307/2411186>, Butler & King (2004) <doi:10.1086/426002>, Hansen et al. (2008) <doi:10.1111/j.1558-5646.2008.00412.x>.

Generates region-specific Suess and Laws corrections for stable carbon isotope data from marine organisms collected between 1850 and 2023. Version 0.1.6 of SuessR contains four built-in regions: the Bering Sea ('Bering Sea'), the Aleutian archipelago ('Aleutian Islands'), the Gulf of Alaska ('Gulf of Alaska'), and the subpolar North Atlantic ('Subpolar North Atlantic'). Users can supply their own environmental data for regions currently not built into the package to generate corrections for those regions.

Converts coefficients, standard errors, significance stars, and goodness-of-fit statistics of statistical models into LaTeX tables or HTML tables/MS Word documents or to nicely formatted screen output for the R console for easy model comparison. A list of several models can be combined in a single table. The output is highly customizable. New model types can be easily implemented. Details can be found in Leifeld (2013), JStatSoft <doi:10.18637/jss.v055.i08>.).