The functions in this package inspect, read, edit and run files for APSIM "Next Generation" ('JSON') and APSIM "Classic" ('XML'). The files with an apsim extension correspond to APSIM Classic (7.x) - Windows only - and the ones with an apsimx extension correspond to APSIM "Next Generation". For more information about APSIM see (<https://www.apsim.info/>) and for APSIM next generation (<https://apsimnextgeneration.netlify.app/>).

An implementation of intervention effect estimation for DAGs (directed acyclic graphs) learned from binary or continuous data. First, parameters are estimated or sampled for the DAG and then interventions on each node (variable) are propagated through the network (do-calculus). Both exact computation (for continuous data or for binary data up to around 20 variables) and Monte Carlo schemes (for larger binary networks) are implemented.

Semi-relaxed inverse optimal transport (IOT) for single-cell state-transition and pseudotime analysis: a self-contained R solver (Anderson-accelerated soft Sinkhorn with exact implicit gradients), feature-weight fitting with a two-stage bias-corrected refit and multi-restart, state transition matrices, random-walk pseudotime, ggplot2 visualisation, soft-gated Seurat and SingleCellExperiment interfaces, reproducible simulated demo data, and bulk-cohort pathway scoring utilities.

Income tax calculations for England, Northern Ireland and Wales. Estimate annual income tax within the different taxation bands at specified levels of both taxable income and the Personal Allowance, emulating the results obtained at <https://www.gov.uk/estimate-income-tax>. Calculate the standard Personal Allowance at various levels of taxable income. Estimate the personal allowance required to recoup a specified amount of income tax.

Fits unimodal and multimodal gambin distributions to species-abundance distributions from ecological data, as in in Matthews et al. (2014) <DOI:10.1111/ecog.00861>. gambin is short for gamma-binomial'. The main function is fit_abundances(), which estimates the alpha parameter(s) of the gambin distribution using maximum likelihood. Functions are also provided to generate the gambin distribution and for calculating likelihood statistics.

Computes G-Wishart normalising constants through a Fourier approach. Either exact analytical results, numerical integration or Monte Carlo estimation are employed. Details at C. Wong, G. Moffa and J. Kuipers (2024), <doi:10.48550/arXiv.2404.06803>. Also includes approximations of the ratio of normalising constants, see details at C. Wong, G. Moffa and J. Kuipers (2025), <doi:10.48550/arXiv.2503.13046>.

The method aims to identify important factors in screening experiments by aggregation over random models as studied in Singh and Stufken (2022) <doi:10.48550/arXiv.2205.13497>. This package provides functions to run the Gauss-Dantzig selector on screening experiments when interactions may be affecting the response. Currently, all functions require each factor to be at two levels coded as +1 and -1.

An implementation of the modelling and reporting features described in reference textbook and guidelines (Briggs, Andrew, et al. Decision Modelling for Health Economic Evaluation. Oxford Univ. Press, 2011; Siebert, U. et al. State-Transition Modeling. Medical Decision Making 32, 690-700 (2012).): deterministic and probabilistic sensitivity analysis, heterogeneity analysis, time dependency on state-time and model-time (semi-Markov and non-homogeneous Markov models), etc.

Vector operations between grapes: An infix-only package! The invctr functions perform common and less common operations on vectors, data frames matrices and list objects: - Extracting a value (range), or, finding the indices of a value (range). - Trimming, or padding a vector with a value of your choice. - Simple polynomial regression. - Set and membership operations. - General check & replace function for NAs, Inf and other values.

An easy way to work with census, survey, and geographic data provided by IPUMS in R. Generate and download data through the IPUMS API and load IPUMS files into R with their associated metadata to make analysis easier. IPUMS data describing 1.4 billion individuals drawn from over 750 censuses and surveys is available free of charge from the IPUMS website <https://www.ipums.org>.

Interact with the Entrez API hosted by the National Center for Biotechnology Information (NCBI), <https://www.ncbi.nlm.nih.gov/books/NBK25499/>. This package is focused on working with sequence metadata and links. It handles pagination and compensates for some API limitations to simplify these tasks. API calls are printed to the console to highlight how high-level queries are translated into individual HTTP requests.

This package implements penalised multivariate regression (i.e., for multiple outcomes and many features) by stacked generalisation (<doi:10.1093/bioinformatics/btab576>). For positively correlated outcomes, a single multivariate regression is typically more predictive than multiple univariate regressions. Includes functions for model fitting, extracting coefficients, outcome prediction, and performance measurement. For optional comparisons, install remMap from GitHub (<https://github.com/cran/remMap>).

An R code with a GUI for microclimate time series, with an emphasis on underground environments. KarsTS provides linear and nonlinear methods, including recurrence analysis (Marwan et al. (2007) <doi:10.1016/j.physrep.2006.11.001>) and filling methods (Moffat et al. (2007) <doi:10.1016/j.agrformet.2007.08.011>), as well as tools to manipulate easily time series and gap sets.

This package provides extensions for packages leaflet & mapdeck', many of which are used by package mapview'. Focus is on functionality readily available in Geographic Information Systems such as Quantum GIS'. Includes functions to display coordinates of mouse pointer position, query image values via mouse pointer and zoom-to-layer buttons. Additionally, provides a feature type agnostic function to add points, lines, polygons to a map.

Evaluates and fits the Linear Time-Variant Logistic Model with Shape Parameter (LTVLMS) for dynamic growth processes. The model combines a linearly time-varying growth rate with a shape parameter for asymmetric trajectories and includes numerically stable prediction utilities. Methodological details are provided by Betrouni and Kernane (2026) "Linear Time-Varying Logistic Model With Shape Parameter for Dynamic Epidemic Modeling" <doi:10.1155/jama/4928447>.

Extends the mlr3 package with a backend to transparently work with databases such as SQLite', DuckDB', MySQL', MariaDB', or PostgreSQL'. The package provides three additional backends: DataBackendDplyr relies on the abstraction of package dbplyr to interact with most DBMS. DataBackendDuckDB operates on DuckDB data bases and also on Apache Parquet files. DataBackendPolars operates on Polars data frames.

Import bathymetric and hypsometric data from the NOAA (National Oceanic and Atmospheric Administration, <https://www.ncei.noaa.gov/products/etopo-global-relief-model>), GEBCO (General Bathymetric Chart of the Oceans, <https://www.gebco.net>) and other sources, plot xyz data to prepare publication-ready figures, analyze xyz data to extract transects, get depth / altitude based on geographical coordinates, or calculate z-constrained least-cost paths.

Generates synthetic Our Future Health cohort datasets for method development, including participant, questionnaire, clinic measurements, outpatient, inpatient, emergency, mortality, primary care medication, and geography outputs. Supports reproducible generation with configurable cohort size and user-defined International Classification of Diseases, Tenth Revision (ICD-10), Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 (OPCS-4), and British National Formulary (BNF) code pools.

The QRI_func() function performs quantile regression analysis using age and sex as predictors to calculate the Quantile Regression Index (QRI) score for each individualâ s regional brain imaging metrics and then averages across the regional scores to generate an average tissue specific score for each subject. The QRI_plot() is used to plot QRI and generate the normative curves for individual measurements.

This package provides models to identify bimodally expressed genes from RNAseq data based on the Bimodality Index. SIBERG models the RNAseq data in the finite mixture modeling framework and incorporates mechanisms for dealing with RNAseq normalization. Three types of mixture models are implemented, namely, the mixture of log normal, negative binomial, or generalized Poisson distribution. See Tong et al. (2013) <doi:10.1093/bioinformatics/bts713>.

Predicts the occurrence times (in day-of-year) of spring phenological events. Three methods, including the accumulated degree days (ADD) method, the accumulated days transferred to a standardized temperature (ADTS) method, and the accumulated developmental progress (ADP) method, were used. See Shi et al. (2017a) <doi:10.1016/j.agrformet.2017.04.001> and Shi et al. (2017b) <doi:10.1093/aesa/sax063> for details.

Compute and visualize the Tissot Indicatrix for map projections. The indicatrix characterizes projection distortion by computing scale factors, angular deformation, areal distortion, and convergence at arbitrary points. Based on the calculations shared by Bill Huber on <https://gis.stackexchange.com/a/5075/482>. Uses PROJ for coordinate transformation and distortion factor computation. Developed using the method published in Snyder, JP (1987) <doi:10.3133/pp1395>.

Estimate vaccine efficacy (VE) using immunogenicity data. The inclusion of immunogenicity data in regression models can increase precision in VE. The methods are described in the publications "Elucidating vaccine efficacy using a correlate of protection, demographics, and logistic regression" and "Improving precision of vaccine efficacy evaluation using immune correlate data in time-to-event models" by Julie Dudasova, Zdenek Valenta, and Jeffrey R. Sachs (2024).

Hamiltonian Monte Carlo for both continuous and discontinuous posterior distributions with a customizable trajectory length termination criterion. See Nishimura et al. (2020) <doi:10.1093/biomet/asz083> for the original Discontinuous Hamiltonian Monte Carlo; Hoffman et al. (2014) <doi:10.48550/arXiv.1111.4246> and Betancourt (2016) <doi:10.48550/arXiv.1601.00225> for the definition of possible Hamiltonian Monte Carlo termination criteria.